Differential utilization of T cell receptor TCRα/TCRδ locus variable region gene segments is mediated by accessibility

Proceedings of the National Academy of Sciences of the United States of America

Volumn 106, Issue 41, 2009, Pages 17487-17492

  Yu, Nee Lee ^a   Alt, Frederick W ^a   Reyes, Julia ^a   Gleason, Megan ^a   Zarrin, Ali A ^a   Jung, David ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Epigenetic regulation; T cell development; VDJ recombination

Indexed keywords

DNA; GENOMIC DNA; NEOMYCIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR DELTA CHAIN;

ANIMAL CELL; ARTICLE; CELL MATURATION; CHROMOSOME REARRANGEMENT; DNA FLANKING REGION; DNA STRUCTURE; ENHANCER REGION; EXON; GENE LOCUS; GENETIC RECOMBINATION; GERM LINE; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE;

ANIMALS; BLOTTING, SOUTHERN; CHIMERA; GENE REARRANGEMENT; GENES, T-CELL RECEPTOR ALPHA; GENES, T-CELL RECEPTOR DELTA; GERM-LINE MUTATION; IMMUNOGLOBULIN VARIABLE REGION; MICE; PLASMIDS; RECOMBINATION, GENETIC; RESTRICTION MAPPING; VDJ RECOMBINASES;

EID: 70350447962     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0909723106     Document Type: Article

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