Reduced phosphorylation of the tgf-β signal transducer smad2 in emphysematous human lung

COPD: Journal of Chronic Obstructive Pulmonary Disease

Volumn 6, Issue 4, 2009, Pages 234-241

  Leppranta, Outi ^a   Myllrniemi, Marjukka ^a   Salmenkivi, Kaisa ^a   Kinnula, Vuokko L ^a   Keski Oja, Jorma ^a   Koli, Katri ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

Author keywords

COPD; Emphysema; Smad2; TGF

Indexed keywords

SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ADULT; ARTICLE; BRONCHUS MUCOSA; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LUNG ALVEOLUS EPITHELIUM; LUNG EMPHYSEMA; LUNG FIBROBLAST; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

BIOPSY; CASE-CONTROL STUDIES; FEMALE; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; PHENOTYPE; PHOSPHORYLATION; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; STATISTICS, NONPARAMETRIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 70350462126     PISSN: 15412555     EISSN: 15412563     Source Type: Journal    
DOI: 10.1080/15412550903049173     Document Type: Article

References (36)

1. Shaker SB, Dirksen A, Bach KS, Mortensen J. Imaging in chronic obstructive pulmonary disease. COPD 2007; 4(2):143-161.
2. Taraseviciene-Stewart L, Voelkel NF. Molecular pathogenesis of emphysema. J Clin Invest 2008; 118(2):394-402.
3. Bartram U, Speer CP. The role of transforming growth factor â in lung development and disease. Chest 2004; 125(2):754-765.
4. Chen H, Zhuang F, Liu YH, Xu B, Del Moral P, Deng W, Chai Y, Kolb M, Gauldie J, Warburton D, Moses HL, Shi W. TGF-â receptor II in epithelia versus mesenchyme plays distinct roles in the developing lung. Eur Respir J 2008; 32(2):285-295.
5. Sheppard D. Transforming growth factor â: A central modulator of pulmonary and airway inflammation and fibrosis. Proc Am Thorac Soc 2006; 3(5):413-417
6. Branton MH, Kopp JB. TGF-â and fibrosis. Microbes Infect 1999; 1(15):1349-1365.
7. Celedon JC, Lange C, Raby BA, Litonjua AA, Palmer LJ, De- Meo DL, Reilly JJ, Kwiatkowski DJ, Chapman HA, Laird N, Sylvia JS, Hernandez M, Speizer FE, Weiss ST, Silverman EK. The transforming growth factor-â1 (TGFB1) gene is associated with chronic obstructive pulmonary disease (COPD). Hum Mol Genet 2004; 13(15):1649-1656.
8. Hersh CP, Demeo DL, Lazarus R, Celedon JC, Raby BA, Benditt JO, Criner G, Make B, Martinez FJ, Scanlon PD, Sciurba FC, Utz JP, Reilly JJ, Silverman EK. Genetic association analysis of functional impairment in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2006; 173(9):977-984.
9. Ning W, Li CJ, Kaminski N, Feghali-Bostwick CA, Alber SM, Di YP, Otterbein SL, Song R, Hayashi S, Zhou Z, Pinsky DJ, Watkins SC, Pilewski JM, Sciurba FC, Peters DG, Hogg JC, Choi AM. Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease. Proc Natl Acad Sci USA 2004; 101(41):14895-14900.
10. Golpon HA, Coldren CD, Zamora MR, Cosgrove GP, MooreMD, Tuder RM, Geraci MW, Voelkel NF. Emphysema lung tissue gene expression profiling. Am J Respir Cell Mol Biol 2004; 31(6):595-600.
11. Sterner-Kock A, Thorey IS, Koli K, Wempe F, Otte J, Bangsow T, Kuhlmeier K, Kirchner T, Jin S, Keski-Oja J, von Melchner H. Disruption of the gene encoding the latent transforming growth factor-â binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancer. Genes Dev 2002; 16(17):2264-2273.
12. Colarossi C, Chen Y, Obata H, Jurukovski V, Fontana L, Dabovic B, Rifkin DB. Lung alveolar septation defects in Ltbp- 3-null mice. Am J Pathol 2005; 167(2):419-428.
13. Neptune ER, Frischmeyer PA, Arking DE, Myers L, Bunton TE, Gayraud B, Ramirez F, Sakai LY, Dietz HC. Dysregulation of TGF-â activation contributes to pathogenesis in Marfan syndrome. Nat Genet 2003; 33407-33411.
14. Wang X, Inoue S, Gu J, Miyoshi E, Noda K, Li W, Mizuno- Horikawa Y, NakanoM, AsahiM, TakahashiM, Uozumi N, Ihara S, Lee SH, Ikeda Y, Yamaguchi Y, Aze Y, Tomiyama Y, Fujii J, Suzuki K, Kondo A, Shapiro SD, Lopez-Otin C, Kuwaki T, Okabe M, Honke K, Taniguchi N. Dysregulation of TGF-â1 receptor activation leads to abnormal lung development and emphysemalike phenotype in core fucose-deficient mice. Proc Natl Acad Sci USA 2005; 102(44):15791-15796.
15. Morris DG, Huang X, Kaminski N, Wang Y, Shapiro SD, Dolganov G, Glick A, Sheppard D. Loss of integrin ávâ6-mediated TGF-â activation causes Mmp12-dependent emphysema. Nature 2003; 422(6928):169-173.
16. Bonniaud P, Kolb M, Galt T, Robertson J, Robbins C, Stampfli M, Lavery C, Margetts PJ, Roberts AB, Gauldie J. Smad3 null mice develop airspace enlargement and are resistant to TGF- â-mediated pulmonary fibrosis. J Immunol 2004; 173(3):2099-2108.
17. Gauldie J, Kolb M, Ask K, Martin G, Bonniaud P, Warburton D. Smad3 signaling involved in pulmonary fibrosis and emphysema. Proc Am Thorac Soc 2006; 3(8):696-702.
18. Pelton RW, Johnson MD, Perkett EA, Gold LI, Moses HL. Expression of transforming growth factor-â1, -â2, and -â3 mRNA and protein in the murine lung. Am J Respir Cell Mol Biol 1991; 5(6):522-530.
19. Hyytïainen M, Penttinen C, Keski-Oja J. Latent TGF-â binding proteins: Extracellular matrix association and roles in TGF-â activation. Crit Rev Clin Lab Sci 2004; 41(3):233-264.
20. Rifkin DB. Latent transforming growth factor-â (TGF-â) binding proteins: Orchestrators of TGF-â availability. J Biol Chem 2005; 280(9):7409-7412.
21. Takizawa H, Tanaka M, Takami K, Ohtoshi T, Ito K, Satoh M, Okada Y, Yamasawa F, Nakahara K, Umeda A. Increased expression of transforming growth factor-â1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). Am J Respir Crit Care Med 2001; 163(6):1476-1483.
22. de Boer WI, van Schadewijk A, Sont JK, Sharma HS, Stolk J, Hiemstra PS, van Krieken JH. Transforming growth factor â1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1998; 158(6):1951-1957.
23. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, Ten Dijke P. TGF-â receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J 1997; 16(17):5353-5362.
24. Koli K, Myll̈arniemi M, Vuorinen K, Salmenkivi K, Ryyn̈anen MJ, Kinnula VL, Keski-Oja J. Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis. Am J Pathol 2006; 169(1):61-71.
25. Dennler S, Itoh S, Vivien D, Ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF â-inducible elements in the promoter of human plasminogen activator inhibitortype 1 gene. EMBO J 1998; 17(11):3091-3100.
26. Kucich U, Rosenbloom JC, Herrick DJ, Abrams WR, Hamilton AD, Sebti SM, Rosenbloom J. Signaling events required for transforming growth factor-â stimulation of connective tissue growth factor expression by cultured human lung fibroblasts. Arch Biochem Biophys 2001; 395(1):103-112.
27. Keski-Oja J, Raghow R, Sawdey M, Loskutoff DJ, Postlethwaite AE, Kang AH, Moses HL. Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-â. Divergent responses in lung fibroblasts and carcinoma cells. J Biol Chem 1988; 263(7):3111-3115.
28. Araya J, Cambier S, Markovics JA,Wolters P, Jablons D, Hill A, FinkbeinerW, Jones K, Broaddus VC, Sheppard D, Barzcak A, Xiao Y, Erle DJ, Nishimura SL. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. J Clin Invest 2007; 117(11):3551-3562.
29. Zandvoort A, Postma DS, Jonker MR, Noordhoek JA, Vos JT, van der Geld YM, Timens W. Altered expression of the Smad signalling pathway: Implications for COPD pathogenesis. Eur Respir J 2006; 28(3):533-541.
30. Springer J, Scholz FR, Peiser C, Groneberg DA, Fischer A. SMAD-signaling in chronic obstructive pulmonary disease: Transcriptional down-regulation of inhibitory SMAD 6 and 7 by cigarette smoke. Biol Chem 2004; 385(7):649-653.
31. Nakao A, Afrakhte M, Moren A, Nakayama T, Christian JL, Heuchel R, Itoh S, Kawabata M, Heldin NE, Heldin CH, Ten Dijke P. Identification of Smad7, a TGF-â-inducible antagonist of TGF-â signalling. Nature 1997; 389(6651):631-635.
32. Afrakhte M, Moren A, Jossan S, Itoh S, Sampath K, Westermark B, Heldin CH, Heldin NE, Ten Dijke P. Induction of inhibitory Smad6 and Smad7 mRNA by TGF-â family members. Biochem Biophys Res Commun 1998; 249(2):505-511.
33. Massague J. TGF-â signal transduction. Annu Rev Biochem 1998; 67753-67791.
34. Ohnishi K, Takagi M, Kurokawa Y, Satomi S, Konttinen YT. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 1998; 78(9):1077-1087.
35. Togo S, Holz O, Liu X, Sugiura H, Kamio K, Wang X, Kawasaki S, Ahn Y, Fredriksson K, Skold CM, Mueller KC, Branscheid D, Welker L, Watz H, Magnussen H, Rennard SI. Lung fibroblast repair functions in patients with chronic obstructive pulmonary disease are altered by multiple mechanisms. Am J Respir Crit Care Med 2008; 178(3):248-260.
36. Araya J, Cambier S, Morris A, Finkbeiner W, Nishimura SL. Integrin-mediated transforming growth factor-â activation regulates homeostasis of the pulmonary epithelial-mesenchymal trophic unit. Am J Pathol 2006; 169(2):405-415.