메뉴 건너뛰기




Volumn 60, Issue 1, 2008, Pages 69-72

Aliskiren: A novel renin inhibitor for hypertension

Author keywords

Aliskiren; Hypertension; Renin inhibitor; SPP100

Indexed keywords

ALISKIREN; AMLODIPINE; ANGIOTENSIN; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; HYDROCHLOROTHIAZIDE; IRBESARTAN; PLACEBO; RAMIPRIL; RENIN; RENIN INHIBITOR; VALSARTAN;

EID: 48749085184     PISSN: 00194832     EISSN: 00194832     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (26)
  • 1
    • 0016256329 scopus 로고
    • The renin-angiotensin system
    • Oparil S, Haber E. The renin-angiotensin system. N Engl J Med 1974;291:381-401,446-457.
    • (1974) N Engl J Med , vol.291 , Issue.381-401 , pp. 446-457
    • Oparil, S.1    Haber, E.2
  • 2
    • 0035048905 scopus 로고    scopus 로고
    • Tissue angiotensin and pathobiology of vascular disease, a unifying hypothesis
    • Dzau VJ. Tissue angiotensin and pathobiology of vascular disease, a unifying hypothesis. Hypertension 2001;37:1047-1052.
    • (2001) Hypertension , vol.37 , pp. 1047-1052
    • Dzau, V.J.1
  • 3
    • 0042134568 scopus 로고    scopus 로고
    • The renin- angiotensin system and the long-term complications of diabetes: Pathophysiological and therapeutic considerations
    • Gilbert RE, Krum H, Wilkinson-Berka J, Kelly DJ. The renin- angiotensin system and the long-term complications of diabetes: pathophysiological and therapeutic considerations. Diabet Med 2003;20:607-621.
    • (2003) Diabet Med , vol.20 , pp. 607-621
    • Gilbert, R.E.1    Krum, H.2    Wilkinson-Berka, J.3    Kelly, D.J.4
  • 4
    • 0344373794 scopus 로고    scopus 로고
    • Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT)
    • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group
    • ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002;288:2981-2997.
    • (2002) JAMA , vol.288 , pp. 2981-2997
  • 5
    • 0015627637 scopus 로고
    • Rapid marked increase in plasma renin in rats treated with inhibitors of the renin system. Effects of 1-sar-8-ala-angiotensin II and of a synthetic converting enzyme inhibitor (nonapeptide, SQ 20.881) on normal and adrenalectomized rats
    • Bing J. Rapid marked increase in plasma renin in rats treated with inhibitors of the renin system. Effects of 1-sar-8-ala-angiotensin II and of a synthetic converting enzyme inhibitor (nonapeptide, SQ 20.881) on normal and adrenalectomized rats. Acta Pathol Microbiol Scand [A] 1973;81:376-378.
    • (1973) Acta Pathol Microbiol Scand [A] , vol.81 , pp. 376-378
    • Bing, J.1
  • 6
    • 0031688757 scopus 로고    scopus 로고
    • Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system
    • Hollenberg NK, Fisher ND, Price DA. Pathways for angiotensin II generation in intact human tissue: Evidence from comparative pharmacological interruption of the renin system. Hypertension 1998;32:387-392.
    • (1998) Hypertension , vol.32 , pp. 387-392
    • Hollenberg, N.K.1    Fisher, N.D.2    Price, D.A.3
  • 7
    • 7444269503 scopus 로고    scopus 로고
    • The (pro)renin receptor: Biology and functional significance
    • Nguyen G, Burckle CA. The (pro)renin receptor: biology and functional significance. Bull Acad Natl Med 2004;188:621-628.
    • (2004) Bull Acad Natl Med , vol.188 , pp. 621-628
    • Nguyen, G.1    Burckle, C.A.2
  • 8
    • 0036266596 scopus 로고    scopus 로고
    • Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin
    • Nguyen G, Delarue F, Burckle C, Bouzhir L, Giller T, Sraer JD. Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 2002;109:1417-1427.
    • (2002) J Clin Invest , vol.109 , pp. 1417-1427
    • Nguyen, G.1    Delarue, F.2    Burckle, C.3    Bouzhir, L.4    Giller, T.5    Sraer, J.D.6
  • 9
    • 27444447364 scopus 로고    scopus 로고
    • Renin, prorenin, and the putative (pro)renin receptor
    • Danser AHJ, Deinum J. Renin, prorenin, and the putative (pro)renin receptor. Hypertension 2005;46:1069-1076.
    • (2005) Hypertension , vol.46 , pp. 1069-1076
    • Danser, A.H.J.1    Deinum, J.2
  • 10
    • 0033941893 scopus 로고    scopus 로고
    • Structure-based drug design: The discovery of novel non peptide orally active inhibitors of human renin
    • Rahuel J, Rasetti V, Maibaum J, et al. Structure-based drug design: the discovery of novel non peptide orally active inhibitors of human renin. Chem Biol 2000;7:493-504.
    • (2000) Chem Biol , vol.7 , pp. 493-504
    • Rahuel, J.1    Rasetti, V.2    Maibaum, J.3
  • 11
    • 9644287897 scopus 로고    scopus 로고
    • Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption
    • Azizi M, Menard J, Bissery A, et al. Pharmacologic demonstration of the synergistic effects of a combination of the renin inhibitor aliskiren and the AT1 receptor antagonist valsartan on the angiotensin II-renin feedback interruption. J Am Soc Nephrol 2004;15:3126-33.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 3126-3133
    • Azizi, M.1    Menard, J.2    Bissery, A.3
  • 12
    • 33644789557 scopus 로고    scopus 로고
    • Renin inhibition with aliskiren: Where are we now, and where are we going?
    • Azizi M, Webb R, Nussberger J, Hollenberg NK. Renin inhibition with aliskiren: where are we now, and where are we going? J Hypertens 2006;24:243-56.
    • (2006) J Hypertens , vol.24 , pp. 243-256
    • Azizi, M.1    Webb, R.2    Nussberger, J.3    Hollenberg, N.K.4
  • 13
    • 0347479295 scopus 로고    scopus 로고
    • Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren
    • Stanton A, Jensen C, Nussberger J, O'Brien E. Blood pressure lowering in essential hypertension with an oral renin inhibitor, aliskiren. Hypertension 2003; 42:1137-1143.
    • (2003) Hypertension , vol.42 , pp. 1137-1143
    • Stanton, A.1    Jensen, C.2    Nussberger, J.3    O'Brien, E.4
  • 14
    • 33846449197 scopus 로고    scopus 로고
    • Once-daily aliskiren provides effective, smooth 24-hour blood pressure control in patients with hypertension
    • Mitchell J, Oh B, Herron J, et al. Once-daily aliskiren provides effective, smooth 24-hour blood pressure control in patients with hypertension. J Clin Hypertens 2006;8:209.
    • (2006) J Clin Hypertens , vol.8 , pp. 209
    • Mitchell, J.1    Oh, B.2    Herron, J.3
  • 15
    • 85069065308 scopus 로고    scopus 로고
    • Vaidyanathan S, Jin Y, Schiller H, Jensen C. Aliskiren, a novel oral renin inhibitor, has no interaction with cytochrome P450 isoenzymes in vitro. Basic Res Pharmacol Toxicol 2005;97(Suppl 1):239.
    • Vaidyanathan S, Jin Y, Schiller H, Jensen C. Aliskiren, a novel oral renin inhibitor, has no interaction with cytochrome P450 isoenzymes in vitro. Basic Res Pharmacol Toxicol 2005;97(Suppl 1):239.
  • 16
    • 14044271546 scopus 로고    scopus 로고
    • Wood JM, Schnell CR, Cumin F, Menard J, Webb RL. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005;23:417-26.
    • Wood JM, Schnell CR, Cumin F, Menard J, Webb RL. Aliskiren, a novel, orally effective renin inhibitor, lowers blood pressure in marmosets and spontaneously hypertensive rats. J Hypertens 2005;23:417-26.
  • 17
    • 34047207774 scopus 로고    scopus 로고
    • Aliskiren for renin inhibition: A new class of antihypertensives
    • Tassell BWV, Munger MA. Aliskiren for renin inhibition: a new class of antihypertensives. Ann Pharmacother 2007;41:456-64.
    • (2007) Ann Pharmacother , vol.41 , pp. 456-464
    • Tassell, B.W.V.1    Munger, M.A.2
  • 18
    • 33749853955 scopus 로고    scopus 로고
    • Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers
    • Vaidyanathan S, Valencia J, Kemp C, et al. Lack of pharmacokinetic interactions of aliskiren, a novel direct renin inhibitor for the treatment of hypertension, with the antihypertensives amlodipine, valsartan, hydrochlorothiazide (HCTZ) and ramipril in healthy volunteers. Int J Clin Pract 2006;60:1343-56.
    • (2006) Int J Clin Pract , vol.60 , pp. 1343-1356
    • Vaidyanathan, S.1    Valencia, J.2    Kemp, C.3
  • 19
    • 0029858320 scopus 로고    scopus 로고
    • Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver
    • Veniant M, Menard J, Bruneval P, Morley S, Gonzales MF, Mullins J. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 1996; 98:1966-1970.
    • (1996) J Clin Invest , vol.98 , pp. 1966-1970
    • Veniant, M.1    Menard, J.2    Bruneval, P.3    Morley, S.4    Gonzales, M.F.5    Mullins, J.6
  • 20
    • 33749866573 scopus 로고    scopus 로고
    • The novel oral renin inhibitor aliskiren provides effective blood pressure control in patients with hypertension when used alone or in combination with hydrochlorothiazide
    • Villamil A, Chrysant S, Calhoun D, Schober B, Hsu H, Zhang J. The novel oral renin inhibitor aliskiren provides effective blood pressure control in patients with hypertension when used alone or in combination with hydrochlorothiazide. J Clin Hypertens 2006;8(Suppl A):A100.
    • (2006) J Clin Hypertens , vol.8 , Issue.SUPPL. A
    • Villamil, A.1    Chrysant, S.2    Calhoun, D.3    Schober, B.4    Hsu, H.5    Zhang, J.6
  • 21
    • 33947192524 scopus 로고    scopus 로고
    • Adding aliskiren to ramipril improves 24-hour blood pressure control compared to ramipril alone in patients with diabetes and hypertension
    • Taylor A, Tschope D, Kilo C, et al. Adding aliskiren to ramipril improves 24-hour blood pressure control compared to ramipril alone in patients with diabetes and hypertension. J Hypertens 2006;24(Suppl 4):S81.
    • (2006) J Hypertens , vol.24 , Issue.SUPPL. 4
    • Taylor, A.1    Tschope, D.2    Kilo, C.3
  • 22
    • 33749847756 scopus 로고    scopus 로고
    • Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension
    • Uresin Y, Taylor A, Kilo C, et al. Aliskiren, a novel renin inhibitor, has greater BP lowering than ramipril and additional BP lowering when combined with ramipril in patients with diabetes and hypertension. J Hypertens 2006;24(Suppl 4):S82.
    • (2006) J Hypertens , vol.24 , Issue.SUPPL. 4
    • Uresin, Y.1    Taylor, A.2    Kilo, C.3
  • 23
    • 33846323219 scopus 로고    scopus 로고
    • Aliskiren as add-on to amlodipine provides significant additional blood pressure lowering without increased oedema associated with doubling the amlodipine dose
    • Munger MA, Drummond W, Essop MR, Maboudian M, Khan M, Keefe DL. Aliskiren as add-on to amlodipine provides significant additional blood pressure lowering without increased oedema associated with doubling the amlodipine dose. Eur Heart J 2006;27(Suppl):117.
    • (2006) Eur Heart J , vol.27 , Issue.SUPPL. , pp. 117
    • Munger, M.A.1    Drummond, W.2    Essop, M.R.3    Maboudian, M.4    Khan, M.5    Keefe, D.L.6
  • 24
    • 0029858320 scopus 로고    scopus 로고
    • Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver
    • Veniant M, Menard J, Bruneval P, Morley S, Gonzales MF, Mullins J. Vascular damage without hypertension in transgenic rats expressing prorenin exclusively in the liver. J Clin Invest 1996;98:1966-1970.
    • (1996) J Clin Invest , vol.98 , pp. 1966-1970
    • Veniant, M.1    Menard, J.2    Bruneval, P.3    Morley, S.4    Gonzales, M.F.5    Mullins, J.6
  • 25
    • 0031297091 scopus 로고    scopus 로고
    • Memorial Lecture. A mouse view of hypertension
    • Smithies O. Theodore Cooper Memorial Lecture. A mouse view of hypertension. Hypertension 1997;30:1318-24.
    • (1997) Hypertension , vol.30 , pp. 1318-1324
    • Theodore Cooper, S.O.1
  • 26
    • 33747332458 scopus 로고    scopus 로고
    • The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal
    • Herron J, Mitchell J, Oh B, et al. The novel renin inhibitor aliskiren is not associated with rebound effects on blood pressure or plasma renin activity following treatment withdrawal. J Clin Hypertens 2006;8(Suppl A):A86.
    • (2006) J Clin Hypertens , vol.8 , Issue.SUPPL. A
    • Herron, J.1    Mitchell, J.2    Oh, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.