Ipomoea obscura (L.) enhances the functions of immunological effector cells, inhibits proinflammatory cytokines and nitric oxide production by LPS induced macrophages

Immunopharmacology and Immunotoxicology

Volumn 31, Issue 2, 2009, Pages 222-229

  Hamsa, T P ^a   Kuttan, Girija ^a  

^a AMALA CANCER RESEARCH CENTRE   (India)

Author keywords

Antibody titer; Ipomoea obscura; Plaque forming cells; Proinflammatory cytokines; esterase

Indexed keywords

ESTERASE; IMMUNOMODULATING AGENT; INTERLEUKIN 1BETA; INTERLEUKIN 6; IPOMOEA OBSCURA EXTRACT; LIPOPOLYSACCHARIDE; METHANOL; NITRIC OXIDE; PLANT EXTRACT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ANTIBODY; CYTOKINE; IMMUNOLOGIC FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBODY TITER; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; IMMUNOMODULATION; IMMUNOSTIMULATION; IPOMOEA; IPOMOEA OBSCURA; LEUKOCYTE COUNT; MACROPHAGE; MALE; MOUSE; NONHUMAN; PLAQUE FORMING CELL; PRIORITY JOURNAL; SHEEP ERYTHROCYTE; SPLEEN CELL; SPLEEN WEIGHT; ANIMAL; ANTAGONISTS AND INHIBITORS; BIOSYNTHESIS; BLOOD; DRUG EFFECTS; IMMUNOLOGY; INFLAMMATION; MACROPHAGE ACTIVATION; SPLEEN;

IPOMOEA OBSCURA; MUS; OVIS ARIES;

ANIMALS; ANTIBODIES; BONE MARROW CELLS; CYTOKINES; ESTERASES; IMMUNOLOGIC FACTORS; INFLAMMATION; IPOMOEA; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MALE; MICE; NITRIC OXIDE; PLANT EXTRACTS; SPLEEN;

EID: 70350686212     PISSN: 08923973     EISSN: 15322513     Source Type: Journal    
DOI: 10.1080/08923970802382227     Document Type: Article

References (50)

1. Anaissie, E.J.; Mc Ginnis, M.R.; Pfaller, M.A. Clinical Mycology. Churchill Livingstone, Philadelphia, USA, 2003, pp. 3-16.
2. Devasagayam, T.P.A.; Sainis, K.B. Immune system and antioxidants, especially those derived from Indian medicinal plants. Ind J Exp Biol. 2002, 71:639-655
3. Pallabi, D.E.; Dasgupta, S.C.; Gomes, A. Immunopotentiating and immunoprophylatic activity of Immune 21 a polyherbal product. Ind J Pharmacol. 1998, 30:163-168.
4. Vogels, M.T.; van der Meer, J.W. Use of immune modulators in nonspecific therapy of bacterial infections. Antimicrob Agents Chemother. 1992, 36:1-5.
5. Wagner, H.; Proksh, A. Immunostimulatory drugs of fungi and higher plants. In: Wagner, H., ed. Economic and Medicinal Plant Research. vol.I. Academic Press, London, New York. 1985, P. 113.
6. Kuttan, G.; Kuttan, R. Immunomodulatory activity of a peptide isolated from Viscum album extract. Immunol Invest. 1992, 21:285-296
7. Davis, L.; Kuttan, G. Immunomodulatory and antitumor activities of Withania sominifera. J Ethnopharmacol. 2000, 71:193-200.
8. Guruvayoor, E. 2007. Asi Pac J Canc Prev. 8:27-32.
9. Atal, C.K.; Sharma, M.L.; Kaul, A.; Khajuria, A. Immunomodulating agents of plant origin. I: Preliminary Screening. J Ethnopharmacol. 1986, 18:133-141.
10. Sainis, K.B.; Sumariwalla, P.F.; Goel, A.; Chintalwar, G.J.; Sipahimalani, A.T.; Banerji, A. Immunomodulatory properties of stem extracts of Tinospora cordifolia cell targets and active principle. In Immunomodulation, Upadhayay, S.N, ed. Narosa Publications, New Delhi, India. 1997, 95.
11. Kawagishi, C.; Kurosaka, K.; Watanabe, N.; Kobayashi, Y. Cytokine production by macrophages in association with phagocytosis of etoposide-treated P388 cells in vitro and in vivo. BBA. 2001, 1541:221-230.
12. Ryffel, B. Role of proinflammatory cytokines in a toxin response: Application of cytokine knockout mice in toxicological research. Toxicol Lett. 1995, 82/83:477-482.
13. Luk, J.M.; Lai, W.; Tam, P.; Koo, M.W.L. Suppression of cytokine production and cell adhesion molecule expression in human monocytic cell line THP-1 by Tripterygium wilfordii polysaccharide moiety. Life Sci. 2000, 67:155-163.
14. Coleman, J.W. Nitric oxide in immunity and inflammation. Int Immunopharmacol. 2001, 1:1397-1406.
15. Jennet-Siems, K.; Weigl, R.; Kaloga, M.; Schulz, J.; Eich, E. Ipobscurine C and D: Macrolactum-type indole alkaloids from the seeds of Ipomoea obscura. Phytochemistry. 2003, 62:1257-1263.
16. Kirticker, K.R.; Basu, B.D. 1980. Ind J Med Plants. 3 (2):1723-1724.
17. Paula, A.C.B.; Hayashi, L.S.S.; Freitas, J.C. Anti-inflammatory and antispasmodic activity of Ipomoea imperati (Vahl) Griseb (Convolvulaceae). Braz. J Med Biol Res. 2003, 36 (1):105-112.
18. Fosberg, F.R.; Sachet, M.H. Convolvulaceae Flora of Micronesia, 3. Smithsonian Contrib. Bot. 1977, 36:1-3.
19. Pongprayoon, U.; Baeckstrom, P.; Jacobsson, U.; Linstrom, M.; Bohlin, C. Antispasmodic activity of beta-damascenone and E-phytol isolated from Ipomoea pes-caprae. Planta Med. 1992, 58:19-21.
20. Sredni, B.; Albeck, M.; Kazimirsky, G.; Shalet, F. Immunomodulator AS101 administered orally as a chemoprotective and radioprotective agent. Int J Immunopharmacol. 1992, 14:613-619.
21. Bancroft, J.D.; Cook, H.F. Manual of Histologic Technique. Churchill Livingstone, London, 1984, pp. 171-174
22. Singh, V.K.; Agarwal, S.S.; Gupta, B.M. Immunostimulatory activity of Panax ginseng extract. Planta Med. 1984, 50:462-465
23. Jerne, N.K.; Nordin, A.A. Plaque formation in agar by single antibody producing cells. Science. 1963, 140:405.
24. Stucher, D.J.; Nathan, C.F. Nitric oxide, a macrophage product responsible for cytostasis and respiratory inhibition in tumour target cells. J Exper Med. 1989, 169:1543-1555
25. Dahanukar, S.A.; Kulkarni, R.A.; Rege, N.N. Pharmacology of medicinal plants and natural products. Ind J Pharmacol. 2000, 32:81-118.
26. Baumann, H.; Gauldie, J. The acute phase response. Immunol Today. 1994, 15 (2):74-80.
27. Chamulitrat, W.; Blazka, M.E.; Jordan, S.J.; Luster, M.I.; Mason, R.P. Tumor necrosis factor-o and nitric oxide production in endotoxin-primed rats administered carbon tetrachloride. Life Sci. 1995, 24:2273-2280
28. Edward, C.K.3rd; Zhou, T.; Zhang, J.; Baker, T.J.; De, M.; Long, R.E.; Borcherding, D.R.; Boulin, T.L.; Bluethmann, H.; Mountz, J.P. Inhibition of superantigen induced proinflammatory cytokine production and inflammatory arthritis in MLR Ipr/ Ipr mice by a transcriptional inhibitor of TNF alpha. J Immunol. 1996, 157:1758-1772
29. Whicher, J.T.; Evans, S.W. Cytokines in disease. Clin Chem. 1990, 36 (7):1269-1281
30. Dinarello, C.A. Biology of interleukin 1. Fed Am Soc Exp Biol. 1988, 2:108-115
31. O'Garra, A. Interleukins and immune system 1. Lancet. 1989, 943-947
32. Hirano, T. Interleukin -6 and its relation to inflammation and disease. Clin Immunol Immunopathol. 1992, 62:60-65.
33. Kim, P.K.M.; Zamora, R.; Petrosko, P.; Billiar, T.R. The regulatory role of nitric oxide in apoptosis. Int Immunopharmacol. 2001, 1:1421-1441.
34. Brüne, B.; Knethen, A.V.; Sandau, K.B. Nitric oxide and its role in apoptosis. Eur J Pharmacol. 1998, 351 (3):261-272.
35. Krönche, K.D.; Fehsel, K.; Suschek, C.; Bachofen, V.K. Inducible nitric oxide synthase-derived nitric oxide in gene regulation, cell death and cell survival. Int Immunopharmacol. 2001, 1:1407-1420.
36. Cifone, M.G.; Ulisse, S.; Santoni, A. Natural killer cells and nitric oxide. Int Immunopharmacol. 2001, 1 (8):1513-1524.
37. Forsythe, P.; Gilchrist, M.; Kulka, M.; Befus, A.D. Mast cells and nitric oxide: Control of production, mechanisms of response. Int Immunopharmacol. 2001, 1 (8):1525-1541. (Pubitemid 32622796)
38. Gross, S.S.; Wolin, M.S. Nitric Oxide Pathophysiological mechanism. Ann Rev Physiol. 1995, 57:737-769.
39. Fernandez-Martynez, E.; Morales, M.S.; Perez-A, R.V.; Muriela, I.P. Immunomodulatory effects of thalidomide analogs on LPS-induced plasma and hepatic cytokines in the rat. Biochem Pharmacol. 2004, 68:1321-1329.
40. Balkwill, F.; Mantovani, A. Inflammation and cancer: Back to Virchow? Lancet. 2001, 357:539-545.
41. Coussens, L.M.; Werb, Z. Inflammatory cells and cancer: Think different! J Exp Med. 2001, 193:F23-F26.
42. Coussens, L.M.; Werb, Z. Inflammation and cancer. Nature. 2002, 420:860-867.
43. Balkwill, F.; Coussens, L.M. Cancer: An inflammatory link. Nature. 2004, 431:405-406.
44. Robinson, S.C.; Coussens, L.M. Soluble mediators of inflammation during tumor development. Adv Cancer Res. 2005, 93:159-187.
45. Aggarwal, B.B.; Shishodia, S.; Sandur, S.K.; Pandey, M.K.; Sethi, G. Inflammation and cancer: How hot is the link? Biochem Pharmacol. 2006, 72:1605-1621.
46. Szlosarek, P.; Charles, K.A.; Balkwill, F.R. Tumour necrosis factor-alpha as a tumour promoter. Eur J Cancer. 2006, 42:745-750.
47. Raman, D.; Baugher, P.J.; Thu, Y.M.; Richmond, A. Role of chemokines in tumor growth. Cancer Lett. 2007, 256:137-165.
48. Hamada, E.; Nishida, T.; Uchiyama, Y.; Nakamura, J.; Isihara, K.; Kazuo, H. Activation of Kupffer cells and caspases-3 involved in rat hepatocyte apoptosis induced by endotoxin. J Hepatol. 1999, 30:807-818
49. Marriot, J.B.; Westby, M.; Cookson, S.; Guckian, M.; Goodbourn, S.; Muller, G. CC-3052: A water-soluble analog of thalidomide and potent inhibitor of activation-induced TNF-a production. J Immunol. 1998, 161:4236-4243
50. Cunha, T.M.; Verri, W.A.Jr; Valerio, D.A.; Guerrero, A.T.; Nogueira, L.G.; Vieira, S.M.; Souza, D.G.; Teixeira, M.M.; Poole, S.; Ferreira, S.H.; Cunha, F.Q. Role of cytokines in mediating mechanical hypernociception in a model of delayed-type hypersensitivity in mice. Eur J Pain. 2008.