메뉴 건너뛰기




Volumn 29, Issue 2, 2009, Pages 193-212

Aliskiren: An oral direct renin inhibitor for the treatment of hypertension

Author keywords

Aliskiren; Hypertension; RAAS; Renin inhibitors; Renin angiotensin Aldosterone system

Indexed keywords

ALISKIREN; ALLOPURINOL; AMLODIPINE; ATENOLOL; ATORVASTATIN; CANDESARTAN; CARVEDILOL; CELECOXIB; CIMETIDINE; CYTOCHROME P450; DIGOXIN; DILTIAZEM; ENALAPRIL; ENALKIREN; FUROSEMIDE; HYDROCHLOROTHIAZIDE; IRBESARTAN; KETOCONAZOLE; LISINOPRIL; LOSARTAN; METOPROLOL TARTRATE; MEVINOLIN; PLACEBO; RAMIPRIL; REMIKIREN; VALSARTAN; WARFARIN; ZANKIREN;

EID: 59949088729     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1592/phco.29.2.193     Document Type: Review
Times cited : (43)

References (65)
  • 1
    • 39749191084 scopus 로고    scopus 로고
    • Heart disease and stroke statistics 2008 update: A report from the American Heart Association statistics committee and stroke statistics subcommittee
    • Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics 2008 update: a report from the American Heart Association statistics committee and stroke statistics subcommittee. Circulation 2008;117: e25-146.
    • (2008) Circulation , vol.117
    • Rosamond, W.1    Flegal, K.2    Furie, K.3
  • 4
    • 34249655660 scopus 로고    scopus 로고
    • Treatment of hypertension in the prevention and management of ischemic heart disease: A scientific statement from the American Heart Association council for high blood pressure research and the councils on clinical cardiology and epidemiology and prevention
    • Rosendorff C, Black HR, Cannon CP, et al. Treatment of hypertension in the prevention and management of ischemic heart disease: a scientific statement from the American Heart Association council for high blood pressure research and the councils on clinical cardiology and epidemiology and prevention. Circulation 2007;115: 2761-88.
    • (2007) Circulation , vol.115 , pp. 2761-2788
    • Rosendorff, C.1    Black, H.R.2    Cannon, C.P.3
  • 5
    • 33847633400 scopus 로고    scopus 로고
    • Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004
    • Ong KL, Cheung BMY, Man YB, Lau CP, Lam KSL. Prevalence, awareness, treatment, and control of hypertension among United States adults 1999-2004. Hypertension 2007;49: 69-75.
    • (2007) Hypertension , vol.49 , pp. 69-75
    • Ong, K.L.1    Cheung, B.M.Y.2    Man, Y.B.3    Lau, C.P.4    Lam, K.S.L.5
  • 6
    • 4143126680 scopus 로고    scopus 로고
    • Expert consensus document on angiotensin-converting enzyme inhibitors in cardio vascular disease : The task force on ACE-inhibitors of the European Society of Cardiology
    • Lopez-Sendon J, Swedberg K, McMurray J, et al. Expert consensus document on angiotensin-converting enzyme inhibitors in cardio vascular disease : the task force on ACE-inhibitors of the European Society of Cardiology. Eur Heart J 2004;25: 1454-70.
    • (2004) Eur Heart J , vol.25 , pp. 1454-1470
    • Lopez-Sendon, J.1    Swedberg, K.2    McMurray, J.3
  • 7
    • 10044290899 scopus 로고    scopus 로고
    • Angiotensin II receptor antagonists: Role in hypertension, cardiovascular disease, and renoprotection
    • Appel GB, Appel AS. Angiotensin II receptor antagonists: role in hypertension, cardiovascular disease, and renoprotection. Prog Cardiovasc Dis 2004;47: 105-15.
    • (2004) Prog Cardiovasc Dis , vol.47 , pp. 105-115
    • Appel, G.B.1    Appel, A.S.2
  • 8
    • 33644874142 scopus 로고    scopus 로고
    • Angiotensin II receptor blockers in congestive heart failure
    • Eisenberg MJ, Gioia LC. Angiotensin II receptor blockers in congestive heart failure. Cardiol Rev 2006;14: 26-34.
    • (2006) Cardiol Rev , vol.14 , pp. 26-34
    • Eisenberg, M.J.1    Gioia, L.C.2
  • 9
    • 10044243902 scopus 로고    scopus 로고
    • The clinical use of angiotensin- converting enzyme inhibitors
    • Wong J, Patel RA, Kowey PR. The clinical use of angiotensin- converting enzyme inhibitors. Prog Cardiovasc Dis 2004;47: 116-30.
    • (2004) Prog Cardiovasc Dis , vol.47 , pp. 116-130
    • Wong, J.1    Patel, R.A.2    Kowey, P.R.3
  • 10
    • 0027517659 scopus 로고
    • The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy
    • Lewis EJ, Hunsicker LG, Bain RP, Rohde RD. The effect of angiotensin-convertingenzyme inhibition on diabetic nephropathy. N Engl J Med 1993;329: 1456-62.
    • (1993) N Engl J Med , vol.329 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rohde, R.D.4
  • 11
    • 0035922447 scopus 로고    scopus 로고
    • Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes
    • Lewis EJ, Hunsicker LG, Clarke WR, et al. Renoprotective effect of the angiotensin-receptor antagonist irbesartan in patients with nephropathy due to type 2 diabetes. N Engl J Med 2001;345: 851-60.
    • (2001) N Engl J Med , vol.345 , pp. 851-860
    • Lewis, E.J.1    Hunsicker, L.G.2    Clarke, W.R.3
  • 12
    • 0033517302 scopus 로고    scopus 로고
    • The effect of spironolactone on morbidity and mortality in patients with severe heart failure
    • Pitt B, Zannad F, Remme WJ, et al. The effect of spironolactone on morbidity and mortality in patients with severe heart failure. N Engl J Med 1999;341: 709-17.
    • (1999) N Engl J Med , vol.341 , pp. 709-717
    • Pitt, B.1    Zannad, F.2    Remme, W.J.3
  • 13
    • 0037417252 scopus 로고    scopus 로고
    • Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
    • Pitt B, Remme W, Zannad F, et al. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003;348: 1309-21.
    • (2003) N Engl J Med , vol.348 , pp. 1309-1321
    • Pitt, B.1    Remme, W.2    Zannad, F.3
  • 14
    • 33847704535 scopus 로고    scopus 로고
    • Direct renin inhibition: A new way of targeting the renin system
    • Brown MJ. Direct renin inhibition: a new way of targeting the renin system. J Renin Angiotensin Aldosterone Syst 2006;7: S7-11.
    • (2006) J Renin Angiotensin Aldosterone Syst , vol.7
    • Brown, M.J.1
  • 15
    • 0034100147 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases
    • Kim S, Iwao H. Molecular and cellular mechanisms of angiotensin II-mediated cardiovascular and renal diseases. Pharmacol Rev 2000;52: 11-34.
    • (2000) Pharmacol Rev , vol.52 , pp. 11-34
    • Kim, S.1    Iwao, H.2
  • 16
    • 2642575030 scopus 로고    scopus 로고
    • Co mbined blockade of the renin- angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists
    • Azizi M, Menard J. Co mbined blockade of the renin- angiotensin system with angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists. Circulation 2004;109: 2492-9.
    • (2004) Circulation , vol.109 , pp. 2492-2499
    • Azizi, M.1    Menard, J.2
  • 17
    • 0028924990 scopus 로고
    • Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients
    • Goldberg MR, Bradstreet TE, McWilliams EJ, et al. Biochemical effects of losartan, a nonpeptide angiotensin II receptor antagonist, on the renin-angiotensin-aldosterone system in hypertensive patients. Hypertension 1995;25: 37-46.
    • (1995) Hypertension , vol.25 , pp. 37-46
    • Goldberg, M.R.1    Bradstreet, T.E.2    McWilliams, E.J.3
  • 18
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher NDL, Price DA. Pathways for angiotensin II generation in intact human tissue: evidence from comparative pharmacological interruption of the renin system. Hypertension 1998;32: 387-92.
    • (1998) Hypertension , vol.32 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.L.2    Price, D.A.3
  • 19
    • 0027414372 scopus 로고
    • Cough and inhibition of the renin-angiotensin system
    • Karlberg BE. Cough and inhibition of the renin-angiotensin system. J Hypertens Suppl 1993;11: S49-52.
    • (1993) J Hypertens Suppl , vol.11
    • Karlberg, B.E.1
  • 21
    • 33144481921 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibitor- induced cough: ACCP evidence-based clinical practice guidelines
    • Dicpinigaitis PV. Angiotensin-converting enzyme inhibitor- induced cough: ACCP evidence-based clinical practice guidelines. Chest 2006;129: S169-73.
    • (2006) Chest , vol.129
    • Dicpinigaitis, P.V.1
  • 22
    • 0346895374 scopus 로고    scopus 로고
    • Therapeutic potential of renin inhibitors in the management of cardiovascular disorders
    • Stanton A. Therapeutic potential of renin inhibitors in the management of cardiovascular disorders. Am J Cardiovasc Drugs 2003;3: 389-94.
    • (2003) Am J Cardiovasc Drugs , vol.3 , pp. 389-394
    • Stanton, A.1
  • 23
    • 43049090108 scopus 로고    scopus 로고
    • The (pro)renin receptor: A new addition to the renin-angiotensin system?
    • Batenburg WW, Danser AHJ. The (pro)renin receptor: a new addition to the renin-angiotensin system? Eur J Pharmacol 2008;585;320-4.
    • (2008) Eur J Pharmacol , vol.585 , pp. 320-324
    • Batenburg, W.W.1    Danser, A.H.J.2
  • 24
    • 33750592956 scopus 로고    scopus 로고
    • Pro renin and its ancient recepto r
    • Burckle C, Bader M. Pro renin and its ancient recepto r. Hypertension 2006;48: 549-51.
    • (2006) Hypertension , vol.48 , pp. 549-551
    • Burckle, C.1    Bader, M.2
  • 25
    • 0037769830 scopus 로고    scopus 로고
    • Renin inhibitors as novel treatments for cardiovascular disease
    • Maibaum J, Feldman DL. Renin inhibitors as novel treatments for cardiovascular disease. Expert Opin Ther Patents 2003;13: 589-603.
    • (2003) Expert Opin Ther Patents , vol.13 , pp. 589-603
    • Maibaum, J.1    Feldman, D.L.2
  • 26
    • 59949102958 scopus 로고    scopus 로고
    • Novartis Pharmaceuticals Corporation. Tekturna (aliskiren) package insert. East Hanover, NJ; 2007
    • Novartis Pharmaceuticals Corporation. Tekturna (aliskiren) package insert. East Hanover, NJ; 2007.
  • 27
    • 33750235228 scopus 로고    scopus 로고
    • Aliskiren: A renin inhibitor offering a new approach for the treatment of hypertension
    • O'Brien E. Aliskiren: a renin inhibitor offering a new approach for the treatment of hypertension. Exp Opin Invest Drugs 2006;15: 1269-77.
    • (2006) Exp Opin Invest Drugs , vol.15 , pp. 1269-1277
    • O'Brien, E.1
  • 28
    • 0042661157 scopus 로고    scopus 로고
    • Structure-based design of aliskiren, a novel orally effective renin inhibitor
    • Wood JM, Maibaum J, Rahuel J, et al. Structure-based design of aliskiren, a novel orally effective renin inhibitor. Biochem Biophys Res Commun 2003;308: 698-705.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 698-705
    • Wood, J.M.1    Maibaum, J.2    Rahuel, J.3
  • 29
    • 25444454353 scopus 로고    scopus 로고
    • Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats
    • Pilz B, Shagdarsuren E, Wellner M, et al. Aliskiren, a human renin inhibitor, ameliorates cardiac and renal damage in double-transgenic rats. Hypertension 2005;46: 569-76.
    • (2005) Hypertension , vol.46 , pp. 569-576
    • Pilz, B.1    Shagdarsuren, E.2    Wellner, M.3
  • 30
    • 14044271546 scopus 로고    scopus 로고
    • S chnell C R, Cumin F, Menard J, Webb RL. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats
    • Wood JM, S chnell C R, Cumin F, Menard J, Webb RL. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005;23: 417-26.
    • (2005) J Hypertens , vol.23 , pp. 417-426
    • Wood, J.M.1
  • 31
  • 32
    • 33750357566 scopus 로고    scopus 로고
    • Vaidyanathan S, Jermany J, Yeh C, Bizot MN, Camisasca R. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br J Clin Pharmacol 2006;62: 690-8.
    • Vaidyanathan S, Jermany J, Yeh C, Bizot MN, Camisasca R. Aliskiren, a novel orally effective renin inhibitor, exhibits similar pharmacokinetics and pharmacodynamics in Japanese and Caucasian subjects. Br J Clin Pharmacol 2006;62: 690-8.
  • 33
    • 33750289480 scopus 로고    scopus 로고
    • Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus
    • Zhao C, Vaidyanathan S, Yeh CM, Maboudian M, Armin Dieterich H. Aliskiren exhibits similar pharmacokinetics in healthy volunteers and patients with type 2 diabetes mellitus. Clin Pharmacokinet 2006;45: 1125-34.
    • (2006) Clin Pharmacokinet , vol.45 , pp. 1125-1134
    • Zhao, C.1    Vaidyanathan, S.2    Yeh, C.M.3    Maboudian, M.4    Armin Dieterich, H.5
  • 34
    • 0036372173 scopus 로고    scopus 로고
    • N ussberger J, Wuerzner G, Jensen C, Brunner HR. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren ( SPP1 00): comparison with enalapril. Hypertension 2002;39: e1-8.
    • N ussberger J, Wuerzner G, Jensen C, Brunner HR. Angiotensin II suppression in humans by the orally active renin inhibitor aliskiren ( SPP1 00): comparison with enalapril. Hypertension 2002;39: e1-8.
  • 35
    • 59949089004 scopus 로고    scopus 로고
    • Vaidyanathan S. Aliskiren, a novel oral renin inhibitor, has no interaction with cytoc hrome P45 0 iso enzymes in vitro [abstract]. Basic Clin Pharmacol Toxicol 2005;97(suppl 1): 239.
    • Vaidyanathan S. Aliskiren, a novel oral renin inhibitor, has no interaction with cytoc hrome P45 0 iso enzymes in vitro [abstract]. Basic Clin Pharmacol Toxicol 2005;97(suppl 1): 239.
  • 36
    • 34547221695 scopus 로고    scopus 로고
    • Absorption, distribution, metabolism and elimination of the direct renin inhibitor aliskiren in healthy volunteers
    • Waldmeier FJ, Glaenzel U, Wirz B, et al. Absorption, distribution, metabolism and elimination of the direct renin inhibitor aliskiren in healthy volunteers. Drug Metab Dispos 2007;35: 1418-28.
    • (2007) Drug Metab Dispos , vol.35 , pp. 1418-1428
    • Waldmeier, F.J.1    Glaenzel, U.2    Wirz, B.3
  • 37
    • 9644287897 scopus 로고    scopus 로고
    • Pharmac o logic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Azizi M, Menard J, Bissery A, et al. Pharmac o logic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004;15: 3126-33.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3126-3133
    • Azizi, M.1    Menard, J.2    Bissery, A.3
  • 38
    • 33947543780 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects
    • Vaidyanathan S, Reynolds C, Yeh CM, et al. Pharmacokinetics, safety, and tolerability of the novel oral direct renin inhibitor aliskiren in elderly healthy subjects. J Clin Pharmacol 2007;47: 453-60.
    • (2007) J Clin Pharmacol , vol.47 , pp. 453-460
    • Vaidyanathan, S.1    Reynolds, C.2    Yeh, C.M.3
  • 39
    • 33846456943 scopus 로고    scopus 로고
    • Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment
    • Vaidyanathan S, Warren V, Yeh C, Bizot MN, Dieterich HA, Dole WP. Pharmacokinetics, safety, and tolerability of the oral renin inhibitor aliskiren in patients with hepatic impairment. J Clin Pharmacol 2007;47: 192-200.
    • (2007) J Clin Pharmacol , vol.47 , pp. 192-200
    • Vaidyanathan, S.1    Warren, V.2    Yeh, C.3    Bizot, M.N.4    Dieterich, H.A.5    Dole, W.P.6
  • 40
    • 34547628374 scopus 로고    scopus 로고
    • Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment
    • Vaidyanathan S, Bigler H, Yeh C, et al. Pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with irbesartan in renal impairment. Clin Pharmacokinet 2007;46: 661-75.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 661-675
    • Vaidyanathan, S.1    Bigler, H.2    Yeh, C.3
  • 41
    • 33947182655 scopus 로고    scopus 로고
    • Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patie nts with hypertension
    • Oh BH, Mitchell J, Herron JR, Chung J, Khan M, Keefe DL. Aliskiren, an oral renin inhibitor, provides dose-dependent efficacy and sustained 24-hour blood pressure control in patie nts with hypertension. J Am Coll Cardiol 2007;49: 1157-63.
    • (2007) J Am Coll Cardiol , vol.49 , pp. 1157-1163
    • Oh, B.H.1    Mitchell, J.2    Herron, J.R.3    Chung, J.4    Khan, M.5    Keefe, D.L.6
  • 42
    • 0347479295 scopus 로고    scopus 로고
    • Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
    • Stanton A, Jensen C, Nussberger J, O'Brien E. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 2003;42: 1137-43.
    • (2003) Hypertension , vol.42 , pp. 1137-1143
    • Stanton, A.1    Jensen, C.2    Nussberger, J.3    O'Brien, E.4
  • 43
    • 14844363404 scopus 로고    scopus 로고
    • Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and place bo -like tolerability in hype rte nsive patients. Circulation 2005;111: 1012-18.
    • Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor, provides dose-dependent antihypertensive efficacy and place bo -like tolerability in hype rte nsive patients. Circulation 2005;111: 1012-18.
  • 44
    • 33846421005 scopus 로고    scopus 로고
    • Aliskiren reduces blo od pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker
    • O'Brien E, Barton J, Nussberger J, et al. Aliskiren reduces blo od pressure and suppresses plasma renin activity in combination with a thiazide diuretic, an angiotensin-converting enzyme inhibitor, or an angiotensin receptor blocker. Hypertension 2007;49: 276-84.
    • (2007) Hypertension , vol.49 , pp. 276-284
    • O'Brien, E.1    Barton, J.2    Nussberger, J.3
  • 45
    • 33845785350 scopus 로고    scopus 로고
    • Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan
    • Pool JL, Schmieder RE, Azizi M, et al. Aliskiren, an orally effective renin inhibitor, provides antihypertensive efficacy alone and in combination with valsartan. Am J Hypertens 2007;20: 11-20.
    • (2007) Am J Hypertens , vol.20 , pp. 11-20
    • Pool, J.L.1    Schmieder, R.E.2    Azizi, M.3
  • 46
    • 34447521458 scopus 로고    scopus 로고
    • Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: A randomised, double-blind trial
    • Oparil S, Yarows SA, Patel S, Fang H, Zhang J, Satlin A. Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trial. Lancet 2007;370: 221-9.
    • (2007) Lancet , vol.370 , pp. 221-229
    • Oparil, S.1    Yarows, S.A.2    Patel, S.3    Fang, H.4    Zhang, J.5    Satlin, A.6
  • 47
    • 33845366982 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide
    • Villamil A, Chrysant SG, Calhoun D, et al. Renin inhibition with aliskiren provides additive antihypertensive efficacy when used in combination with hydrochlorothiazide. J Hypertens 2007;25: 217-26.
    • (2007) J Hypertens , vol.25 , pp. 217-226
    • Villamil, A.1    Chrysant, S.G.2    Calhoun, D.3
  • 48
    • 34247867955 scopus 로고    scopus 로고
    • Direct renin inhibition with aliskiren in obese patients with arterial hypertension
    • Jordan J, Engeli S, Boye SW, Le Breton S, Keefe DL. Direct renin inhibition with aliskiren in obese patients with arterial hypertension. Hypertension 2007;49: 1047-55.
    • (2007) Hypertension , vol.49 , pp. 1047-1055
    • Jordan, J.1    Engeli, S.2    Boye, S.W.3    Le Breton, S.4    Keefe, D.L.5
  • 49
    • 38649102508 scopus 로고    scopus 로고
    • Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension
    • Uresin Y, Taylor AA, Kilo C, et al. Efficacy and safety of the direct renin inhibitor aliskiren and ramipril alone or in combination in patients with diabetes and hypertension. J Renin Angiotensin Aldosterone Syst 2007;8: 190-8.
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , pp. 190-198
    • Uresin, Y.1    Taylor, A.A.2    Kilo, C.3
  • 51
    • 65649099918 scopus 로고    scopus 로고
    • Effect of the direct renin inhibitor aliskiren, either alone or in combination with losartan, compared to losartan, on left ventricular mass in patients with hypertension and left ventricular hypertrophy: The aliskiren left ventricular assessment o f hypertrophy (ALLAY) trial
    • Presented at the session of the American College of Cardiology, Chicago, IL, March 29-April 1
    • Solomon SD, Appelbaum E, Manning WJ, et al. Effect of the direct renin inhibitor aliskiren, either alone or in combination with losartan, compared to losartan, on left ventricular mass in patients with hypertension and left ventricular hypertrophy: the aliskiren left ventricular assessment o f hypertrophy (ALLAY) trial. Presented at the 57th annual scientific session of the American College of Cardiology, Chicago, IL, March 29-April 1, 2008.
    • (2008) 57th annual scientific
    • Solomon, S.D.1    Appelbaum, E.2    Manning, W.J.3
  • 52
    • 39649085668 scopus 로고    scopus 로고
    • Neurohumoral effects of a new oral direct renin inhibitor in stable heart failure: The aliskiren observation of heart failure treatment study (ALOFT) [abstract 2491]
    • Pitt B, McMurray JJ, Latini R, et al. Neurohumoral effects of a new oral direct renin inhibitor in stable heart failure: the aliskiren observation of heart failure treatment study (ALOFT) [abstract 2491]. Circulation 2007;116: II549.
    • (2007) Circulation , vol.116
    • Pitt, B.1    McMurray, J.J.2    Latini, R.3
  • 55
    • 34548855067 scopus 로고    scopus 로고
    • A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension
    • Strasser RH, Puig JG, Farsang C, Croket M, Li J, van Ingen H. A comparison of the tolerability of the direct renin inhibitor aliskiren and lisinopril in patients with severe hypertension. J Hum Hypertens 2007;21: 780-7.
    • (2007) J Hum Hypertens , vol.21 , pp. 780-787
    • Strasser, R.H.1    Puig, J.G.2    Farsang, C.3    Croket, M.4    Li, J.5    van Ingen, H.6
  • 56
    • 59949092828 scopus 로고    scopus 로고
    • Novartis Pharmaceutical C orp oration. Tekturna HCT, hydrochlorothiazide and aliskiren package insert. East Hanover, NJ; 2008
    • Novartis Pharmaceutical C orp oration. Tekturna HCT ( hydrochlorothiazide and aliskiren) package insert. East Hanover, NJ; 2008.
  • 57
    • 34447128795 scopus 로고    scopus 로고
    • Nonallergic angioedema: Role of bradykinin
    • Bas M, Adams V, Suvorava T, et al. Nonallergic angioedema: role of bradykinin. Allergy 2007;62: 842-56.
    • (2007) Allergy , vol.62 , pp. 842-856
    • Bas, M.1    Adams, V.2    Suvorava, T.3
  • 58
    • 28044453329 scopus 로고    scopus 로고
    • C orynen S, Vaidyanathan S, Mann J. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine
    • Dieterle W, C orynen S, Vaidyanathan S, Mann J. Pharmacokinetic interactions of the oral renin inhibitor aliskiren with lovastatin, atenolol, celecoxib and cimetidine. Int J Clin Pharmacol Ther 2005;43: 527-35.
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 527-535
    • Dieterle, W.1
  • 59
    • 33749853955 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
    • Vaidyanathan S, ValenciaJ, Kemp C, et al. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract 2006;60: 1343-56.
    • (2006) Int J Clin Pract , vol.60 , pp. 1343-1356
    • Vaidyanathan, S.1    Valencia, J.2    Kemp, C.3
  • 60
    • 41149087776 scopus 로고    scopus 로고
    • A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects
    • Ayalasomayajula S, Tchaloyan S, Yeh CM, et al. A study of the pharmacokinetic interactions of the direct renin inhibitor aliskiren with allopurinol, celecoxib and cimetidine in healthy subjects. Curr Med Res Opin 2008;24: 717-26.
    • (2008) Curr Med Res Opin , vol.24 , pp. 717-726
    • Ayalasomayajula, S.1    Tchaloyan, S.2    Yeh, C.M.3
  • 61
    • 4744348177 scopus 로고    scopus 로고
    • C orynen S, Mann J. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmaco- dynamics of a single dose of warfarin in healthy subjects
    • Dieterle W, C orynen S, Mann J. Effect of the oral renin inhibitor aliskiren on the pharmacokinetics and pharmaco- dynamics of a single dose of warfarin in healthy subjects. Br J Clin Pharmacol 2004;58: 433-6.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 433-436
    • Dieterle, W.1
  • 62
    • 59949100706 scopus 로고    scopus 로고
    • Vaidyanathan S, Reynolds C, Yeh CM, et. al. The pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with the P-glycoprotein modulators ketoconazole, digoxin, and atorvastatin in healthy subjects [abstract]. Clin Pharmacol Ther 2007;81: S109.
    • Vaidyanathan S, Reynolds C, Yeh CM, et. al. The pharmacokinetics of the oral direct renin inhibitor aliskiren alone and in combination with the P-glycoprotein modulators ketoconazole, digoxin, and atorvastatin in healthy subjects [abstract]. Clin Pharmacol Ther 2007;81: S109.
  • 63
    • 34547907203 scopus 로고    scopus 로고
    • Assessment of the pharmacokinetic interaction between the oral direct renin inhibitor aliskiren and furosemide: A study in healthy volunteers [abstract]
    • Zhao C, Vaidyanathan S, Dieterich HA, Yeh C, Howard D, Dole WP. Assessment of the pharmacokinetic interaction between the oral direct renin inhibitor aliskiren and furosemide: a study in healthy volunteers [abstract]. Clin Pharmacol Ther 2007;81: S110.
    • (2007) Clin Pharmacol Ther , vol.81
    • Zhao, C.1    Vaidyanathan, S.2    Dieterich, H.A.3    Yeh, C.4    Howard, D.5    Dole, W.P.6
  • 64
    • 33744966030 scopus 로고    scopus 로고
    • Major congenital malformations after first-trimester exposure to ACE inhibitors
    • Cooper WO, Hernandez-Diaz S, Arbogast PG, et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med 2006;354: 2443-51
    • (2006) N Engl J Med , vol.354 , pp. 2443-2451
    • Cooper, W.O.1    Hernandez-Diaz, S.2    Arbogast, P.G.3
  • 65
    • 59949096001 scopus 로고    scopus 로고
    • Drugstore.com. Prescription price checker. Available from http://www.drugstore.com/pharmacy/drugindex/default.asp?aid= 332828&aparam=sespider&trx=3888. Accessed August 14, 2008
    • Drugstore.com. Prescription price checker. Available from http://www.drugstore.com/pharmacy/drugindex/default.asp?aid= 332828&aparam=sespider&trx=3888. Accessed August 14, 2008


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.