Immunomodulation of Rheum tanguticum polysaccharide (RTP) on the immunosuppressive effects of dexamethasone (DEX) on the treatment of colitis in rats induced by 2,4,6-trinitrobenzene sulfonic acid

International Immunopharmacology

Volumn 9, Issue 13-14, 2009, Pages 1568-1577

  Liu, Li ^a   Yuan, Shifang ^b   Long, Yin ^b   Guo, Zhenjun ^a   Sun, Yang ^a   Li, Yuhua ^a   Niu, Yinbo ^c   Li, Chen ^a   Mei, Qibing ^a  

^a FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c NORTHWESTERN POLYTECHNICAL UNIVERSITY   (China)

Author keywords

2,4,6 trinitrobenzene sulfonic acid; Colitis; Dexamethasone; Immunomodulation; Rheum tanguticum polysaccharide

Indexed keywords

DEXAMETHASONE; GAMMA INTERFERON; I KAPPA B ALPHA; INTERLEUKIN 4; INTERLEUKIN 5; MANNOSE RECEPTOR; MICROSPHERE; MYELOPEROXIDASE; PLANT EXTRACT; POLYSACCHARIDE; RHEUM TANGUTICUM POLYSACCHARIDE; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; TRINITROBENZENESULFONIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; COLITIS; COLON INJURY; COMMENSAL; CONTROLLED STUDY; CYTOKINE PRODUCTION; DISEASE EXACERBATION; DRUG DELIVERY SYSTEM; EMULSION; ENTEROBACTERIACEAE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOMODULATION; INTESTINE FLORA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RHEUM TANGUTICUM; RHUBARB; TH1 CELL; TH2 CELL; THYMUS ATROPHY; TREATMENT OUTCOME;

ANIMALS; ATROPHY; COLITIS; COLON; DEXAMETHASONE; IMMUNOMODULATION; IMMUNOSUPPRESSIVE AGENTS; INTESTINAL DISEASES; MALE; NANOCAPSULES; NF-KAPPA B; POLYSACCHARIDES; RATS; RATS, SPRAGUE-DAWLEY; RHEUM; THYMUS GLAND; TOLL-LIKE RECEPTOR 4; TRINITROBENZENESULFONIC ACID;

EID: 70350568185     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2009.09.013     Document Type: Article

References (27)

1. Liu L., Wang Z.P., Xu C.T., Pan B.R., Mei Q.B., Long Y., et al. Effects of Rheum tanguticum polysaccharide on TNBS-induced colitis and CD4+T cells in rats. World J Gastroenterol 9 (2003) 2284-2288
2. Liu L., Mei Q.B., Wang Z.P., Zhou Y.M., and Long Y. The effects of Rheum tanguticum polysaccharide on polarization of Th1 and Th2 cells in TNBS-induced colitis in murine. IJBS 1 (2005) 23-32
3. Liu L., Guo Z.J., Lv Z.G., Sun Y., Cao W., Zhang R., et al. The beneficial effect of Rheum tanguticum polysaccharide on protecting against diarrhea, colonic inflammation and ulceration in rats with TNBS-induced colitis: the role of macrophage mannose receptor in inflammation and immune response. Int Immunopharmacol 8 (2008) 1481-1492
4. Schreiber S., Nikolaus S., and Hampe J. Activation of nuclear factor κB in inflammatory bowel disease. Gut 42 (1998) 477-484
5. Islam Z., and Pestka J.J. LPS priming potentiates and prolongs proinflammatory cytokine response to the trichothecene deoxynivalenol in the mouse. Toxicol Appl Pharmacol 211 (2006) 53-63
6. Strober W., Fuss I., and Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 117 (2007) 514-521
7. Zhao A., Urban Jr. J.F., Anthony R.M., Sun R., Stiltz J., van Rooijen N., et al. Th2 cytokine-induced alterations in intestinal smooth muscle function depend on alternatively activated macrophages. Gastroenterology 135 (2008) 217-225
8. Rakoff-Nahoum S., Paglino J., Eslami-Varzaneh F., Edberg S., and Medzhitov R. Recognition of commensal microflora by toll-like receptors is required for intestinal homeostasis. Cell 118 (2004) 229-241
9. Souvannavong V., Saidji N., and Chaby R. Lipopolysaccharide from Salmonella enterica activates NF-κB through both classical and alternative pathways in primary B lymphocytes. Infect Immun 75 (2007) 4998-5003
10. Singh J.C., Cruickshank S.M., Newton D.J., Wakenshaw L., Graham A., Lan J., et al. Toll-like receptor-mediated responses of primary intestinal epithelial cells during the development of colitis. Am J Physiol Gastrointest Liver Physiol 288 (2005) G514-G524
11. Cario E. Bacterial interactions with cells of the intestinal mucosa: toll-like receptors and NOD2. Gut 54 (2005) 1182-1193
12. Fukata M., Chen A., Vamadevan A.S., Cohen J., Breglio K., Krishnareddy S., et al. Toll-like receptor-4 promotes the development of colitis-associated colorectal tumors. Gastroenterology 133 (2007) 1869-1881
13. Greten F.R., Eckmann L., Greten T.F., Park J.M., Li Z.W., Egan L.J., et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004) 285-296
14. Rakoff-Nahoum S., and Medzhhitov R. Regulation of spontaneous intestinal tumorigenesis through the adaptor protein MyD88. Science 317 (2007) 124-127
15. Gribar S.C., Anand R.J., Sodhi C.P., and Hackam D.J. The role of epithelial Toll-like receptor signaling in the pathogenesis of intestinal inflammation. J Leukoc Biol 83 (2008) 493-498
16. Kawai T., and Akira S. Signaling to NF-κB by Toll-like receptors. Trends Mol Med 13 (2007) 460-469
17. Lodes M.J., Cong Y., Elson C.O., Mohamath R., Landers C.J., Targan S.R., et al. Bacterial flagellin is a dominant antigen in Crohn disease. J Clin Invest 113 (2004) 1296-1306
18. Fukata M., Michelsen K.S., Eri R., Thomas L.S., Hu B., Lukasek K., et al. Toll-like receptor-4 is required for intestinal response to epithelial injury and limiting bacterial translocation in a murine model of acute colitis. Am J Physiol Gastrointest Liver Physiol 288 (2005) G1055-G1065
19. Zhao Y., Liu L., Yang X.B., Li X.Y., Sun X.L., and Zhang S.Y. Determination of monosaccharides in Rheum tanguticum maxim polysaccharide by high performance capillary electrophoresis. Herald Med 24 (2005) 981-983 [in Chinese with English abstract]
20. Nakase H., Okazaki K., Tabata Y., and Chiba T. Biodegradable microspheres targeting mucosal immune-regulating cells: new approach for treatment of inflammatory bowel disease. J Gastroenterol 15 (2003) 59-62
21. Okazaki K., Nakase H., Watanabe N., Tabata Y., Ikada Y., and Chiba T. Intestinal drug delivery systems with biodegradable microspheres targeting mucosal immune-regulating cells for chronic inflammatory colitis. J Gastroenterol 37 (2002) 44-52
22. Gupta M., and Gupta A.K. In vitro cytotoxicity studies of hydrogel pullulan nanoparticles prepared by AOT/N-hexane micellar system. J Pharm Pharm Sci 7 (2004) 38-46
23. Krawisz J.E., Sharon P., and Stenson W.F. Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rats and hamster models. Gastroenterology 87 (1984) 1344-1350
24. Lakatos P.L., and Lakatos L. Ulcerative proctitis: a review of pharmacotherapy and management. Expert Opin Pharmacother 9 (2008) 741-749
25. Bäckhed F., Normark S., Schweda E.K., Oscarson S., and Richter-Dahlfors A. Structural requirements for TLR4-mediated LPS signalling: a biological role for LPS modifications. Microbes Infect 5 (2003) 1057-1063
26. Ortega-Cava C.F., Ishihara S., Rumi M.A., Kawashima K., Ishimura N., Kazumori H., et al. Strategic compartmentalization of Toll-Like receptor 4 in the mouse gut. J Immunol 170 (2003) 3977-3985
27. Abreu M.T., Fukata M., and Arditi M. TLR signaling in the gut in health and disease. J Immunol 174 (2005) 4453-4460