Brain renin-angiotensin system in cognitive function: Pre-clinical findings and implications for prevention and treatment of dementia

Acta Neurologica Belgica

Volumn 109, Issue 3, 2009, Pages 171-180

  Ciobica, Alin ^a,c   Bild, Walther ^a,b   Hritcu, Lucian ^c   Haulica, Ion ^a  

^a ACADEMY OF ROMANIAN SCIENTISTS   (Romania)

^b GRIGORE T POPA UNIVERSITY OF MEDICINE AND PHARMACY   (Romania)

^c ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

Author keywords

Angiotensin 1 7; Angiotensin II; Angiotensin III; Angiotensin IV; Angiotensin (3 7); Brain renin angiotensin system; Cognitive functions; Neurodegenerative disorders

Indexed keywords

1 (4 AMINO 3 METHYLBENZYL) 5 DIPHENYLACETYL 4,5,6,7 TETRAHYDROIMIDAZO[4,5 C]PYRIDINE 6 CARBOXYLIC ACID; AMINOPEPTIDASE; ANGIOTENSIN; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN RECEPTOR ANTAGONIST; CAPTOPRIL; DIPEPTIDYL CARBOXYPEPTIDASE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; LISINOPRIL; LOSARTAN; MEMBRANE METALLOENDOPEPTIDASE; OXYTOCIN;

ALZHEIMER DISEASE; ANXIETY DISORDER; BIOCHEMISTRY; CENTRAL NERVOUS SYSTEM; COGNITION; COGNITIVE DEFECT; DEMENTIA; DRUG MECHANISM; GENETIC SUSCEPTIBILITY; LONG TERM DEPRESSION; LONG TERM POTENTIATION; MENTAL DETERIORATION; MORBIDITY; MULTIINFARCT DEMENTIA; NEUROLOGIC DISEASE; NONHUMAN; PATHOPHYSIOLOGY; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ANIMALS; BRAIN; COGNITION; DEMENTIA; HUMANS; NOOTROPIC AGENTS; RENIN-ANGIOTENSIN SYSTEM;

EID: 70350512081     PISSN: 03009009     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (83)

1. Akhavan MM, Emami-Abarghoie M, SadighiMoghaddam B, Safari M, Yousefi Y et al. Hippocampal angiotensin II receptors play an important role in mediating the effect of voluntary exercise on learning and memory in rat. Brain Res. 2008;1232:132-138
2. Albiston AL, Pederson ES, Burns P, Purcell B, Wright JW, Harding JW et al. Attenuation of scopolamine- induced learning deficits by LVV-hemorphin-7 in rats in the passive avoidance and water maze paradigms. Behav Brain Res. 2004;154:239-243 (Pubitemid 39070471)
3. Alenina N, Xu P, Rentzsch B, Patkin EL, Bader M. Genetically altered animal models for Mas and angiotensin-(1-7). Exp Physiol. 2008;93:528-537
4. Amouyel P, Richard F, Berr C, David-Fromentin I, Helbecque N. The renin angiotensin system and Alzheimer's disease. Ann N Y Acad Sci. 2000;903: 437-441 (Pubitemid 30251585)
5. Baltatu O, Lippoldt A, Hansson A, Ganten D, Bader M. Local renin-angiotensin system in the pineal gland. Mol Brain Res. 1998;54:237-242. (Pubitemid 28171787)
6. Baltatu O, Nishimura H, Hoffmann S, Stoltenburg G, Haulica I. et al. High levels of human chymase expression in the pineal and pituitary glands. Brain Res. 1997;752:269-278. (Pubitemid 27143923)
7. Becker C, Jick SS, Meier CR. Use of antihypertensives and the risk of Parkinson disease. Neurology. 2008;70:1438-1444
8. Bild W, Hritcu L, Ciobica A, Artenie V, Haulica I. Comparative effects of captopril, losartan and PD123319 on the memory processes in rats. European Psychiatry. 2009;24:S860.
9. Bonini JS, Bevilaqua LR, Zinn CG, Kerr DS, Medina JH. et al. Angiotensin II disrupts inhibitory avoidance memory retrieval. Horm Behav. 2006;50:308-313
10. Braszko JJ, Kulakowska A, Karwowska-Polecka W. CGP 42112A antagonism of the angiotensin II and angiotensin II(3-7) facilitation of recall in rats. Pharmacol Res. 1998;38:461-468
11. Braszko JJ, Walesiuk A, Wielgat P. Cognitive effects attributed to angiotensin II may result from its conversion to angiotensin IV. J Renin Angiotensin Aldosterone Syst. 2006;7:168-174 (Pubitemid 44740952)
12. Braszko JJ, Własienko J, Koziołkiewicz W, Janecka A, Wi niewski K. The 3-7 fragment of angiotensin II is probably responsible for its psychoactive properties. Brain Res. 1991;542:49-54.
13. Braszko JJ. AT(2) but not AT(1) receptor antagonism abolishes angiotensin II increase of the acquisition of conditioned avoidance responses in rats. Behav Brain Res. 2002;131:79-86.
14. Braszko JJ. D2 dopamine receptor blockade prevents cognitive effects of Ang IV and des-Phe6 Ang IV. Physiol Behav. 2006;88:152-159
15. Braszko JJ. Involvement of D1 dopamine receptors in the cognitive effects of angiotensin IV and des-Phe6 angiotensin IV. Peptides. 2004;25:1195-1203 (Pubitemid 38885734)
16. Cervilla JA, Prince M, Joels S, Lovestone S, Mann A. Longterm predictors of cognitive outcome in a cohort of older people with hypertension. Br J Psychiatry. 2000;177:66-71. (Pubitemid 30450667)
17. Chai SY, Bastias MA, Clune EF, Matsacos DJ, Mustafa T. et al. Distribution of angiotensin IV binding sites (AT4 receptor) in the human forebrain, midbrain and pons as visualised by in vitro receptor autoradiography. J Chem Neuroanat. 2000;20:339-348. (Pubitemid 32162891)
18. Chai SY, Yeatman HR, Parker MW, Ascher DB, Thompson PE. et al. Development of cognitive enhancers based on inhibition of insulin-regulated aminopeptidase. BMC Neurosci. 2008;2:S14.
19. Chalas A, Conway EL. No evidence for involvement of angiotensin II in spatial learning in water maze in rats. Behav Brain Res. 1996;81:199-205. (Pubitemid 26384979)
20. Culman J, Blume A, Gohlke P, Unger T. The renin- angiotensin system in the brain: possible therapeutic implications for AT(1)-receptor blockers. J Hum Hypertens. 2002;16:64-70. (Pubitemid 35021380)
21. De Bundel D, Smolders I, Vanderheyden P, Michotte Y. Ang II and Ang IV: unraveling the mechanism of action on synaptic plasticity, memory, and epilepsy. CNS Neurosci Ther. 2008;14:315-339
22. Fogari R, Mugellini A, Zoppi A, Derosa G, Pasotti C, Fogari E. et al. Influence of losartan and atenolol on memory function in very elderly hypertensive patients. J Hum Hypertens. 2003;17:781-785. (Pubitemid 37441435)
23. Fogari R, Mugellini A, Zoppi A, Lazzari P, Destro M. et al. Effect of telmisartan/hydrochlorothiazide vs lisinopril/hydrochlorothiazide combination on ambulatory blood pressure and cognitive function in elderly hypertensive patients. J Hum Hypertens. 2006;20:177-185
24. Fogari R, Zoppi A. Effect of antihypertensive agents on quality of life in the elderly. Drugs Aging. 2004;21:377-393 (Pubitemid 38608506)
25. Forette F, Seux M-L, Staessen JA. et al. Prevention of dementia in randomised double-blind placebo- controlled Systolic Hypertension in Europe (Syst- Eur) trial. Lancet. 1998;352:1347-1351 (Pubitemid 28510916)
26. Gard PR, Daw P, Mashhour ZS, Tran P. Interactions of angiotensin IV and oxytocin on behaviour in mice. J Renin Angiotensin Aldosterone Syst. 2007; 8:133-138 (Pubitemid 350148450)
27. Gard PR. Cognitive-enhancing effects of angiotensin IV. BMC Neurosci. 2008;9 (Suppl 2):S15.
28. Gendron L, Payet MD, Gallo-Payet N. The angiotensin type 2 receptor of angiotensin II and neuronal differentiation: from observation to mechanisms. J Mol Endocrinol. 2003;31:359-372. (Pubitemid 38054511)
29. Hanon O, Leys D. Cognitive decline and dementia in the elderly hypertensive. J Renin Angiotensin Aldosterone Syst. 2002;3:32-38 (Pubitemid 35345624)
30. Haulica I, Bild W, Boisteanu D. Biosynthesis and physiopharmacological actions of angiotensin peptides: 2. Physio-pharmacological properties. Rev Med Chir Soc Med Nat Iasi. 2006;110:384-390
31. Haulica I, Neamtu C, Stratone A, Petrescu G, Branisteanu D. et al. Evidence for the involvement of cerebral renin-angiotensin system (RAS) in stress analgesia. Pain. 1986;27:237-245 (Pubitemid 17184950)
32. Haulica I, Petrescu G, Slatineanu S, Bild W. Present data concerning the renin-angiotensin system of extrarenal origin. Rom J Physiol. 1999;36:153-163
33. Hellner K, Walther T, Schubert M, Albrecht D. Angiotensin-(1-7) enhances LTP in the hippocampus through the G-protein-coupled receptor Mas. Mol Cell Neurosci. 2005;29:427-435
34. Hou DR, Wang Y, Zhou L, Chen K, Tian Y, Song Z et al. Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease. Chin Med J (Engl). 2008;121:2320-2323
35. Hritcu L, Bild W, Ciobica A, Artenie V, Haulica I. Behavioral changes induced by angiotensin AT1 receptors blockade in the rat brain. European Psychiatry. 2009;24:S859.
36. Hritcu L., Ciobica A., Artenie V. The role of cholinergic- noradrenergic interactions in the mediation of the cognitive behavior of rats. Romanian Journal of Physiology. 2008;43:19-29.
37. Jennings JR, Muldoon MF, Price J, Christie IC, Meltzer CC. Cerebrovascular support for cognitive processing in hypertensive patients is altered by blood pressure treatment. Hypertension. 2008;52: 65-71.
38. Kehoe PG, Wilcock GK. Is inhibition of the renin-angiotensin system a new treatment option for Alzheimer's disease. Lancet Neurol. 2007;6:373-378.
39. Kerr DS, Bevilaqua LR, Bonini JS, Rossato JI, Kohler CA, Medina JH. et al. Angiotensin II blocks memory consolidation through an AT2 receptor- dependent mechanism. Psychopharmacology (Berl). 2005;179:529-535.
40. Kostenis E, Milligan G, Christopoulos A, Sanchez- Ferrer CF, Heringer-Walther S. G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor. Circulation. 2005; 111:1806-1813 (Pubitemid 40525146)
41. Kramar EA, Armstrong DL, Ikeda S, Wayner MJ, Harding JW. et al. The effects of angiotensin IV analogs on long-term potentiation within the CA1 region of the hippocampus in vitro. Brain Res. 2001;897:114-121. (Pubitemid 32244358)
42. Kumaran D, Udayabanu M, Kumar M, Aneja R, Katyal A. Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats. Neuroscience. 2008;155:626-639
43. Kuziemka-Leska M, Car H, Wi niewski K. Baclofen and AII 3-7 on learning and memory processes in rats chronically treated with ethanol. Pharmacol Biochem Behav. 1999;62:39-43.
44. Kuziemka-Leska M, Car H, Wi niewski K. Effect of bicuculline and angiotensin II fragment 3-7 on learning and memory processes in rats chronically treated with ethanol. Pol J Pharmacol. 1998;50:15-22. (Pubitemid 28179838)
45. Lee J, Albiston AL, Allen AM, Mendelsohn FA, Ping SE. et al. Effect of I.C.V. injection of AT4 receptor ligands, NLE1-angiotensin IV and LVV-hemorphin 7, on spatial learning in rats. Neuroscience. 2004;124:341-349 (Pubitemid 38229654)
46. Llorens-Cortes C, Mendelsohn FA. Organisation and functional role of the brain angiotensin system. J Renin Angiotensin Aldosterone Syst. 2002;1:39-48. (Pubitemid 35345625)
47. Lopez-Real A, Rey P, Soto-Otero R, Mendez-Alvarez E, Labandeira-Garcia JL. Angiotensin-reduces oxidative stress and protects dopaminergic neurons in a 6-hydroxydopamine rat model of Parkinsonism. J Neurosci Res. 2005;81:865-873 (Pubitemid 41532152)
48. Maul B, Von Bohlen Und Halbach O, Becker A, Sterner- Kock A, Voigt JP. et al. Impaired spatial memory and altered dendritic spine morphology in angiotensin II type 2 receptor-deficient mice. J Mol Med. 2008;86:563-571
49. Mc Kinley MJ, Albiston AL, Allen AM, Mathai ML, May CN. et al. The brain renin-angiotensin system: location and physiological roles. Int J Biochem Cell Biol. 2003;35:901-918 (Pubitemid 36379330)
50. Ohrui T, Matsui T, Yamaya M, Arai H, Ebihara S. et al. Angiotensin-Converting enzyme inhibitors and incidence of Alzheimer's disease in Japan. J Am Geriatr Soc. 2004;52:649-650. (Pubitemid 38480653)
51. Ohrui T, Tomita N, Sato-Nakagawa T, Matsui T, Maruyama M. et al. Effects of brain-penetrating ACE inhibitors on Alzheimer disease progression. Neurology. 2004;63:1324-1325. (Pubitemid 39350046)
52. Olson ML, Olson EA, Quails JH, Stratton JJ, Harding JW, Wright JW. Norleucine1-Angiotensin IV alleviates mecamylamine-induced spatial memory deficits. Peptides. 2004;25:233-241 (Pubitemid 38520053)
53. Phillips MI, De Oliveira EM. Brain renin angiotensin in disease. J Mol Med. 2008;86:715-722
54. Roberts KA, Krebs LT, Kramár EA. Autoradiographic identification of brain angiotensin IV binding sites and differential c-fos expression following intracerebroventricular injection of angiotensin II and IV in rats. Brain Res. 1995;682:13-21.
55. Sanoski CA. Aliskiren: an oral direct renin inhibitor for the treatment of hypertension. Pharmacotherapy. 2009;29:193-212.
56. Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP. et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci USA. 2003;100:8258-8263
57. Sarma GR, Kamath V, Mathew T, Roy AK. A case of Parkinsonism worsened by losartan: a probable new adverse effect. Mov Disord. 2008;23:1055. Letter to the editor.
58. Silva AQ, Santos RA, Fontes MA. Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone. Hypertension. 2005;46:341-348
59. Starr JM, Whalley LJ, Deary IJ. The effects of antihypertensive treatment on cognitive function: results from the HOPE study. J Am Geriatr Soc. 1996;44:411-415
60. Stoll M, Unger T. Angiotensin and its AT2 receptor: new insights into an old system. Regul Pept. 2001;99: 175-182. (Pubitemid 32522545)
61. Stragier B, De Bundel D, Sarre S, Smolders I, Vauquelin G. et al. Involvement of insulin-regulated aminopeptidase in the effects of the renin- angiotensin fragment angiotensin IV: a review. Heart Fail Rev. 2008;13:321-337
62. Sun C, Sellers KW, Sumners C, Raizada MK. NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II. Circ Res. 2005;96:659-666. (Pubitemid 40478333)
63. Tayal V, Kalra BS. Aliskiren: a novel renin inhibitor for hypertension. Indian Heart J. 2008;60:69-72.
64. Tchekalarova J, AlbrechT D. Angiotensin II suppresses long-term potentiation in the lateral amygdala of mice via L-type calcium channels. Neurosci Lett. 2007;415:68-72. (Pubitemid 46356714)
65. Tedesco MA, Ratti G, Mennella S, Manzo G, Grieco M. Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients. Am J Hypertens. 1999;12:1130-1134
66. Thomas WG, Mendelsohn FA. Angiotensin receptors: form and function and distribution. Int J Biochem Cell Biol. 2003;35:774-779. (Pubitemid 36379318)
67. Tom B, Dendorfer A, Jan Danser AH. Bradykinin, angiotensin-(1-7), and ACE inhibitors: how do they interact? Int J Biochem Cell Biol. 2003;35:792-801.
68. Vanderheyden PM. From angiotensin IV binding site to AT(4) receptor. Mol Cell Endocrinol. 2009;302: 159-166
69. Vauquelin G, Michotte Y, Smolders I, Sarre S, Ebinger G, Dupont A. et al. Cellular targets for angiotensin II fragments: pharmacological and molecular evidence. J Renin Angiotensin Aldosterone Syst. 2002;3:195-204. (Pubitemid 36187374)
70. Von Bohlen und Halbach O, Albrecht D. Angiotensin II inhibits long-term potentiation within the lateral nucleus of the amygdala through AT1 receptors. Peptides. 1998;19:1031-1036 (Pubitemid 28383799)
71. Von Bohlen und Halbach O, Albrecht D. The CNS renin- angiotensin system. Cell Tissue Res. 2006;326:599-616.
72. Walther T, Balschun D, Voigt JP, Fink H, Zuschratter W. et al. Sustained long term potentiation and anxiety in mice lacking the Mas protooncogene. J Biol Chem. 1998;273:11867-11873 (Pubitemid 28272093)
73. Walther T, Voigt JP, Fink H, Bader M. Sex specific behavioural alterations in Mas-deficient mice. Behav Brain Res. 2000;107:105-109
74. Walther T, Voigt JP, Fukamizu A, Fink H, Bader M. Learning and anxiety in angiotensin-deficient mice. Behav Brain Res. 1999;100:1-4.
75. Wayner MJ, Armstrong DL, Phelix CF, Wright JW, Harding JW. Angiotensin IV enhances LTP in rat dentate gyrus in vivo. Peptides. 2001;22:1403-1414.
76. Winnicka MM, Braszko JJ, Wi niewski K. 6-OHDA lesions to amygdala and hippocampus attenuate memory-enhancing effect of the 3-7 fragment of angiotensin II. Gen Pharmacol. 1998;30:801-805
77. Winnicka MM, Wi niewski K. Disruption of temporoentorhinal connections abolishes recognition memory-enhancing effect of angiotensins in rats. Gen Pharmacol. 1999;33:91-97
78. Winnicka MM. Dopaminergic projection to the nucleus accumbens mediates the memory-enhancing effect of angiotensins in rats. Pharmacol Biochem Behav. 1999;62:625-630 (Pubitemid 29127167)
79. Wisniewski K, Borawska M, Car H. The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory. Pol J Pharmacol. 1993;45:23-29. (Pubitemid 23278652)
80. Wright JW, Clemens JA, Panetta JA, Smalstig EB, Weatherly LA. et al. Effects of LY231617 and angiotensin IV on ischemia-induced deficits in circular water maze and passive avoidance performance in rats. Brain Res. 1996;717:1-11.
81. Wright JW, Harding JW. The angiotensin AT4 receptor subtype as a target for the treatment of memory dysfunction associated with Alzheimer's disease. J Renin Angiotensin Aldosterone Syst. 2008;9: 226-237
82. Wright JW, Kramar EA, Myers ED, Davis CJ, Harding JW. Ethanol-induced suppression of LTP can be attenuated with an angiotensin IV analog. Regul Pept. 2003;113:49-56.
83. Yamin G. NMDA receptor-dependent signaling pathways that underlie amyloid beta-protein disruption of LTP in the hippocampus. J Neurosci Res. 2009;87: 1729-1736