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Volumn 219, Issue 3, 2009, Pages 337-346

Frequent PIK3CA gene amplification and its clinical significance in colorectal cancer

Author keywords

Adjuvant therapy; Colorectal cancer; FISH; Gene amplification; PIK3CA gene; Tissue microarray

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN PIK 3 CA; UNCLASSIFIED DRUG;

EID: 70350468730     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2601     Document Type: Article
Times cited : (48)

References (41)
  • 1
    • 33644987603 scopus 로고    scopus 로고
    • Al-Eid HSAS. King Faisal Specialist Hospital and Research Centre. May
    • Al-Eid HSAS. Cancer Incidence Report Saudi Arabia 1999-2000. King Faisal Specialist Hospital and Research Centre. May 2004.
    • (2004) Cancer Incidence Report Saudi Arabia 1999-2000
  • 2
    • 40949096092 scopus 로고    scopus 로고
    • Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways
    • Bavi PP, Abubaker JA, Jehan ZD, Al-Jomah NA, Siraj AK, Al-Harbi SR, et al. Colorectal carcinomas from Middle East. Molecular and tissue microarray analysis of genomic instability pathways. Saudi Med J 2008;29:75-80.
    • (2008) Saudi Med J , vol.29 , pp. 75-80
    • Bavi, P.P.1    Abubaker, J.A.2    Jehan, Z.D.3    Al-Jomah, N.A.4    Siraj, A.K.5    Al-Harbi, S.R.6
  • 4
    • 33344462540 scopus 로고    scopus 로고
    • Mutation of the PIK3CA oncogene in human cancers
    • DOI 10.1038/sj.bjc.6602970
    • Karakas B, Bachman KE, Park BH. Mutation of the PIK3CA oncogene in human cancers. Br J Cancer 2006;94:455-459. (Pubitemid 43289745)
    • (2006) British Journal of Cancer , vol.94 , Issue.4 , pp. 455-459
    • Karakas, B.1    Bachman, K.E.2    Park, B.H.3
  • 5
    • 33646706052 scopus 로고    scopus 로고
    • Oncogenic PI3K and its role in cancer
    • Samuels Y, Ericson K. Oncogenic PI3K and its role in cancer. Curr Opin Oncol 2006;18:77-82.
    • (2006) Curr Opin Oncol , vol.18 , pp. 77-82
    • Samuels, Y.1    Ericson, K.2
  • 7
    • 0032929762 scopus 로고    scopus 로고
    • Signalling through phosphoinositide 3-kinases: The lipids take centre stage
    • DOI 10.1016/S0955-0674(99)80029-5
    • Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999;11:219-225. (Pubitemid 29164037)
    • (1999) Current Opinion in Cell Biology , vol.11 , Issue.2 , pp. 219-225
    • Leevers, S.J.1    Vanhaesebroeck, B.2    Waterfield, M.D.3
  • 8
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-AKT pathway in human cancer
    • Vivanco I, Sawyers CL. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nature Rev 2002;2:489-501. (Pubitemid 37328931)
    • (2002) Nature Reviews Cancer , vol.2 , Issue.7 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 12
    • 0035360282 scopus 로고    scopus 로고
    • Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification
    • Singh B, Gogineni SK, Sacks PG, Shaha AR, Shah JP, Stoffel A, et al. Molecular cytogenetic characterization of head and neck squamous cell carcinoma and refinement of 3q amplification. Cancer Res 2001;61:4506-4513. (Pubitemid 32685781)
    • (2001) Cancer Research , vol.61 , Issue.11 , pp. 4506-4513
    • Singh, B.1    Gogineni, S.K.2    Sacks, P.G.3    Shaha, A.R.4    Shah, J.P.5    Stoffel, A.6    Rao, P.H.7
  • 16
    • 0142157144 scopus 로고    scopus 로고
    • TERC Identified as a Probable Target within the 3q26 Amplicon That Is Detected Frequently in Non-Small Cell Lung Cancers
    • Yokoi S, Yasui K, Iizasa T, Imoto I, Fujisawa T, Inazawa J. TERC identified as a probable target within the 3q26 amplicon that is detected frequently in non-small cell lung cancers. Clin Cancer Res 2003;9:4705-4713. (Pubitemid 37323272)
    • (2003) Clinical Cancer Research , vol.9 , Issue.13 , pp. 4705-4713
    • Yokoi, S.1    Yasui, K.2    Iizasa, T.3    Imoto, I.4    Fujisawa, T.5    Inazawa, J.6
  • 19
    • 51249099962 scopus 로고    scopus 로고
    • Distinct gene expression profiles: Nodal versus extranodal diffuse large B-cell lymphoma
    • Jehan Z, Siraj AK, Abubaker J, Ruiz C, Simon R, Sultana M, et al. Distinct gene expression profiles: nodal versus extranodal diffuse large B-cell lymphoma. Oncology 2008;75:71-80.
    • (2008) Oncology , vol.75 , pp. 71-80
    • Jehan, Z.1    Siraj, A.K.2    Abubaker, J.3    Ruiz, C.4    Simon, R.5    Sultana, M.6
  • 20
    • 20144381465 scopus 로고    scopus 로고
    • Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed
    • Yen CC, Chen YJ, Pan CC, Lu KH, Chen PC, Hsia JY, et al. Copy number changes of target genes in chromosome 3q25.3-qter of esophageal squamous cell carcinoma: TP63 is amplified in early carcinogenesis but down-regulated as disease progressed. World J Gastroenterol 2005;11:1267-1272.
    • (2005) World J Gastroenterol , vol.11 , pp. 1267-1272
    • Yen, C.C.1    Chen, Y.J.2    Pan, C.C.3    Lu, K.H.4    Chen, P.C.5    Hsia, J.Y.6
  • 21
    • 0036581160 scopus 로고    scopus 로고
    • Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR
    • Pfaffl MW, Horgan GW, Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucleic Acids Res 2002;30:e36.
    • (2002) Nucleic Acids Res , vol.30
    • Pfaffl, M.W.1    Horgan, G.W.2    Dempfle, L.3
  • 22
    • 44649183930 scopus 로고    scopus 로고
    • Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma
    • Bavi P, Abubaker J, Hussain A, Sultana M, Al-Dayel F, Uddin S, et al. Reduced or absent cyclin H expression is an independent prognostic marker for poor outcome in diffuse large B-cell lymphoma. Hum Pathol 2008;39:885-894.
    • (2008) Hum Pathol , vol.39 , pp. 885-894
    • Bavi, P.1    Abubaker, J.2    Hussain, A.3    Sultana, M.4    Al-Dayel, F.5    Uddin, S.6
  • 23
    • 53749104732 scopus 로고    scopus 로고
    • Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers
    • Uddin S, Siraj AK, Al-Rasheed M, Ahmed M, Bu R, Myers JN, et al. Fatty acid synthase and AKT pathway signaling in a subset of papillary thyroid cancers. J Clin Endocrinol Metab 2008;93:4088-4097.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 4088-4097
    • Uddin, S.1    Siraj, A.K.2    Al-Rasheed, M.3    Ahmed, M.4    Bu, R.5    Myers, J.N.6
  • 24
    • 8444244786 scopus 로고    scopus 로고
    • X-tile: A new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization
    • DOI 10.1158/1078-0432.CCR-04-0713
    • Camp RL, Dolled-Filhart M, Rimm DL. X-tile: a new bio-informatics tool for biomarker assessment and outcome-based cut-point optimization. Clin Cancer Res 2004;10:7252-7259. (Pubitemid 39487712)
    • (2004) Clinical Cancer Research , vol.10 , Issue.21 , pp. 7252-7259
    • Camp, R.L.1    Dolled-Filhart, M.2    Rimm, D.L.3
  • 26
    • 22344432122 scopus 로고    scopus 로고
    • Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer
    • DOI 10.1158/1078-0432.CCR-05-0158
    • McCarthy MM, Sznol M, DiVito KA, Camp RL, Rimm DL, Kluger HM. Evaluating the expression and prognostic value of TRAIL-R1 and TRAIL-R2 in breast cancer. Clin Cancer Res 2005;11:5188-5194. (Pubitemid 41003705)
    • (2005) Clinical Cancer Research , vol.11 , Issue.14 , pp. 5188-5194
    • McCarthy, M.M.1    Sznol, M.2    Divito, K.A.3    Camp, R.L.4    Rimm, D.L.5    Kluger, H.M.6
  • 33
    • 25144517586 scopus 로고    scopus 로고
    • Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab
    • Mass RD, Press MF, Anderson S, Cobleigh MA, Vogel CL, Dybdal N, et al. Evaluation of clinical outcomes according to HER2 detection by fluorescence in situ hybridization in women with metastatic breast cancer treated with trastuzumab. Clin Breast Cancer 2005;6:240-246. (Pubitemid 47050800)
    • (2005) Clinical Breast Cancer , vol.6 , Issue.3 , pp. 240-246
    • Mass, R.D.1    Press, M.F.2    Anderson, S.3    Cobleigh, M.A.4    Vogel, C.L.5    Dybdal, N.6    Leiberman, G.7    Slamon, D.J.8    Paton, V.E.9
  • 35
    • 27244443759 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A southwest oncology group study
    • DOI 10.1200/JCO.2005.01.2823
    • Hirsch FR, Varella-Garcia M, McCoy J, West H, Xavier AC, Gumerlock P, et al. Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: a Southwest Oncology Group Study. J Clin Oncol 2005;23:6838-6845. (Pubitemid 46260270)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.28 , pp. 6838-6845
    • Hirsch, F.R.1    Varella-Garcia, M.2    McCoy, J.3    West, H.4    Xavier, A.C.5    Gumerlock, P.6    Bunn Jr., P.A.7    Franklin, W.A.8    Crowley, J.9    Gandara, D.R.10
  • 37
    • 0033870292 scopus 로고    scopus 로고
    • Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer
    • Jarvinen TA, Tanner M, Rantanen V, Barlund M, Borg A, Grenman S, et al. Amplification and deletion of topoisomerase IIalpha associate with ErbB-2 amplification and affect sensitivity to topoisomerase II inhibitor doxorubicin in breast cancer. Am J Pathol 2000;156:839-847. (Pubitemid 30626942)
    • (2000) American Journal of Pathology , vol.156 , Issue.3 , pp. 839-847
    • Jarvinen, T.A.H.1    Tanner, M.2    Rantanen, V.3    Barlund, M.4    Borg, A.5    Grenman, S.6    Isola, J.7
  • 38
    • 63049111794 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    • Ogino S, Nosho K, Kirkner GJ, Shima K, Irahara N, Kure S, et al. PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 2009;27:1477-1484.
    • (2009) J Clin Oncol , vol.27 , pp. 1477-1484
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Shima, K.4    Irahara, N.5    Kure, S.6
  • 39
    • 62449302407 scopus 로고    scopus 로고
    • PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies
    • Sartore-Bianchi A, Martini M, Molinari F, Veronese S, Nichelatti M, Artale S, et al. PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies. Cancer Res 2009;69:1851-1857.
    • (2009) Cancer Res , vol.69 , pp. 1851-1857
    • Sartore-Bianchi, A.1    Martini, M.2    Molinari, F.3    Veronese, S.4    Nichelatti, M.5    Artale, S.6
  • 41
    • 48749110337 scopus 로고    scopus 로고
    • Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms
    • Weaver J, Downs-Kelly E, Goldblum JR, Turner S, Kulkarni S, Tubbs RR, et al. Fluorescence in situ hybridization for MDM2 gene amplification as a diagnostic tool in lipomatous neoplasms. Mod Pathol 2008;21:943-949.
    • (2008) Mod Pathol , vol.21 , pp. 943-949
    • Weaver, J.1    Downs-Kelly, E.2    Goldblum, J.R.3    Turner, S.4    Kulkarni, S.5    Tubbs, R.R.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.