Mechanisms of defence from Fe(II) toxicity in human intestinal Caco-2 cells

Toxicology in Vitro

Volumn 23, Issue 8, 2009, Pages 1510-1515

  Natoli, Manuela ^a   Felsani, Armando ^a   Ferruzza, Simonetta ^b   Sambuy, Yula ^b   Canali, Raffaella ^b   Scarino, Maria Laura ^b  

^a CNR   (Italy)

^b ISTITUTO NAZIONALE DELLA NUTRIZIONE   (Italy)

Author keywords

Apoptosis; Claudin 4 delocalization; Epithelial permeability; Necrosis; Oxidative stress; Phenol red passage; RT PCR; Trans epithelial resistance

Indexed keywords

ASCORBIC ACID; CLAUDIN 4; FERRITIN; FERRITIN HEAVY CHAIN; FERROUS ION; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEAT SHOCK PROTEIN 70; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MANGANESE SUPEROXIDE DISMUTASE; METALLOTHIONEIN II; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL COMPARTMENTALIZATION; CELL DEATH; CELL MEMBRANE PERMEABILITY; CELL STRAIN CACO 2; CELL STRUCTURE; CELL SURVIVAL; CELLULAR STRESS RESPONSE; CONCENTRATION (PARAMETERS); CONCENTRATION RESPONSE; CONTROLLED STUDY; DETOXIFICATION; GENE CONTROL; HUMAN; HUMAN CELL; INTESTINE CELL; IRON OVERLOAD; NUCLEOTIDE SEQUENCE; PROTEIN INDUCTION; PROTEIN LOCALIZATION; TIGHT JUNCTION;

APOPTOSIS; CACO-2 CELLS; GENE EXPRESSION REGULATION; HSP70 HEAT-SHOCK PROTEINS; HUMANS; IRON; METALLOTHIONEIN; NECROSIS; NF-KAPPA B; OXIDATIVE STRESS; PERMEABILITY; TIGHT JUNCTIONS;

EID: 70350708343     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.06.016     Document Type: Article

References (31)

1. Andrews G.K. Regulation of metallothionein gene expression by oxidative stress and metal ions. Biochemical Pharmacology 59 (2000) 95-104
2. Banan A., Zhang L.J., Shaikh M., Field J.Z., Farhadi A., and Keshavarzian A. Novel effect of NF-kappaB activation: carbonylation and nitration injury to cytoskeleton and disruption of monolayer barrier in intestinal epithelium. American Journal of Physiology, Cell Physiology 287 (2004) C1139-C1151
3. Banan A., Keshavarzian L., Zhang L., Shaikh M., Forsyth C.B., Tang Y., and Fields J.Z. NF-kB activation as a key mechanism in ethanol-induced disruption of the F-actin cytoskeleton and monolayer barrier integrity in intestinal epithelium. Alcohol 41 (2007) 447-460
4. Bubici C., Papa S., Dean K., and Franzoso G. Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance. Oncogene 25 (2006) 6731-6748
5. Catalioto R.M., Festa C., Triolo A., Altamura M., Maggi C.A., and Giuliani S. Journal of Pharmaceutical Sciences 98 (2009) 713-727
6. Dokladny K., Moseley P.L., and Ma T.Y. Physiologically relevant increase in temperature causes an increase in intestinal epithelial tight junction permeability. American Journal of Physiology, Gastrointestinal Liver Physiology 290 (2006) G204-G212
7. Fernandez A.L., Koval M., Fan X., and Guidot D.M. Chronic alcohol ingestion alters claudin expression in the alveolar epithelium of rats. Alcohol 41 (2007) 371-379
8. Ferruzza S., Scarino M.L., Rotilio G., Ciriolo M.R., Santaroni P., Onetti-Muda A., and Sambuy Y. Copper treatment alters the permeability of tight junctions in cultured human intestinal Caco-2 cells. American Journal of Physiology, Gastrointestinal Liver Physiology 277 (1999) G1138-G1148
9. Ferruzza S., Scacchi M., Scarino M.L., and Sambuy Y. Iron and copper alter tight junction permeability in human intestinal Caco-2 cells by distinct mechanisms. Toxicology In Vitro 16 (2002) 399-404
10. Ferruzza S., Scarino M.L., Gambling L., Natella F., and Sambuy Y. Biphasic effect of iron on human intestinal Caco-2 cells: early effect on tight junction permeability with delayed onset of oxidative cytotoxic damage. Cellular and Molecular Biology 49 (2003) 89-99
11. Gebhardt B.R., Ries J., Caspary W.F., Boehles H., and Stein J. Superoxide: a major factor for stress protein induction in reoxygenation injury in the intestinal cell line Caco-2. Digestion 60 (1999) 238-245
12. Guo S., Wharton W., Moseley P., and Shi H. Heat shock protein 70 regulates cellular redox status by modulating glutathione-related enzyme activities. Cell Stress Chaperones 12 (2007) 245-254
13. Haddad J.J. Redox and oxidant-mediated regulation of apoptosis signaling pathways: immuno-pharmaco-redox conception of oxidative siege versus cell death commitment. International Immunopharmacology 4 (2004) 475-493
14. Hentze M.W., Muckenthaler M.U., and Andrews N.C. Balancing acts: molecular control of mammalian iron metabolism. Cell 117 (2004) 285-297
15. Holmes J.L., Van Itallie C.M., Rasmussen J.E., and Anderson J.M. Claudin profiling in the mouse during postnatal intestinal development and along the gastrointestinal tract reveals complex expression patterns. Gene Expression Patterns 6 (2006) 581-588
16. Krause G., Winkler L., Mueller S.L., Haseloff R.F., Piontek J., and Blasig I.E. Structure and function of claudins. Biochimica et Biophysica Acta 1778 (2008) 631-645
17. Kusakabe T., Nakajima K., Nakazato K., Suzuki K., Takada H., Satoh T., Oikawa M., Arakawa K., and Nagamine T. Changes of heavy metal, metallothionein and heat shock proteins in Sertoli cells induced by cadmium exposure. Toxicology In Vitro 22 (2008) 1469-1475
18. Lambert D., Padfield P.J., McLaughlin J., Cannell S., and O'Neill C.A. Ochratoxin A displaces claudins from detergent resistant membrane microdomains. Biochemical and Biophysical Research Communications 358 (2007) 632-636
19. Menez C., Buyse M., Chacun H., Farinotti R., and Barratt G. Modulation of intestinal barrier properties by miltefosine. Biochemical Pharmacology 71 (2006) 486-496
20. Nchito M., Friis H., Michaelsen K.F., Mubila L., and Olsen A. Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia. Transactions of the Royal Society of Tropical Medicine and Hygiene 100 (2006) 791-794
21. Papa S., Zazzeroni F., Pham C.G., Bubici C., and Franzoso G. Linking JNK signaling to NF-kappaB: a key to survival. Journal of Cell Science 117 (2004) 5197-5208
22. Perkins N.D., and Gilmore T.D. Good cop, bad cop: the different faces of NF-kappaB. Cell Death and Differentiation 13 (2006) 759-772
23. Puntarulo S. Iron, oxidative stress and human health. Molecular Aspects of Medicine 26 (2005) 299-312
24. Ranaldi G., Marigliano I., Vespignani I., Perozzi G., and Sambuy Y. The effect of chitosan and other polycations on tight junction permeability in the human intestinal Caco-2 cell line. Journal Nutritional Biochemistry 13 (2002) 157-167
25. Ranaldi G., Mancini E., Ferruzza S., Sambuy Y., and Perozzi G. Effects of red wine on ocratoxin A toxicity in intestinal Caco-2/TC7 cells. Toxicology In Vitro 21 (2007) 204-210
26. Reinecke F., Levanets O., Olivier Y., Louw R., Semete B., Grobler A., Hidalgo J., Smeitink J., Olckers A., and Van der Westhuizen F.H. Metallothionein isoform 2A expression is inducible and protects against ROS-mediated cell death in rotenone-treated HeLa cells. Biochemical Journal 395 (2006) 405-415
27. Sambuy Y., De Angelis I., Ranaldi G., Scarino M.L., Stammati A., and Zucco F. The Caco-2 cell line as a model of the intestinal barrier: influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biology and Toxicology 21 (2005) 1-26
28. Sharp P., and Srai S.K. Molecular mechanisms involved in intestinal iron absorption. World Journal of Gastroenterology 13 (2007) 4716-4724
29. Tapiero H., Gate L., and Tew K.D. Iron: deficiencies and requirements. Biomedicine and Pharmacotherapy 55 (2001) 324-332
30. Thornalley P.J., and Vasàk M. Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals. Biochimica et Biophysica Acta 827 (1985) 36-44
31. Wang T.G., Gotoh Y., Jennings M.H., Rhoads C.A., and Aw T.Y. Lipid hydroperoxide-induced apoptosis in human colonic Caco-2 cells is associated with an early loss of cellular redox balance. FASEB Journal 14 (2000) 1567-1576