Oxygen sensing in the carotid body

Annals of the New York Academy of Sciences

Volumn 1177, Issue , 2009, Pages 119-131

  López Barneo, José ^a   Ortega Sáenz, Patricia ^a   Pardal, Ricardo ^a   Pascual, Alberto ^a   Piruat, José I ^a   Durán, Rocío ^a   Gómez Díaz, Raquel ^a  

^a HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

Author keywords

Acute hypoxia; Carotid body (CB); Chronic hypoxia; Ion channels; Oxygen sensing; Stem cells

Indexed keywords

HEME OXYGENASE 2; HYPOXIA INDUCIBLE FACTOR 1ALPHA; POTASSIUM CHANNEL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE (UBIQUINONE);

CAROTID BODY; CELL COUNT; CELL DIFFERENTIATION; CHEMOSENSITIZATION; CONFERENCE PAPER; ENZYME DEFICIENCY; HYPOXIA; NEURAL CREST CELL; NONHUMAN; OXYGEN SENSING; OXYGEN TENSION; STEM CELL;

GLOMUS; MUS;

EID: 70350418247     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2009.05033.x     Document Type: Conference Paper

References (73)

1. López-Barneo, J., R. Pardal&P.Ortega-Sáenz. 2001. Cellular mechanism of oxygen sensing. Annu. Rev. Physiol. 63: 259-287.
2. Kameda, Y. 2005. Mash1 is required for glomus cell formation in the mouse carotid body. Dev. Biol. 283: 128-139.
3. Le Douarin, N.M. 1986. Cell line segregation during peripheral nervous system ontogeny. Science 231: 1515-1522.
4. Pardal,R. et al. 2007. Glia-like stem cells sustain physiologic neurogenesis in the adult mammalian carotid body. Cell 131: 364-377.
5. Chai, Y. et al. 2000. Fate of the mammalian cranial neural crest during tooth and mandibular morphogenesis. Development 127: 1671-1679.
6. Jiang, X. et al. 2000. Fate of the mammalian cardiac neural crest. Development 127: 1607-1616.
7. Peers, C. & K.J. Buckler. 1995. Transduction of chemostimuli by the type I carotid body cell. J.Membr. Biol. 144: 1-9.
8. Garcia-Fernandez, M. et al. 2007. Mechanisms of low-glucose sensitivity in carotid body glomus cells. Diabetes 56: 2893-2900.
9. Pardal, R. & J. López-Barneo. 2002. Low glucosesensing cells in the carotid body. Nat. Neurosci. 5: 197-198. (Pubitemid 34171130)
10. Zhang, M., J. Buttigieg & C.A. Nurse. 2007. Neurotransmitter mechanisms mediating low-glucose signalling in cocultures and fresh tissue slices of rat carotid body. J. Physiol. 578: 735-750.
11. Duchen, M.R. et al. 1988. Biophysical studies of the cellular elements of the rabbit carotid body. Neuroscience 26: 291-311.
12. 2 in type I chemoreceptor cells. Science 241: 580-582.
13. Nurse, C. 2005. Neurotransmission and neuromodulation in the chemosensory carotid body. Auton. Neurosci. 120: 1-9.
14. 2+ entry and quantal dopamine secretion in carotid body glomus cells. Proc. Natl. Acad. Sci. USA 91: 10208-10211.
15. Montoro, R.J. et al. 1996. Oxygen sensing by ion channels and chemotransduction in single glomus cells. J. Gen. Physiol. 107: 133-143.
16. 2+ currents by dopamine in glomus cells of the carotid body. Eur. J. Neuroci. 2: 809-812.
17. Zhang, M. et al. 2000. Co-release of ATP and ACh mediates hypoxic signalling at rat carotid body chemoreceptors. J. Physiol. 525: 143-158.
18. Arias-Stella, J. & J. Valcarcel. 1976. Chief cell hyperplasia in the human carotid body at high altitudes; physiologic and pathologic significance. Hum. Pathol. 7: 361-373.
19. McGregor, K.H., J. Gil & S. Lahiri. 1984. A morphometric study of the carotid body in chronically hypoxic rats. J. Appl. Physiol. 57: 1430-1438. (Pubitemid 15216436)
20. Wang, Z.Y. & G.E. Bisgard. 2002. Chronic hypoxiainduced morphological and neurochemical changes in the carotid body. Microsc. Res. Tech. 59: 168-177.
21. Edwards, C.,D.Heath & P.Harris.1971. The carotid body in emphysema and left ventricular hypertrophy. J. Pathol. 104: 1-13.
22. Heath, D., P. Smith & R. Jago. 1982. Hyperplasia of the carotid body. J. Pathol. 138: 115-127.
23. Ureña, J. et al. 1989. Ionic currents in dispersed chemoreceptor cells of the mammalian carotid body. J. Gen. Physiol. 93: 979-999.
24. Peers, C. & P. Kemp. 2001. Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors. Respir. Res. 2: 145-149.
25. Lahiri, S. et al. 2006. Oxygen sensing in the body. Prog. Biophys. Mol. Biol. 91: 249-286.
26. Lopez-Barneo, J. et al. 2008. Carotid body oxygen sensing. Eur. Respir. J. 32: 1386-1398.
27. Guz,A. 1975.Regulation of respiration in man. Annu. Rev. Physiol. 37: 303-323.
28. Hescheler, J. et al. 1989. Ionic currents on type-I cells of the rabbit carotid bodymeasured by voltage-clamp experiments and the effect of hypoxia. Brain Res. 486: 79-88.
29. 2+-activated K+ current. Neurosci. Lett. 119: 253-256. (Pubitemid 20379269)
30. 2-sensitive rat carotid body cells grown in short- and long-term culture. Pflügers Arch. 418: 93-101.
31. 2 tension. Proc. Natl. Acad. Sci. USA 88: 2927-2930.
32. Ganfornina, M.D. & J. López-Barneo. 1992. Potassium channel types in arterial chemoreceptor cells and their selectivemodulation by oxygen. J. Gen. Physiol. 100: 401-426.
33. 2 J. Gen. Physiol. 100: 427-455.
34. 2+-activated K+ channels in isolated type I cells of the neonatal rat carotid body. J. Physiol. 483: 559-565.
35. López-López, J.R., C. Gonzalez & M.T. Perez- Garcia. 1997. Properties of ionic currents from isolated adult rat carotid body chemoreceptor cells: effect of hypoxia. J. Physiol. 499: 429-441.
36. Buckler, K.J. 1997. A novel oxygen-sensitive potassium current in rat carotid body type I cells. J. Physiol. 498: 649-662.
37. Pérez-García, M.T. et al. 2004. Characterization of the Kv channels of mouse carotid body chemoreceptor cells and their role in oxygen sensing. J. Physiol. 557: 457-471.
38. 2+ increase via suppression of K+ channels in cultured rat adrenal chromaffin cells. J. Neurochem. 69: 377-387.
39. Thompson, R.J., A. Jackson & C.A. Nurse. 1997. Developmental loss of hypoxic chemosensitivity in rat adrenomedullary chromaffin cells. J. Physiol. 498: 503-510.
40. Youngson, C. et al. 1993. Oxygen sensing in airway chemoreceptors. Nature 365: 153-155.
41. 2- sensitiveK+ current.Am. J. Physiol. 271: C658-C665.
42. Post, J.M. et al. 1992. Direct role for potassium channel inhibition in hypoxic pulmonary vasoconstriction. Am. J. Physiol. 262: C882-C890.
43. Yuan, X.J. et al. 1993. Hypoxia reduces potassium currents in cultured rat pulmonary but not mesenteric arterial myocytes. Am. J. Physiol. 264: L116-L123.
44. López-Barneo, J., A.R. Benot & J. Ureña. 1993. Oxygen-sensing and the electrophysiology of arterial chemoreceptor cells. News Physiol. Sci. 8: 191-195.
45. Buckler, K.J. & R.D. Vaughan-Jones. 1994. Effects of hypoxia on membrane potential and intracellular calcium in rat neonatal carotid body type I cells. J. Physiol. 476: 423-428.
46. Pardal, R. et al. 2000. Secretory responses of intact glomus cells in thin slices of rat carotid body to hypoxia and tetraethylammonium. Proc. Natl. Acad. Sci. USA 97: 2361-2366.
47. Ortega-Sáenz, P. et al. 2003. Rotenone selectively occludes sensitivity to hypoxia in rat carotid body glomus cells. J. Physiol. 548: 789-800.
48. Ortega-Sáenz, P. et al. 2006. Acute oxygen sensing in heme oxygenase-2 null mice. J. Gen. Physiol. 128: 405-411.
49. Semenza, G.L. 2004. Hydroxylation of HIF-1: oxygen sensing at themolecular level. Physiology 19: 176-182.
50. Schofield, C.J. & P.J. Ratcliffe. 2005. Signalling hypoxia byHIF hydroxylases. Biochem. Biophys. Res. Commun. Rev. 338: 617-626.
51. Kline, D.D. et al. 2002. Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxiainducible factor 1 alpha. Proc. Natl. Acad. Sci. USA 99: 821-826.
52. Peng, Y.J. et al. 2006. Heterozygous HIF-1 deficiency impairs carotid body-mediated cardio-respiratory responses and ROS generation in mice exposed to chronic intermittent hypoxia. J. Physiol. 577: 705-716.
53. Ortega-Sáenz, P. et al. 2007. Mechanisms of acute oxygen sensing by the carotid body: lessons from genetically modified animals. Respir. Physiol. Neurobiol. 157: 140-147.
54. Donnelly, D.F. 1996. Chemoreceptor nerve excitation may not be proportional to catecholamine secretion. J. Appl. Physiol. 81: 657-664.
55. 2-regulated prolyl hydroxylation. Science 292: 468-472.
56. Del Toro, R. et al. 2003. Induction of T-type calcium channel gene expression by chronic hypoxia. J. Biol. Chem. 278: 22316-22324.
57. Baysal, B.E. et al. 2000. Mutations in SDHD, a mitochondrial complex II gene in hereditary paraganglioma. Science 287: 848-851.
58. Astrom,K. et al. 2003. Altitude is a phenotypic modifier in hereditary paraganglioma type 1: evidence for an oxygen-sensing defect. Hum. Genet. 113: 228-237.
59. Baysal, B.E. 2003. On the association of succinate dehydrogenase mutations with hereditary paraganglioma. Trends Endocrinol. Metab. 14: 453-459.
60. Piruat, J.I. et al. 2004. Mitochondrial SDHDdeficient mice show persistent carotid body glomus cell activation with full responsiveness to hypoxia. Mol. Cell. Biol. 24: 10933-10940.
61. Shibahara, S. R. et al. 1985. Cloning and expression of cDNA for rat heme oxygenase. Proc. Natl. Acad. Sci. USA 82: 7865-7869.
62. Poss, K.D. et al. 1995. Hippocampal long-termpotentiation is normal in heme oxygenase-2 mutant mice. Neuron 15: 867-873.
63. Maines, M.D. 1997. The hemo oxygenase system: a regulator of second messenger gases. Annu. Rev. Pharmacol. Toxicol. 37: 517-554.
64. Doré, S. 2002. Decreased activity of the antioxidant heme oxygenase enzyme: implications in ischemia and in Alzheimer's disease. Free Radic. Biol. Med. 32: 1276-1282.
65. Williams, S.E. et al. 2004. Hemoxygenase-2 is an oxygen sensor for a calcium-sensitive potassium channel. Science 306: 2093-2097.
66. Wang, R. & L.Wu. 1997. The chemicalmodification of KCa channels by carbon monoxide in vascular smooth muscle cells. J. Biol. Chem. 272: 8222-8226. (Pubitemid 27147775)
67. Adachi, T. et al. 2004. Hypoxemia and blunted hypoxic ventilatory response in mice lacking hemeoxygenase-2. Biochem. Biophys. Res. Commun. 320: 514-522.
68. Arjona, V. et al. 2003. Autotransplantation of carotid body cell aggregates for treatment of Parkinson's disease. Neurosurgery 53: 321-330.
69. Minguez-Castellanos, A. et al. 2007. Carotid body autotransplantation in Parkinson disease: a clinical and PET study. J. Neurol. Neurosurg. Psychiat. 78: 825-831.
70. Paciga, M. et al. 1999. Role of ET-1 in hypoxiainduced mitosis of cultured rat carotid body chemoreceptors. Neuroreport 10: 3739-3744.
71. Toledo-Aral, J. et al. 2003. Throfic restoration of the nigrostriatal dopaminergic pathway in long-term carotid body grafted parkinsonian rats. J. Neurosci. 23: 141-148.
72. Villadiego, J. et al. 2005. Selective glial cell linederived neurotrophic factor production in adult dopaminergic carotid body cells in situ and after intrastriatal transplantation. J. Neurosci. 25: 4091-4098.
73. Pascual, A. et al. 2008. Absolute requirement of GDNF for adult catecholaminergic neuron survival. Nat. Neurosci. 11: 755-761.