11C-PK11195 PET for the in vivo evaluation of neuroinflammation in the rat brain after cortical spreading depression

Journal of Nuclear Medicine

Volumn 50, Issue 11, 2009, Pages 1904-1911

  Cui, Yilong ^a   Takashima, Tadayuki ^a   Takashima Hirano, Misato ^a   Wada, Yasuhiro ^a   Shukuri, Miho ^a   Tamura, Yasuhisa ^a   Doi, Hisashi ^a   Onoe, Hirotaka ^a   Kataoka, Yosky ^a   Watanabe, Yasuyoshi ^a  

^a RIKEN   (Japan)

Author keywords

Binding potential; Microglia; Migraine; Peripheral benzodiazepine receptor

Indexed keywords

[1 (2 CHLOROPHENYL N METHYL N (1 METHYL PROPYL) 3 ISOQUINOLINECARBOXAMIDE] C 11; BENZODIAZEPINE RECEPTOR; LIGAND; TRACER; UNCLASSIFIED DRUG; (R) (11C)1 (2 CHLOROPHENYL) N METHYL N (1 METHYLPROPYL) 3 ISOQUINOLINECARBOXAMIDE; (R)-(11C)1-(2-CHLOROPHENYL)-N-METHYL-N-(1-METHYLPROPYL)-3-ISOQUINOLINECARBOXAMIDE; AMIDE; DIAGNOSTIC AGENT; ISOQUINOLINE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN CORTEX; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DIAGNOSTIC PROCEDURE; DRUG BINDING; DRUG UPTAKE; IN VIVO STUDY; INFLAMMATION; MALE; MICROGLIA; MIGRAINE; NEUROLOGIC DISEASE; NOCICEPTION; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; SPREADING CORTICAL DEPRESSION; TECHNIQUE; ANIMAL; IMMUNOHISTOCHEMISTRY; NEUROGENIC INFLAMMATION; PATHOPHYSIOLOGY; SCINTISCANNING; SPRAGUE DAWLEY RAT;

AMIDES; ANIMALS; CEREBRAL CORTEX; CORTICAL SPREADING DEPRESSION; IMMUNOHISTOCHEMISTRY; ISOQUINOLINES; MALE; NEUROGENIC INFLAMMATION; POSITRON-EMISSION TOMOGRAPHY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 70350724578     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.109.066498     Document Type: Article

References (41)

1. Kreutzberg GW. Microglia: a sensor for pathological events in the CNS. Trends Neurosci. 1996;19:312-318.
2. Streit WJ, Mrak RE, Griffin WS. Microglia and neuroinflammation: a pathological perspective. J Neuroinflammation. 2004;1:14.
3. Dalessio DJ. A classification of headache. Int Ophthalmol Clin. 1970;10: 647-665.
4. Markowitz S, Saito K, Moskowitz MA. Neurogenically mediated leakage of plasma protein occurs from blood vessels in dura mater but not brain. J Neurosci. 1987;7:4129-4136. (Pubitemid 18012423)
5. Moskowitz MA. The neurobiology of vascular head pain. Ann Neurol. 1984;16:157-168.
6. Arnold G, Reuter U, Kinze S, Wolf T, Einhaupl KM. Migraine with aura shows gadolinium enhancement which is reversed following prophylactic treatment. Cephalalgia. 1998;18:644-646. (Pubitemid 29009496)
7. Iizuka T, Sakai F, Suzuki K, Igarashi H, Suzuki N. Implication of augmented vasogenic leakage in the mechanism of persistent aura in sporadic hemiplegic migraine. Cephalalgia. 2006;26:332-335.
8. Goadsby PJ, Edvinsson L, Ekman R. Vasoactive peptide release in the extracerebral circulation of humans during migraine headache. Ann Neurol. 1990;28:183-187. (Pubitemid 20244522)
9. Peroutka SJ. Neurogenic inflammation and migraine: implications for the therapeutics. Mol Interv. 2005;5:304-311.
10. Moran LB, Duke DC, Turkheimer FE, Banati RB, Graeber MB. Towards a transcriptome definition of microglial cells. Neurogenetics. 2004;5:95-108.
11. Benavides J, Guilloux F, Rufat P, et al. In vivo labelling in several rat tissues of 'peripheral type' benzodiazepine binding sites. Eur J Pharmacol. 1984;99:1-7.
12. Cagnin A, Gerhard A, Banati RB. In vivo imaging of neuroinflammation. Eur Neuropsychopharmacol. 2002;12:581-586.
13. Casellas P, Galiegue S, Basile AS. Peripheral benzodiazepine receptors and mitochondrial function. Neurochem Int. 2002;40:475-486. (Pubitemid 34159148)
14. Price CJ, Wang D, Menon DK, et al. Intrinsic activated microglia map to the peri-infarct zone in the subacute phase of ischemic stroke. Stroke. 2006;37: 1749-1753. (Pubitemid 44297724)
15. Banati RB, Newcombe J, Gunn RN, et al. The peripheral benzodiazepine binding site in the brain in multiple sclerosis: quantitative in vivo imaging of microglia as a measure of disease activity. Brain. 2000;123:2321-2337. (Pubitemid 30823947)
16. Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet. 2001;358:461-467. (Pubitemid 32769854)
17. 11C](R)-PK11195 PET in idiopathic Parkinson's disease. Neurobiol Dis. 2006;21:404-412.
18. Pavese N, Gerhard A, Tai YF, et al. Microglial activation correlates with severity in Huntington disease: a clinical and PET study. Neurology. 2006;66: 1638-1643. (Pubitemid 43964614)
19. Leao AAP. Spreading depression of activity in the cerebral cortex. J Neurophysiol. 1944;7:359-390.
20. Nedergaard M, Hansen AJ. Spreading depression is not associated with neuronal injury in the normal brain. Brain Res. 1988;449:395-398. (Pubitemid 18127226)
21. Cui Y, Kataoka Y, Li QH, et al. Targeted tissue oxidation in the cerebral cortex induces local prolonged depolarization and cortical spreading depression in the rat brain. Biochem Biophys Res Commun. 2003;300:631-636. (Pubitemid 36268882)
22. Milner PM. Note on a possible correspondence between the scotomas of migraine and spreading depression of Leao. Electroencephalogr Clin Neurophysiol. 1958;10:705.
23. Lauritzen M, Skyhoj Olsen T, Lassen NA, Paulson OB. Changes in regional cerebral blood flow during the course of classic migraine attacks. Ann Neurol. 1983;13:633-641.
24. Olesen J, Larsen B, Lauritzen M. Focal hyperemia followed by spreading oligemia and impaired activation of rCBF in classic migraine. Ann Neurol. 1981;9:344-352. (Pubitemid 11106551)
25. Hadjikhani N, Sanchez Del Rio M, Wu O, et al. Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001;98:4687-4692. (Pubitemid 32295037)
26. Eikermann-Haerter K, Moskowitz MA. Animal models of migraine headache and aura. Curr Opin Neurol. 2008;21:294-300. (Pubitemid 351653979)
27. Lauritzen M. Pathophysiology of the migraine aura: the spreading depression theory. Brain. 1994;117:199-210. (Pubitemid 24103394)
28. Guide for the Care and Use of Laboratory Animals. Washington, DC: Government Printing Office; 1985. NIH publication 85-123
29. 11C]PK 11195 and comparison of their behaviours as radioligands for PK binding sites in rats. Nucl Med Biol. 1994;21:573-581.
30. Schweinhardt P, Fransson P, Olson L, Spenger C, Andersson JL. A template for spatial normalisation of MR images of the rat brain. J Neurosci Methods. 2003;129:105-113. (Pubitemid 37162881)
31. Logan J, Fowler JS, Volkow ND, Wang GJ, Ding YS, Alexoff DL. Distribution volume ratios without blood sampling from graphical analysis of PET data. J Cereb Blood Flow Metab. 1996;16:834-840. (Pubitemid 26292051)
32. Back T, Kohno K, Hossmann KA. Cortical negative DC deflections following middle cerebral artery occlusion and KCl-induced spreading depression: effect on blood flow, tissue oxygenation, and electroencephalogram. J Cereb Blood Flow Metab. 1994;14:12-19. (Pubitemid 24006489)
33. Boutin H, Chauveau F, Thominiaux C, et al. 11C-DPA-713: a novel peripheral benzodiazepine receptor PET ligand for in vivo imaging of neuroinflammation. J Nucl Med. 2007;48:573-581. (Pubitemid 47571413)
34. Gulyas B, Halldin C, Vas A, et al. [11C]vinpocetine: a prospective peripheral benzodiazepine receptor ligand for primate PET studies. J Neurol Sci. 2005; 229-230:219-223. (Pubitemid 40341586)
35. 11C](R)-PK11195 positron emission tomography imaging of activated microglia in vivo in Rasmussen's encephalitis. Neurology. 1999;53:2199-2203.
36. 11C] (R)-PK11195-PET following herpes encephalitis reveals projected neuronal damage beyond the primary focal lesion. Brain. 2001;124:2014-2027.
37. Stephenson DT, Schober DA, Smalstig EB, Mincy RE, Gehlert DR, Clemens JA. Peripheral benzodiazepine receptors are colocalized with activated microglia following transient global forebrain ischemia in the rat. J Neurosci. 1995; 15:5263-5274.
38. Vowinckel E, Reutens D, Becher B, et al. PK11195 binding to the peripheral benzodiazepine receptor as amarker ofmicroglia activation inmultiple sclerosis and experimental autoimmune encephalomyelitis. J Neurosci Res. 1997;50:345-353. (Pubitemid 27473649)
39. Cui Y, Kataoka Y, Inui T, et al. Up-regulated neuronal COX-2 expression after cortical spreading depression is involved in non-REM sleep induction in rats. J Neurosci Res. 2008;86:929-936. (Pubitemid 351357773)
40. Caggiano AO, Kraig RP. Eicosanoids and nitric oxide influence induction of reactive gliosis from spreading depression in microglia but not astrocytes. J Comp Neurol. 1996;369:93-108.
41. Itzhak Y, Baker L, Norenberg MD. Characterization of the peripheral-type benzodiazepine receptors in cultured astrocytes: evidence for multiplicity. Glia. 1993;9:211-218.