Separation, characterization and dose-effect relationship of the PPARγ-activating bio-active constituents in the chinese herb formulation 'San-ao decoction'

Molecules

Volumn 14, Issue 10, 2009, Pages 3942-3951

  Zhou, Ling ^a   Tang, Yu Ping ^a   Gao, Lu ^b   Fan, Xin Sheng ^a   Liu, Chun Mei ^a   Wu, De Kang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Does effect; PPAR ; Quatropde time of flight mass spectrometry; San ao decoction; UPLC

Indexed keywords

HERBACEOUS AGENT; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SAN AO DECOCTION; SAN-AO DECOCTION;

ANIMAL; ARTICLE; CHEMISTRY; CHO CELL; CRICETULUS; DOSE RESPONSE; DRUG POTENTIATION; HAMSTER; HUMAN;

ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; HUMANS; PPAR GAMMA;

EID: 70350509280     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules14103942     Document Type: Article

References (18)

1. Xue, T.; Roy, R. Studying traditional Chinese medicine. Science 2003, 300, 740-741.
2. The State Pharmacopoeia Commission of P.R. China. The Pharmacopoeia of the People's Republic of China; Chemical Industry Publishing Press: Beijing, China, 2005; pp. 59, 140, 223.
3. Wang, Z.J.; Wo, S.K.; Wang, L.; Lau, C.B.S.; Lee, V.H.L.; Chow, M.S.S.; Zuo, Z. Simultaneous quantification of active components in the herbs and products of Si-Wu-Tang by high performance liquid chromatography-mass spectrometry. J. Pharm. Biomed. Anal. 2009, 50, 232-244.
4. Qi, L.W.; Cao, J.; Li, P.; Wang, Y.X. Rapid, sensitive quantitation of major constituents in Danggui Buxue Tang by ultrafast HPLC-TOF/MS. J. Pharm. Biomed. Anal. 2008, 49, 502-507.
5. Chen, X.J.; Ji, H.; Zhang, Q.W.; Tu, P.F.; Wang, Y.T.; Guo, B.L.; Li, S.P. A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography. J. Pharm. Biomed. Anal. 2008, 46, 226-235.
6. Li, X.; Xiong, Z.; Ying, X.; Cui, L.; Zhu, W.; Li, F. A rapid ultra-performance liquid chromatography-eletrospray ionization tandem mass spectrometric method for the qualitative and the quantitative analysis of the constituents of the flower of Trollius ledibouri Reichb. Anal. Chim. Acta 2006, 580, 170-180.
7. Yoshida, T.; Majors, R.E. High speed analyses using rapid resolution liquid chromatography on 1.8-μm porous particles. J. Sep. Sci. 2006, 29, 2421-2432.
8. Ren, L.; Xue, X.; Zhang F.; Xu Q.; Liang X. High performance liquid chromatography-mass spectrometry analysis of protoberberine alkaloids in medicine herb. J. Sep. Sci. 2007, 30, 833-842.
9. Kersten, S.; Desvergne, B.; Wahli, W. Roles of PPARs in health and disease. Nature 2000, 405, 421-424.
10. Schoonjans, K.; Staels, B.; Auwerx, J. The peroxisome proliferator-activated receptor (PPARs) and their effects on lipid metabolism and adipocyte differentiation. Biochim. Biophys. Acta 1996, 1302, 93-109.
11. He, T.C.; Chan, T.A.; Vogelstein, B.; Kinzler, K.W. PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 1999, 99, 335-345.
12. Hansen, J.B.; Zhang, H.; Rasmussen, T.H.; Petersen, R.K.; Flindt, E.N.; Kristiansen, K. Peroxisome Proliferator-activated Receptor δ (PPARδ) -mediated regulation of preadipocyte proliferation and gene expression is dependent on cAMP signaling. J. Biol. Chem. 2001, 276, 3175-3182.
13. Rangwala, S.M.; Lazar, M.A. Peroxisome proliferator-activated receptor γ in diabetes and metabolism. Trends Pharm. Sci. 2004, 25, 331-336.
14. Murphy, G.J.; Holder, J.C. PPAR-γ agonists: therapeutic role in diabetes, in inflammation and cancer. Trends Pharm. Sci. 2000, 21, 469-474.
15. Clark, R.B. The role of PPARs in inflammation and immunity. J. Leukoc. Biol. 2002, 71, 388-400.
16. Marx, N.; Mach, F.; Sauty, A; Leung, J.H.; Sarafi, M.N.; Ransohoff, R.M.; Libby, P.; Plutzky, J.; Luster, A.D. PPARg activators inhibit Interferon-gamma-induced expression of the T cell-active CXC chemokines IP-10, Mig, and I-TAC in human endothelial cells. J. Immunol. 2000, 164, 6503-6508.
17. Ricote, M.; Li, A.C.; Willson, T.M.; Kelly, C.J.; Glass, C.K. The peroxisome proliferatoractivated receptor-gamma is a negative regulator of macrophage activation. Nature 1998, 391, 79-82.
18. Shen, P.M.; Liu, H.T.; Ng, Y.; Chan, Y.H.; Yong, E.L. Differential effects of isoflavones, from Astragalus membranaceus and Pueraria thomsonii, on the activation of PPARa, PPARg, and adipocyte differentiation in vitro. J. Nutr. 2006, 136, 899-905.