Neuropathic pain: Peripheral and central mechanisms

European Journal of Pain Supplements

Volumn 3, Issue 2, 2009, Pages 33-36

  Jensen, Troels Staehelin ^a   Finnerup, Nanna Brix ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Central neurons; Neuropathic pain; Pathophysiology; Primary afferents; Sensitization

Indexed keywords

4 AMINOBUTYRIC ACID; BRAIN DERIVED NEUROTROPHIC FACTOR; MITOGEN ACTIVATED PROTEIN KINASE P38; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; HUMAN; NERVE CELL; NERVE CELL EXCITABILITY; NEUROPATHIC PAIN; PAIN ASSESSMENT; PATHOPHYSIOLOGY; PERIPHERAL NERVE INJURY; PRIORITY JOURNAL; SENSITIZATION; SENSORY NERVE;

EID: 70350569997     PISSN: 17543207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eujps.2009.07.012     Document Type: Article

References (29)

1. Baron R. Reflex sympathetic dystrophy and causalgia. Suppl Clin Neurophysiol 57 (2004) 24-38
2. Baron R., and Saguer M. Mechanical allodynia in postherpetic neuralgia: evidence for central mechanisms depending on nociceptive C-fiber degeneration. Neurology 45 (1995) S63-65
3. Black J.A., Nikolajsen L., Kroner K., Jensen T.S., and Waxman S.G. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann Neurol 64 (2008) 644-653
4. Campbell J.N., and Meyer R.A. Mechanisms of neuropathic pain. Neuron 52 (2006) 77-92
5. Cavanaugh D.J., Lee H., Lo L., Shields S.D., Zylka M.J., Basbaum A.I., et al. Distinct subsets of unmyelinated primary sensory fibers mediate behavioral responses to noxious thermal and mechanical stimuli. Proc Natl Acad Sci USA 106 (2009) 9075-9080
6. Costigan M., Scholz J., and Woolf C.J. Neuropathic pain: a maladaptive response of the nervous system to damage. Annu Rev Neurosci 32 (2009) 1-32
7. Hains B.C., Saab C.Y., Klein J.P., Craner M.J., and Waxman S.G. Altered sodium channel expression in second-order spinal sensory neurons contributes to pain after peripheral nerve injury. J Neurosci 24 (2004) 4832-4839
8. Hunt S.P., and Mantyh P.W. The molecular dynamics of pain control. Nat Rev Neurosci 2 (2001) 83-91
9. Jensen T.S., and Baron R. Translation of symptoms and signs into mechanisms in neuropathic pain. Pain 102 (2003) 1-8
10. Jensen T.S., Gottrup H., Kasch H., Nikolajsen L., Terkelsen A.J., and Witting N. Has basic research contributed to chronic pain treatment?. Acta Anaesth Scand 45 (2001) 1128-1135
11. Liu X.J., Gingrich J.R., Vargas-Caballero M., Dong Y.N., Sengar A., Beggs S., et al. Treatment of inflammatory and neuropathic pain by uncoupling Src from the NMDA receptor complex. Nat Med 14 (2008) 1325-1332
12. Luo Z.D., Chaplan S.R., Higuera E.S., Sorkin L.S., Stauderman K.A., Williams M.E., and Yaksh T.L. Upregulation of dorsal root ganglion (alpha)2(delta) calcium channel subunit and its correlation with allodynia in spinal nerve-injured rats. J Neurosci 21 (2001) 1868-1875
13. Merskey H., and Bogduk N. Classification of chronic pain: descriptions of chronic pain syndromes and definitions of pain terms. In: Merskey H., and Bogduk N. (Eds). Classification of chronic pain (1994), IASP Press, Seattle 180-181
14. Nystrom B., and Hagbarth K.E. Microelectrode recordings from transected nerves in amputees with phantom limb pain. Neurosci Lett 27 (1981) 211-216
15. Ochoa J.L., Campero M., Serra J., and Bostock H. Hyperexcitable polymodal and insensitive nociceptors in painful human neuropathy. Muscle Nerve 32 (2005) 459-472
16. Orstavic K, Jørum E. Microneurographic findings of relevance to pain in patients with erythromelalgia and patients with diabetic neuropathy. Neurosci Lett, 2009 [May 28 Epub].
17. Ren K., and Dubner R. Pain facilitation and activity-dependent plasticity in pain modulatory circuitry: role of BDNF-TrkB signaling and NMDA receptors. Mol Neurobiol 35 (2007) 224-235
18. Saab C.Y., Waxman S.G., and Hains B.C. Alarm or curse? The pain of neuroinflammation. Brain Res Rev 58 (2008) 226-235
19. Saadé N.E., and Jabbur S.J. Nociceptive behavior in animal models for peripheral neuropathy: spinal and supraspinal mechanisms. Prog Neurobiol 86 (2008) 22-47
20. Scholz J., and Woolf C.J. Can we conquer pain?. Nat Neurosci 5 Suppl. (2002) 1062-1067
21. Scholz J., Broom D.C., Youn D.H., Mills C.D., Kohno T., Suter M.R., et al. Blocking caspase activity prevents transsynaptic neuronal apoptosis and the loss of inhibition in lamina II of the dorsal horn after peripheral nerve injury. J Neurosci 25 (2005) 7317-7323
22. Tegeder I., Costigan M., Griffin R.S., Abele A., Belfer I., Schmidt H., et al. GTP cyclohydrolase and tetrahydrobiopterin regulate pain sensitivity and persistence. Nat Med 12 (2006) 1269-1277
23. Thacker M.A., Clark A.K., Marchand F., and McMahon S.B. Pathophysiology of peripheral neuropathic pain: immune cells and molecules. Anesth Analg 105 (2007) 838-847
24. Treede R.D., Jensen T.S., Campbell J.N., Cruccu G., Dostrovsky J.O., Griffin J.W., et al. Neuropathic pain: redefinition and a grading system for clinical and research purposes. Neurology 70 (2008) 1630-1635
25. Truini A, Padua L, Biasiotta A, Caliandro P, Pazzaglia C, Galeotti F, et al. Differential involvement of A-delta and A-beta fibres in neuropathic pain related to carpal tunnel syndrome. Pain, 2009 [June 15 Epub].
26. Ueda H. Molecular mechanisms of neuropathic pain-phenotypic switch and initiation mechanisms. Pharmacol Ther 109 (2006) 57-77
27. Watkins L.R., and Maier S.F. Immune regulation of central nervous system functions: from sickness responses to pathological pain. J Intern Med 257 (2005) 139-155
28. Woolf C.J. Pain: moving from symptom control toward mechanism-specific pharmacologic management. Ann Intern Med 140 (2004) 441-451
29. Woolf C.J., and Decosterd I. Implications of recent advances in the understanding of pain pathophysiology for the assessment of pain in patients. Pain S6 (1999) S141-S147