The TC10-exo70 complex is essential for membrane expansion and axonal specification in developing neurons

Journal of Neuroscience

Volumn 29, Issue 42, 2009, Pages 13292-13301

  Dupraz, Sebastián ^a   Grassi, Diego ^a   Bernis, María Eugenia ^a   Sosa, Lucas ^a,c   Bisbal, Mariano ^b   Gastaldi, Laura ^b   Jausoro, Ignacio ^b   Cáceres, Alfredo ^b   Pfenninger, Karl H ^c   Quiroga, Santiago ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b INSTITUTO DE INVESTIGACIÓN MÉDICA MERCEDES Y MARTÍN FERREYRA   (Argentina)

^c Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EXOCYST 70; HYBRID PROTEIN; INSULIN GROWTH FACTOR 1; PROTEIN TC10; SOMATOMEDIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BIOGENESIS; CELL DIFFERENTIATION; CELL MEMBRANE; CELL POLARITY; COMPLEX FORMATION; CONTROLLED STUDY; HIPPOCAMPUS; NERVE FIBER GROWTH; NERVE FIBER MEMBRANE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PYRAMIDAL NERVE CELL; RAT;

ANIMALS; AXONS; CELLS, CULTURED; CELLULAR STRUCTURES; CHROMONES; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; ENZYME INHIBITORS; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; INSULIN-LIKE GROWTH FACTOR I; MORPHOLINES; PROTEIN TRANSPORT; PYRAMIDAL CELLS; RATS; RECEPTOR, IGF TYPE 1; RHO GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; TIME FACTORS; TRANSFECTION; VESICULAR TRANSPORT PROTEINS;

EID: 70350324643     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3907-09.2009     Document Type: Article

References (37)

1. Arimura N, Kaibuchi K (2007) Neuronal polarity: from extracellular signals to intracellular mechanisms. Nat Rev Neurosci 3:194-205. (Pubitemid 46294662)
2. Bisbal M, Conde C, Donoso M, Bollati F, Sesma J, Quiroga S, Díaz Añel A, Malhotra V, Marzolo MP, Cáceres A (2008) Protein kinase D regulates trafficking of dendritic membrane proteins in developing neurons. J Neurosci 28:9297-9308.
3. Chiang SH, Baumann CA, Kanzaki M, Thurmond DC, Watson RT, Neudauer CL, Macara IG, Pessin JE, Saltiel AR (2001) Insulin-stimulated GLUT4 translocation requires the CAP-dependent activation of TC10. Nature 410:944-948. (Pubitemid 32335841)
4. Craig AM, Banker G (1994) Neuronal polarity. Annu Rev Neurosci 17:267-310.
5. Craig AM, Wyborski RJ, Banker GA (1995) Preferential addition of newly synthetized membrane protein at axonal growth cones. Nature 375:592-594.
6. Dequidt C, Danglot L, Alberts P, Galli T, Choquet D, Thoumine O (2007) Fast turnover of L1 adhesions in neuronal growth cones involving both surface diffusion and exo/endocytosis of L1 molecules. Mol Biol Cell 8:3131-3143. (Pubitemid 47235317)
7. Finger FP, Hughes TE, Novick P (1998) Sec3p is a spatial landmark for polarized secretion in budding yeast. Cell 92:559-571.
8. Futerman AH, Banker GA (1996) The economics of neurite outgrowth - the addition of new membrane to growing axons. Trends Neurosci 19:144-149.
9. Grindstaff KK, Yeaman C, Anandasabapathy N, Hsu SC, Rodriguez-Boulan E, Scheller RH, Nelson WJ (1998) Sec6/8 complex is recruited to cell-cell contacts and specifies transport vesicle delivery to the basal-lateral membrane in epithelial cells. Cell 93:731-740. (Pubitemid 28257580)
10. Guo W, Roth D, Walch-Solimena C, Novick P (1999) The exocyst is an effector for Sec4p, targeting secretory vesicles to sites of exocytosis. EMBO J 18:1071-1080. (Pubitemid 29082285)
11. Hazuka CD, Foletti DL, Hsu SC, Kee Y, Hopf FW, Scheller RH (1999) The Sec6/8 complex is located at neurites outgrowth and axonal synapse-assembly domains. J Neurosci 19:1324-1334. (Pubitemid 29088915)
12. Inoue M, Chang L, Hwang J, Chiang SH, Saltiel AR (2003) The exocyst complex is required for targeting of Glut4 to the plasma membrane by insulin. Nature 422:629-633. (Pubitemid 36460418)
13. Kawase K, Nakamura T, Takaya A, Aoki K, Namikawa K, Kiyama H, Inagaki S, Takemoto H, Saltiel AR, Matsuda M (2006) GTP hydrolysis by the Rho family GTPase TC10 promotes exocytic vesicle fusion. Dev Cell 3:411-421. (Pubitemid 44283945)
14. Laurino L, Wang XX, de la Houssaye BA, Sosa L, Dupraz S, Cáceres A, Pfenninger KH, Quiroga S (2005) PI3K activation by IGF-1 is essential for the regulation of membrane expansion at the nerve growth cone. J Cell Sci 118:3653-3662. (Pubitemid 41309412)
15. Lohse K, Helmke SM, Wood MR, Quiroga S, de la Houssaye BA, Miller VE, Negre-Aminou P, Pfenninger KH (1996) Axonal origin and purity of growth cones isolated from fetal rat brain. Dev Brain Res 96:83-96. (Pubitemid 26348285)
16. Mascotti F, Cáceres A, Pfenninger KH, Quiroga S (1997) Expression and distribution of IGF-1 receptors containing a β-subunit variant (βgc) in developing neurons. J Neurosci 4:1447-1459. (Pubitemid 27073744)
17. Ménager C, Arimura N, Fukata Y, Kaibuchi K (2004) PIP3 is involved in neuronal polarization and axon formation. J Neurochem 89:109-118. (Pubitemid 38420679)
18. Murthy M, Garza D, Scheller RH, Schwarz TL (2003) Mutations in the exocyst component Sec5 disrupt neuronal membrane traffic, but neurotransmitter release persists. Neuron 37:433-447. (Pubitemid 36183365)
19. Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuchi K (2005) PAR-6-PAR-3 mediates Cdc42-induced Rac activation through the Rac GEFs STEF/Tiam. Nat Cell Biol 7:270-277. (Pubitemid 40331128)
20. Paglini G, Kunda P, Quiroga S, Kosik K, Cáceres A (1998) Suppression of radixin and moesin alters growth cone morphology, motility, and process formation in primary cultured neurons. J Cell Biol 143:443-455. (Pubitemid 28487862)
21. Pfenninger KH (2009) Plasma membrane expansion: a neuron's Herculean task. Nat Rev Neurosci 4:251-261.
22. Pfenninger KH, Friedman LB (1993) Sites of plasmalemmal expansion in growth cones. Dev Brain Res 71:181-192. (Pubitemid 23058502)
23. Pfenninger KH, Maylié-Pfenninger MF (1981) Lectin labelling of sprouting neurons. II. Relative movement and appearance of glyconjugates during plasmalemmal expansion. J Cell Biol 89:547-559.
24. Pfenninger KH, Ellis L, Johnson MP, Friedman LB, Somlo S (1983) Nerve growth cones isolated from fetal rat brain: subcellular fractionation and characterization. Cell 35:573-584. (Pubitemid 14202935)
25. Pfenninger KH, Laurino L, Peretti D, Wang X, Rosso S, Morfini G, Cáceres A, Quiroga S (2003) Regulation of membrane expansion at the nerve growth cone. J Cell Sci 116:1209-1217. (Pubitemid 36410660)
26. Pommereit D, Wouters FS (2007) An NGF-induced Exo70-TC10 complex locally antagonises Cdc42-mediated activation of N-WASP to modulate neurite outgrowth. J Cell Sci 120:2694-2705. (Pubitemid 47323876)
27. Quiroga S, Garofalo RS, Pfenninger KH (1995) Insulin-like growth factor I receptors of fetal brain are enriched in nerve growth cones and contain a β-subunit variant. Proc Natl Acad Sci U S A 92:4309-4312.
28. Rosso S, Bollati F, Bisbal M, Peretti D, Sumi T, Nakamura T, Quiroga S, Ferreira A, Cáceres A (2004) LIMK1 regulates Golgi dynamics, traffic of Golgi-derived vesicles, and process extension in primary cultured neurons. Mol Biol Cell 15:3433-3449. (Pubitemid 38850135)
29. Sans N, Prybylowski K, Petralia RS, Chang K, Wang YX, Racca C, Vicini S, Wenthold RJ (2003) NMDA receptor trafficking through an interaction between PDZ proteins and the exocyst complex. Nat Cell Biol 5:520-530. (Pubitemid 36781085)
30. Shi SH, Jan LY, Jan YN (2003) Hippocampal neuronal polarity specified by spatially localized mPar3/mPar6 and PI 3-kinase activity. Cell 112:63-75.
31. Sosa L, Dupraz S, Laurino L, Bollati F, Bisbal M, Cáceres A, Pfenninger KH, Quiroga S (2006) IGF-1 receptor is essential for the establishment of hippocampal neuronal polarity. Nat Neurosci 8:993-995. (Pubitemid 44264907)
32. TerBush DR, Novick P (1995) Sec6, Sec8, and Sec15 are components of a multisubunit complex which localizes to small bud tips in Saccharomyces cerevisiae. J Cell Biol 130:299-312.
33. TerBush DR, Maurice T, Roth D, Novick P (1996) The exocyst is a multiprotein complex required for exocytosis in Saccharomyces cerevisiae. EMBO J 15:6483-6494.
34. Vega IE, Hsu SC (2001) The exocyst complex associates with microtubules to mediate vesicle targeting and neurite outgrowth. J Neurosci 21:3839-3848.
35. Xia XG, Zhou H, Ding H, Affar el B, Shi Y, Xu Z (2003) An enhanced U6 promoter for synthesis of short hairpin RNA. Nucleic Acids Res 31:e100.
36. Yeaman C, Grindstaff KK, Wright JR, Nelson WJ (2001) Sec6/8 complex on trans-Golgi network and plasma membrane regulate late stages of exocytosis in mammalian cells. J Cell Biol 155:593-604. (Pubitemid 34289317)
37. Yudowski GA, Puthenveedu MA, von Zastrow M (2006) Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane. Nat Neurosci 9:622-627. (Pubitemid 44012259)