Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: A dynamic contrast-enhanced MRI study

Journal of Magnetic Resonance Imaging

Volumn 30, Issue 5, 2009, Pages 1139-1144

  Zhang, Ya Feng ^a   Wang, Yi Xiang J ^a   Griffith, James F ^a   Kwong, William K M ^a   Ma, Heather T ^a   Qin, Ling ^a   Kwok, Timothy C Y ^a  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Blood perfusion; Dynamic contrast enhanced; Femur; Hypertension; Magnetic resonance imaging

Indexed keywords

GADOTERIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE; BONE DENSITY; BONE MARROW; CANCELLOUS BONE; CONTRAST ENHANCEMENT; CONTROLLED STUDY; FEMUR; FEMUR HEAD; FEMUR SHAFT; HYPERTENSION; LIMB PERFUSION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PERFUSION WEIGHTED IMAGING; PRIORITY JOURNAL; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; WISTAR KYOTO RAT;

ANIMALS; BLOOD PRESSURE; BONE DENSITY; BONE MARROW; BONE MARROW CELLS; CONTRAST MEDIA; FEMUR; HYPERTENSION; MAGNETIC RESONANCE IMAGING; MALE; PERFUSION; PRESSURE; RATS; RATS, INBRED SHR; RATS, INBRED WKY;

EID: 70350452815     PISSN: 10531807     EISSN: 15222586     Source Type: Journal    
DOI: 10.1002/jmri.21954     Document Type: Article

References (37)

1. Rosamond W, Flegal K, Furie K, et al. Heart disease and stroke statistics - 2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008;117:e25-146.
2. Cole ZA, Dennison EM, Cooper C. Osteoporosis epidemiology update. Curr Rheumatol Rep 2008;10:92-96.
3. Cappuccio FP, Meilahn E, Zmuda JM, Cauley JA. High blood pressure and bone-mineral loss in elderly white women: a prospective study. Study of Osteoporotic Fractures Research Group. Lancet 1999;354:971-975. (Pubitemid 29438401)
4. Mathiassen ON, Buus NH, Sihm I, et al. Small artery structure is an independent predictor of cardiovascular events in essential hypertension. J Hypertens 2007;25:1021-1026. (Pubitemid 46573121)
5. Ois A, Gomis M, Rodriguez-Campello A, et al. Factors associated with a high risk of recurrence in patients with transient ischemic attack or minor stroke. Stroke 2008;39:1717-1721.
6. Nangaku M. Chronic hypoxia and tubulointerstitial injury: a final common pathway to end-stage renal failure. J Am Soc Nephrol 2006;17:17-25.
7. Laroche M. Arteriosclerosis and osteoporosis. Presse Med 1996;25:52-54.
8. Griffith JF, Yeung DK, Antonio GE, et al. Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 2005;236:945-951.
9. Griffith JF, Yeung DK, Tsang PH, et al. Compromised bone marrow perfusion in osteoporosis. J Bone Miner Res 2008;23:1068-1075.
10. Izawa Y, Sagara K, Kadota T, Makita T. Bone disorders in spontaneously hypertensive rat. Calcif Tissue Int 1985;37:605-607. (Pubitemid 16197168)
11. Miyagawa K, Ohashi M, Yamashita S, et al. Increased oxidative stress impairs endothelial modulation of contractions in arteries from spontaneously hypertensive rats. J Hypertens 2007;25:415-421. (Pubitemid 46071940)
12. Gendron G, Gobeil F Jr, Morin J, D'Orléans-Juste P, Regoli D. Contractile responses of aortae from WKY and SHR to vasoconstrictors. Clin Exp Hypertens 2004;26:511-523. (Pubitemid 39445741)
13. Wang YX, Zhang YF, Griffith JF, et al. Vertebral blood perfusion reduction associated with vertebral bone mineral density reduction: a dynamic contrast-enhanced MRI study in a rat orchiectomy model. J Magn Reson Imaging 2008;28:1515-1518.
14. Reckelhoff JF, Zhang H, Granger JP. Testosterone exacerbates hypertension and reduces pressure-natriuresis in male spontaneously hypertensive rats. Hypertension 1998;31:435-439. (Pubitemid 28124754)
15. Khalil RA. Sex hormones as potential modulators of vascular function in hypertension. Hypertension 2005;46:249-254.
16. Shih TT, Chang CJ, Tseng WY, et al. Effect of calcium channel blockers on vertebral bone marrow perfusion of the lumbar spine. Radiology 2004;231:24-30.
17. Tokuda O, Hayashi N, Taguchi K, Matsunaga N. Dynamic contrast-enhanced perfusion MR imaging of diseased vertebrae: analysis of three parameters and the distribution of the time-intensity curve patterns. Skeletal Radiol 2005;34:632-638. (Pubitemid 41440005)
18. Levy BI, Ambrosio G, Pries AR, Struijker-Boudier HA. Microcirculation in hypertension: a new target for treatment? Circulation 2001;104:735-740.
19. Baskurt OK, Meiselman HJ. Blood rheology and hemodynamics. Semin Thromb Hemost 2003;29:435-450.
20. Ungvari Z, Csiszar A, Kaminski PM, Wolin MS, Koller A. Chronic high pressure-induced arterial oxidative stress: involvement of protein kinase C-dependent NAD(P)H oxidase and local renin-angiotensin system. Am J Pathol 2004;165:219-226. (Pubitemid 38821829)
21. Pries AR, Secomb TW, Gaehtgens P. Structural autoregulation of terminal vascular beds: vascular adaptation and development of hypertension. Hypertension 1999;33:153-161. (Pubitemid 29061856)
22. Isbell DC, Epstein FH, Zhong X, et al. Calf muscle perfusion at peak exercise in peripheral arterial disease: measurement by first-pass contrast-enhanced magnetic resonance imaging. J Magn Reson Imaging 2007;25:1013-1020. (Pubitemid 46697572)
23. Prewitt RL, Chen II, Dowell R. Development of microvascular rarefaction in the spontaneously hypertensive rat. Am J Physiol 1982;243:H243-251. (Pubitemid 12051559)
24. Levy BI, Schiffrin EL, Mourad JJ, et al. Impaired tissue perfusion: a pathology common to hypertension, obesity, and diabetes mellitus. Circulation 2008;118:968-976.
25. DeLano FA, Parks DA, Ruedi JM, Babior BM, Schmid-Schönbein GW. Microvascular display of xanthine oxidase and NADPH oxidase in the spontaneously hypertensive rat. Microcirculation 2006;13:551-566. (Pubitemid 44446635)
26. Chen WT, Shih TT, Chen RC, et al. Blood perfusion of vertebral lesions evaluated with gadolinium-enhanced dynamic MRI: in comparison with compression fracture and metastasis. J Magn Reson Imaging 2002;15:308-314.
27. Wang YX, Griffith JF, Kwok A, et al. Reduced bone perfusion in proximal femur of subjects with decreased bone mineral density preferentially affects the femoral neck. Bone [Epub ahead of print].
28. Moon ES, Mehlman CT. Risk factors for avascular necrosis after femoral neck fractures in children: 25 Cincinnati cases and meta-analysis of 360 cases. J Orthop Trauma 2006;20:323-329.
29. Parker MJ, Raghavan R, Gurusamy K. Incidence of fracture-healing complications after femoral neck fractures. Clin Orthop Relat Res 2007;458:175-179. (Pubitemid 46701374)
30. Vogt CJ, Schmid-Schönbein GW. Microvascular endothelial cell death and rarefaction in the glucocorticoid-induced hypertensive rat. Microcirculation 2001;8:129-139. (Pubitemid 33600465)
31. Demmler K, Otte P, Bartl R, Burkhardt R, Frisch B, Jahn A. Osteopenia, marrow atrophy and capillary circulation. Comparative studies of the human iliac crest and 1st lumbar vertebra. Z Orthop Ihre Grenzgeb 1983;121:223-227.
32. Bloomfield SA, Hogan HA, Delp MD. Decreases in bone blood flow and bone material properties in aging Fischer-344 rats. Clin Orthop Relat Res 2002;396:248-257.
33. van der Woude HJ, Bloem JL, Verstraete KL, Taminiau AH, Nooy MA, Hogendoorn PC. Osteosarcoma and Ewing's sarcoma after neoadjuvant chemotherapy: value of dynamic MR imaging in detecting viable tumor before surgery. AJR Am J Roentgenol 1995;165:593-598.
34. Bollow M, Knauf W, Korfel A, et al. Initial experience with dynamic MR imaging in evaluation of normal bone marrow versus malignant bone marrow infiltrations in humans. J Magn Reson Imaging 1997;7:241-250. (Pubitemid 28365668)
35. Cova M, Kang YS, Tsukamoto H, et al. Bone marrow perfusion evaluated with gadolinium-enhanced dynamic fast MR imaging in a dog model. Radiology 1991;179:535-539.
36. Sheng H, Zhang G, Wang YX, et al. Functional perfusion MRI predicts steroid-associated osteonecrosis: an experiment study in rabbits. J Orthop Res 2009;27:742-747.
37. Wang YX. In vivo magnetic resonance imaging of animal models of knee osteoarthritis. Lab Anim 2008;42:246-264.