Expression of adipokines and estrogen receptors in adipose tissue and placenta of patients with gestational diabetes mellitus

Molecular and Cellular Endocrinology

Volumn 314, Issue 1, 2010, Pages 150-156

  Kleiblova, P ^a   Dostalova, I ^a   Bartlova, M ^a   Lacinova, Z ^a   Ticha, I ^a   Krejci, V ^a   Springer, D ^a   Kleibl, Z ^a   Haluzik, M ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Estrogen receptors; Gestational diabetes mellitus; Leptin; Placenta; Subcutaneous adipose tissue; Visceral adipose tissue

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ADIPONECTIN RECEPTOR 1; ADIPONECTIN RECEPTOR 2; CD68 ANTIGEN; CHEMOKINE; CYTOKINE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; INTERLEUKIN 6; INTERLEUKIN 8; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; RESISTIN; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ADULT; ARTICLE; CESAREAN SECTION; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; GENETIC ANALYSIS; HUMAN; INSULIN RESISTANCE; PATHOGENESIS; PLACENTA; PREGNANCY DIABETES MELLITUS; PREGNANT WOMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS FAT;

ADIPOKINES; ADIPOSE TISSUE; ADULT; ANTHROPOMETRY; DIABETES, GESTATIONAL; FEMALE; HUMANS; INFANT, NEWBORN; PLACENTA; PREGNANCY; RECEPTORS, ESTROGEN;

EID: 70350341501     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.08.002     Document Type: Article

References (63)

1. Alonso A., Del Rey C.G., Navarro A., Tolivia J., and González C.G. Effects of gestational diabetes mellitus on proteins implicated in insulin signaling in human placenta. Gynecol. Endocrinol. 22 (2006) 526-535
2. Barros R.P., Morani A., Moriscot A., and Machado U.F. Insulin resistance of pregnancy involves estrogen-induced repression of muscle GLUT4. Mol. Cell. Endocrinol. 295 (2008) 24-31
3. Bastard J.P., Maachi M., Van Nhieu J.T., Jardel C., Bruckert E., Grimaldi A., Robert J.J., Capeau J., and Hainque B. Adipose tissue IL-6 content correlates with resistance to insulin activation of glucose uptake both in vivo and in vitro. J. Clin. Endocrinol. Metab. 87 (2002) 2084-2089
4. Beischer N.A., Wein P., Sheedy M.T., and Dargaville R.M. Effect of follow-up of women with gestational diabetes on the ratio of IDDM to NIDDM in pregnancy. Diab. Care 19 (1996) 653-655
5. Boucher J., Castan-Laurell I., Daviaud D., Guigné C., Buléon M., Carpéné C., Saulnier-Blache J.S., and Valet P. Adipokine expression profile in adipocytes of different mouse models of obesity. Horm. Metab. Res. 37 (2005) 761-767
6. Brann D.W., De Sevilla L., Zamorano P.L., and Mahesh V.B. Regulation of leptin gene expression and secretion by steroid hormones. Steroids 64 (1999) 659-663
7. Catalano P.M., Nizielski S.E., Shao J., Preston L., Qiao L., and Friedman J.E. Downregulated IRS-1 and PPARgamma in obese women with gestational diabetes: relationship to FFA during pregnancy. Am. J. Physiol. Endocrinol. Metab. 282 (2002) E522-533
8. Coppack S.W. Pro-inflammatory cytokines and adipose tissue. Proc. Nutr. Soc. 60 (2001) 349-356
9. Coughlan M.T., Oliva K., Georgiou H.M., Permezel J.M., and Rice G.E. Glucose-induced release of tumour necrosis factor-alpha from human placental and adipose tissues in gestational diabetes mellitus. Diabet. Med. 18 (2001) 921-927
10. Cseh K., Baranyi E., Melczer Z., Csákány G.M., Speer G., Kovács M., Gerö G., Karádi I., and Winkler G. The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance: negative correlation with anthropometric parameters of neonates in gestational diabetes. Gynecol. Endocrinol. 16 (2002) 453-460
11. Deroo B.J., and Korach K.S. Estrogen receptors and human disease. J. Clin. Invest. 116 (2006) 561-570
12. Dolinková M., Dostálová I., Lacinová Z., Michalský D., Haluzíková D., Mráz M., Kasalický M., and Haluzík M. The endocrine profile of subcutaneous and visceral adipose tissue of obese patients. Mol. Cell. Endocrinol. 291 (2008) 63-70
13. Festa A., Shnawa N., Krugluger W., Hopmeier P., Schernthaner G., and Haffner S.M. Relative hypoleptinaemia in women with mild gestational diabetes mellitus. Diabet. Med. 16 (1999) 656-662
14. Foryst-Ludwig A., Clemenz M., Hohmann S., Hartge M., Sprang C., Frost N., Krikov M., Bhanot S., Barros R., Morani A., Gustafsson J.A., Unger T., and Kintscher U. Metabolic actions of estrogen receptor beta (ERbeta) are mediated by a negative cross-talk with PPARgamma. PLoS Genet. 4 (2008) e1000108
15. Friedman J.E., Ishizuka T., Shao J., Huston L., Highman T., and Catalano P. Impaired glucose transport and insulin receptor tyrosine phosphorylation in skeletal muscle from obese women with gestational diabetes. Diabetes 48 (1999) 1807-1814
16. Gabbe S.G. Gestational diabetes mellitus. N. Engl. J. Med. 315 (1986) 1025-1026
17. Gao X.L., Yang H.X., and Zhao Y. Variations of tumor necrosis factor-alpha, leptin and adiponectin in mid-trimester of gestational diabetes mellitus. Chin. Med. J. (Engl). 121 (2008) 701-705
18. Greenberg A.S., and McDaniel M.L. Identifying the links between obesity, insulin resistance and beta-cell function: potential role of adipocyte-derived cytokines in the pathogenesis of type 2 diabetes. Eur. J. Clin. Invest. 32 (2002) 24-34
19. Havel P.J. Control of energy homeostasis and insulin action by adipocyte hormones: leptin, acylation stimulating protein, and adiponectin. Curr. Opin. Lipidol. 13 (2002) 51-59
20. Heine P.A., Taylor J.A., Iwamoto G.A., Lubahn D.B., and Cooke P.S. Increased adipose tissue in male and female estrogen receptor-alpha knockout mice. Proc. Natl. Acad. Sci. USA 97 (2000) 12729-12734
21. Hennige A.M., Stefan N., Kapp K., Lehmann R., Weigert C., Beck A., Moeschel K., Mushack J., Schleicher E., and Häring H.U. Leptin down-regulates insulin action through phosphorylation of serine-318 in insulin receptor substrate 1. FASEB. J. 20 (2006) 1206-1208
22. Henson M.C., and Castracane V.D. Leptin: roles and regulation in primate pregnancy. Semin. Reprod. Med. 20 (2002) 113-122
23. Hernández Valencia M., and Zárate A. Recent concepts in gestational diabetes' etiopathogenesis. Ginecol. Obstet. Mex. 73 (2005) 371-377
24. Housa D., Housová J., Vernerová Z., and Haluzík M. Adipocytokines and cancer. Physiol. Res. 55 (2006) 233-244
25. Jansson P.A., Eliasson B., Lindmark S., and Eriksson J.W. Endocrine abnormalities in healthy first-degree relatives of type 2 diabetes patients--potential role of steroid hormones and leptin in the development of insulin resistance. Eur. J. Clin. Invest. 32 (2002) 172-178
26. Kautzky-Willer A., Pacini G., Tura A., Bieglmayer C., Schneider B., Ludvik B., Prager R., and Waldhäusl W. Increased plasma leptin in gestational diabetes. Diabetologia 44 (2001) 164-172
27. Kern P.A., Ranganathan S., Li C., Wood L., and Ranganathan G. Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. Am. J. Physiol. Endocrinol. Metab. 280 (2001) E745-E751
28. Kim C., Newton K.M., and Knopp R.H. Gestational diabetes and the incidence of type 2 diabetes: a systematic review. Diab. Care 25 (2002) 1862-1868
29. Kirwan J.P., Hauguel-De Mouzon S., Lepercq J., Challier J.C., Huston-Presley L., Friedman J.E., Kalhan S.C., and Catalano P.M. TNF-alpha is a predictor of insulin resistance in human pregnancy. Diabetes 51 (2002) 2207-2213
30. Kleiblová P., Springer D., and Haluzík M. The influence of hormonal changes during menstrual cycle on serum adiponectin concentrations in healthy women. Physiol. Res. 55 (2006) 661-666
31. Kuzmicki M., Telejko B., Zonenberg A., Szamatowicz J., Kretowski A., Nikolajuk A., Laudanski P., and Gorska M. Circulating pro- and anti-inflammatory cytokines in Polish women with gestational diabetes. Horm. Metab. Res. 40 (2008) 556-560
32. Lamounier-Zepter V., Bornstein S.R., Kunes J., Zicha J., Krsek M., Ehrhart-Bornstein M., Ziegler C.G., Kiessling A., Funk R.H., and Haluzik M. Adrenocortical changes and arterial hypertension in lipoatrophic A-ZIP/F-1 mice. Mol. Cell. Endocrinol. 280 (2008) 39-46
33. Lappas M., Yee K., Permezel M., and Rice G.E. Release and regulation of leptin, resistin and adiponectin from human placenta, fetal membranes, and maternal adipose tissue and skeletal muscle from normal and gestational diabetes mellitus-complicated pregnancies. J. Endocrinol. 186 (2005) 457-465
34. Lea R.G., Howe D., Hannah L.T., Bonneau O., Hunter L., and Hoggard N. Placental leptin in normal, diabetic and fetal growth-retarded pregnancies. Mol. Hum. Reprod. 6 (2000) 763-769
35. Lepercq J., Cauzac M., Lahlou N., Timsit J., Girard J., Auwerx J., and Hauguel-de Mouzon S. Overexpression of placental leptin in diabetic pregnancy: a critical role for insulin. Diabetes 47 (1998) 847-850
36. Lim S., Choi S.H., Park Y.J., Park K.S., Lee H.K., Jang H.C., Cho N.H., and Metzger B.E. Visceral fatness and insulin sensitivity in women with a previous history of gestational diabetes mellitus. Diab. Care 30 (2007) 348-353
37. Maghbooli Z., Hossein-Nezhad A., Rahmani M., Shafaei A.R., and Larijani B. Relationship between leptin concentration and insulin resistance. Horm. Metab. Res. 39 (2007) 903-907
38. Masuzaki H., Ogawa Y., Sagawa N., Hosoda K., Matsumoto T., Mise H., Nishimura H., Yoshimasa Y., Tanaka I., Mori T., and Nakao K. Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nat. Med. 3 (1997) 1029-1033
39. McNeely M.J., Boyko E.J., Weigle D.S., Shofer J.B., Chessler S.D., Leonnetti D.L., and Fujimoto W.Y. Association between baseline plasma leptin levels and subsequent development of diabetes in Japanese Americans. Diab. Care 22 (1999) 65-70
40. Meller M., Qiu C., Vadachkoria S., Abetew D.F., Luthy D.A., and Williams M.A. Changes in placental adipocytokine gene expression associated with gestational diabetes mellitus. Physiol. Res. 55 (2006) 501-512
41. Moller D.E. Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab. 11 (2000) 212-217
42. Naaz A., Zakroczymski M., Heine P., Taylor J., Saunders P., Lubahn D., and Cooke P.S. Effect of ovariectomy on adipose tissue of mice in the absence of estrogen receptor alpha (ERalpha): a potential role for estrogen receptor beta (ERbeta). Horm. Metab. Res. 34 (2002) 758-763
43. Nathanielsz P.W., Poston L., and Taylor P.D. In utero exposure to maternal obesity and diabetes: animal models that identify and characterize implications for future health. Clin. Perinatol. 34 (2007) 515-526
44. Pendegrass M., Fayioni E., and DeFronyo R. NIDDM and GDM: same disease, another name?. Diab. Rev. 3 (1995) 556-583
45. Pfaffl M.W., Horgan G.W., and Dempfle L. Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR. Nucl. Acids Res. 30 (2002) e36
46. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucl. Acids. Res. 29 (2001) e45
47. Pratley R.E., Ren K., Milner M.R., and Sell S.M. Insulin increases leptin mRNA expression in abdominal subcutaneous adipose tissue in humans. Mol. Genet. Metab. 70 (2000) 19-26
48. Qiu C., Williams M.A., Vadachkoria S., Frederick I.O., and Luthy D.A. Increased maternal plasma leptin in early pregnancy and risk of gestational diabetes mellitus. Obstet. Gynecol. 103 (2004) 519-525
49. Radaelli T., Varastehpour A., Catalano P., and Hauguel-de Mouzon S. Gestational diabetes induces placental genes for chronic stress and inflammatory pathways. Diabetes 52 (2003) 2951-2958
50. Ranheim T., Haugen F., Staff A.C., Braekke K., Harsem N.K., and Drevon C.A. Adiponectin is reduced in gestational diabetes mellitus in normal weight women. Acta. Obstet. Gynecol. Scand. 83 (2004) 341-347
51. Salvatores M., Gennarelli G., Menato G., and Massobrio M. Leptin as a possible marker of augmented metabolic risk during pregnancy. Minerva. Ginecol. 58 (2006) 1-10
52. Shahid A., Lone K.P., Saeed S., and Arslan M. Male offspring of both diabetic parents have higher insulin resistance and serum leptin levels compared to those with one diabetic parent. Hormones. (Athens) 7 (2008) 313-319
53. Shin J.H., Hur J.Y., Seo H.S., Jeong Y.A., Lee J.K., Oh M.J., Kim T., Saw H.S., and Kim S.H. The ratio of estrogen receptor alpha to estrogen receptor beta in adipose tissue is associated with leptin production and obesity. Steroids 72 (2007) 592-599
54. Simmons D., and Breier B.H. Fetal overnutrition in polynesian pregnancies and in gestational diabetes may lead to dysregulation of the adipoinsular axis in offspring. Diab. Care 25 (2002) 1539-1544
55. Sivan E., Whittaker P.G., Sinha D., Homko C.J., Lin M., Reece E.A., and Boden G. Leptin in human pregnancy: the relationship with gestational hormones. Am. J. Obstet. Gynecol. 179 (1998) 1128-1132
56. Steppan C.M., Bailey S.T., Bhat S., Brown E.J., Banerjee R.R., Wright C.M., Patel H.R., Ahima R.S., and Lazar M.A. The hormone resistin links obesity to diabetes. Nature 409 (2001) 307-312
57. Tanaka M., Nakaya S., Kumai T., Watanabe M., Tateishi T., Shimizu H., and Kobayashi S. Effects of estrogen on serum leptin levels and leptin mRNA expression in adipose tissue in rats. Horm. Res. 56 (2001) 98-104
58. Wagenknecht L.E., Langefeld C.D., Scherzinger A.L., Norris J.M., Haffner S.M., Saad M.F., and Bergman R.N. Insulin sensitivity, insulin secretion, and abdominal fat: the Insulin Resistance Atherosclerosis Study (IRAS) Family Study. Diabetes 52 (2003) 2490-2496
59. Wajchenberg B.L. Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr. Rev. 21 (2000) 697-738
60. Wauters M., Considine R., Löfgren A., Van Broeckhoven C., Van der Auwera J.C., De Leeuw I., and Van Gaal L. Associations of leptin with body fat distribution and metabolic parameters in non-insulin-dependent diabetic patients: no effect of apolipoprotein E polymorphism. Metabolism 49 (2000) 724-730
61. Weyer C., Funahashi T., Tanaka S., Hotta K., Matsuzawa Y., Pratley R.E., and Tataranni P.A. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J. Clin. Endocrinol. Metab. 86 (2001) 1930-1935
62. Yi K.W., Shin J.H., Seo H.S., Lee J.K., Oh M.J., Kim T., Saw H.S., Kim S.H., and Hur J.Y. Role of estrogen receptor-alpha and -beta in regulating leptin expression in 3T3-L1 adipocytes. Obesity (Silver Spring) 16 (2008) 2393-2399
63. Yura S., Sagawa N., Itoh H., Kakui K., Nuamah M.A., Korita D., Takemura M., and Fujii S. Resistin is expressed in the human placenta. J. Clin. Endocrinol. Metab. 88 (2003) 1394-1397