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Volumn 2, Issue 4, 2001, Pages 279-281

Autoimmunity versus horror autotoxicus: The struggle for recognition

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; ART; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; FEMALE; HISTORY; HUMAN; IMMUNOLOGY; MALE; PAROXYSMAL NOCTURNAL HEMOGLOBINURIA;

EID: 0035320525     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/86280     Document Type: Note
Times cited : (100)

References (52)
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    • The Donath-Landsteiner finding raised a number of interesting epistemological and semantic ques­tions that are discussed in detail in Silverstein, A. M
    • The Donath-Landsteiner finding raised a number of interesting epistemological and semantic ques­tions that are discussed in detail in Silverstein, A. M. Cell. Immunol. 97, 173-188 (1898).
    • (1898) Cell. Immunol , vol.97 , pp. 173-188
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    • 37, 453-458 and 681-687 (1900); 38, 251-257 and569-574 (1901). (Translations: Ehrlich, P. in The Collected Papers of Paul Ehrlich Vol. II, Pergamon, New York, 1957.)
    • Ehrlich, P. and Morgenroth, J. Berlin klin.Wochenschr. 36, 6-9 and 481-486 (1899); 37, 453-458 and 681-687 (1900); 38, 251-257 and569-574 (1901). (Translations: Ehrlich, P. in The Collected Papers of Paul Ehrlich Vol. II, Pergamon, New York, 1957.)
    • (1899) Berlin Klin.Wochenschr , vol.36
    • Ehrlich, P.1    Morgenroth, J.2
  • 8
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    • (Translations: Ehrlich, P. in Collected Studies on Immunity, p. 388, Wiley, New York, 1906.)
    • Ehrlich, P. 73 Verh. Ges. Dtsch. Naturforsch.Aerzte 1, 250-275 (1902). (Translations: Ehrlich, P. in Collected Studies on Immunity, p. 388, Wiley, New York, 1906.)
    • (1902) 73 Verh. Ges. Dtsch. Naturforsch.Aerzte , vol.1 , pp. 250-275
    • Ehrlich, P.1
  • 11
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    • For an excellent exposition of the meaning of horror autotoxicus, see the monograph by Dietlinde Goltz, Horror Autotoxicus, Thesis, Univerity of Munster
    • For an excellent exposition of the meaning of horror autotoxicus, see the monograph by Dietlinde Goltz, Horror Autotoxicus: Ein Beitrag zur Geschichte und Theorie der Autoimmunpathologie im Spiegel eines vielzitierten Begriffes (Thesis, Univerity of Munster, 1980).
    • (1980) Ein Beitrag Zur Geschichte Und Theorie Der Autoimmunpathologie Im Spiegel Eines Vielzitierten Begriffes
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    • Landsteiner would later discover the M, N and P erythrocyte antigen system with Philip Levine [Proc. Soc. Soc. Exp. Biol. Med. 24, 600-602 and 941-942 (1926)] and the Rh antigen system with Alexander Wiener [Proc. Soc. Soc. Exp. Biol. Med. 43, 223-224 (1940)]
    • Wien, klin. Wochenschr. 14, 1132-1134 (1901). Landsteiner would later discover the M, N and P erythrocyte antigen system with Philip Levine [Proc. Soc. Soc. Exp. Biol. Med. 24, 600-602 and 941-942 (1926)] and the Rh antigen system with Alexander Wiener [Proc. Soc. Soc. Exp. Biol. Med. 43, 223-224 (1940)].
    • (1901) Wochenschr , vol.14 , pp. 1132-1134
    • Wien, K.1
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    • Erq, Allq. Pathol. 11, 515-644 (1907), p. 565.
    • (1907) Pathol , vol.11 , Issue.515-644 , pp. 565
    • Erq, A.1
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    • Almost simultaneously, Roitt et al. published similar findings in human Hashimoto’s disease [Lancet 2, 820-822 (1956)]
    • Rose, N. R. and Witebsky, E. J. Immunol. 76, 417-427 (1956). Almost simultaneously, Roitt et al. published similar findings in human Hashimoto’s disease [Lancet 2, 820-822 (1956)].
    • (1956) J. Immunol , vol.76 , pp. 417-427
    • Rose, N.R.1    Witebsky, E.2
  • 35
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    • I have expanded elsewhere on the conceptual changes that occurred during immunology’s first cen­tury in Silverstein, A. M
    • I have expanded elsewhere on the conceptual changes that occurred during immunology’s first cen­tury in Silverstein, A. M. Cell. Immunol. 132, 515-531 (1991).
    • (1991) Cell. Immunol , vol.132 , pp. 515-531
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    • For example, Kabat E. E. and Mayer, M. M, C.Thomas, Springfield IL
    • For example, Kabat E. E. and Mayer, M. M. Experimental Immunochemistry (Chas. C.Thomas, Springfield IL, 1948).
    • (1948) Experimental Immunochemistry (Chas
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    • For example, Pressman, D. and Grossberg, A. The Structural Basis of Antibody Specifcity (Benjamin, New York, 1968); Kabat, E. A. Structural Concepts in Immunology and Immunochemistry (Holt, Rinehart, andWinston, New York
    • For example, Pressman, D. and Grossberg, A. The Structural Basis of Antibody Specifcity (Benjamin, New York, 1968); Kabat, E. A. Structural Concepts in Immunology and Immunochemistry (Holt, Rinehart, andWinston, New York, 1968).
    • (1968)
  • 40
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    • For example, Wells, H. G. The Chemical Aspects of Immunity (Chemical Catalog Co., New York, 1924) and Marrack, J. R. The Chemistry of Antigens and Antibodies (HR Stationery Office, London, 1934). Only in 1963 would texts appear aimed primarily at biologists and physicians, Humphrey, J. H. andWhite, R. G. Immunology for Students of Medicine (Davis, Philadelphia, 1963) and Gell, P. G. H. and Coombs, R. R.A. Clinical Aspects of Immunology (Blackwell, Oxford, 1963)
    • For example, Wells, H. G. The Chemical Aspects of Immunity (Chemical Catalog Co., New York, 1924) and Marrack, J. R. The Chemistry of Antigens and Antibodies (HR Stationery Office, London, 1934). Only in 1963 would texts appear aimed primarily at biologists and physicians, Humphrey, J. H. andWhite, R. G. Immunology for Students of Medicine (Davis, Philadelphia, 1963) and Gell, P. G. H. and Coombs, R. R.A. Clinical Aspects of Immunology (Blackwell, Oxford, 1963).
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    • These were the instruction theories of antibody formation, which held that the antigen controlled the organization of the specific site on the antibody molecule.
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    • The concept of immunological tolerance was implicit in Ray Owen’s report on chimerism [Owen, R. D. Science 102, 400-401 (1945)], made explicit in F. M. Burnet andF. Fenner’s
    • The concept of immunological tolerance was implicit in Ray Owen’s report on chimerism [Owen, R. D. Science 102, 400-401 (1945)], made explicit in F. M. Burnet andF. Fenner’s The Production of Antibodies 2nd edn (Macmillan, New York, 1949), and proved experimentally by R. E. Billingham, L. Brent, andP. B. Medawar [Nature 172, 603-606 (1953)].The demonstration earned for Burnet and Medawar the Nobel Prize in Physiology or Medicine for 1960.
    • (1960) The Demonstration Earned for Burnet and Medawar the Nobel Prize in Physiology Or Medicine For
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    • For example, Bergsma, D. andGood, R.A, National Foundation, New York
    • For example, Bergsma, D. andGood, R.A. (eds) Immunological Defciency Diseases in Man (National Foundation, New York, 1968).
    • (1968) Immunological Defciency Diseases in Man


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