Genetic variants in the cell cycle control pathways contribute to early onset colorectal cancer in Lynch syndrome

Cancer Causes and Control

Volumn 20, Issue 9, 2009, Pages 1769-1777

  Chen, Jinyun ^a   Etzel, Carol J ^a,c   Amos, Christopher I ^a,c   Zhang, Qing ^a   Viscofsky, Nancy ^a   Lindor, Noralane M ^b   Lynch, Patrick M ^a   Frazier, Marsha L ^a,c  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b MAYO CLINIC   (United States)

^c UNIVERSITY OF TEXAS   (United States)

Author keywords

Age of onset; Cell cycle pathway; Lynch syndrome; Polymorphisms; Tree model

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; PROTEIN MDM2; PROTEIN P53; PROTEIN P73; SOMATOMEDIN C; TRANSCRIPTION FACTOR E2F2;

ADULT; AGED; ARTICLE; CELL CYCLE REGULATION; COLORECTAL CANCER; CONTROLLED STUDY; FAMILIAL CANCER; FEMALE; GENE INTERACTION; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PRIORITY JOURNAL;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; AGED, 80 AND OVER; CELL CYCLE; COLORECTAL NEOPLASMS, HEREDITARY NONPOLYPOSIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; YOUNG ADULT;

EID: 70350591968     PISSN: 09575243     EISSN: 15737225     Source Type: Journal    
DOI: 10.1007/s10552-009-9416-x     Document Type: Article

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