Shock: Classification, Pathophysiology, and Approach to Management

Critical Care Medicine: Principles of Diagnosis and Management in the Adult

Volumn , Issue , 2008, Pages 379-422

  Kumar, Anand ^a,b,c   Parrillo, Joseph E ^b,d  

^a UNIVERSITY OF MANITOBA   (Canada)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c ST BONIFACE GENERAL HOSPITAL   (Canada)

^d Division of Female Pelvic Medicine and Reconstructive Surgery   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 70350458305     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-032304841-5.50024-8     Document Type: Chapter

References (396)

1. Heath Statistics 2003. National Center for Health Statistics, CDC, 2003.
2. National Center for Health Statistics Health, United States, 1986. DHHS pub no (PHS) 87-1232 1986, Government Printing Office, Washington, DC.
3. Committee on Trauma Research Injury in America 1985, National Academy Press, Washington, DC.
4. Eastman AB, West JG Field triage. Trauma 1991, 67-79. Appleton & Lange, Norwalk, CT. E.E. Moore, K.L. Mattox, D.V. Feliciano (Eds.).
5. Finland M Changing ecology of bacterial infections as related to antibacterial therapy. J Infect Dis 1970, 122:419-431.
6. Increase in National Hospital Discharge Survey rates for septicemia in the United States, 1979-1987. JAMA 1990, 263:937.
7. Centers for Disease Control and Prevention National Center for Health Statistics. Mortality patterns-United States, 1990. Monthly Vital Statistics Report 1993, 41:5.
8. Dellinger RP Cardiovascular management of septic shock. Crit Care Med 2003, 31(3):946-955.
9. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med 2003, 348(16):1546-1554.
10. Clarke J: Translation from the French original of H.F. Le Dran (1737). A Treatise, or Reflections Drawn from Practice on Gun-Shot Wounds. London, 1743.
11. Morris EA: A Practical Treatise on Shock after Operations and Injuries. London, 1867.
12. Blalock A Acute circulatory failure as exemplified by shock and hemorrhage. Surg Gynecol Obstet 1934, 58:551-566.
13. Fischer H: Ueber den Shock. Samml klin Vortr No 10, 1870.
14. Goltz FR Ueber den Tonus der Gerfaesse und seine Bedeutung fuer die Blutbewegung. Arch F Path Anat U Physiol 1864, 29:394-417.
15. Mapother ED Shock: Its nature, duration, and mode of treatment. BMJ 1879, 2:1023-1042.
16. Crile GW An Experimental Research into Surgical Shock 1899, Lippincott, Philadelphia.
17. Cannon WB Traumatic Shock 1923, Appleton, New York.
18. Keith NM Blood Volume Changes in Wound Shock and Primary Hemorrhage (Special Report Series No. 27) 1919, Medical Research Council, London.
19. Archibald EW, McLean WS Observations upon shock, with particular reference to the condition as seen in war surgery. Trans Am Surg Assoc Phila 1917, 35:522-532.
20. Simeone FA Foreword. Trauma, Sepsis, and Shock: The Physiological Basis of Therapy 1988, iii-iv. Dekker, New York, . G.H.A. Clowes (Ed.).
21. Blalock A Experimental shock: Cause of low blood pressure produced by muscle injury. Arch Surg 1930, 20:959-996.
22. Beecher HK, Simeone FA, Burnett CH, et al. The internal state of the severely wounded man on entry to the most forward hospital. Surgery 1947, 22:672-711.
23. Cournand A, Riley RL, Bradley SE, et al. Studies of the circulation in clinical shock. Surgery 1943, 13:964-995.
24. Wiggers CJ The Physiology of Shock 1950, Harvard University Press, Cambridge, Mass.
25. Battle Casualties in Korea. Surgical Research Team in Korea 1954, Vol 1. Army Medical Graduate School, Walter Reed Medical Center, Washington, DC.
26. Warren JC Surgical Pathology and Therapeutics 1895, Saunders, Philadelphia.
27. Simeone FA Shock. Christopher's Textbook of Surgery 1964, 58. Saunders, Philadelphia. L. Davis (Ed.).
28. Fink MP Shock: An overview. Intensive Care Medicine 1991, 1417-1435. Little, Brown, Boston. J.M. Rippe, R.S. Irwin, J.S. Alpert (Eds.).
29. Cerra FB Shock. Surgical Physiology 1983, 497. Saunders, Philadelphia. J.F. Burke (Ed.).
30. Laennec RTH Traite de L'uscultation Mediate et des Maladies des Poumons et du Coeur 1831, JS Chaude, Paris.
31. Boise E The differential diagnosis of shock, hemorrhage, and sepsis. Trans Am Assoc Obstet 1897, 9:433-438.
32. Fishberg AM, Hitzig WM, King FH Circulatory dynamics in myocardial infarction. Arch Intern Med 1934, 54:997-1019.
33. Blalock A Shock: Further studies with particular reference to the effects of hemorrhage. Arch Surg 1937, 29:837-857.
34. Weil MH Bacterial shock. Diagnosis and Treatment of Shock 1967, 10. Williams & Wilkins, Baltimore. M.H. Weil, H. Shubin (Eds.).
35. Hinshaw LB, Cox BG The Fundamental Mechanisms of Shock 1972, Plenum Press, New York.
36. Reilly JM, Cunnion RE, Burch-Whitman C, et al. A circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock. Chest 1989, 95:1072-1080.
37. Ognibene FP, Parker MM, Natanson C, et al. Depressed left ventricular performance: Response to volume infusion in patients with sepsis and septic shock. Chest 1988, 93:903-910.
38. Parker MM, Shelhamer JH, Bacharach SL, et al. Profound but reversible myocardial depression in patients with septic shock. Ann Intern Med 1984, 100:483-490.
39. Walley KR, Cooper DJ Diastolic stiffness impairs left ventricular function during hypovolemic shock in pigs. Am J Physiol 1991, 260:H702-H712.
40. Alyono D, Ring WS, Chao RYN, et al. Character of ventricular function in severe hemorrhagic shock. Surgery 1983, 94:250-258.
41. Bond RF, Johnson GI Vascular adrenergic interactions during hemorrhagic shock. Fed Proc 1985, 44:281-289.
42. Thiemermann C, Szabö C, Mitchell JA, et al. Vascular hyporeactivity to vasoconstrictor agents and hemodynamic decompensation in hemorrhagic shock is mediated by nitric oxide. Proc Natl Acad Sci U S A 1993, 90:267-271.
43. Sarnoff SJ, Case RB, Waitag PE, et al. Insufficient coronary flow and myocardial failure as a complicating factor in late hemorrhagic shock. Am J Physiol 1954, 176:439-444.
44. Sander-Jenson K, Secher NH, Bie P, et al. Vagal slowing of the heart during hemorrhage: Observations from twenty consecutive hypotensive patients. BMJ 1986, 295:364-366.
45. Rackow EC, Falk JL, Fein IA, et al. Fluid resuscitation in circulatory shock: A comparison of the cardiorespiratory effects of albumin, hetastarch, and saline solutions in patients with hypovolemic and septic shock. Crit Care Med 1983, 11:839-850.
46. Shenkin HA, Cheney RH, Govons SR, et al. On the diagnosis of hemorrhage in man: A study in volunteers bled large amounts. Am J Med Sci 1944, 208:421-436.
47. Knopp R, Claypool R, Leonardt D Use of the tilt test in measuring acute blood loss. Ann Emerg Med 1980, 9:72-75.
48. Rush BF Irreversibility in post-transfusion phase of hemorrhagic shock. Adv Exp Med Biol 1971, 23:215-234.
49. Dunham C, Siegel J, Weireter L Oxygen debt and metabolic acidemia as quantitative predictors of mortality and the severity of the ischemia insult in hemorrhagic shock. Crit Care Med 1991, 19:231-243.
50. Viteck V, Cowley R Blood lactate in the prognosis of various forms of shock. Ann Surg 1971, 173:308-313.
51. Goldberg RJ, Gore JM, Alpert JS, et al. Cardiogenic shock after acute myocardial infarction: Incidence and mortality from a community-wide perspective. N Engl J Med 1991, 325:1117-1122.
52. Wackers FJ, Lie KI, Becker AE Coronary artery disease in patients dying from cardiogenic shock or congestive heart failure in the setting of acute myocardial infarction. Br Heart J 1976, 38:906-910.
53. Afifi AA, Chang PC, Liu VY, et al. Prognostic indexes in acute myocardial infarction complicated by shock. Am J Cardiol 1974, 33:826-832.
54. Page DL, Caulfield JB, Kastor JA Myocardial changes associated with cardiogenic shock. N Engl J Med 1971, 285:133-137.
55. Alonso DR, Scheidt S, Post M, et al. Pathophysiology of cardiogenic shock: Quantification of myocardial necrosis: Clinical, pathologic, and electrocardiographic correlation. Circulation 1973, 48:588-596.
56. Weber KT, Ratshin RA, Janicki JS Left ventricular dysfunction following acute myocardial infarction: A clinicopathologic and hemodynamic profile of shock and failure. Am J Med 1973, 54:697-705.
57. Scheidt S, Ascheim R, Killip T Shock after acute myocardial infarction: A clinical and hemodynamic profile. Am J Cardiol 1970, 26:556-564.
58. Simoons ML, Vander Brand M, DeZwaan M Improved survival after early thrombolysis in acute myocardial infarction. Lancet 1985, 578-581.
59. Chesebro JH, Knatterud G, Roberts R, et al. Thrombolysis in Myocardial Infarction (TIMI) Trial, Phase I: A comparison between intravenous tissue plasminogen activator and intravenous streptokinase: Clinical findings through hospital discharge. Circulation 1987, 76:142-154.
60. Kennedy JW, Ritchie JL, Davis KB, et al. Western Washington randomized trial of intracoronary streptokinase in acute myocardial infarction. N Engl J Med 1983, 309:1477-1482.
61. The Gusto Investigators An international randomized trial comparing four thrombolytic strategies for acute myocardial infarction. N Engl J Med 1993, 329:673-682.
62. Hollenberg SM, Kavinsky CJ, Parrillo JE Cardiogenic shock. Ann Intern Med 1999, 131:47-59.
63. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico (GISSI) Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet 1986, 1:397-402.
64. Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock?. N Engl J Med 1999, 341:625-634.
65. Berger PB, Holmes DR, Stebbins AL, et al. Impact of an aggressive invasive catheterization and revascularization strategy on mortality in patients with cardiogenic shock in the Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries (GUSTO-1) trial: An observational study. Circulation 1997, 96:122-127.
66. Wei HY, Hutchins GM, Bulkley BH Papillary muscle rupture in fatal acute myocardial infarction: A potentially treatable form of cardiogenic shock. Ann Intern Med 1979, 90:149-152.
67. Felix SB, Baumann G, Hashemi T, et al. Characterization of cardiovascular events mediated by platelet activating factor during systemic anaphylaxis. J Cardiovasc Pharmacol 1990, 15:987-997.
68. Cohn JN, Guiha NH, Broder MI, et al. Right ventricular infarction: Clinical and hemodynamic features. Am J Cardiol 1974, 33:209-214.
69. Roberts N, Harrison DG, Reimer KA, et al. Right ventricular infarction with shock but without significant left ventricular infarction: A new clinical syndrome. Am Heart J 1985, 110:1047-1053.
70. Leinbach RC Right ventricular infarction. J Cardiovasc Med 1980, 5:499-509.
71. Lloyd EA, Gersh BJ, Kennelly BM Hemodynamic spectrum of "dominant" right ventricular infarction in 19 patients. Am J Cardiol 1981, 48:1016-1022.
72. Zehender M, Kasper W, Kauder E, et al. Right ventricular infarction as an independent predictor of prognosis after acute inferior myocardial infarction. N Engl J Med 1993, 328:981-988.
73. Da Luz P, Weil MH, Shubin H Plasma volume prior to and following volume loading during shock complicating acute myocardial infarction. Circulation 1974, 49:98-105.
74. Reddy PS, Curtiss EI, O'Toole JD, et al. Cardiac tamponade: Hemodynamic observations in man. Circulation 1978, 58:265-272.
75. London RE, London SB Rupture of the heart: A critical analysis of 47 consecutive autopsy cases. Circulation 1965, 31:202-208.
76. McMullen MH, Kilgore TL, Dear HD, et al. Sudden blowout rupture of the myocardium after infarction: Urgent management. J Thorac Cardiovasc Surg 1985, 89:259-263.
77. Sharma GVRK, McIntyre KM, Sharma S, et al. Clinical and hemodynamic correlates in pulmonary embolism. Clin Chest Med 1984, 5:421-437.
78. McIntyre KM, Sasahara AA The hemodynamic response to pulmonary embolism in patients without prior cardiopulmonary disease. Am J Cardiol 1971, 28:288-294.
79. Wood KE The presence of shock defines the threshold to initiate thrombolytic therapy in patients with pulmonary embolism. Intensive Care Med 2002, 28:1537-1546.
80. Wood KE Major pulmonary embolism: Review of a pathophysiologic approach to the golden hour of hemodynamically significant pulmonary embolism. Chest 2002, 121:877-905.
81. Parrillo JE Pathogenetic mechanisms of septic shock. N Engl J Med 1993, 328:1471-1477.
82. Cohn JD, Greenspan M, Goldstein CR, et al. Arteriovenous shunting in high cardiac output shock syndromes. Surg Gynecol Obstet 1968, 127:282-288.
83. Thijs LG, Groenveld ABJ Peripheral circulation in septic shock. Appl Cardiopulm Pathol 1988, 2:203-214.
84. Wright CJ, Duff JH, McLean APH, et al. Regional capillary blood flow and oxygen uptake in severe sepsis. Surg Gynecol Obstet 1971, 132:637-644.
85. Finley RJ, Duff JH, Holliday RL, et al. Capillary muscle blood flow in human sepsis. Surgery 1975, 78:87-94.
86. Cronenwett JL, Lindenauer SM Direct measurement of arteriovenous anastomic blood flow in the septic canine hindlimb. Surgery 1979, 85:275-282.
87. Dantzker D Oxygen delivery and utilization in sepsis. Crit Care Clin 1989, 5:81-98.
88. Wolf YG, Cotev S, Perel A, et al. Dependence of oxygen consumption on cardiac output in sepsis. Crit Care Med 1987, 15:198-203.
89. Shoemaker WC, Chang P, Czer L, et al. Cardiorespiratory monitoring in postoperative patients: I. Prediction of outcome and severity of illness. Crit Care Med 1979, 7:237-242.
90. Haupt MT, Gilbert EM, Carlson RW Fluid loading increases oxygen consumption in septic patients with lactic acidosis. Am Rev Respir Dis 1985, 131:912-916.
91. Samsel RW, Nelson DP, Sanders WM, et al. Effect of endotoxin on systemic and skeletal muscle oxygen extraction. J Appl Physiol 1988, 65:1377-1382.
92. Vincent JL, Roman A, DeBacker D, et al. Oxygen uptake/supply dependency: Effects of short-term dobutamine infusion. Am Rev Respir Dis 1990, 142:2-8.
93. Fenwick JC, Dodek PM, Ronco JJ, et al. Increased concentrations of plasma lactate predict pathological dependence of oxygen consumption on oxygen delivery in patients with adult respiratory distress syndrome. J Crit Care 1990, 5:81-87.
94. Gutierrez G, Pohil RJ Oxygen consumption is linearly related to oxygen supply in critically ill patients. J Crit Care 1986, 1:45-53.
95. Astiz M, Rackow EC, Weil MH, et al. Early impairment of oxidative metabolism and energy production in severe sepsis. Circ Shock 1988, 26:311-320.
96. Mizock B Septic shock: A metabolic perspective. Arch Intern Med 1984, 144:579-585.
97. Song SK, Hotchkiss RS, Karl IE, et al. Concurrent quantification of tissue metabolism and blood flow via 2H/31P NMR in vivo: III. Alterations of muscle blood flow and metabolism during sepsis. Magn Reson Med 1992, 25:67-77.
98. Hotchkiss RS, Karl IE Reevaluation of the role of cellular hypoxia and bioenergetic failure in sepsis. JAMA 1992, 267:1503-1510.
99. Solomon MA, Correa R, Alexander HR, et al. Myocardial energy metabolism and morphology in a canine model of sepsis. Am J Physiol 1994, 266:H757-H768.
100. Hotchkiss RS, Rust RS, Dence CS, et al. Evaluation of the role of cellular hypoxia in sepsis by the hypoxic marker [18F] fluoromisonidazole. Am J Physiol 1991, 261:R965-R972.
101. Hotchkiss RS, Song SK, Neil JJ, et al. Sepsis does not impair tricarboxylic acid cycle in the heart. Am J Physiol 1991, 260:C50-C57.
102. Chaudry IH, Wichterman KA, Baue AE Effect of sepsis on tissue adenine nucleotide levels. Surgery 1979, 85:205-211.
103. Geller ER, Tankauskas S, Kirpatrick JR Mitochondrial death in sepsis: A failed concept. J Surg Res 1986, 40:514-517.
104. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med 2006, 34:1589-1596.
105. The Veterans Administration Systemic Sepsis Cooperative Study Group The effect of high dose glucocorticoid therapy on mortality in patients with clinical signs of systemic sepsis. N Engl J Med 1987, 317:659-665.
106. Ziegler EJ, Fisher CJ, Sprung C, et al. Treatment of gram-negative bacteremia and septic shock with HA-1A human monoclonal antibody against endotoxin. N Engl J Med 1991, 324:429-436.
107. Bauer S, Kirschning CJ, Hacker H, et al. Human TLR9 confers responsiveness to bacterial DNA via species-specific CpG motif recognition. Proc Natl Acad Sci U S A 2001, 98:9237-9242.
108. Dziarski R, Wang Q, Miyake K, et al. MD-2 enables Toll-like receptor 2 (TLR2)-mediated responses to lipopolysaccharide and enhances TLR2-mediated responses to gram-positive and gram-negative bacteria and their cell wall components. J Immunol 2001, 166:1938-1944.
109. Yang RB, Mark MR, Gray A, et al. Toll-like receptor-2 mediates lipopolysaccharide-induced cellular signalling. Nature 1998, 395:284-288.
110. Lien E, Sellati TJ, Yoshimura A, et al. Toll-like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J Biol Chem 1999, 274:33419-33425.
111. Schwandner R, Dziarski R, Wesche H, et al. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J Biol Chem 1999, 274:17406-17409.
112. Parker MM, Shelhamer JH, Natanson C, et al. Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: Heart rate as an early predictor of prognosis. Crit Care Med 1987, 15:923-929.
113. Teule GJJ, Van Lingen A, Verweij-van Vught MA, et al. Role of peripheral pooling in porcine Escherichia coli sepsis. Circ Shock 1984, 12:115-123.
114. Natanson C, Fink MP, Ballantyne HK, et al. Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock. J Clin Invest 1986, 78:259-270.
115. Carroll GC, Snyder JV Hyperdynamic severe intravascular sepsis depends on fluid administration in cynomolgus monkey. Am J Physiol 1982, 243:131-141.
116. Teule GJJ, Den Hollander W, Bronsveld W, et al. Effect of volume loading and dopamine on hemodynamics and red cell distribution in canine endotoxic shock. Circ Shock 1983, 10:41-50.
117. Magder S, Vanelli G Circuit factors in the high cardiac output of sepsis. J Crit Care 1996, 11:155-166.
118. Donnino M, Nguyen HB, Rivers EP A hemodynamic comparison of early and late phase severe sepsis and septic shock. Chest 2002, 122:4S.
119. MacLean LD, Mulligan WG, McLean APH, et al. Patterns of septic shock in man: A detailed study of 56 patients. Ann Surg 1967, 166:543-562.
120. Eichenholz PW, Eichacker PQ, Hoffman WD, et al. Tumor necrosis factor challenges in canines: Patterns of cardiovascular dysfunction. Am J Physiol 1992, 263:H668-H675.
121. Vincent JL, Bakker J, Marecaux G, et al. Administration of anti-TNF antibody improves left ventricular function in septic shock patients: Results of a pilot study. Chest 1992, 101:810-815.
122. Hosenpud JD, Campbell SM, Mendelson DJ Interleukin-1-induced myocardial depression in an isolated beating heart preparation. J Heart Transplant 1989, 8:460-464.
123. Kumar A, Krieger A, Symeoneides S, et al. Myocardial dysfunction in septic shock: Part II. Role of cytokines and nitric oxide. J Cardiovasc Thorac Anesth 2001, 15:485-511.
124. Massey CV, Kohout TR, Gaa ST, et al. Molecular and cellular actions of platelet-activating factor in rat heart cells. J Clin Invest 1991, 88:2106-2116.
125. Schutzer KM, Haglund U, Falk A Cardiopulmonary dysfunction in a feline septic model: Possible role of leukotrienes. Circ Shock 1989, 29:13-25.
126. Werdan K, Muller U, Reithmann C "Negative inotropic cascades" in cardiomyocytes triggered by substances relevant to sepsis. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 787-834. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
127. Pathan N, Hemingway CA, Alizadeh AA, et al. Role of interleukin 6 in myocardial dysfunction of meningococcal septic shock. Lancet 2004, 363:203-209.
128. Bochner BS, Lichtenstein LM Anaphylaxis. N Engl J Med 1991, 324:1785-1790.
129. Chrusch C, Sharma S, Unruh H, et al. Histamine H3 receptor blockade improves cardiac function in canine anaphylaxis. Am J Respir Crit Care Med 1999, 160:1142-1149.
130. Parrillo JE Cardiovascular dysfunction in human septic shock. Prog Clin Biol Res 1989, 308:191-199.
131. Otero E, Onufer JR, Reiss CK, et al. Anaphylaxis-induced myocardial depression treated with amrinone. Lancet 1991, 337:682.
132. Raper RF, Fisher MMD Profound reversible myocardial depression after anaphylaxis. Lancet 1988, 1:386-388.
133. Silverman HJ, Van Hook C, Haponik EF Hemodynamic changes in human anaphylaxis. Am J Med 1984, 77:341-344.
134. Smith PL, Kagey-Sobotka A, Bleecker ER, et al. Physiologic manifestations of human anaphylaxis. J Clin Invest 1980, 66:1072-1080.
135. Rao RH, Vagnucci AH, Amico JH Bilateral massive adrenal hemorrhage: Early recognition and treatment. Ann Intern Med 1989, 110:227-235.
136. Chin R Adrenal crisis. Crit Care Clin 1991, 7:23-42.
137. Burke CW Adrenocortical insufficiency. Clin Endocrinol Metab 1985, 14:948-976.
138. Claussen MS, Landercasper J, Cogbill TH Acute adrenal insufficiency presenting as shock after trauma and surgery: Three cases and review of the literature. J Trauma 1992, 32:94-100.
139. Dorin RI, Kearns PJ High output circulatory failure in acute adrenal insufficiency. Crit Care Med 1988, 16:296-297.
140. Annane D, Bellissant E, Sebille V, et al. Impaired pressor sensitivity to noradrenaline in septic shock patients with and without impaired adrenal function reserve. Br J Clin Pharmacol 1998, 46:589-597.
141. Annane D, Sebille V, Troche G, et al. A 3-level prognostic classification in septic shock based on cortisol levels and cortisol response to corticotropin. JAMA 2000, 283:1038-1045.
142. Rothwell PM, Udwadia ZF, Lawler PG Cortisol response to corticotropin and survival in septic shock. Lancet 1991, 337:582-583f.
143. Soni A, Pepper M, Wyrwinski PM, et al. Adrenal insufficiency occurring during septic shock: Incidence, outcome, and relationship to peripheral cytokine levels. Am J Med 1995, 28:266-271.
144. Marik PE, Zaloga GP Adrenal insufficiency during septic shock. Crit Care Med 2003, 31:141-145.
145. Bollaert PE, Charpentier C, Levy B, et al. Reversal of late septic shock with supraphysiologic doses of hydrocortisone. Crit Care Med 1998, 26:645-650.
146. Briegel J, Forst H, Haller M, et al. Stress doses of hydrocortisone reverse hyperdynamic septic shock: A prospective randomized, double-blind, single-center study. Crit Care Med 1999, 27:723-732.
147. Annane D, Sebille V, Charpentier C, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288:862-871.
148. Confalonieri M, Urbino R, Potena A, et al. Hydrocortisone infusion for severe community-acquired pneumonia: A preliminary randomized study. Am J Respir Crit Care Med 2005, 171:242-248.
149. Guyton AC Textbook of Medical Physiology 1991, Saunders, Philadelphia. 8th ed.
150. Bond RF Peripheral macro- and microcirculation. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 893-907. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
151. Calvin JE, Driedger AA, Sibbald WJ Does the pulmonary wedge pressure predict left ventricular preload in critically ill patients?. Crit Care Med 1981, 9:437-443.
152. Braunwald E, Frahm CJ Studies on Starling's law of the heart: IV. Observations on hemodynamic functions of the left atrium in man. Circulation 1961, 24:633-642.
153. Sylvester JT, Goldberg HS, Permutt S The role of the vasculature in the regulation of cardiac output. Clin Chest Med 1983, 4:111-126.
154. Bressack MA, Raffin TA Importance of venous return, venous resistance, and mean circulatory pressure in the physiology and management of shock. Chest 1987, 92:906-912.
155. Milnor WR Arterial impedance as ventricular afterload. Circ Res 1975, 36:565-570.
156. Carabello BA, Spann JF The uses and limitations of end-systolic indices of left ventricular function. Circulation 1984, 69:1058-1064.
157. Magder S, De Verennes B Clinical death and the measurement of stressed vascular volume. Crit Care Med 1998, 26:1061-1064.
158. Deschamps A, Magder S Baroreflex control of regional capacitance and blood flow distribution with or without alpha adrenergic blockade. Am J Physiol 1992, 262:H1755-H1763.
159. Deschamps A, Magder S Effects of heat stress on vascular capacitance. Am J Physiol 1994, 266:H2122-H2129.
160. Rothe CF Reflex control of veins and vascular capacitance. Physiol Rev 1983, 63:1281-1295.
161. Guyton AC, Jones CE, Coleman TG Circulatory Physiology: Cardiac Output and Its Regulation 1973, Saunders, Philadelphia. 2nd ed.
162. Permutt S, Riley S Hemodynamics of collapsible vessels with tone: The vascular waterfall. J Appl Physiol 1963, 18:924-932.
163. Brinkley PF, Murray KD, Watson KM, et al. Dobutamine increases cardiac output of the total artificial heart. Circulation 1991, 84:1210-1215.
164. Marino RJ, Romagnoli A, Keats AS Selective venoconstriction by dopamine in comparison with isoproterenol and phenylephrine. Anesthesiology 1975, 43:570-572.
165. Pinsky MR, Matushek M Hemodynamic changes in endotoxic shock. J Crit Care 1986, 1:18-31.
166. Stephan F, Novara A, Tournier B, et al. Determination of total effective vascular compliance in patients with sepsis syndrome. Am J Respir Crit Care Med 1998, 157:50-56.
167. Astiz ME, Tilly E, Rackow EC, et al. Peripheral vascular tone in sepsis. Chest 1991, 99:1072-1075.
168. Bressack MA, Morton NS, Hortop J Group B streptococcal sepsis in the piglet: Effects of fluid therapy on venous return, organ edema, and organ blood flow. Circ Res 1987, 61:659.
169. Schumacker PT Peripheral vascular responses in septic shock: Direct or reflex effects?. Chest 1991, 99:1057-1058.
170. Calvin JE, Sibbald WJ Applied cardiovascular physiology in the critically ill with special reference to diastole and ventricular interaction. Textbook of Critical Care 1989, 312-325. Saunders, Philadelphia. W.C. Shoemaker, S. Ayres, A. Grenvik (Eds.).
171. Suga H, Sagawa K Instantaneous pressure-volume relationships and their ratio in the excised, supported canine left ventricle. Circ Res 1974, 35:117-126.
172. Katz AM Influence of altered inotropy and lusitropy on ventricular pressure-volume loops. J Am Coll Cardiol 1988, 11:438-445.
173. Johnson PC Autoregulation of blood flow. Circ Res 1986, 59:483-495.
174. Gutteriez G, Brown SD Response of the macrocirculation. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 215-229. Springer-Verlag, Berlin. R. Schlag, H. Redl (Eds.).
175. Wang P, Hauptman JG, Chaudry IH Hemorrhage produces depression in microvascular blood flow which persists despite fluid resuscitation. Circ Shock 1990, 32:307-318.
176. Bowton DL, Bertels NH, Prough DS, et al. Cerebral blood flow is reduced in patients with sepsis syndrome. Crit Care Med 1989, 17:399-403.
177. Ekstrom-Jodal B, Haggendal E, Larsson LE Cerebral blood flow and oxygen uptake in endotoxic shock: An experimental study in dogs. Acta Anaesthesiol Scand 1982, 26:163-170.
178. Cunnion RE, Schaer GL, Parker MM, et al. The coronary circulation in human septic shock. Circulation 1986, 73:637-644.
179. Dhainaut JF, Huyghebaert MF, Monsallier JF, et al. Coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. Circulation 1987, 75:533-541.
180. Cryer HM, Kaebrick H, Harris PD, et al. Effect of tissue acidosis on skeletal muscle microcirculatory responses to hemorrhagic shock in unanesthetized rats. J Surg Res 1985, 39:59-67.
181. Coleman B, Glaviano VV Tissue levels of norepinephrine in hemorrhagic shock. Science 1963, 139:54.
182. Chernow B, Roth BL Pharmacologic manipulation of the peripheral vasculature in shock: Clinical and experimental approaches. Circ Shock 1986, 18:141-155.
183. Koyama S, Aibiki M, Kanai K, et al. Role of the central nervous system in renal nerve activity during prolonged hemorrhagic shock in dogs. Am J Physiol 1988, 254:R761-R769.
184. Lorente JA, Landin L, Renes E, et al. Role of nitric oxide in the hemodynamic changes of sepsis. Crit Care Med 1993, 21:759-767.
185. Carden DI, Smith JK, Zimmerman BJ, et al. Reperfusion injury following circulatory collapse: The role of reactive oxygen metabolites. J Crit Care 1989, 4:294-300.
186. Kubes P Nitric oxide modulates microvascular permeability. Am J Physiol 1992, 262:H611-H615.
187. Wang LF, Patel M, Razavi HM, et al. Role of inducible nitric oxide synthase in pulmonary microvascular protein leak in murine sepsis. Am J Respir Crit Care Med 2002, 165:1634-1639.
188. Redl H, Schlag G, Kneidinger R, et al. Activation/adherence phenomena of leukocytes and endothelial cells in trauma and sepsis. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 549-563. Springer-Verlag, Berlin. H. Redl, G. Schlag (Eds.).
189. Shah DM, Dutton RE, Newell JC, et al. Vascular autoregulatory failure following trauma and shock. Surg Forum 1977, 28:11-13.
190. Hurd TC, Dasmahapatra KS, Rush BF, et al. Red blood cell deformability in human and experimental sepsis. Arch Surg 1988, 123:217-220.
191. Van Rossum GD The relation of sodium and potassium ion transport to respiration and adenine nucleotide content of liver slices treated with inhibitors of respiration. Biochem J 1972, 129:427-438.
192. Vogt MT, Fraber E The effects of ethionine treatment on the metabolims of liver mitochondria. Arch Biochem Biophys 1970, 141:162-173.
193. Chaudry IH Cellular mechanisms in shock and ischemia and their correction. Am J Physiol 1983, 245:R117-R134.
194. Horpacsy G, Schnells G Metabolism of adenine nucleotides in the kidney during hemorrhagic hypotension and after recovery. J Surg Res 1980, 29:11-17.
195. Chaudry IH, Sayeed MM, Baue AE Alteration in high-energy phosphates in hemorrhagic shock as related to tissue and organ function. Surgery 1976, 79:666-668.
196. Chaudry IH, Sayeed MM, Baue AE Effect of adenosine triphosphate-magnesium chloride administration in shock. Surgery 1974, 75:220-227.
197. Chaudry IH, Sayeed MM, Baue AE Effect of hemorrhagic shock on tissue adenine nucleotides in conscious rats. Can J Physiol Pharmacol 1974, 52:131-137.
198. Chaudry IH, Ohkawa M, Clemens MG, et al. Alterations in electron transport and cellular metabolism with shock and trauma. Prog Clin Biol Res 1983, 111:67-88.
199. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
200. Ayala A, Perrin MM, Meldrum DR, et al. Hemorrhage induces an increase in serum TNF which is not associated with elevated levels of endotoxin. Cytokine 1990, 2:170-174.
201. Calandra T, Baumgartner J, Grau GE, et al. Prognostic values of tumor necrosis factor/cachectin, interleukin-1, and interferonγ in the serum of patients with septic shock. J Infect Dis 1990, 161:982-987.
202. Girardin E, Grau GE, Dayer JM, et al. Plasma tumor necrosis factor and interleukin-1 in the serum of children with severe infectious purpura. N Engl J Med 1989, 319:397-400.
203. Zanotti S, Kumar A, Kumar A Cytokine modulation in sepsis and septic shock. Expert Opinion Invest Drugs 2002, 11:1061-1075.
204. Bone RC The pathogenesis of sepsis. Ann Intern Med 1991, 115:457-469.
205. Tracey KJ, Lowry SF, Beutler B, et al. Cachectin/tumor necrosis factor mediates changes of skeletal muscle plasma membrane potential. J Exp Med 1986, 164:1368-1373.
206. Levine B, Kalman J, Mayer L, et al. Elevated circulating levels of tumor necrosis factor in severe chronic heart failure. N Engl J Med 1990, 323:236-241.
207. Pathan N, Sandiford C, Harding SE, et al. Characterization of a myocardial depressant factor in meningococcal septicemia. Crit Care Med 2002, 30:2191-2198.
208. Calandra T, Echtenacher B, Roy DL, et al. Protection from septic shock by neutralization of macrophage migration inhibitory factor. Nat Med 2000, 6:164-170.
209. Calandra T, Glauser MP Immunocompromised animal models for the study of antibiotic combinations. Am J Med 1986, 80:45-52.
210. Wang H, Yang H, Czura CJ, et al. HMGB1 as a late mediator of lethal systemic inflammation. Am J Respir Crit Care Med 2001, 164(10 Pt 1):1768-1773.
211. Parrillo JE, Burch C, Shelhamer JH, et al. A circulating myocardial depressant substance in humans with septic shock: Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance. J Clin Invest 1985, 76:1539-1553.
212. Hallstrom S, Vogl C, Redl H, et al. Net inotropic plasma activity in canine hypovolemic traumatic shock: Low molecular weight plasma fraction after prolonged hypotension depresses cardiac muscle performance in-vitro. Circ Shock 1990, 30:129-144.
213. Brar R, Kumar A, Schaer GL, et al. Myocardial infarction and reperfusion produces soluble myocardial depressant activity that correlates with infarct size. Crit Care Med 1996, 24:A30.
214. Coraim F, Trubel W, Ebermann R, et al. Isolation of low molecular weight peptides in hemofiltrated patients with cardiogenic shock: A new aspect of myocardial depressant substances. Contrib Nephrol 1991, 93:237-240.
215. 2+ current in cardiomyocytes. Am J Physiol 1991, 260:H869-H876.
216. Kumar A, Thota V, Dee L, et al. Tumor necrosis factor-alpha and interleukin-1 beta are responsible for depression of in vitro myocardial
217. Kumar A, Brar R, Wang P, et al. The role of nitric oxide and cyclic GMP in human septic serum-induced depression of cardiac myocyte contractility. Am J Physiol 1999, 276:R265-R276.
218. Cain BS, Meldrum DR, Dinarello CA, et al. Tumor necrosis factorα and interleukin-1β synergistically depress human myocardial function. Crit Care Med 1999, 27:1309-1318.
219. Nathan C Nitric oxide as a secretory product of mammalian cells. FASEB J 1992, 6:3051-3064.
220. Kilbourn RG, Gross SS, Jubran A, et al. N-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: Implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A 1990, 87:3623-3629.
221. Beckman JS, Beckman TW, Chen J, et al. Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide. Proc Natl Acad Sci U S A 1990, 87:1620-1624.
222. Szabo C, Salzman AL, Ischiropoulos H Endotoxin triggers the expression of an inducible isoform of nitric oxide synthase and the formation of peroxynitrite in the rat aorta in vivo. FEBS Lett 1995, 363:235-238.
223. Brovkovych V, Patton S, Brovkovych S, et al. In situ measurement of nitric oxide, superoxide and peroxynitrite during endotoxemia. J Physiol Pharmacol 1997, 48:633-644.
224. Pryor WA, Squadrito GL The chemistry of peroxynitrite: A product from the reaction of nitric oxide with superoxide. Am J Physiol 1995, 268(5 Pt 1):L699-L722.
225. Wizemann TM, Gardner CR, Laskin JD, et al. Production of nitric oxide and peroxynitrite in the lung during acute endotoxemia. J Leukoc Biol 1994, 56:759-768.
226. Balligand JL, Cannon PJ Nitric oxide synthases and cardiac muscle: Autocrine and paracrine influences. Arterioscl Thromb Vasc Biol 1997, 17:1846-1858.
227. Crow JP, Beckman JS Reactions between nitric oxide, superoxide, and peroxynitrite: Footprints of peroxynitrite in vivo. Adv Pharmacol (New York) 1995, 34:17-43.
228. Hausladen A, Fridovich I Superoxide and peroxynitrite inactivate aconitases, nitric oxide does not. J Biol Chem 1994, 269:29405-29408.
229. Szabo C, Salzman AL Endogenous peroxynitrite is involved in the inhibition of mitochondrial respiration in immunostimulated J774.2 macrophages. Biochem Biophys Res Commun 1995, 209:739-743.
230. Bolanos JP, Heales SJ, Land JM, et al. Effect of peroxynitrite on the mitochondrial respiratory chain: Differential susceptibility of neurones and astrocytes in primary culture. J Neurochem 1995, 64:1965-1972.
231. Zingarelli B, Day BJ, Crapo JD, et al. The potential role of peroxynitrite in the vascular contractile and cellular energetic failure in endotoxic shock. Br J Pharmacol 1997, 120:259-267.
232. Radi R, Rodriguez M, Castro L, et al. Inhibition of mitochondrial electron transport by peroxynitrite. Arch Biochem Biophys 1994, 308:89-95.
233. Zingarelli B, Hasko G, Salzman AL, et al. Effects of a novel guanylyl cyclase inhibitor on the vascular actions of nitric oxide and peroxynitrite in immunostimulated smooth muscle cells and in endotoxic shock. Crit Care Med 1999, 27:1701-1707.
234. Shen W, Xu X, Ochoa M, et al. Role of nitric oxide in regulation of oxygen consumption in conscious dogs. Circ Res 1994, 75:1086-1095.
235. Shen W, Hintze TH, Wolin MS Nitric oxide: an important singaling mechanism between vascular endothelium and parenchymal cells in the regulation of oxygen consumption. Circulation 1995, 92:3503-3508.
236. Poderoso JJ, Peralta JG, Lisdero CL, et al. Nitric oxide regulates oxygen uptake and hydrogen peroxide release by the isolated beating rat heart. Am J Physiol 1998, 274(1 Pt 1):C112-C119.
237. Szabo C, Zingarelli B, Salzman AL Role of poly-ADP ribosyltransferase activation in the vascular contractile and energetic failure elicited by exogenous and endogenous nitric oxide peroxynitrite. Circ Res 1996, 78:1051-1063.
238. Stoclet JC, Muller B, Gyorgy K, et al. The inducible nitric oxide synthase in vascular and cardiac tissue. Eur J Pharmacol 1999, 375:139-155.
239. Tarpey MM, Beckman JS, Ischiropoulos H, et al. Peroxynitrite stimulates vascular smooth muscle cell cyclic GMP synthesis. FEBS Lett 1995, 364:314-318.
240. Mayer B, Schrammel A, Klatt P, et al. Peroxynitrite-induced accumulation of cyclic GMP in endothelial cells and stimulation of purified soluble guanylyl cyclase: Dependence on glutathione and possible role of S-nitrosation. J Biol Chem 1995, 270:17355-17360.
241. Iesaki T, Gupte SA, Kaminski PM, et al. Inhibition of guanylate cyclase stimulation by NO and bovine arterial relaxation to peroxynitrite and H2O2. Am J Physiol 1999, 277(3 Pt 2):H978-H985.
242. Ma XL, Lopez BL, Liu GL, et al. Peroxynitrite aggravates myocardial reperfusion injury in the isolated perfused rat heart. Cardiovasc Res 1997, 36:195-204.
243. Szabo C The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 1996, 6:79-88.
244. Liaudet L, Soriano FG, Szabo C Biology of nitric oxide signaling. Crit Care Med 2000, 28(Suppl):N37-N52.
245. McCord JM Oxygen-derived free radicals. New Horiz 1993, 1:70-76.
246. Saugstad OD, Ostrem T Hypoxanthine and urate levels of plasma during and after hemorrhagic hypotension in dogs. Eur Surg Res 1977, 9:48-56.
247. Yokoyama Y, Parks DA Circulating xanthine oxidase: Release of xanthine oxidase from isolated rat liver. Gastroenterology 1988, 94:607-611.
248. Jolly SR, Kane WJ, Bailie MB, et al. Canine myocardial reperfusion injury: Its reduction by the combined administration of superoxide dismutase and catalase. Circ Res 1984, 54:277-285.
249. Przyklenk K, Kloner RA Superoxide dismutase plus catalase improve contractile function in the canine model of the "stunned myocardium.". Circ Res 1986, 58:148-156.
250. Granger DN, Rutili G, McCord JM Superoxide radicals in feline intestinal ischemia. Gastroenterology 1981, 81:22-29.
251. Peitzman AB, Shires GTI, Illner H, et al. Effect of intravenous ATP-MgCl2 on cellular function in liver and muscle in hemorrhagic shock. Curr Surg 1981, 38:300.
252. Murphy K, Haudek SB, Thompson M, et al. Molecular biology of septic shock. New Horiz 1998, 6:181-193.
253. Mira J, Cariou A, Grall F, et al. Susceptibility to and mortality of septic shock are associated with TNF2, a TNF-alpha promotor polymorphism: A multicenter study. JAMA 1999, 282:561-568.
254. Stuber F, Petersen M, Bokelmann F, et al. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis. Crit Care Med 1996, 24:381-384.
255. Libert C, Wielockx B, Hammond GL, et al. Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock. Genomics 1999, 55:284-289.
256. Fang XM, Schroder S, Hoeft A, et al. Comparison of two polymorphisms of the interleukin-1 gene family: Interleukin-1 receptor antagonist polymorphism contributes to susceptibility to severe sepsis. Crit Care Med 1999, 27:1330-1334.
257. Holmes CL, Russell JA, Walley KR Genetic polymorphisms in sepsis and septic shock: Role in prognosis and potential for therapy. Chest 2003, 124:1103-1115.
258. Lightfoot EJ, Horton JW, Maass DL, et al. Major burn trauma in rats promotes cardiac and gastrointestinal apoptosis. Shock 1999, 11:29-34.
259. Xu YX, Wichmann MW, Ayala A, et al. Trauma-hemorrhage induces increased thymic apoptosis while decreasing IL-3 release and increasing GM-CSF. J Surg Res 1997, 68:24-30.
260. Kumar A, Kumar A, Michael P, et al. Human serum from patients with septic shock activates transcription factors STAT1, IRF1 and NFkB and induces apoptosis in human cardiac myocytes. J Biol Chem 2005, 280:42619-42626.
261. Chien S Role of the sympathetic nervous system in hemorrhage. Physiol Rev 1967, 47:214-288.
262. Bond RF, Green HD Cardiac output redistribution durng bilateral common carotid artery occlusion. Am J Physiol 1969, 216:393-403.
263. Woolf PD Endocrinology of shock. Ann Emerg Med 1986, 15:1401-1405.
264. Haupt MT The use of crystalloidal and colloidal solution for volume replacement in hypovolemic shock. CRC Crit Rev Clin Lab Sci 1989, 27:1-23.
265. Skillman JJ, Awwad HK, Moore FD Plasma protein kinetics of the early transcapillary refill after hemorrhage in man. Surg Gynecol Obstet 1967, 125:983-996.
266. Forsyth RP, Hoffbrand BI, Melmon KL Redistribution of cardiac output during hemorrhage in the unanesthetized monkey. Circ Res 1970, 27:311-320.
267. Kaihara S, Rutherford RB, Schwentker EP, et al. Distribution of cardiac output in experimental hemorrhagic shock in dogs. J Appl Physiol 1969, 27:218-222.
268. Harper AM Autoregulation of cerebral blood flow: Influence of the arterial blood pressure on the blood flow though the cerebral cortex. J Neurol Neurosurg Psychiatry 1966, 29:398-403.
269. Sprung CL, Peduzzi PN, Shatney CH, et al. Impact of encephalopathy on mortality in the sepsis syndrome. The Veterans Administration Systemic Sepsis Cooperative Study Group. Crit Care Med 1990, 18:801-806.
270. Douglas ME, Downs JB, Dannemiller FB, et al. Acute respiratory failure and intravascular coagulation. Surg Gynecol Obstet 1976, 143:555-560.
271. Roussos C, Macklem PT The respiratory muscles. N Engl J Med 1982, 307:786-797.
272. Hou SH, Bushinsky DA, Wish JB, et al. Hospital acquired renal insufficiency: A prospective study. Am J Med 1983, 74:243-248.
273. Myer B, Moran S Hemodynamically mediated acute renal failure. N Engl J Med 1986, 314:97-105.
274. Rose BD Meaning and application of urine chemistries. Clinical Physiology of Acid-Base and Electrolyte Disorders 1984, 271-278. McGraw-Hill, New York, .
275. Diamond JR, Yoburn DC Nonoliguric acute renal failure associated with a low fractional excretion of sodium. Ann Intern Med 1982, 96:597-600.
276. Mainous MR, Deitch EA Bacterial translocation. Pathophysiology of Shock, Sepsis and Organ Failure 1993, 265-278. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
277. Lillehei RC, MacLean LD The intestinal factor in irreversible endotoxin shock. Ann Surg 1958, 148:513-519.
278. Champion HR, Jones RT, Trump BF, et al. A clinicopathologic study of hepatic dysfunction following shock. Surg Gynecol Obstet 1976, 142:657-663.
279. Garcia-Barreno P, Balibrea JL, Aparicio P Blood coagulation changes in shock. Surg Gynecol Obstet 1978, 147:6-12.
280. Counts HB, Haisch C, Simon TL, et al. Hemostasis in massively transfused trauma patients. Ann Surg 1979, 190:91-99.
281. Arnold J, Leinhardt D, Little RA Metabolic response to trauma. Pathophysiology of Shock Sepsis and Organ Failure 1993, 145-160. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
282. Hoyt DB, Junger WG, Ozkan AN Humoral mechanisms. Pathophysiology of Shock Sepsis and Organ Failure 1993, 111-130. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
283. Stephan R, Ayala A, Chaudry IH Monocyte and lymphocyte responses following trauma. Pathophysiology of Shock Sepsis and Organ Failure 1993, 131-144. Springer-Verlag, Berlin. G. Schlag, H. Redl (Eds.).
284. Devins SS, Miller A, Herndon BL, et al. The effects of dopamine on T-cell proliferative response and serum prolactin in critically ill patients. Crit Care Med 1992, 20:1644-1649.
285. Oud L, Haupt MT Persistent gastric intramucosal ischemia in patients with sepsis following resuscitation from shock. Chest 1999, 115:1390-1396.
286. Wo CC, Shoemaker WC, Appel PL, et al. Unreliability of blood pressure and heart rate to evaluate cardiac output in emergency resuscitation and critical illness. Crit Care Med 1993, 21:218-223.
287. Ward KR, Ivantury RR, Barbee WR Endpoints of resuscitation for the victim of trauma. J Intensive Care Med 2001, 16:55-75.
288. Rady MY, Rivers EP, Nowak RM Resuscitation of the critically ill in the ED: Responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 1996, 14:218-225.
289. Gilbert EM, Haupt MT, Mandanas RY, et al. The effect of fluid loading, blood transfusion, and catecholamine infusion on oxygen delivery and consumption in patients with sepsis. Am Rev Respir Dis 1986, 134:873-878.
290. Bakker J, Coffemils M, Leon M, et al. Blood lactate levels are superior to oxygen-derived variables in predicting outcome in human septic shock. Chest 1992, 99:956-962.
291. Weil MH, Afifi AA Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 1970, 41:989-1001.
292. Henning RJ, Weil MH, Weiner F Blood lactate as a prognostic indicator of survival in patients with acute myocardial infarction. Circ Shock 1982, 9:307-315.
293. Vincent JL, Roman A, Kahn RJ Dobutamine administration in septic shock: Addition to a standard protocol. Crit Care Med 1990, 18:689-693.
294. Cain SM Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol 1977, 42:228-234.
295. Cilley R, Scharenberg A, Bongiorno P, et al. Low oxygen delivery produced by anemia, hypoxia, and low cardiac output. J Surg Res 1991, 51:425-433.
296. Madias NE Lactic acidosis. Kidney Int 1986, 29:752-774.
297. Eldridge F, Sulzer J Effect of respiratory alkalosis on blood lactate and pyruvate in humans. J Appl Physiol 1967, 22:461-468.
298. Waxman K, Nolan LS, Shoemaker WC Sequential perioperative lactate determination: Physiological and clinical implications. Crit Care Med 1982, 10:96-99.
299. James JH, Luchette FA, McCarter FD, et al. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. Lancet 1999, 354:505-508.
300. Cohn JN Blood pressure measurement in shock: Mechanism of inaccuracy in auscultatory and palpatory methods. JAMA 1967, 199:118-122.
301. Pauca AL, Wallenhaupt SL, Kon ND, et al. Does radial artery pressure accurately reflect aortic pressure?. Chest 1992, 102:1193-1198.
302. Packman MI, Rackow EC Optimum left heart filling pressure during fluid resuscitation of patients with hypovolemic and septic shock. Crit Care Med 1983, 11:165-169.
303. Weisul RD, Vito L, Dennis RC, et al. Myocardial depression during sepsis. Am J Surg 1977, 133:512-521.
304. Connors AF, McCaffree DR, Gray BA Evaluation of right-heart catheterization in the critically ill patient without acute myocardial infarction. N Engl J Med 1983, 308:263-267.
305. Connors AF, Dawson NV, McCaffree DR, et al. Assessing hemodynamic status in critically ill patients: Do physicians use clinical information optimally?. J Crit Care 1987, 2:174-180.
306. Connors AF, Speroff T, Dawson NV, et al. The effectiveness of right heart catheterization in the initial care of critically ill patients. JAMA 1996, 276:889-897.
307. Rhodes A, Cusack RJ, Newman PJ, et al. A randomised, controlled trial of the pulmonary artery catheter in critically ill patients. Intensive Care Med 2002, 28:256-264.
308. Sandham JD, Hull RD, Brant RF, et al. A randomized, controlled trial of the use of pulmonary-artery catheters in high-risk surgical patients. N Engl J Med 2003, 348:5-14.
309. Richard C, Warszawski J, Anguel N, et al. Early use of the pulmonary artery catheter and outcomes in patients with shock and acute respiratory distress syndrome: A randomized controlled trial. JAMA 2003, 290:2713-2720.
310. Binanay C, Califf RM, Hasselblad V, et al. Evaluation study of congestive heart failure and pulmonary artery catheterization effectiveness: The ESCAPE trial. JAMA 2005, 294:1625-1633.
311. Harvey S, Harrison DA, Singer M, et al. Assessment of the clinical effectiveness of pulmonary artery catheters in management of patients in intensive care (PAC-Man): A randomised controlled trial. Lancet. 2005, 366:472-477.
312. Shahid M, Rodger IW Enhancement of amrinone-induced positive inotropy in rabbit papillary muscles with depressed contractile function: Effects on cyclic nucleotide levels and phosphodiesterase isoenzymes. J Pharm Pharmacol 1991, 43:88-94.
313. Ivanov R, Allen J, Calvin JE The incidence of major morbidity in critically ill patients managed with pulmonary artery catheters: A meta-analysis. Crit Care Med 2000, 28:615-619.
314. Friese RS, Shafi S, Gentilello LM, et al. Pulmonary artery catheter use is associated with reduced mortality in severely injured patients: A National Trauma Data Bank analysis of 53,312 patients. Crit Care Med 2006, 34:1597-1601.
315. Goldman RH, Klughaupt M, Metcalf T, et al. Measurement of central venous oxygen saturation in patients with myocardial infarction. Circulation 1968, 38:941-946.
316. Weber K, Janicki J, Muskin C Pathophysiology of cardiac failure. Am J Cardiol 1985, 56:3B-7B.
317. Simmons D, Alpas A, Tashkin D, et al. Hyperlactatemia due to arterial hypoxemia or reduced cardiac output or both. J Appl Physiol 1978, 45:195-202.
318. Ralston AC, Webb RK, Runciman WB Potential errors in pulse oximetry: III. Effects of interferences, dyes, dyshaemoglobins and other pigments. Anaesthesia 1991, 46:291-295.
319. Norley I Erroneous actuation of the pulse oximeter. Anaesthesia 1987, 42:1116.
320. Palve H, Vuori A Pulse oximetry during low cardiac output and hypothermia states immediately after open heart surgery. Crit Care Med 1989, 17:66-69.
321. Abraham E, Smith M, Silver L Continuous monitoring of critically ill patients with transcutaneous oxygen and carbon dioxide, and conjunctival oxygen sensors. Ann Emerg Med 1984, 13:1021-1026.
322. 2 monitoring of high risk surgical patients during the perioperative period. Crit Care Med 1982, 10:762-764.
323. Tremper KK, Shoemaker WC Transcutaneous oxygen monitoring of critically ill adults, with and without low flow shock. Crit Care Med 1981, 9:706-709.
324. Abraham E, Oye R, Smith M Detection of blood volume deficits through conjunctival oxygen tension monitoring. Crit Care Med 1984, 12:931-934.
325. Tremper KK, Keenan B, Applebaum R, et al. Clinical and experimental monitoring with transcutaneous PO2 during hypoxia, shock, cardiac arrest, and CPR. J Clin Invest 1981, 6:149.
326. Waxman K, Sulder R, Eisner M Transcutaneous oxygen monitoring of emergency department patients. Am J Surg 1983, 146:35-38.
327. Abraham E, Smith M, Silver S Conjunctival and transcutaneous oxygen monitoring during cardiac arrest and cardiopulmonary resuscitation. Crit Care Med 1984, 12:419-421.
328. Montgomery A, Hartmann M, Jonsson K, et al. Intramucosal pH measurement with tonometers for detecting gastrointestinal ischemia in porcine hemorrhagic shock. Circ Shock 1989, 29:319-327.
329. Nelson DP, Samsel RW, Wood LD, et al. Pathological supply dependency of systemic and intestinal O2 uptake during endotoxemia. J Appl Physiol 1988, 64:2410-2419.
330. Gutierrez G, Bismar H, Dantzker D, et al. Comparison of gastric intramucosal pH with measures of oxygen transport and consumption in critically ill patients. Crit Care Med 1992, 20:451-457.
331. Maynard N, Bihari D, Beal R, et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993, 270:1203-1210.
332. Fiddian-Green RG, Haglund U, Gutierrez G, et al. Goals for the resuscitation of shock. Crit Care Med 1993, 21:S25-S31.
333. Gutierrez G, Palizas F, Poglia G, et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992, 339:195-199.
334. Cohn SM, Varela JE, Giannotti G, et al. Splanchnic perfusion evaluation during hemorrhage and resuscitation with gastric near-infrared spectroscopy. J Trauma Inj Infect Crit Care 2001, 50:629-634.
335. Beilman GJ, Groehler KE, Lazaron V, et al. Near-infrared spectroscopy measurement of regional tissue oxyhemoglobin saturation during hemorrhagic shock. Shock 1999, 12:196-200.
336. 2 saturation during resuscitation of traumatic shock monitored using near infrared spectrometry. J Trauma Inj Infect Crit Care 2000, 48:637-642.
337. Rhee P, Langdale L, Mock C, et al. Near-infrared spectroscopy: Continuous measurement of cytochrome oxidation during hemorrhagic shock. Crit Care Med 1997, 25:166-170.
338. Cairns CB, Moore FA, Haenel JB, et al. Evidence for early supply independent mitochondrial dysfunction in patients developing multiple organ failure after trauma. J Trauma Inj Infect Crit Care 1997, 42:532-536.
339. Puyana JC, Soller BR, Zhang S, et al. Continuous measurement of gut pH with near-infrared spectroscopy during hemorrhagic shock. J Trauma Inj Infect Crit Care 1999, 46:9-15.
340. Griebel JA, Moore FA, Piantadosi CA In-vivo responses of mitochondrial redox levels to Escherichia coli bacteremia in primates. J Crit Care 1990, 5:1-9.
341. Ogata H, Mishio M, Luo XX, et al. Significance of elevated cytochrome aa3 in a state of endotoxemia in dogs. Resuscitation 1996, 33:63-68.
342. Porembka DT Transesophageal echocardiography. Crit Care Clin 1996, 12:875-918.
343. ten Wolde M, Sohne M, Quak E, et al. Prognostic value of echocardiographically assessed right ventricular dysfunction in patients with pulmonary embolism. Arch Intern Med 2004, 164:1685-1689.
344. 2 Collaborative Group.
345. Hayes MA, Timmins AC, Yau EHS, et al. Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 1994, 330:1717-1722.
346. Durham RM, Neunaber K, Mazuski JE, et al. The use of oxygen consumption and delivery as endpoints for resuscitation in critically ill patients. J Trauma 1996, 41:32-40.
347. Yu M, Takanishi D, Myers SA, et al. Frequency of mortality and myocardial infarction during maximizing oxygen delivery: A prospective, randomized trial. Crit Care Med 1995, 23:1025-1032.
348. Blow O, Magliore L, Claridge JA, et al. The golden hour and the silver day: Detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma Inj Infect Crit Care 1999, 47:964-969.
349. Boersma E, Maas AC, Deckers JW, et al. Early thrombolytic treatment in acute myocardial infarction: Reappraisal of the golden hour. Lancet 1996, 348:771-775.
350. Vincent JL, Bernard GR, Beale R, et al. Drotrecogin alfa (activated) treatment in severe sepsis from the global open-label trial ENHANCE: Further evidence for survival and safety and implications for early treatment. Crit Care Med 2005, 33:2266-2277.
351. Cooper DJ, Walley KR, Wiggs BR, et al. Bicarbonate does not improve hemodynamics in critically ill patients who have lactic acidosis: A prospective, controlled clinical study. Ann Intern Med 1990, 112:492-498.
352. Humphrey H, Hall J, Sznajder I, et al. Improved survival in ARDS patients associated with a reduction in pulmonary capillary wedge pressure. Chest 1990, 97:1176-1180.
353. Lillehei RC, MacLean LD The intestinal factor in irreversible hemorrhagic shock. Surgery 1958, 42:1043-1054.
354. Haupt MT, Kaufman BS, Carlson RW Fluid resuscitation in patients with increased vascular permeability. Crit Care Clin 1992, 8:341-353.
355. Bissoni RS, Holtgrave DR, Lawler R, et al. Colloids versus crystalloids in fluid resuscitation: An analysis of randomized control trials. J Fam Pract 1991, 32:387-393.
356. Velanovich V Crystalloid versus colloid fluid resuscitation: A meta-analysis of mortality. Surgery 1989, 105:65-71.
357. Human albumin administration in critically ill patients Systematic review of randomised controlled trials. Cochrane Injuries Group Albumin Reviewers. BMJ 1998, 317:235-240.
358. Finfer S, Bellomo R, Boyce N, et al. A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 2004, 350:2247-2256.
359. Hebert PC, Wells G, Blajchman MA, et al. A multicenter, randomized, controlled clinical trial of transfusion requirements in critical care. Transfusion Requirements in Critical Care Investigators, Canadian Critical Care Trials Group. N Engl J Med 1999, 340:409-417.
360. Hebert PC, Yetisir E, Martin C, et al. Is a low transfusion threshold safe in critically ill patients with cardiovascular diseases?. Crit Care Med 2001, 29:227-234.
361. Hebert PC, Fergusson D, Blajchman MA, et al. Clinical outcomes following institution of the Canadian universal leukoreduction program for red blood cell transfusions. JAMA. 2003, 289:1941-1949.
362. Shorr AF, Duh MS, Kelly KM, et al. Red blood cell transfusion and ventilator-associated pneumonia: A potential link?. Crit Care Med 2004, 32:666-674.
363. Shorr AF, Jackson WL, Kelly KM, et al. Transfusion practice and blood stream infections in critically ill patients. Chest 2005, 127:1722-1728.
364. Jackson WL, Shorr AF, Jackson WLJ, et al. Blood transfusion and the development of acute respiratory distress syndrome: More evidence that blood transfusion in the intensive care unit may not be benign. Crit Care Med 2005, 33:1420-1421.
365. Levitski A From epinephrine to cyclic AMP. Science 1988, 241:800-806.
366. Fedida D, Braun AP, Giles WR Alpha-1 adrenoreceptors in myocardium: Functional aspects and transmembrane signalling mechanisms. Physiol Rev 1993, 73:469-487.
367. Ruffolo RR, Nichols AJ, Stadel JM, et al. Structure and function of alpha-adrenoreceptors. Pharmacol Rev 1991, 43:475-505.
368. Landzberg JS, Parker JD, Gauthier DF, et al. Effects of myocardial alpha-1 adrenergic receptor stimulation and blockade on contractility in humans. Circulation 1991, 84:1608-1614.
369. Goldberg LI Dopamine: Clinical uses of an endogenous catecholamine. N Engl J Med 1974, 291:707.
370. Colucci WS, Wright RF, Braunwald E New positive inotropic agents in the treatment of heart failure: Mechanisms of action and recent clinical developments, II. N Engl J Med 1986, 314:349-358.
371. Nasraway SA, Rackow EC, Astiz ME, et al. Inotropic response to digoxin and dopamine in patients with severe sepsis, cardiac failure, and systemic hypoperfusion. Chest 1989, 95:612-615.
372. Landry DW, Levin HR, Gallant EM, et al. Vasopressin deficiency contributes to the vasodilatation of septic shock. Circulation 1997, 95:1122-1125.
373. Landry DW, Levin HR, Gallant EM, et al. Vasopressin pressor sensitivity in vasodilatory septic shock. Crit Care Med 1997, 25:1279-1282.
374. Malay MB, Ashton RC, Landry DW, et al. Low-dose vasopressin in the treatment of vasodilatory septic shock. J Trauma Inj Infect Crit Care 1999, 47:699-703.
375. Morales D, Madigan J, Cullinane S, et al. Reversal by vasopressin of intractable hypotension in the late phase of hemorrhagic shock. Circulation 1999, 100:226-229.
376. Hilberman M, Maseda J, Stinson EB, et al. The diuretic properties of dopamine in patients after open-heart operations. Anesthesiology 1984, 61:489-494.
377. Schaer GL, Fink MP, Parrillo JE Norepinephrine alone versus norepinephrine plus low-dose dopamine: Enhanced renal blood flow with combination pressor therapy. Crit Care Med 1985, 13:492-496.
378. Breckenridge A, Orme M, Dollery CT The effect of dopamine on renal blood flow in man. Eur J Clin Pharm 1971, 3:131-136.
379. Kenakin TP An in-vitro quantitative analysis of the alpha-adrenoreceptor partial agonist activity of dobutamine and its relevance to inotropic selectivity. J Pharmacol Exp Ther 1981, 216:210-219.
380. Ruffolo RR The pharmacology of dobutamine. Am J Med Sci 1987, 294:244-248.
381. Akhtar N, Mikulic E, Cohn JN, et al. Hemodynamic effects of dobutamine in patients with severe heart failure. Am J Cardiol 1975, 36:202-205.
382. Butterworth JF, Strickland RA, Mark LJ, et al. Dobutamine increases heart rate more than epinephrine in patients recovering from aortocoronary bypass surgery. J Cardiothorac Vasc Anesth 1992, 6:535-541.
383. Ligget SB Desensitization of the beta-adrenergic receptor: Distinct molecular determinants of phosphorylation by specific kinases. Pharmacol Res 1991, 24:29-41.
384. Shoemaker WC, Appel PL, Kram HB, et al. Comparison of hemodynamic and oxygen transport effects of dopamine and dobutamine in critically ill surgical patients. Chest 1989, 96:120-126.
385. DiSesa VJ, Brown D, Mudge GH, et al. Hemodynamic comparison of dopamine and dobutamine in the postoperative volume-loaded, pressure-loaded, and normal ventricle. J Thorac Cardiovasc Surg 1982, 83:256-263.
386. Fowler MB, Alderman EL, Oesterle SN, et al. Dobutamine and dopamine after cardiac surgery: Greater augmentation of myocardial blood flow with dopamine. Circulation 1984, 70(Suppl I):I-103-I-111.
387. Tuchschmidt J, Fried J, Astiz M, et al. Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 1992, 102:216-220.
388. Edwards JD, Brown GCS, Nightingale P, et al. Use of survivors cardiorespiratory values as therapeutic goals in septic shock. Crit Care Med 1989, 17:1098-1103.
389. Royster RL, Butterworth JF, Prielipp RC, et al. A randomized, blinded, placebo-controlled evaluation of calcium chloride and epinephrine for inotropic support after emergence from cardiopulmonary bypass. Anesth Analg 1992, 74:3-13.
390. Sung BH, Robinson C, Thadani U, et al. Effects of 1-epinephrine on hemodynamics and cardiac function in coronary disease: Dose response studies. Clin Pharmacol Ther 1988, 43:308-316.
391. Konstram MA, Cohen SR, Weiland DS, et al. Relative contribution of inotropic and vasodilator effects to amrinone-induced hemodynamic improvement in congestive heart failure. Am J Cardiol 1986, 57:242-248.
392. Hermiller JB, Mehegan JP, Nadkarni VM, et al. Amrinone during porcine intraperitoneal sepsis. Circ Shock 1991, 34:247-251.
393. Hoffman P, Schockenhoff B Amrinone in catecholamine-refractory cardiac failure in septic shock. Anaesthetist 1985, 34:663-669.
394. Gold J, Cullinane S, Chen J, et al. Vasopressin in the treatment of milrinone-induced hypotension in severe heart failure. Am J Cardiol 2000, 85:506-508.
395. Morales DL, Gregg D, Helman DN, et al. Arginine vasopressin in the treatment of 50 patients with postcardiotomy vasodilatory shock. Ann Thorac Surg 2000, 69:102-106.
396. Chen JM, Cullinane S, Spanier TB, et al. Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. Circulation 1999, 100(19 Suppl):II-244-II-246.