A phase II, open-label, sequential-cohort, dose-escalation study of romiplostim in Japanese patients with chronic immune thrombocytopenic purpura

International Journal of Hematology

Volumn 90, Issue 2, 2009, Pages 157-165

  Shirasugi, Yukari ^a   Ando, Kiyoshi ^a   Hashino, Satoshi ^b   Nagasawa, Toshiro ^c   Kurata, Yoshiyuki ^d   Kishimoto, Yuji ^e   Iwato, Koji ^f   Ohtsu, Tomoko ^g   Berger, Dietmar P ^h  

^a TOKAI UNIVERSITY HOSPITAL   (Japan)

^b HOKKAIDO UNIVERSITY HOSPITAL   (Japan)

^c UNIVERSITY OF TSUKUBA HOSPITAL   (Japan)

^d OSAKA UNIVERSITY HOSPITAL   (Japan)

^e KANSAI MEDICAL UNIVERSITY   (Japan)

^f ATOMIC BOMB SURVIVORS HOSPITAL   (Japan)

^g Amgen KK   (Japan)

^h AMGEN INC   (United States)

Author keywords

Immune thrombocytopenic purpura; Platelet production; Romiplostim; Thrombopoiesis

Indexed keywords

ROMIPLOSTIM; THROMBOPOIETIN;

ADULT; AGED; ARTHRALGIA; ARTICLE; BACKACHE; BLEEDING; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTACT DERMATITIS; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE ESCALATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; EPISTAXIS; FATIGUE; FEMALE; FLUSHING; HEADACHE; HEMATOMA; HUMAN; IDIOPATHIC THROMBOCYTOPENIC PURPURA; JAPANESE; MALAISE; MALE; MULTICENTER STUDY; MUSCLE TIGHTNESS; ORAL BLEEDING; PHASE 2 CLINICAL TRIAL; PURPURA; SIDE EFFECT; THROMBOCYTE COUNT; THROMBOCYTOPOIESIS; TONGUE HEMATOMA; TREATMENT RESPONSE;

ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; CARRIER PROTEINS; CHRONIC DISEASE; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; MALE; MIDDLE AGED; PLATELET COUNT; PURPURA, THROMBOCYTOPENIC, IDIOPATHIC; RECEPTORS, FC; RECOMBINANT FUSION PROTEINS; THROMBOPOIESIS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 70350574127     PISSN: 09255710     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12185-009-0361-y     Document Type: Article

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