Mice with glycine receptor subunit mutations are both sensitive and resistant to volatile anesthetics

Anesthesia and Analgesia

Volumn 95, Issue 3, 2002, Pages 578-582

  Quinlan, Joseph J ^a   Ferguson, Carolyn ^a   Jester, Katherine ^a   Firestone, Leonard L ^a   Homanics, Gregg E ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ENFLURANE; GLYCINE RECEPTOR; HALOTHANE; MIDAZOLAM; PENTOBARBITAL; PROTEIN SUBUNIT;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ACTIVITY; FEMALE; GENE MUTATION; HOMOZYGOSITY; HYPNOSIS; IN VIVO STUDY; MALE; MINIMUM LUNG ALVEOLUS CONCENTRATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SLEEP;

EID: 0036713907     PISSN: 00032999     EISSN: None     Source Type: Journal    
DOI: 10.1213/00000539-200209000-00016     Document Type: Article

References (18)

1. Volatile anesthetic requirements differ in mice selectively bred for sensitivity or resistance to diazepam: Implications for the site of anesthesia
2. Anesthesia sensitivity in mice that lack the β3 subunit of the γ-aminobutyric acid type A receptor
3. Enhancement of homomeric glycine receptor function by long-chain alcohols and anaesthetics
4. Effects of inhalational general anaesthetics on native glycine receptors in rat medullary neurones and recombinant glycine receptors in Xenopus oocytes
5. The spastic mouse: Aberrant splicing of glycine receptor beta subunit mRNA caused by intronic insertion of L1 element
6. Glycine receptor alteration in the mutant mouse spastic
7. A missense mutation in the gene encoding the alpha 1 subunit of the inhibitory glycine receptor in the spasmodic mouse
8. Phenotypic heterogeneity and disease course in three murine strains with mutations in genes encoding for α1 and β glycine receptor subunits
9. Narcotic properties of carbon dioxide in the dog
10. Temperature dependence of halothane and cyclopropane anesthesia in dogs: Correlation with some theories of anesthetic action
11. On biological assays involving quantal responses
12. Anesthetic potencies of secondary alcohol enantiomers
13. Anesthetic potencies and the unitary theory of narcosis
14. Halothane, isoflurane, and enflurane MAC in pregnant and nonpregnant female and male mice and rats
15. A and glycine receptors expressed in Xenopus laevis oocytes: A comparative study
16. 1, GABA receptors
17. Mutations of γ-aminobutyric acid and glycine receptors change alcohol cutoff: Evidence for an alcohol receptor?
18. Sites of alcohol and volatile anaesthetic action on GABA(A) and glycine receptors