High frequency of genomic deletions induced by Me-lex, a sequence selective N3-adenine methylating agent, at the Hprt locus in Chinese hamster ovary cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 671, Issue 1-2, 2009, Pages 58-66

  Russo, Debora ^a   Fronza, Gilberto ^a   Ottaggio, Laura ^a   Monti, Paola ^a   Inga, Alberto ^a   Iyer, Prema ^b   Gold, Barry ^b   Menichini, Paola ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Hamster cells; Hprt; Me lex; Mutation induction

Indexed keywords

[1 METHYL 4 [1 METHYL 4 (3 METHOXYSULFONYLPROPANAMIDO)PYRROLE 2 CARBOXAMIDO]PYRROLE 2 CARBOXAMIDO]PROPANE; CYTOTOXIC AGENT; DNA POLYMERASE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; AT RICH SEQUENCE; CHO CELL; CONTROLLED STUDY; CYTOTOXICITY; DNA ADDUCT; GENE DELETION; GENE LOCUS; GENE REARRANGEMENT; GENETIC RECOMBINATION; GENOMIC INSTABILITY; MUTAGENICITY; MUTATIONAL ANALYSIS; NONHUMAN; NUCLEIC ACID BASE SUBSTITUTION; PRIORITY JOURNAL; SEQUENCE ANALYSIS;

ADENINE; ANIMALS; BASE SEQUENCE; CHO CELLS; CRICETINAE; CRICETULUS; DNA METHYLATION; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTAGENS; SEQUENCE DELETION;

CRICETINAE; CRICETULUS GRISEUS;

EID: 70350345543     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2009.08.013     Document Type: Article

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