β 2-glycoprotein I: Antiphospholipid syndrome and T-cell reactivity

Thrombosis Research

Volumn 114, Issue 5-6 SPEC. ISS., 2004, Pages 347-355

  Kuwana, Masataka ^a  

^a KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

2 glycoprotein I; Antiphospholipid syndrome; Autoimmune disease; Autoreactive T cell; Cryptic epitope

Indexed keywords

BETA2 GLYCOPROTEIN 1; CD40 ANTIGEN; CD40 LIGAND; CYTOKINE; IMMUNOGLOBULIN G; INTERLEUKIN 6; PHOSPHOLIPID ANTIBODY; T LYMPHOCYTE RECEPTOR; AUTOANTIBODY; GLYCOPROTEIN; HLA DR ANTIGEN; HLA DR53; HLA-DR53; PEPTIDE;

ANTIBODY PRODUCTION; ANTIBODY RESPONSE; ANTIGEN RECOGNITION; ANTIPHOSPHOLIPID SYNDROME; AUTOIMMUNE DISEASE; B LYMPHOCYTE ACTIVATION; CELL CULTURE; CONFERENCE PAPER; HELPER CELL; HUMAN; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; IMMUNOREACTIVITY; LYMPHOCYTE FUNCTION; MONONUCLEAR CELL; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; T LYMPHOCYTE ACTIVATION; THROMBOSIS; ANTIGEN PRESENTATION; BINDING SITE; BIOLOGICAL MODEL; BIOSYNTHESIS; CD4+ T LYMPHOCYTE; CHEMISTRY; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROTEIN MOTIF; REVIEW; SYSTEMIC LUPUS ERYTHEMATOSUS;

AMINO ACID MOTIFS; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIGEN PRESENTATION; ANTIGENS, CD40; ANTIPHOSPHOLIPID SYNDROME; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; BINDING SITES; CD4-POSITIVE T-LYMPHOCYTES; CD40 LIGAND; GLYCOPROTEINS; HLA-DR ANTIGENS; HUMANS; INTERLEUKIN-6; LUPUS ERYTHEMATOSUS, SYSTEMIC; MODELS, BIOLOGICAL; PEPTIDES;

EID: 7044285918     PISSN: 00493848     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.thromres.2004.06.029     Document Type: Conference Paper

References (48)

1. J.S. Levine, D.W. Branch, and J. Rauch The antiphospholipid syndrome N. Engl. J. Med. 346 2002 752 763
2. J. Arnout, and J. Vermylen Current status and implications of autoimmune antiphospholipid antibodies in relation to thrombotic disease J. Thromb. Haemost. 1 2003 931 942
3. 2-glycoprotein-I but no antibodies detectable in standard antiphospholipid assays Am. J. Med. 101 1996 472 481
4. W.A. Wilson, A.E. Gharavi, T. Koike, M.D. Lockshin, D.W. Branch, and J.C. Piette International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome Arthritis Rheum. 42 1999 1309 1311
5. 2-glycoprotein I (apolipoprotein H) interactions with phospholipid vesicles Int. J. Biochem. 16 1984 511 515
6. 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulant Blood 81 1993 1255 1262
7. 2- glycoprotein I and induce endothelial activation Arthritis Rheum. 40 1997 551 561
8. 2- glycoprotein I contains a phospholipid binding site (Cys281-Lys288) and a region recognized by anticardiolipin antibodies J. Immunol. 152 1994 653 659
9. 2-glycoprotein I to phospholipids based on its crystal structure EMBO J. 18 1999 5166 5174
10. 2-glycoprotein I is a major protein associated with very rapidly cleared liposomes in vivo, suggesting a significant role in the immune clearance of "non-self" particles J. Biol. Chem. 270 1995 25845 25849
11. 2-glycoprotein I mediates autoantibody-dependent uptake of oxidized low density lipoprotein by macrophages J. Lipid Res. 42 2001 697 709
12. D.W. Branch, D.J. Dudley, M.D. Mitchell, K.A. Creighton, T.M. Abbott, and E.H. Hammond Immunoglobulin G fractions from patients with antiphospholipid antibodies cause fetal death in BALB/c mice: a model for autoimmune fetal loss Am. J. Obstet. Gynecol. 163 1990 210 216
13. M. Blank, J. Cohen, V. Toder, and Y. Shoenfeld Induction of anti-phospholipid syndrome in naive mice with mouse lupus monoclonal and human polyclonal anti-cardiolipin antibodies Proc. Natl. Acad. Sci. U. S. A. 88 1991 3069 3073
14. J.H. Rand Molecular pathogenesis of the antiphospholipid syndrome Circ. Res. 90 2002 29 37
15. S.S. Pierangeli, M. Colden-Stanfield, X. Liu, J.H. Barker, G.L. Anderson, and E.N. Harris Anti-phospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo Circulation 99 1999 1997 2002
16. 2- glycoprotein I: implication as an atherogenic autoantigen J. Lipid Res. 44 2003 716 726
17. 2-glycoprotein I antibodies in patients with systemic lupus erythematosus: relationship with antiphospholipid syndrome J. Rheumatol. 25 1998 675 680
18. Y. Levy, L. Ziporen, B. Gilburd, J. George, S. Polak-Charcon, and H. Amital Membranous nephropathy in primary antiphospholipid syndrome: description of a case and induction of renal injury in SCID mice Hum. Antib. Hybrid. 7 1996 91 96
19. 2- glycoprotein I (apolipoprotein H) J. Clin. Invest. 90 1992 1105 1109
20. 2-glycoprotein I) induces experimental antiphospholipid antibody syndrome in naive mice J. Autoimmun. 7 1994 441 455
21. M. Blank, I. Krause, N. Lanir, P. Vardi, B. Gilburd, and A. Tincani Transfer of experimental antiphospholipid syndrome by bone marrow cell transplantation: the importance of the T cell Arthritis Rheum. 38 1995 115 122
22. 2-glycoprotein I in patients with antiphospholipid syndrome and healthy individuals Arthritis Rheum. 43 2000 65 75
23. 2-glycoprotein I in patients with systemic lupus erythematosus and the antiphospholipid syndrome Rheumatology 41 2002 395 400
24. 2- glycoprotein-1 in patients with the antiphospholipid syndrome J. Immunol. 162 1999 6919 6925
25. 2-glycoprotein-I-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies J. Immunol. 165 2000 2258 2262
26. 2- glycoprotein -I-specific T lymphocytes is associated with thrombosis and fetal loss in patients with antiphospholipid antibodies". The Journal of Immunology 2000; 165:2258-2262 J. Immunol. 169 2002 1135
27. M. Kuwana, T.A. Medsger Jr., and T.M. Wright Highly restricted TCR-αβ usage by autoreactive human T cell clones specific for DNA topoisomerase I: recognition of an immunodominant epitope J. Immunol. 158 1997 485 491
28. M. Kuwana, J. Kaburaki, and Y. Ikeda Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura: role in production of anti-platelet autoantibody J. Clin. Invest. 102 1998 1393 1402
29. 2-glycoprotein I in patients with antiphospholipid syndrome: preferential recognition of the major phospholipid-binding site Blood 98 2001 1889 1896
30. G.D. Sebastiani, M. Galeazzi, G. Morozzi, and R. Marcolongo The immunogenetics of the antiphospholipid syndrome, anticardiolipin antibodies, and lupus anticoagulant Semin. Arthritis Rheum. 25 1996 414 420
31. 2-glycoprotein I antibody-associated autoimmunity Hum. Immunol. 61 2000 366 377
32. H. Kobayashi, T. Kokubo, Y. Abe, K. Sato, S. Kimura, and N. Miyokawa Analysis of anchor residues in a naturally processed HLA-DR53 ligand Immunogenetics 44 1996 366 371
33. A.E. Gharavi, S.S. Pierangeli, M. Colden-Stanfield, X. Liu, R.G. Espinola, and E.N. Harris GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro J. Immunol. 163 1999 2922 2927
34. 2-glycoprotein I in patients with antiphospholipid syndrome Blood 99 2002 2499 2504
35. M. Kuwana, C.A. Feghali, T.A. Medsger Jr., and T.M. Wright Autoreactive T cells to topoisomerase I in monozygotic twins discordant for systemic sclerosis Arthritis Rheum. 44 2001 1654 1659
36. P.V. Lehmann, T. Forsthuber, A. Miller, and E.E. Sercarz Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen Nature 358 1992 155 157
37. E.E. Sercarz, P.V. Lehmann, A. Ametani, G. Benichou, A. Miller, and K. Moudgil Dominance and crypticity of T cell antigenic determinants Annu. Rev. Immunol. 11 1993 729 766
38. A. Lanzavecchia How can cryptic epitopes trigger autoimmunity? J. Exp. Med. 181 1995 1945 1948
39. M.G. Warnock, and J.A. Goodacre Cryptic T-cell epitopes and their role in the pathogenesis of autoimmune diseases Br. J. Rheumatol. 36 1997 1144 1150
40. 2-glycoprotein I induces the production of anti-phospholipid antibodies J. Autoimmun. 15 2000 21 32
41. 2-glycoprotein I bound to apoptotic thymocytes J. Autoimmun. 11 1998 413 424
42. P.D. Simitsek, D.G. Campbell, A. Lanzavecchia, N. Fairweather, and C. Watts Modulation of antigen processing by bound antibodies can boost or suppress class II major histocompatibility complex presentation of different T cell determinants J. Exp. Med. 181 1995 1957 1963
43. G. Zandman-Goddard, M. Blank, and Y. Shoenfeld Antiphospholipid antibodies and infections-drugs R.A. Asherson R. Cervera J.C. Piette Y. Shoenfeld The antiphospholipid syndrome II 2002 Elsevier Amsterdam, The Netherlands 343 360
44. R.A. Asherson, R. Cervera, J.C. Piette, J. Font, J.T. Lie, and A. Burcoglu Catastrophic antiphospholipid syndrome: clinical and laboratory features of 50 patients Medicine 77 1998 195 207
45. M.J. Mamula, S. Fatenejad, and J. Craft B cells process and present lupus autoantigens that initiate autoimmune T cell responses J. Immunol. 152 1994 1453 1461
46. M.J. Mamula, and C.A. Janeway Jr. Do B cells drive the diversification of immune responses? Immunol. Today 14 1993 151 152
47. 2-glycoprotein-I accounts for the infectious etiology of antiphospholipid syndrome J. Clin. Invest. 109 2002 797 804
48. 2- glycoprotein I in patients with antiphospholipid syndrome Autoimmun. Rev. 2 2003 192 198