The antiphospholipid/cofactor syndromes: A primary variant with antibodies to β2-glycoprotein-I but no antibodies detectable in standard antiphospholipid assays

American Journal of Medicine

Volumn 101, Issue 5, 1996, Pages 472-481

  Cabral, Antonio R ^a,b   Amigo, Mary Carmen ^a   Cabiedes, Javier ^a   Alarcon Segovia, Donato ^a  

^a INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^b INSTITUTO NACIONAL DE CIENCIAS MÉDICAS Y NUTRICIÓN SALVADOR ZUBIRÁN   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; BETA2 GLYCOPROTEIN 1; BLOOD CLOTTING FACTOR 5; CARDIOLIPIN; EPITOPE; GLYCOPROTEIN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PROTEIN C;

ADULT; ANIMAL; ARTICLE; BLOOD; CASE REPORT; CATTLE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENOTYPE; HUMAN; IMMUNOLOGY; ISOLATION AND PURIFICATION; MALE; MIDDLE AGED; MUTATION; SYNDROME; THROMBOSIS; WESTERN BLOTTING;

ADULT; ANIMALS; AUTOANTIBODIES; BETA 2-GLYCOPROTEIN I; BLOTTING, WESTERN; CARDIOLIPINS; CATTLE; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FACTOR V; FEMALE; GENOTYPE; GLYCOPROTEINS; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; MALE; MIDDLE AGED; MUTATION; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; PROTEIN C; SYNDROME; THROMBOSIS;

EID: 0030280337     PISSN: 00029343     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9343(96)00254-9     Document Type: Article

References (60)

1. Galli M, Comfurius P, Maassen C, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet. 1990;335:1544-1547.
2. 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci. 1990;87:4120-4124.
3. Matsuura E, Igarashi Y, Fujimoto M, et al. Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet. 1990;336:177-178. Letter
4. 2-glycoprotein-I for reactivity of antibodies from patients with primary antiphospholipid syndrome. J Autoimmunity. 1992;5:787-801.
5. Alarcón-Segovia D, Cabral AR. Antiphospholipid antibodies: where do they come from? Where do they go? J Rheumatol. 1994;21:982-989.
6. 2-glycoprotein I structure altered by interacting with an oxygen modified solid phase surface. J Exp Med. 1994;179:457-462.
7. 2-glycoprotein I in the absence of phospholipid: importance of Ag density and bivalent binding. J Immunol. 1995;154:954-960.
8. Viard JP, Amoura Z, Bach JP. Association of anti-β2glycoprotein I antibodies with lupus-type circulating anticoagulant and thrombosis in systemic lupus erythematosus. Am J Med. 1992;93:181-186.
9. 2-glycoprotein-I than with antiphospholipid antibodies. J Rheumatol. 1995;22:1899-1906.
10. Balestrieri G, Tincani A, Spatola L, et al. Anti-beta2-glycoprotein I antibodies: a marker of antiphospholipid syndrome? Lupus. 1995;4:122-130.
11. 2-glycoprotein I and anticardiolipin antibodies. J Rheumatol. 1995;22:2233-2237.
12. 2-glycoprotein-I in the serum of patients with primary antiphospholipid syndrome. J Rheumatol. 1995;22:1894-1898.
13. 2-glycoprotein I is potentiated by a distinct subgroup of anticardiolipin antibodies. Thromb Haemostas. 1992;68:297-300.
14. Sugi T, Mcintyre JA. Autoantibodies to phosphatydilethanolamine (PE) recognize a kininogen-PE complex. Blood. 1995;86:3083-3089.
15. Cabral AR, Cabiedes J, Alarcón-Segovia D. Hemolytic anemia related to an IgM autoantibody to phosphatidylcholine that binds in vitro to stored and to bromelain-treated erythrocytes. J Autoimmunity. 1990;3:773-787.
16. Castor CW, Cabral AR. Connective Tissue Activating Peptides. Orlando, Florida: Academic Press; 1988;1:731-748.
17. Kuno H, Kihara HK. Simple in vitro assay of protein with membrane filter. Nature. 1967;215:974-975.
18. Loizou S, McCrea JD, Rudge AC. Measurement of anticardiolipin antiboides by enzyme-linked immunoabsorbent assay (ELISA). Standarization and quantitation of results. Clin Exp Immunol. 1985;62:738-745.
19. Gharavi AE, Harris EN, Asherson RA. Anticardiolipin antibodies, isotype distribution and phospholipid specificity. Ann Rheum Dis. 1987;46:1-6.
20. Delezé M, Oria CV, Alarcón-Segovia D. Occurrence of both hemolytic anemia and thrombocytopenic purpura (Evan's syndrome) in systemic lupus erythematosus. Relationship to antiphospholipid antibodies. J Rheumatol. 1988;15:611-615.
21. Gharavi AE, Sammaritano LR, Wen J, Elkon KB. Induction of antiphospholipid autoantibodies by immunization with β2 glycoprotein I (Apolipoprotein H). J Clin Invest. 1992;90:1105-1109.
22. Zilversmit DB, Davis AK. Microdetermination of plasma phospholipids by trichloroacetic acid precipitation. J Lab Clin Med. 1950;35:155-160.
23. Mangold KH. Aliphatic Lipids. New York: Springer-Verlag; 1969;2:363-420.
24. Zöller B, Dahlbäck B. Linkage between inherited resistance to activated protein C and factor V gene mutation in venous thrombosis. Lancet. 1994;343:1536-1538.
25. Ruíz-Argüelles A, Garcés-Eisele J, Alarcón-Segovia D. Activated protein C resistance phenotype and genotype in patients with primary antiphospholipid syndrome. Blood Coagul Fibrinol. 1996;7:344-348.
26. Oyama VI, Eagle H. Measurement of cell growth in tissue culture with a phenol reagent (Folin-Ciocalteau). Proc Soc Exp Biol Med. 1956;91:305-307.
27. Exner T, Rickard KA, Kronenberg H. A sensitive test demonstrating lupus anticoagulant and its behavioural patterns. Br J Hematol. 1978;40:143-151.
28. 2-glycoprotein-I and their unmasking by heat. Clin Exp Rheum. 1994;12:123-127.
29. Alarcón-Segovia D, Pérez-Vázquez ME, Villa AR, et al. Preliminary classification criteria for the antiphospholipid syndrome within systemic lupus erythematosus. Semin Arthritis Rheum. 1992;21:275-286.
30. Dizon-Townson D, Hutchison C, Silver R, et al. The factor V Leiden mutation which predisposes to thrombosis is not common in patients with antiphospholipid syndrome. Thromb Haemostas. 1995;74:1029-1031.
31. 2-glycoprotein I antibodies derived from patients with the antiphospholipid syndrome. J Immunol. 1995;155:1629-1636.
32. Kato H, Enjoyi K. Amino acid sequence and location of disulfide bonds in bovine β 2 glycoprotein I. The presence of five Sushi domains. Biochemistry. 1991;30:11687-11694.
33. 2-glycoprotein-I structure recognized by anticardiolipin antibodies. Lupus. 1995;1:S13-S17.
34. Blank M, Faden D, Tincani A, et al. Immunization with anticardiolipin cofactor (beta-2-glycoprotein I) induces experimental antiphospholipid syndrome in naive mice. J Autoimmunity. 1994;7:441-455.
35. Puurunen M, Vaarala O, Julkunen H, et al. Antibodies to phospholipid-binding plasma proteins and ocurrence of thrombosis in patients with systemic lupus erythematosus. Clin Immunol Immunopathol. 1996;80:16-22.
36. 2-glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood. 1985;66:1086-1091.
37. 2-glycoprotein I. Biochem Biophys Acta.1986;884:142-149.
38. 2-glycoprotein I to platelets: effect of adenylate cyclase activity. Thromb Res. 1980;19:225-237.
39. 2-glycoprotein I. Br J Haematol. 1995;90:204-206.
40. 2-glycoprotein-I of the factor-Xa generating activity of platelets. Thromb Haemostas. 1993;70:342-345.
41. 2-glycoprotein I. Br J Haematol. 1993;81:568-573.
42. 2-glycoprotein I. Thromb Haemostas. 1993;70:336-341.
43. Bowie WEJ, Thompson JH, Pascuzzi CA, Owen GA. Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Clin Invest. 1963;62:416-430.
44. Alarcón-Segovia D, Osmundson PJ. Peripheral vascular syndromes associated with systemic lupus erythematosus. Ann Intern Med. 1965;62:907-919.
45. 2-glycoprotein I. J Clin Invest. 1992;90:1100-1104.
46. 2-glycoprotein I inhibit phospholipid dependent coagulation reactions. Thromb Haemostas. 1993;70:598-602.
47. Ruíz-Argüelles GJ, Ruíz-Argüelles A, Alarcón-Segovia D, et al. Natural anticoagulants in systemic lupus erythematosus: deficiency of protein S bound to C4bp with recent history of venous thromboses, antiphospholipid antibodies, and the antiphospholipid syndrome. J Rheumatol. 1991;18:552-558.
48. Ruíz-Argüelles A, Vázquez-Prado J, Delezé M, et al. Presence of serum antibodies to coagulation protein C in patients with systemic lupus erythematosus is not associated with antigenic or functional protein C deficiencies. Am J Hematol. 1993;44:58-59.
49. 2-glycoprotein I is a requirement for anticardiolipin antibodies binding to activated platelets: differences with lupus anticoagulant. Blood. 1993;81:1255-1262.
50. 2-glycoprotein-I and through it IgG antiphospholipid antibodies. Studies in platelets from patients with anyiphospholipid syndrome and normal subjects. J Autoimmunity. 1994;7:335-348.
51. Alarcón-Segovia D, Cabral AR. Antiphospholipid/cofactor syndromes. J Rheumatol. 1996;23:1319-1322.
52. Hughes GRV, Harris EN, Gharavi AE. The anticardiolipin syndrome. J Rheumatol. 1987;13:486-489.
53. Alarcón-Segovia D, Delezé M, Oria CV, et al. Antiphospholipid antibodies and the antiphospholipid syndrome in systemic lupus erythematosus. A prospective analysis of 500 consecutive patients. Medicine. 1989;68:353-365.
54. Alarcón-Segovia D, Sánchez-Guerrero J. Primary antiphospholipid syndrome. J Rheumatol. 1989;16:482-489.
55. Asherson RA, Khamashta MA, Ordi-Ros J, et al. The "primary" antiphospholipid syndrome. Major clinical and serological features. Medicine. 1989;68:366-374.
56. Mackworth-Young CG, Loizou S, Walport MJ. Primary antiphospholipid syndrome: features of patients with raised anticardiolipin antibodies and no other disorder. Ann Rheum Dis. 1989;48:362-367.
57. Whitmer KJ, Ansari A, Gershwin ME. The pathogenesis of autoimmunity in New Zealand mice. Semin Clin Immunol. 1994;8:35-53.
58. Hentati B, Payelle-Brogard B, Jouanne C, et al. Natural autoantibodies are involved in the haemolytic anaemia of NZB mice. J Autoimmunity. 1994;7:425-439.
59. Cabral AR, Cabiedes J, Alarcón-Segovia D. Hemolytic anemia (HA) in systemic lupus erythematosus (SLE) a ssociates strongly with IgM anti-phosphatidylcholine antibodies (aPTC). Clin Exp Rheumatol. 1990;8:212 Abstract.
60. 2-glycoprotein-I but persitently negative antiphospholipid antibodies. 1996. Submitted.