Differential influence of selective 5-HT5A vs 5-HT1A, 5-HT1B, or 5-HT2C receptor blockade upon light-induced phase shifts in circadian activity rhythms: Interaction studies with citalopram

European Neuropsychopharmacology

Volumn 19, Issue 12, 2009, Pages 887-897

  Gannon, Robert L ^a   Peglion, Jean Louis ^b   Millan, Mark J ^c  

^a VALDOSTA STATE UNIVERSITY   (United States)

^b INSTITUT DE RECHERCHES SERVIER   (France)

^c INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Biological rhythms; Raphe nucleus; Selective serotonin reuptake inhibitors; Serotonin receptors; Suprachiasmatic nucleus

Indexed keywords

2,3,6,7 TETRAHYDRO 1' METHYL 5 [[2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL) 4 BIPHENYLYL]CARBONYL]SPIRO[FURO[2,3 F]INDOLE 3,4' PIPERIDINE]; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 6 CHLORO 5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL]INDOLINE; A 843277; CITALOPRAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SB 399885; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN 1B ANTAGONIST; SEROTONIN 1B RECEPTOR; SEROTONIN 2A ANTAGONIST; SEROTONIN 2C ANTAGONIST; SEROTONIN 2C RECEPTOR; SEROTONIN 5A RECEPTOR; SEROTONIN 5A RECEPTOR ANTAGONIST; SEROTONIN 6 ANTAGONIST; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG; VOLINANSERIN;

ANIMAL EXPERIMENT; ARTICLE; CIRCADIAN RHYTHM; CONTROLLED STUDY; DRUG POTENTIATION; HAMSTER; IN VIVO STUDY; LIGHT; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM;

ANIMALS; CIRCADIAN RHYTHM; CITALOPRAM; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG INTERACTIONS; LIGHT; MALE; MESOCRICETUS; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTOR, SEROTONIN, 5-HT1B; RECEPTOR, SEROTONIN, 5-HT2C; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SEROTONIN UPTAKE INHIBITORS; TIME FACTORS;

EID: 70350430654     PISSN: 0924977X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2009.06.011     Document Type: Article

References (76)

1. 1B receptors in the regulation of serotonin cell firing and release in the rat brain. J. Neurochem. 79 (2001) 172-182
2. 1A autoreceptor antagonist-induced 5-HT release in the hamster suprachiasmatic nuclei: effects on circadian clock resetting. Neurosci. Lett. 282 (2000) 97-100
3. 1A antagonists. Trends Neurosci. 19 (1996) 378-383
4. Barnes N.M., and Sharp T. A review of central 5-HT receptors and their function. Neuropharmacology 38 (1999) 1083-1152
5. 7 receptors in the mouse suprachiasmatic nucleus. J. Comp. Neurol. 432 (2001) 371-388
6. Benedetti F., Colombo C., Pontiggia A., Bernasconi A., Florita M., and Smeraldi E. Morning light treatment hastens the antidepressant effect of citalopram: a placebo-controlled trial. J. Clin. Psychiatry 64 (2003) 648-653
7. B receptor-mediated presynaptic inhibition of GABA release in the suprachiasmatic nucleus. J. Neurophysiol. 93 (2005) 3157-3164
8. Bunney J.N., and Potkin S.G. Circadian abnormalities, molecular clock genes and chronobiological treatments in depression. Brit. Med. Bull. 86 (2008) 23-32
9. Cremers T.I.F.H., Rea K., Bosker F.J., Wikstrom H.V., Hogg S., Mork A., and Westerink B.H.C. Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies. Neuropsychopharmacology 32 (2007) 1550-1557
10. Drescher, K.U., Amberg, W., Kling, A., Gross, G., Schoemaker, H., Sullivan, J.P. and Garcia-Ladona, F.J. (2006) 5-HT5A antagonists, like atypical antipsychotics, increase acetylcholine (ACh) release in medial prefrontal cortex of freely moving rats. Program No 33.2 2006 Neuroscience Meeting Planner, Society for Neuroscience CD-ROM.
11. 1A receptors. Neurochem. Res. 21 (1996) 557-562
12. Duncan W.C. Circadian rhythms and the pharmacology of affective illness. Pharmacol. Ther. 71 (1996) 253-312
13. Duncan M.J., and Davis V.A. Cyclic AMP mediates circadian phase shifts induced by microinjection of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Res. 1058 (2005) 10-16
14. Duncan M.J., Grear K.E., and Hoskins M.A. Aging and SB-269970-A, a selective 5-HT7 receptor antagonist, attenuate circadian phase advances induced by microinjections of serotonergic drugs in the hamster dorsal raphe nucleus. Brain Res. 1008 (2004) 40-48
15. 5A receptors in discrete regions of the circadian timing system in the Syrain hamster. Brain Res. 869 (2000) 178-185
16. Ebert, U., Kling, A., Amberg, W., Garcia-Ladona, F.J., Gross, G., Schoemaker, H. and Sullivan, J.P. (2006) Selective 5-HT5A antagonists induce a specific pattern of Fos activation in rat brain. Program No. 529.25 2006 Neuroscience Meeting Planner, Society for Neuroscience. CD-ROM.
17. Engleman E.A., Robertson D.W., Thompson D.C., Perry K.W., and Wong D.T. Antagonism of serotonin 5-HT1A receptors potentiates the increases in extracellular monoamines induced by duloxetine in rat hypothalamus. J. Neurochem. 66 (1996) 599-603
18. Forster E.A., Cliffe I.A., Bill D.J., Dover G.M., Jones D., Reilly Y., and Fletcher A. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281 (1995) 81-88
19. 7 receptors in the rodent suprachiasmatic nucleus. J. Biol. Rhythms 16 (2001) 19-24
20. 1A mixed agonists/antagonists elicit large-magnitude phase shifts in hamster circadian wheel-running rhythms. Neuroscience 119 (2003) 567-576
21. 2C receptors. Neuroscience 137 (2006) 287-299
22. Gannon R.L., and Millan M.J. Evaluation of serotonin, noradrenaline and dopamine reuptake inhibitors on light-induced phase advances in hamster circadian activity rhythms. Psychopharmacology 195 (2007) 325-332
23. 5A receptor. Program No 331.B73 2006 Neuroscience Meeting Planner, Society for Neuroscience CD-ROM.
24. 7 receptor knockout mouse. Neuroscience 152 (2008) 245-253
25. Germain A., and Kupfer D.J. Circadian rhythm disturbances in depression. Hum. Psychopharmacol. Clin. Exp. 23 (2008) 571-585
26. B agonists and antagonists alter the phase-shifting effects of light when microinjected into the suprachiasmatic region. Brain Res. 759 (1997) 181-189
27. Gobert A., and Millan M.J. Modulation of dialysate levels of dopamine, noradrenaline, and serotonin (5-HT) in the frontal cortex of freely-moving rats by (-)-pindolol alone and in association with 5-HT reuptake inhibitors: comparative roles of beta-adrenergic, 5-HT1A, and 5-HT1B receptors. Neuropsychopharmacology 21 (1999) 268-284
28. Guo H., Brewer J.M., Lehman M.N., and Bittman E.L. Suprachiasmatic regulation of circadian rhythms of gene expression in hamster peripheral organs: effects of transplanting the pacemaker. J. Neurosci. 26 (2006) 6406-6412
29. Healy D., and Waterhouse J.M. The circadian system and the therapeutics of the affective disorders. Pharmacol. Ther. 65 (1995) 241-263
30. Hjorth S. (-)-pindolol, but not buspirone, potentiates the citalopram-induced rise in extracellular 5-hydroxytryptamine. Eur. J. Pharm. 303 (1996) 183-186
31. Johnson R.F., Morin L.P., and Moore R.Y. Retinohypothalamic projections in the hamster and rat demonstrated using cholera toxin. Brain Res. 462 (1988) 0301-0312
32. Kohler M., Kalkowski A., and Wollnik F. Serotonin agonist quipazine induces photic-like phase shifts of the circadian activity rhythm and c-Fos expression in the rat suprachiasmatic nucleus. J. Biol. Rhythms 14 (1999) 131-140
33. 7) implicated in the regulation of mammalian circadian rhythms. Neuron 11 (1993) 449-458
34. Kehne J.H., Baron B.M., Carr A.A., Chaney S.F., Elands J., Feldman D.J., Frank R.A., van Giersbergen P.L., McCloskey T.C., Johnson M.P., McCarty D.R., Poirot M., Senyah Y., Siegel B.W., and Widmaier C. Preclinical characterization of the potential of the putative atypical antipsychotic MDL 100, 907 as a potent 5-HT2A antagonist with a favorable CNS safety profile. J. Pharmacol. Exp. Ther. 277 (1996) 968-981
35. Keller J., Flores B., Gomez R.G., Solvason H.B., Kenna H., Williams G.H., and Schatzberg A.F. Cortisol circadian rhythm alterations in psychotic major depression. Biol. Psychiatry 60 (2006) 275-281
36. Kennaway D.J., and Moyer R.W. Serotonin 5-HT2c agonists mimic the effects of light pulses on circadian rhythms. Brain Res. 806 (1998) 257-270
37. Kennett G.A., Wood M.D., Bright F., Trail B., Riley G., Holland V., Avenell K.Y., Stean T., Upton N., Bromidge S., Forbes I.T., Brown A.M., Middlemiss D.N., and Blackburn T.P. SB 242, 084, a selective and brain penetrant 5-HT2C receptor antagonist. Neuropharm. 36 (1997) 609-620
38. Kessler E.J., Sprouse J., and Harrington M.E. NAN-190 potentiates the circadian response to light and speeds re-entrainment to advanced light cycles. Neuroscience 154 (2008) 1187-1194
39. Kohsaka A., and Bass J. A sense of time: how molecular clocks organize metabolism. Trends Endocrinol. Metab. 18 (2006) 4-11
40. 2 receptors in rats. Psychopharmacology 140 (1998) 69-74
41. Lall G.S., and Harrington M.E. Potentiation of the resetting effects of light on circadian rhythms of hamsters using serotonin and neuropeptide Y receptor antagonists. Neuroscience 141 (2006) 1545-1552
42. Legutko R., and Gannon R.L. Serotonin transporter localization in the hamster suprachiasmatic nucleus. Brain Res. 893 (2001) 77-83
43. Lewy A.J., Lefler B.J., Emens J.S., and Bauer V.K. The circadian basis of winter depression. Proc. Nat. Acad. Sci. USA 103 (2006) 7414-7419
44. Meyer-Bernstein E.L., and Morin L.P. Differential serotonergic innervation of the suprachiasmatic nucleus and the intergeniculate leaflet and its role in circadian rhythm modulation. J. Neurosci. 16 (1996) 2097-2111
45. Millan M.J. The neurobiology and control of anxious states. Prog. Neurobiol. 70 (2003) 83-244
46. Millan M.J. Serotonin 5-HT2C receptors as a target for the treatment of depressive and anxious states: focus on novel therapeutic strategies. Therapie 60 (2005) 441-460
47. Millan M.J. Multi-target strategies for the improved treatment of depressive states: conceptual foundations and neuronal substrates, drug discovery and therapeutic application. Pharmacol. Ther. 110 (2006) 135-370
48. Millan M.J., Canton H., and Lavielle G. Targeting multiple serotonin receptors: mixed 5-HT1A agonists/5-HT1C/2 antagonists as therapeutic agents. Drug News Perspectives 5 (1992) 397-406
49. Millan M.J., Marin P., Bockaert J., and Mannoury la Cour C. Signaling at G-protein-coupled serotonin receptors: recent advances and future research directions. Trends Pharm. Sci. 29 (2008) 454-464
50. Mlinar B., Tatini F., Ballini C., Nencioni S., Della Corte L., and Corradetti R. Differential autoinhibition of 5-hydroxytryptamine neurons by 5-hydroxytryptamine in the dorsal raphe nucleus. NeuroReport 16 (2005) 1351-1355
51. Mooney R.D., Shi M.Y., and Rhoades R.W. Modulation of retinotectal transmission by presynaptic 5-HT1B receptors in the superior colliculus of the adult hamster. J. Neurophysiol. 72 (1994) 3-13
52. Morin L.P. Serotonin and the regulation of mammalian circadian rhythmicity. Ann. Med. 31 (1999) 12-33
53. Morin L.P., and Blanchard J. Depletion of brain serotonin by 5, 7-DHT modifies hamster circadian rhythm response to light. Brain Res. 566 (1991) 173-185
54. Pickard G.E., Weber E.T., Scott P.A., Riberdy A.F., and Rea M.A. 5HT1B receptor agonists inhibit light-induced phase shifts of behavioural circadian rhythms and expression of the immediate-early gene c-fos in the suprachiasmatic nucleus. J. Neurosci. 16 (1996) 8208-9220
55. 1B receptor-mediated presynaptic inhibition of retinal input to the suprachiasmatic nucleus. J. Neurosci. 19 (1999) 4034-4045
56. Prosser R.A. Serotonin phase-shifts the mouse suprachiasmatic circadian clock in vitro. Brain Res. 966 (2003) 110-115
57. Prosser R.A., Dean R.R., Edgar D.M., Heller H.C., and Miller J.D. Serotonin and the mammalian circadian system: I. In vitro phase shifts by serotonergic agonists and antagonists. J. Biol. Rhythms 8 (1993) 1-16
58. Ralph M.R., Foster R.G., Davis F.C., and Menaker M. Transplanted suprachiasmatic nucleus determines circadian period. Science 247 (1990) 975-978
59. Rea M.A., Glass J.D., and Colwell C.S. Serotonin modulates photic responses in the hamster suprachiasmatic nuclei. J. Neurosci. 14 (1994) 3635-3642
60. 1A antagonist WAY-100635 selectively potentiates the presynaptic effects of serotonergic antidepressants in rat brain. Neurosci. Lett. 219 (1996) 123-126
61. Rueter, L.E., Wicke, K., Basso, A.M., Jomgen-Relo, A.L., Van Gaalen, M.M., Gross, G., Decker, M.W., Kling, A., Schoemaker, H., Sullivan, J.P., Amberg, W. and Garcia-Ladona, F.X. (2006) Characterization of 5-HT5A antagonists in models of depression and anxiety. Program No 33.3 2006 Neuroscience Meeting Planner, Society for Neuroscience CD-ROM.
62. Savelieva K.V., Zhao S., Pogorelov V.M., Rajan I., Yang Q., Cullinan E., and Lanthorn T.H. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behaviour in models sensitive to antidepressants. PloS ONE 3 (2008) e3301
63. Sharp T., Boothman L., Raley J., and Queree P. Important messages in the 'post': recent discoveries in 5-HT neurone feedback control. Trends Pharm. Sci. 28 (2007) 629-636
64. 1A receptor agonist, on the circadian rhythm of firing rate in the rat suprachiasmatic nuclei in vitro. Brain Res. 582 (1992) 353-356
65. Smale L., Michels K.M., Moore R.Y., and Morin L.P. Destruction of the hamster serotonergic system by 5, 7-DHT: effects on circadian rhythm phase, entrainment and response to triazolam. Brain Res. 515 (1990) 9-19
66. Smart C.M., and Biello S.M. WAY-100635, a specific 5-HT1A antagonist, can increase the responsiveness of the mammalian circadian pacemaker to photic stimuli. Neurosci. Lett. 305 (2001) 33-36
67. 1A receptor knockout mice. Neuroscience 157 (2008) 513-523
68. 7 receptor knockout mice: 5-HT and 8-OH-DPAT-induced phase advances of SCN neuronal firing. J. Biol. Rhythms. 20 (2005) 122-131
69. 5A receptors?. Synapse 54 (2004) 111-118
70. 1A mixed agonist/antagonist NAN-190: intra-suprachiasmatic nucleus pathway. Neuroscience 153 (2008) 571-580
71. Tischler R.C., and Morin L.P. Reciprocal serotonergic connections between the hamster median and dorsal raphe nuclei. Brain Res. 981 (2003) 126-132
72. 5A receptor in guinea pig brain. Neuropharmacology 51 (2006) 566-577
73. Tominaga K., Shibata S., Ueki S., and Watanabe S. Effects of 5-HT1A receptor agonists on the circadian rhythm of wheel-running activity in hamsters. Eur. J. Pharmacol. 214 (1992) 79-84
74. 2C receptors acutely induces Per gene expression in the rat suprachiasmatic nucleus at night. Mol. Brain Res. 119 (2003) 192-200
75. Weber E.T., Gannon R.L., and Rea M.A. Local administration of serotonin agonists blocks light-induced phase advances of the circadian activity rhythm in the hamster. J. Biol. Rhythms 13 (1998) 209-218
76. Wirz-Justice A. Biological rhythm disturbances in mood disorders. Int. Clin. Psychopharmacol. 21 suppl1 (2006) S11-S15