Overexpression of low-density lipoprotein receptor and lipid accumulation in intestinal polyps in Min mice

International Journal of Cancer

Volumn 125, Issue 11, 2009, Pages 2505-2510

  Mutoh, Michihiro ^a   Komiya, Masami ^a   Teraoka, Naoya ^a   Ueno, Toshiya ^a   Takahashi, Mami ^a   Kitahashi, Tsukasa ^a   Sugimura, Takashi ^a   Wakabayashi, Keiji ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Apc deficient mice; Intestinal polyp; Lipid accumulation; Low density lipoprotein receptor; Triglyceride

Indexed keywords

CYCLOOXYGENASE 2; FAT DROPLET; LOW DENSITY LIPOPROTEIN RECEPTOR; MESSENGER RNA; APC PROTEIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ELECTRON MICROSCOPY; EPITHELIUM CELL; GENE OVEREXPRESSION; IMMUNOHISTOCHEMISTRY; INTESTINE MUCOSA; INTESTINE POLYP; LIPID STORAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; ANIMAL; C57BL MOUSE; DISEASE MODEL; ENZYME IMMUNOASSAY; GENETICS; LIPID METABOLISM; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; BLOTTING, WESTERN; CHOLESTEROL, LDL; CYCLOOXYGENASE 2; DISEASE MODELS, ANIMAL; IMMUNOENZYME TECHNIQUES; INTESTINAL MUCOSA; INTESTINAL POLYPS; LIPID METABOLISM; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 70350736113     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.24667     Document Type: Article

References (29)

1. Le Marchan L, Wilkens LR, Kolonel LN, Hankin JH, Lyu LC. Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer. Cancer Res 1997;57:4787-4794
2. Abu-Abid S, Szold A, Klausner J. Obesity and cancer. J Med 2002;33:73-86.
3. Yamada K, Araki S, Tamura M, Sakai I, Takahashi Y, Kashihara H, Kono S. Relation of serum total cholesterol, serum triglycerides and fasting plasma glucose to colorectal carcinoma in situ. Int J Epidemiol 1998;27:794-798 (Pubitemid 28504966)
4. Kaye JA, Meier CR, Walker AM, Jick H. Statin use, hyperlipidaemia, and the risk of breast cancer. Br J Cancer 2002;86:1436-1439 (Pubitemid 34548066)
5. Otani T, Iwasaki M, Ikeda S, Kozu T, Saito H, Mutoh M, Wakabayashi K, Tsugane S. Serum triglycerides and colorectal adenoma in a case-control study among cancer screening examinees (Japan). Cancer Causes Control 2006;17:1245-1252 (Pubitemid 44772824)
6. Niho N, Takahashi M, Kitamura T, Shoji Y, Itoh M, Noda T, Sugimura T, Wakabayashi K. Concomitant suppression of hyperlipidemia and intestinal polyp formation in Apc-deficient mice by peroxisome proliferator-activated receptor ligands. Cancer Res 2003;63:6090-6095 (Pubitemid 37187515)
7. Niho N, Takahashi M, Shoji Y, Takeuchi Y, Matsubara S, Sugimura T, Wakabayashi K. Dose-dependent suppression of hyperlipidemia and intestinal polyp formation in Min mice by pioglitazone, a PPAR gamma ligand. Cancer Sci 2003;94:960-964 (Pubitemid 37508978)
8. Niho N, Mutoh M, Takahashi M, Tsutsumi K, Sugimura T, Wakabayashi K. Concurrent suppression of hyperlipidemia and intestinal polyp formation by NO-1886, increasing lipoprotein lipase activity in Min mice. Proc Natl Acad Sci USA 2005;102:2970-2974 (Pubitemid 40299900)
9. Gehrisch S. Common mutations of the lipoprotein lipase gene and their clinical significance. Curr Atheroscler Rep 1999;1:70-78
10. Mead JR, Irvine SA, Ramji DP. Lipoprotein lipase: structure, function, regulation, and role in disease. J Mol Med 2002;80:753-769 (Pubitemid 35478124)
11. Jones PJH, Kubow S. Lipids, sterols, and their metabolites. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern nutrition in health and disease, 9th edn. Baltimore, MD: Williams & Wilkins, 1999. 67-94.
12. Habenicht AJR, Salbach PD, Jansssen-Timmen U. LDL receptor-dependent polyunsaturated fatty acid transport and metabolism. Eicosanoids 1992;5:529-531
13. Lum DF, McQuaid KR, Gilbertson VL, Hughes-Fulford M. Coordinate up-regulation of low-density lipoprotein receptor and cyclo-oxygenase-2 gene expression in human colorectal cells and in colorectal adenocarcinoma biopsies. Int J Cancer 1999;83:162-166 (Pubitemid 29449091)
14. Moser AR, Pitot HC, Dove WF. A dominant mutation that predisposes to multiple intestinal neoplasia in the mouse. Science 1990;247:322-324 (Pubitemid 120031324)
15. Green H, Kehinde O. An established preadipose cell line and its differentiation in culture. II. Factors affecting the adipose conversion. Cell 1975;5:19-27.
16. Swertfeger DK, Bu G, Hui DY. Low density lipoprotein receptor-related protein mediates apolipoprotein E inhibition of smooth muscle cell migration. J Biol Chem 2002;277:4141-4146 (Pubitemid 34968674)
17. Oshima M, Dinchuk JE, Kargman SL, Oshima H, Hancock B, Kwong E, Trzaskos JM, Evans JF, Taketo MM. Suppression of intestinal polyposis in Apc716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell 1996;87:803-809 (Pubitemid 26404280)
18. Accioly MT, Pacheco P, Maya-Monteiro CM, Carrossini N, Robbs BK, Oliveira SS, Kaufmann C, Morgado-Diaz JA, Bozza PT, Viola JP. Lipid bodies are reservoirs of cyclooxygenase-2 and sites of prostaglandin-E2 synthesis in colon cancer cells. Cancer Res 2008;68:1732-1740
19. Stolt PC, Bock HH. Modulation of lipoprotein receptor functions by intracellular adaptor proteins. Cell Signal 2006;18:1560-1571
20. Stolt PC, Chen Y, Liu P, Bock HH, Blacklow SC, Herz J. Phosphoinositide binding by the disabled-1 PTB domain is necessary for membrane localization and reelin signal transduction. J Biol Chem 2005;280:9671-9677 (Pubitemid 40409665)
21. Franke TF, Kaplan DR, Cantley LC. PI3K: downstream AKTion blocks apoptosis. Cell 1997;88:435-437
22. Burgering BM, Coffer PJ. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 1995;376:599-602.
23. Franke TF, Yang SI, Chan TO, Datta K, Kazlauskas A, Morrison DK, Kaplan DR, Tsichlis PN. The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 1995;81:727-736
24. Norata GD, Grigore L, Raselli S, Redaelli L, Hamsten A, Maggi F, Eriksson P, Catapano AL. Post-prandial endothelial dysfunction in hypertriglyceridemic subjects: molecular mechanisms and gene expression studies. Atherosclerosis 2007;193:321-327 (Pubitemid 47064402)
25. Sachinidis A, Ko Y, Wieczorek A, Weisser B, Locher R, Vetter W, Vetter H. Lipoproteins induce expression of the early growth response gene-1 in vascular smooth muscle cells from rat. Biochem Biophys Res Commun 1993;192:794-799 (Pubitemid 23227392)
26. Carusso MG, Notarnicola M, Cavallini A, Guerra V, Misciangna G, Di Leo A. Demonstration of low density lipoprotein receptor in human colonic carcinoma and surrounding mucosa by immunoenzymatic assay. Ital J Gastroenterol 1993;25:361-367 (Pubitemid 23349193)
27. Gueddari N, Favre G, Hachem H, Marek E, Le Gaillard F, Soula G. Evidence for up-regulated low density lipoprotein receptor in human lung adenocarcinoma cell line A549. Biochimie 1993;75:811-819 (Pubitemid 23337721)
28. Notarnicola M, Altomare DF, Calvani M, Orlando A, Bifulco M, D'Attoma B, Caruso MG. Fatty acid synthase hyperactivation in human colorectal cancer: relationship with tumor side and sex. Oncology 2006;71:327-332 (Pubitemid 47573693)
29. Sonoshita M, Takaku K, Sasaki N, Sugimoto Y, Ushikubi F, Narumiya S, Oshima M, Taketo MM. Acceleration of intestinal polyposis through prostaglandin receptor EP2 in ApcDelta 716 knockout mice. Nat Med 2001;7:1048-1051 (Pubitemid 32937386)