A CASCADE of effects of bisphenol A

Reproductive Toxicology

Volumn 28, Issue 4, 2009, Pages 563-567

  Bondesson, Maria ^a   Jönsson, Jill ^a   Pongratz, Ingemar ^a   Olea, Nicholas ^b   Cravedi, Jean Pierre ^c   Zalko, Daniel ^c   Håkansson, Helen ^a   Halldin, Krister ^a   Di Lorenzo, Diego ^d   Behl, Christian ^e   Manthey, Dieter ^e   Balaguer, Patrick ^f   Demeneix, Barbara ^g   Fini, Jean Baptiste ^g   Laudet, Vincent ^h   Gustafsson, Jan Åke ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UNIVERSITY OF GRANADA   (Spain)

^c CEMAGREF   (France)

^d Brescia Civic Hospital   (Italy)

^e JOHANNES GUTENBERG UNIVERSITY   (Germany)

^f UNIV MONTPELLIER   (France)

^g MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^h UNIVERSITÉ DE LYON   (France)

Author keywords

Bisphenol A; Development; Endocrine disruption; Hormone receptors; Low dose effects; Risk assessment

Indexed keywords

4,4' ISOPROPYLIDENEDIPHENOL; ANDROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; PREGNANE X RECEPTOR; THYROID HORMONE;

CARDIOVASCULAR DISEASE; DEVELOPMENTAL DISORDER; DIABETES MELLITUS; EMBRYOTOXICITY; ENVIRONMENTAL EXPOSURE; FETOTOXICITY; FOOD CONTAMINATION; FOOD SAFETY; HEALTH HAZARD; HUMAN; LETTER; LIVER HYPERTROPHY; NONHUMAN; OCCUPATIONAL EXPOSURE; RISK ASSESSMENT; SIGNAL TRANSDUCTION; WEIGHT REDUCTION;

ANIMALS; CANADA; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCRINE DISRUPTORS; EUROPE; EUROPEAN UNION; FEMALE; FETUS; FOOD CONTAMINATION; GOVERNMENT REGULATION; HALOGENATION; HUMANS; INFANT, NEWBORN; PHENOLS; PREGNANCY; RATS; RISK ASSESSMENT; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION;

EID: 70350423246     PISSN: 08906238     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.reprotox.2009.06.014     Document Type: Letter

References (62)

1. vom Saal F.S., Akingbemi B.T., Belcher S.M., Birnbaum L.S., Crain D.A., Eriksen M., et al. Chapel Hill bisphenol A expert panel consensus statement: integration of mechanisms, effects in animals and potential to impact human health at current levels of exposure. Reprod Toxicol 24 2 (2007) 131-138
2. Health Canada. Significant New Activity Notice No. 15290 (Section 85 of the Canadian Environmental Protection Act, 1999) Publication of final decision on the screening assessment of a substance - Phenol, 4,4′-(1-methylethylidene)bis-(bisphenol A), CAS No. 80-05-7 - specified on the Domestic Substances List [subsection 77(6) of the Canadian Environmental Protection Act, 1999]; 2008;142(42). Available on-line at: www.canadagazette.gc.ca/partI/2008/20081018/html/notice-e.html#d101.
3. National Toxicology Program - Center for the Evaluation of Risks to Human Reproduction (NTP-CERHR). NTP-CERHR Monograph on the Potential Human Reproductive and Developmental Effects of Bisphenol A; 2008. NIH Publication no: 80-5994. Available on-line at: www.cerhr.niehs.nih.gov/chemicals/bisphenol/bisphenol.pdf.
4. U.S. Food and Drug Administration (FDA). Draft assessment of Bisphenol A for use in food contact applications. Draft version August 14, 2008. Available online at: www.fda.gov/ohrms/dockets/ac/08/briefing/2008-0038b1_01_02_FDA%20BPA%20D raft%20Assessment.pdf.
5. European Chemicals Bureau (ECB) European Union Risk Assessment Report 4,4′-isopropylidenediphenol (bisphenol-A); 2003. CAS No: 80-05-7 EINECS No: 201-245-8. Available online at: www.ecb.jrc.it/Documents/Existing-Chemicals/RISK_ASSESSMENT/REPORT/bisph enolareport325.pdf.
6. Consumer Products Safety & Quality (CPS&Q) (former European Chemicals Bureau (ECB)). Updated European Risk Assessment Report 4,4′-isopropylidenediphenol (Bisphenol-A); 2008. CAS No: 80-05-7 EINECS No: 201-245-8. Available online at: www.ecb.jrc.it/documents/Existing-Chemicals/RISK_ASSESSMENT/ADDENDUM/bis phenola_add_325.pdf.
7. European Food Safety Authority (EFSA). Opinion of the scientific panel on food additives, flavourings, processing aids and materials in contact with food on a request from the commission related to 2,2-bis(4-hydroxyphenyl)propane (bisphenol A); 2006. Question No: EFSA-Q-2005-100. EFSA J 428:1-75. Available online at: www.efsa.europa.eu/cs/BlobServer/Scientific_Opinion/afc_op_ej428_bpa_op_ en,3.pdf?ssbinary=true.
8. European Food Safety Authority (EFSA). Toxicokinetics of bisphenol A - scientific opinion of the panel on food additives, flavourings, processing aids and materials in contact with food (AFC); 2008. Question No: EFSA-Q-2008-382. EFSA J 759:1-10. Available online at: www.efsa.europa.eu/cs/BlobServer/Scientific_Opinion/afc_ej759_bpa_%20tox icokinetics_op_en.pdf?ssbinary=true.
9. Vandenberg L.N., Hauser R., Marcus M., Olea N., and Welshons W.V. Human exposure to bisphenol A (BPA). Reprod Toxicol 24 2 (2007) 139-177
10. Dekant W., and Völkel W. Human exposure to bisphenol A by biomonitoring: methods, results and assessment of environmental exposures. Toxicol Appl Pharmacol 228 1 (2008) 114-134
11. Fernandez M.F., Arrebola J.P., Taoufiki J., Navalón A., Ballesteros O., Pulgar R., et al. Bisphenol-A and chlorinated derivatives in adipose tissue of women. Reprod Toxicol 24 (2007) 259-264
12. Tyl R.W., Myers C.B., Marr M.C., Thomas B.F., Keimowitz A.R., Brine D.R., et al. Three-generation reproductive toxicity study of dietary bisphenol A in CD Sprague-Dawley rats. Toxicol Sci 68 1 (2002) 121-146
13. Tyl R.W., Myers C.B., Marr M.C., Sloan C.S., Castillo N.P., Veselica M.M., et al. Two-generation reproductive toxicity study of dietary bisphenol A (BPA) in CD-1 (Swiss) mice. Toxicol Sci 104 2 (2008) 362-384
14. Sekizawa J. Low-dose effect of bisphenol A: a serious threat to human health?. J Toxicol Sci 33 4 (2008) 389-403
15. Crain D.A., Eriksen M., Iguchi T., Jobling S., Laufer H., LeBlanc G.A., et al. An ecological assessment of bisphenol-A: evidence from comparative biology. Reprod Toxicol 24 2 (2007) 225-239
16. Keri R.A., Ho S.M., Hunt P.A., Knudsen K.E., Soto A.M., and Prins G.S. An evaluation of evidence for the carcinogenic activity of bisphenol A. Reprod Toxicol 24 2 (2007) 240-252
17. Richter C.A., Birnbaum L.S., Farabollini F., Newbold R.R., Rubin B.S., Talsness C.E., et al. In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol 24 (2007) 199-224
18. Wetherill Y.B., Akingbemi B.T., Kanno J., McLachlan J.A., Nadal A., Sonnenschein C., et al. In vitro molecular mechanisms of bisphenol A action. Reprod Toxicol 24 2 (2007) 178-198
19. Domoradzki J.Y., Thornton C.M., Pottenger L.H., Hansen S.C., Card T.L., Markham D.A., et al. Age and dose dependency of pharmacokinetics and metabolism of bisphenol A in neonatal Sprague-Dawley rats following oral administration. Toxicol Sci 77 (2004) 230-242
20. FDA Science Board Subcommittee on Bisphenol A (FDA-SBS). Scientific peer-review of the draft assessment of bisphenol A for use in food contact applications. Draft October 31, 2008. Available online at: www.fda.gov/ohrms/dockets/ac/08/briefing/2008-4386b1-05.pdf.
21. Myers J.P., vom Saal F., Akingbem B.T., Arizono K., Belcher S., Colborn T., et al. Why public health agencies cannot depend upon 'good laboratory practices' as a criterion for selecting data: the case of bisphenol-A. Environ Health Perspect 117 3 (2009) 309-315
22. Leranth C., Hajszan T., Szigeti-Buck K., Bober J., and MacLusky N.J. Bisphenol A prevents the synaptogenic response to estradiol in hippocampus and prefrontal cortex of ovariectomized nonhuman primates. Proc Natl Acad Sci USA 105 37 (2008) 14187-14191
23. Lang I.A., Galloway T.S., Scarlett A., Henley W.E., Depledge M., Wallace R.B., et al. Association of urinary bisphenol A concentration with medical disorders and laboratory abnormalities in adults. JAMA 300 11 (2008) 1303-1310
24. Paris F., Balaguer P., Térouanne B., Servant N., Lacoste C., Cravedi J.P., et al. Phenylphenols, biphenols, bisphenol-A and 4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines. Mol Cell Endocrinol 193 1-2 (2002) 43-49
25. Mnif W., Pascussi J.M., Pillon A., Escande A., Bartegi A., Nicolas J.C., et al. Estrogens and antiestrogens activate hPXR. Toxicol Lett 170 1 (2007) 19-29
26. Okada H., Tokunaga T., Liu X., Takayanagi S., Matsushima A., and Shimohigashi Y. Direct evidence revealing structural elements essential for the high binding ability of bisphenol A to human estrogen-related receptor-gamma. Environ Health Perspect 116 1 (2008) 32-38
27. Abad M.C., Askari H., O'Neill J., Klinger A.L., Milligan C., Lewandowski F., et al. Structural determination of estrogen-related receptor gamma in the presence of phenol derivative compounds. J Steroid Biochem Mol Biol 108 1-2 (2008) 44-54
28. Matsushima A., Kakuta Y., Teramoto T., Koshiba T., Liu X., Okada H., et al. Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. J Biochem 142 4 (2007) 517-524
29. Moriyama K., Tagami T., Akamizu T., Usui T., Saijo M., Kanamoto N., et al. Thyroid hormone action is disrupted by bisphenol A as an antagonist. J Clin Endocrinol Metab 87 (2002) 5185-5190
30. Baba K., Okada K., Kinoshita T., and Imaoka S. Bisphenol A disrupts Notch signaling by inhibiting gamma-secretase activity and causes eye dysplasia of Xenopus laevis. Toxicol Sci 108 2 (2009) 344-355
31. Fini J.B., Dolo L., Cravedi J.P., Demeneix B., and Zalko D. Metabolism of the endocrine disruptor BPA by Xenopus laevis tadpoles. Trends Comp Endocrinol Neurobiol: Ann NY Acad Sci 1163 (2009) 394-397
32. Fini J.B., Le Mevel S., Turque N., Palmier K., Zalko D., Cravedi J.P., et al. An in vivo multiwell-based fluorescent screen for monitoring vertebrate thyroid hormone disruption. Environ Sci Technol 41 16 (2007) 5908-5914
33. Heimeier RA, Das B, Buchholz DR, Shi YB. The xenoestrogen bisphenol A inhibits postembryonic vertebrate development by antagonizing gene regulation by thyroid hormone. Endocrinology 2009; doi:10.1210/en.2008-1503.
34. Tsutsui T., Tamura Y., Yagi E., Hasegawa K., Takahashi M., Naizumi N., et al. Bisphenol-A induces cellular transformation, aneuploidy and DNA adduct formation in cultured Syrian Hamster embryo cells. Int J Cancer 75 (1998) 290-294
35. Nakagomi M., Suzuki E., Usimi K., Saitoh Y., Yoshimura S., Nagao T., et al. Bisphenol-A induces cell cycle delay and alters centrosome and spindle microtubular organisation in oocytes during meiosis. Terarog Carcinog Mutagen 21 (2001) 453-462
36. Suiarja M., Hassold T.J., Freeman E., and Hunt P.A. Bisphenol A exposure causes meiotic aneuploidy in female mouse. PLoS Genet 3 (2007) e5
37. Hunt P.A., Koehler K.E., Susiarjo M., Hodges C.A., Ilagan A., Voigt R.C., et al. Bisphenol A exposure in utero disrupts early oogenesis in the mouse. Curr Biol 13 (2003) 546-553
38. George O., Bryant B.K., Chinnasamy R., Corona C., Arterburn J.B., and Shuster C.B. Bisphenol A directly targets tubulin to disrupt spindle organization in embryonic and somatic cells. ACS Chem Biol 3 3 (2008) 167-179
39. Eichenlaub-Ritter U., Vogt E., Cukurcam S., Sun F., Pacchierotti F., and Parry J. Exposure of mouse oocytes to bisphenol A causes meiotic arrest but not aneuploidy. Mutat Res 651 1-2 (2008) 82-92
40. Pacchierotti F., Ranaldi R., Eichenlaub-Ritter U., Attia S., and Adler I.D. Evaluation of aneugenic effects of bisphenol A in somatic and germ cells of the mouse. Mutat Res 651 1-2 (2008) 64-70
41. Maul H., Longo M., Saade G.R., and Garfield R.E. Nitric oxide and its role during pregnancy: from ovulation to delivery. Curr Pharm Des 9 5 (2003) 359-380
42. Pallares P., Garcia-Fernandez R.A., Criado L.M., Letelier C.A., Esteban D., Fernandez-Toro J.M., et al. Disruption of the endothelial nitric oxide synthase gene affects ovulation, fertilization and early embryo survival in a knockout mouse model. Reproduction 136 5 (2008) 573-579
43. Zhang J. The mouse oocyte as a model in reproductive toxicology studies (2007), Karolinska University Press. 978-91-7357-163-0
44. Patisaul H.B., and Polston E.K. Influence of endocrine active compounds on the developing rodent brain. Brain Res. Rev 57 2 (2008) 352-362
45. Le H.H., Carlson E.M., Chua J.P., and Belcher S.M. Bisphenol A is released from polycarbonate drinking bottles and mimics the neurotoxic actions of estrogen in developing cerebellar neurons. Toxicol Lett 176 2 (2008) 149-156
46. Ogiue-Ikeda M., Tanabe N., Mukai H., Hojo Y., Murakami G., Tsurugizawa T., et al. Rapid modulation of synaptic plasticity by estrogens as well as endocrine disrupters in hippocampal neurons. Brain Res Rev 57 2 (2008) 363-375
47. Lee Y.M., Seong M.J., Lee J.W., Lee Y.K., Kim T.M., Nam S.Y., et al. Estrogen receptor independent neurotoxic mechanism of bisphenol A, an environmental estrogen. J Vet Sci 8 1 (2007) 27-38
48. Xu X., Liu Y., Sadamatsu M., Tsutsumi S., Akaike M., Ushijima H., et al. Perinatal bisphenol A affects the behavior and SRC-1 expression of male pups but does not influence on the thyroid hormone receptors and its responsive gene. Neurosci Res 58 2 (2007) 149-155
49. Monje L., Varayoud J., Luque E.H., and Ramos J.G. Neonatal exposure to bisphenol A modifies the abundance of estrogen receptor alpha transcripts with alternative 5′-untranslated regions in the female rat preoptic area. J Endocrinol 194 1 (2007) 201-212
50. Ceccarelli I., Della Seta D., Fiorenzani P., Farabollini F., and Aloisi A.M. Estrogenic chemicals at puberty change ERalpha in the hypothalamus of male and female rats. Neurotoxicol Teratol 29 1 (2007) 108-115
51. Nakamura K., Itoh K., Yaoi T., Fujiwara Y., Sugimoto T., and Fushiki S. Murine neocortical histogenesis is perturbed by prenatal exposure to low-doses of bisphenol A. J Neurosci Res 85 (2006) 1197-1205
52. Yaoi T., Itoh K., Nakamura K., Ogi H., Fujiwara Y., and Fushiki S. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun 376 3 (2008) 563-567
53. Prins G.S., Tang W.Y., Belmonte J., and Ho S.M. Perinatal exposure to oestradiol and bisphenol A alters the prostate epigenome and increases susceptibility to carcinogenesis. Basic Clin Pharmacol Toxicol 102 2 (2008) 134-138
54. Masuno H., Iwanami J., Kidani T., Sakayama K., and Honda K. Bisphenol a accelerates terminal differentiation of 3T3-L1 cells into adipocytes through the phosphatidylinositol 3-kinase pathway. Toxicol Sci 84 2 (2005) 319-327
55. Di Lorenzo D., Rando G., Ciana P., and Maggi A. Molecular imaging, an innovative methodology for whole-body profiling of endocrine disrupter action. Toxicol Sci 106 2 (2008) 304-311
56. Alonso-Magdalena P., Ropero A.B., Carrera M.P., Cederroth C.R., Baquié M., Gauthier B.R., et al. Pancreatic insulin content regulation by the estrogen receptor ER alpha. PLoS ONE 3 4 (2008) e2069
57. Ropero A.B., Alonso-Magdalena P., García-García E., Ripoll C., Fuentes E., and Nadal A. Bisphenol-A disruption of the endocrine pancreas and blood glucose homeostasis. Int J Androl 2 (2008) 194-200
58. Jaeg J.P., Perdu E., Dolo L., Debrauwer L., Cravedi J.P., and Zalko D. Characterization of new bisphenol A metabolites produced by CD1 mice liver microsomes and S9 fractions. J Agric Food Chem 52 (2004) 4935-4942
59. Zalko D., Soto A.M., Dolo L., Dorio C., Rathahao E., Debrauwer L., et al. Biotransformations of bisphenol A in a mammalian model: answers and new questions raised by low-dose metabolic fate studies in pregnant CD1 mice. Environ Health Perspect 111 (2003) 309-319
60. Zalko D., Prouillac C., Riu A., Perdu E., Dolo L., Jouanin I., et al. Biotransformation of the flame retardant tetrabromo-bisphenol A by human and rat sub-cellular liver fractions. Chemosphere 64 2 (2006) 318-327
61. Zalko D., Antignac J.P., Riu A., Cariou R., Berrebi A., Perdu E., et al. Major results from French research programs on brominated flame retardants. Organohalogen Compd 69 (2007) 674-677
62. Arbeli Z., Ronen Z., and Díaz-Báez M.C. Reductive dehalogenation of tetrabromobisphenol-A by sediment from a contaminated ephemeral streambed and an enrichment culture. Chemosphere 64 9 (2006) 1472-1478