Genetic effects in drosophila on the potency of diverse general anesthetics: A distinctive pattern of altered sensitivity

Journal of Neurogenetics

Volumn 23, Issue 4, 2009, Pages 412-421

  Campbell, Joseph L ^a   Gu, Qun ^a   Guo, Dongyu ^a   Nash, Howard A ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Arousal; Cocaine; Ethanol; Locomotion; Volatile anesthetics

Indexed keywords

ALCOHOL; COCAINE; DESFLURANE; ENFLURANE; HALOTHANE; ISOFLURANE; METHOXYFLURANE; SEVOFLURANE;

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DARKNESS; DROSOPHILA; DRUG POTENCY; DRUG SENSITIVITY; GENE INSERTION; GENE LOCUS; GENE MUTATION; LIGHT EXPOSURE; MALE; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PHENOTYPE; PRIORITY JOURNAL;

ANESTHETICS, INHALATION; ANIMALS; CHROMOSOME MAPPING; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; DRUG HYPERSENSITIVITY; GENE EXPRESSION REGULATION; HALOTHANE; ISOFLURANE; MALE; MOVEMENT; MUTATION; PHENOTYPE; SENSITIVITY AND SPECIFICITY;

EID: 70350688148     PISSN: 01677063     EISSN: 15635260     Source Type: Journal    
DOI: 10.3109/01677060903177800     Document Type: Article

References (46)

1. Alone, D. P., Rodriguez, J. C., Noland, C. L. & Nash, H. A. (2009). Impact of gene copy number variation on anesthesia in Drosophila melanogaster. Anesthesiology, 111, 15-24.
2. Altenhein, B., Becker, A., Busold, C., Beckmann, B., Hoheisel, J. D. & Technau, G. M. (2006). Expression profiling of glial genes during Drosophila embryogenesis. Dev Biol, 296, 545-560.
3. Anholt, R. R., Dilda, C. L., Chang, S., Fanara, J. J., Kulkarni, N. H., Ganguly, I., et al. (2003). The genetic architecture of odor-guided behavior in Drosophila: epistasis and the transcriptome. Nat Genet, 35, 180-184.
4. Bainton, R. J., Tsai, L. T., Schwabe, T., DeSalvo, M., Gaul, U. & Heberlein, U. (2005). Moody encodes two GPCRs that regulate cocaine behaviors and blood-brain barrier permeability in Drosophila. Cell, 123, 145-156.
5. Benzer, S. (1967). Behavioral mutants of Drosophila isolated by countercurrent distribution. Genetics, 58, 1112-1119.
6. Bovill, J. G. (2008). Inhalation anaesthesia: from diethyl ether to xenon. Handb Exp Pharmacol, 182, 121-142.
7. Campbell, D. B. & Nash, H. A. (1994). Use of Drosophila mutants to distinguish among volatile general anesthetics. Proc Natl Acad Sci USA, 91, 2135-2139.
8. Campbell, J. L. & Nash, H. A. (2001). Volatile general anesthetics reveal a neurobiological role for the white and brown genes of Drosophila melanogaster. J Neurobiol, 49, 339-349.
9. Cheng, Y. & Nash, H. A. (2007). Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus. Proc Natl Acad Sci USA, 104, 17730-17734.
10. Cheng, Y. & Nash, H. A. (2008). Visual mutations reveal opposing effects of illumination on arousal in Drosophila. Genetics, 178, 2413-2416.
11. Chintapalli, V. R., Wang, J. & Dow, J. A. (2007). Using FlyAtlas to identify better Drosophila melanogaster models of human disease. Nat Genet, 39, 715-720.
12. Connolly, J. B., & Tully, T. (1998). Behaviour, learning, and memory. In Roberts, D. B. (Ed.), Drosophila: A Practical Approach. Oxford: Oxford University Press, 265-317.
13. Conover, W. J. (1999). Practical Nonparametric Statistics. New York: John Wiley.
14. de Belle, J. S. & Heisenberg, M. (1996). Expression of Drosophila mushroom body mutations in alternative genetic backgrounds: a case study of the mushroom body miniature gene (mbm). Proc Natl Acad Sci USA, 93, 9875-9880.
15. Eger, E. I., 2nd, Tang, M., Liao, M., Laster, M. J., Solt, K., Flood, P., et al. (2008). Inhaled anesthetics do not combine to produce synergistic effects regarding minimum alveolar anesthetic concentration in rats. Anesth Analg, 107, 479-485.
16. Gamo, S., Tomida, J., Dodo, K., Keyakidani, D., Matakatsu, H., Yamamoto, D., et al. (2003). Calreticulin mediates anesthetic sensitivity in Drosophila melanogaster. Anesthesiology, 99, 867-875.
17. Guan, Z., Scott, R. L. & Nash, H. A. (2000). A new assay for the genetic study of general anesthesia in Drosophila melanogaster: use in analysis of mutations in the 12E region. J Neurogenet, 14, 25-42.
18. Huang, A. M., Rehm, E. J. & Rubin, G. M. (2000). Recovery of DNA sequences flanking P-element insertions: inverse PCR and plasmid rescue. In Sullivan, W., Ashburner, M., & Hawley, R. S. (Eds.), Drosophila Protocols. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
19. Humphrey, J. A., Hamming, K. S., Thacker, C. M., Scott, R. L., Sedensky, M. M., Snutch, T. P., et al. (2007). A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Curr Biol, 17, 624-629.
20. Keene, A. C., Krashes, M. J., Leung, B., Bernard, J. A. & Waddell, S. (2006). Drosophila dorsal paired medial neurons provide a general mechanism for memory consolidation. Curr Biol, 16, 1524-1530.
21. Mayer, F., Mayer, N., Chinn, L., Pinsonneault, R. L., Kroetz, D. & Bainton, R. J. (2009). Evolutionary conservation of vertebrate blood-brain barrier chemoprotective mechanisms in Drosophila. J Neurosci, 29, 3538-3550.
22. Moore, M. S., DeZazzo, J., Luk, A. Y., Tully, T., Singh, C. M. & Heberlein, U. (1998). Ethanol intoxication in Drosophila: genetic and pharmacological evidence for regulation by the cAMP signaling pathway. Cell, 93, 997-1007.
23. Morgan, P. G. & Sedensky, M. M. (1994). Mutations conferring new patterns of sensitivity to volatile anesthetics in Caenorhabditis elegans. Anesthesiology, 81, 888-898.
24. Motulsky, M. & Christopoulos, A. (2004). Fitting Models to Biological Data Using Linear and Nonlinear Regression. New York: Oxford University Press.
25. Nash, H. A. (2002). In vivo genetics of anesthetic action. Brit J Anesth, 89, 143-155.
26. Pittson, S., Himmel, A. M., & MacIver, M. B. (2004). Multiple synaptic and membrane sites of anesthetic action in the CA1 region of rat hippocampal slices. BMC Neurosci, 5, 52.
27. Quinlan, J. J., Ferguson, C., Jester, K., Firestone, L. L., & Homanics, G. E. (2002). Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics. Anesth Analg, 95, 578-582 (table of contents).
28. Quinlan, J. J., Homanics, G. E. & Firestone, L. L. (1998). Anesthesia sensitivity in mice that lack the beta3 subunit of the gamma-aminobutyric acid type A receptor. Anesthesiology, 88, 775-780.
29. Rajaram, S., Scott, R. L. & Nash, H. A. (2005). Retrograde signaling from the brain to the retina modulates the termination of the light response in Drosophila. Proc Natl Acad Sci USA, 102, 17840-17845.
30. Ross, E. M. & Kenakin, T. P. (2001). Pharmacodynamics: mechanisms of drug action and the relationship between drug concentration and effect. In Hardman, J. G., & Limbird, L. E. (Eds.), Goodman & Gilman's the Pharmacological Basis of Therapeutics (pp. 31-43). New York: McGraw Hill.
31. Rudolph, U. & Antkowiak, B. (2004). Molecular and neuronal substrates for general anaesthetics. Nat Rev Neurosci, 5, 709-720.
32. Singh, S. (1993). Quantification of countercurrent distribution: from molecular partition to animal behavior. Biochem Biophys Res Commun, 196, 430-434.
33. Sokal, R. R. & Rohlf, F. J. (1995). Biometry (3rd ed). New York: W. H. Freeman.
34. Sonner, J. M. (2002). Issues in the design and interpretation of minimum alveolar anesthetic concentration (MAC) studies. Anesth Analg, 95, 609-614.
35. Spradling, A. C., Stern, D., Beaton, A., Rhem, E. J., Laverty, T., Mozden, N., et al. (1999). The Berkeley Drosophila Genome Project gene disruption project: single P-element insertions mutating 25% of vital Drosophila genes. Genetics, 153, 135-177.
36. Stork, T., Engelen, D., Krudewig, A., Silies, M., Bainton, R. J. & Klambt, C. (2008). Organization and function of the blood-brain barrier in Drosophila. J Neurosci, 28, 587-597.
37. Tinklenberg, J. A., Segal, I. S., Tianzhi, G. & Maze, M. (1991). Analysis of anesthetic action on the potassium channels of the Shaker mutant of Drosophila. Ann N Y Acad Sci, 625, 532-539.
38. Tsai, L. T., Bainton, R. J., Blau, J. & Heberlein, U. (2004). Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors. PLoS Biol, 2, e408.
39. Urban, B. W., Bleckwenn, M. & Barann, M. (2006). Interactions of anesthetics with their targets: non-specific, specific or both? Pharmacol Ther, 111, 729-770.
40. Uthaman, S. B., Godenschwege, T. A. & Murphey, R. K. (2008). A mechanism distinct from highwire for the Drosophila ubiquitin conjugase bendless in synaptic growth and maturation. J Neurosci, 28, 8615-8623.
41. Walcourt, A., Scott, R. L. & Nash, H. A. (2001). Blockage of one class of potassium channel alters the effectiveness of halothane in a brain circuit of Drosophila. Anesth Analg, 92, 535-541.
42. Waud, D. R. (1972). On biological assays involving quantal responses. J Pharmacol Exp Ther, 183, 577-607.
43. Weber, K. E. (1988). An apparatus for measurement of resistance to gas-phase agents. Drosophila Info Serv, 67, 91-93.
44. Wolf, F. W., Eddison, M., Lee, S., Cho, W. & Heberlein, U. (2007). GSK-3/Shaggy regulates olfactory habituation in Drosophila. Proc Natl Acad Sci USA, 104, 4653-4657.
45. Woodbury, J. W., D'Arrigo, J. S., & Eyring, H. (1975). Physiological mechanism of general anesthesia: synaptic blockade. In Fink, B. R. (Ed.), Molecular Mechanisms of Anesthesia, New York, Raven Press (pp. 53-91).
46. Yang, J., McCart, C., Woods, D. J., Terhzaz, S., Greenwood, K. G., ffrench-Constant, R. H., et al. (2007). A Drosophila systems approach to xenobiotic metabolism. Physiol Genom, 30, 223-231.