Iron supplementation increases small intestine permeability in primary schoolchildren in Lusaka, Zambia

Transactions of the Royal Society of Tropical Medicine and Hygiene

Volumn 100, Issue 8, 2006, Pages 791-794

  Nchito, M ^a   Friis, H ^b   Michaelsen, K F ^c   Mubila, L ^a   Olsen, A ^d  

^a UNIVERSITY OF ZAMBIA   (Zambia)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d DANISH BILHARZIASIS LABORATORY   (Denmark)

Author keywords

Ascaris lumbricoides; Geophagy; Intestinal permeability; Iron; Multi micronutrients; Schoolchildren; Zambia

Indexed keywords

ALBENDAZOLE; ALPHA TOCOPHEROL; ASCORBIC ACID; COPPER; CYANOCOBALAMIN; FERRITIN; FOLIC ACID; HEMOGLOBIN; IODINE; IRON; IRON DEXTRAN; LACTULOSE; MANNITOL; NICOTINIC ACID; PLACEBO; PYRIDOXINE; RETINOL; RIBOFLAVIN; SELENIUM; THIAMINE; TRACE ELEMENT; VITAMIN D; ZINC;

ARTICLE; ASCARIASIS; ASCARIS LUMBRICOIDES; BOY; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FACTORIAL ANALYSIS; FEMALE; FERRITIN BLOOD LEVEL; FOLLOW UP; GIRL; HELMINTHIASIS; HUMAN; INTESTINE INJURY; INTESTINE MUCOSA PERMEABILITY; IRON THERAPY; MAJOR CLINICAL STUDY; MALE; MORBIDITY; SCHOOL CHILD; SINGLE DRUG DOSE; ZAMBIA;

ADOLESCENT; CHILD; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTESTINAL MUCOSA; IRON; LACTULOSE; MALE; MANNITOL; MICRONUTRIENTS; PERMEABILITY; RANDOMIZED CONTROLLED TRIALS; ZAMBIA;

EID: 33744981843     PISSN: 00359203     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.trstmh.2005.10.016     Document Type: Article

References (18)

1. Dewey K.G., Domellöf M., Cohen R.J., Rivera L.L., Hernell O., and Lönnerdal B. Iron supplementation affects growth and morbidity of breast-fed infants: results of a randomized trial in Sweden and Honduras. J. Nutr. 132 (2002) 3249-3255
2. Ferruzza S., Scarino M.L., Gambling L., Natella F., and Sambuy Y. Biphasic effect of iron on human intestinal Caco-2 cells: early effect on tight junction permeability with delayed onset of oxidative cytotoxic damage. Cell. Mol. Biol. 49 (2003) 89-99
3. Gera T., and Sachdev H.P.S. Effect of iron supplementation on incidence of infectious illness in children: systematic review. Br. Med. J. 325 (2002) 1142-1151
4. Goto K., Chew F., Torún B., Peerson J.M., and Brown K.H. Epidemiology of altered intestinal permeability to lactulose and mannitol in Guatemalan infants. J. Pediatr. Gastroenterol. Nutr. 28 (1999) 282-290
5. Lunn P.G., and Northrop-Clewes C.A. Intestinal permeability: update on the enzymatic assay of mannitol. Clin. Chim. Acta 205 (1992) 151-152
6. Lunn P.G., Northrop-Clewes C.A., and Downes R.M. Recent developments in the nutritional management of diarrhoea. 2. Chronic diarrhoea and malnutrition in The Gambia: studies on intestinal permeability. Trans. R. Soc. Trop. Med. Hyg. 85 (1991) 8-11
7. Morais M.B., and Lifschitz C.H. Intestinal permeability to lactulose and mannitol in growing rats with iron-deficiency anemia. Biol. Trace Elem. Res. 99 (2004) 233-240
8. National Research Council FaNB, 1989. Recommended Dietary Allowances, tenth edition. National Academy Press, Washington, DC.
9. Nchito, M., 2004. Effects of iron and multi-micronutrient supplementation on geophagy, Ascaris lumbricoides reinfection, iron status and growth among Zambian schoolchildren in Lusaka. PhD Thesis. Faculty of Science, University of Copenhagen and DBL-Institute for Health Research and Development, Denmark.
10. Nchito M., Geissler P.W., Mubila L., Friis H., and Olsen A. Effects of iron and multimicronutrient supplementation on geophagy: a two-by-two factorial study among Zambian schoolchildren in Lusaka. Trans. R. Soc. Trop. Med. Hyg. 98 (2004) 218-227
11. Northrop C.A., Lunn P.G., Wainwright M., and Evans J. Plasma albumin concentrations and intestinal permeability in Bangladeshi children infected with Ascaris lumbricoides. Trans. R. Soc. Trop. Med. Hyg. 81 (1987) 811-815
12. Northrop C.A., Lunn P.G., and Behrens R.H. Automated enzymatic assays for the determination of intestinal permeability probes in urine. 1. Lactulose and lactose. Clin. Chim. Acta 187 (1990) 79-88
13. Northrop-Clewes C.A., Rousham E.K., Mascie-Taylor C.G.N., and Lunn P.G. Anthelmintic treatment of rural Bangladeshi children: effect on host physiology, growth, and biochemical status. Am. J. Clin. Nutr. 73 (2001) 53-60
14. Oppenheimer S.J. Iron and its relation to immunity and infectious disease. J. Nutr. 131 (2001) 616S-635S
15. Oppenheimer S.J., Macfarlane S.B., Moody J.B., and Harrison C. Total dose iron infusion, malaria and pregnancy in Papua New Guinea. Trans. R. Soc. Trop. Med. Hyg. 80 (1986) 818-822
16. Raj S.M., Sein K.T., Anuar A.K., and Mustaffa B.E. Effect of intestinal helminthiasis on intestinal permeability of early primary schoolchildren. Trans. R. Soc. Trop. Med. Hyg. 90 (1996) 666-669
17. Valko M., Morris H., and Cronin M.T. Metals, toxicity and oxidative stress. Curr. Med. Chem. 12 (2005) 1161-1208
18. WHO, 1991. Basic Laboratory Methods in Medical Parasitology. World Health Organization, Geneva.