Transgenic and other experimental models of pancreas and islet damage

Diabetes, Obesity and Metabolism

Volumn 11, Issue SUPPL. 4, 2009, Pages 91-96

  Herrera, P L ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

Author keywords

Ablation; Diabetes; Insulin; Islet; Mouse; Pancreas; Pancreatectomy; Regeneration; Transgenic

Indexed keywords

ARTICLE; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL REGENERATION; CELL RENEWAL; EXPERIMENTAL MODEL; GENETICS; HUMAN; INSULIN RESISTANCE; MOLECULAR MECHANICS; NONHUMAN; PANCREAS INJURY; PANCREAS ISLET BETA CELL; PANCREAS ISLET DISEASE; PANCREAS RESECTION; TISSUE REGENERATION; TRANSGENIC ANIMAL;

ANIMALS; ANIMALS, GENETICALLY MODIFIED; CELL COUNT; CELL DIFFERENTIATION; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; INSULIN; ISLETS OF LANGERHANS; MICE; PANCREAS; RATS; REGENERATION;

EID: 70350315739     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2009.01104.x     Document Type: Article

References (60)

1. Shaw J, Latimer E. Regeneration of pancreatic tissue from the transplanted pancreatic duct in the dog. American J Physiol 1925, 76:49-53.
2. Berrocal T, Luque AA, Pinilla I, Lassaletta L. Pancreatic regeneration after near-total pancreatectomy in children with nesidioblastosis. Pediatr Radiol 2005, 35:1066-1070.
3. Schonau E, Deeg KH, Huemmer HP, Akcetin YZ, Bohles HJ. Pancreatic growth and function following surgical treatment of nesidioblastosis in infancy. Eur J Pediatr 1991, 150:550-553.
4. Weir GC, Bonner-Weir S. Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes 2004, 53(Suppl 3):S16-S21.
5. Prentki M, Nolan CJ. Islet beta cell failure in type 2 diabetes. J Clin Invest 2006, 116:1802-1812.
6. Meier JJ, Lin JC, Butler AE, Galasso R, Martinez DS, Butler PC. Direct evidence of attempted beta cell regeneration in an 89-year-old patient with recent-onset type 1 diabetes. Diabetologia 2006, 49:1838-1844.
7. Kodama S, Toyonaga T, Kondo T. Enhanced expression of PDX-1 and Ngn3 by exendin-4 during beta cell regeneration in STZ-treated mice. Biochem Biophys Res Commun 2005, 327:1170-1178.
8. Rosenberg L. Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc Res Tech 1998, 43:337-346.
9. Rosenberg L, Brown RA, Duguid WP. A new approach to the induction of duct epithelial hyperplasia and nesidioblastosis by cellophane wrapping of the hamster pancreas. J Surg Res 1983, 35:63-72.
10. Bonner-Weir S, Sharma A. Pancreatic stem cells. J Pathol 2002, 197:519-526.
11. Peshavaria M, Larmie BL, Lausier J. Regulation of pancreatic beta-cell regeneration in the normoglycemic 60% partial-pancreatectomy mouse. Diabetes 2006, 55:3289-3298.
12. Dor Y, Brown J, Martinez OI, Melton DA. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
13. Hardikar AA, Karandikar MS, Bhonde RR. Effect of partial pancreatectomy on diabetic status in BALB/c mice. J Endocrinol 1999, 162:189-195.
14. Liu YQ, Montanya E, Leahy JL. Increased islet DNA synthesis and glucose-derived lipid and amino acid production in association with beta-cell hyperproliferation in normoglycaemic 60% pancreatectomy rats. Diabetologia 2001, 44:1026-1033.
15. Liu YQ, Nevin PW, Leahy JL. Beta-cell adaptation in 60% pancreatectomy rats that preserves normoinsulinemia and normoglycemia. Am J Physiol 2000, 279:E68-E73.
16. Lee CS, De Leon DD, Kaestner KH, Stoffers DA. Regeneration of pancreatic islets after partial pancreatectomy in mice does not involve the reactivation of neurogenin-3. Diabetes 2006, 55:269-272.
17. Jetton TL, Liu YQ, Trotman WE, Nevin PW, Sun XJ, Leahy JL. Enhanced expression of insulin receptor substrate-2 and activation of protein kinase B/Akt in regenerating pancreatic duct epithelium of 60%-partial pancreatectomy rats. Diabetologia 2001, 44:2056-2065.
18. Brockenbrough JS, Weir GC, Bonner-Weir S. Discordance of exocrine and endocrine growth after 90% pancreatectomy in rats. Diabetes 1988, 37:232-236.
19. Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 1993, 42:1715-1720.
20. Oh BK, Seong JK, Lee JE. Induction of telomerase activity during an early burst of proliferation in pancreatic regeneration. Cancer Lett 2002, 186:93-98.
21. Sharma A, Zangen DH, Reitz P. The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration. Diabetes 1999, 48:507-513.
22. Finegood DT, Weir GC, Bonner-Weir S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am J Physiol 1999, 276:E822-E827.
23. De Breuck S, Lardon J, Rooman I, Bouwens L. Netrin-1 expression in fetal and regenerating rat pancreas and its effect on the migration of human pancreatic duct and porcine islet precursor cells. Diabetologia 2003, 46:926-933.
24. Baeyens L, De Breuck S, Lardon J, Mfopou JK, Rooman I, Bouwens L. In vitro generation of insulin-producing beta cells from adult exocrine pancreatic cells. Diabetologia 2005, 48:49-57.
25. De Breuck S, Baeyens L, Bouwens L. Expression and function of leukaemia inhibitory factor and its receptor in normal and regenerating rat pancreas. Diabetologia 2006, 49:108-116.
26. Xu X, D'Hoker J, Stange G. Beta cells can be generated from endogenous progenitors in injured adult mouse pancreas. Cell 2008, 132:197-207.
27. Lenzen S. The mechanisms of alloxan- and streptozotocin-induced diabetes. Diabetologia 2008, 51:216-226.
28. Bolzan AD, Bianchi MS. Genotoxicity of streptozotocin. Mutat Res 2002, 512:121-134.
29. Like AA, Rossini AA. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976, 193:415-417.
30. Li L, Yi Z, Seno M, Kojima I. Activin A and betacellulin: effect on regeneration of pancreatic beta-cells in neonatal streptozotocin-treated rats. Diabetes 2004, 53:608-615.
31. Thyssen S, Arany E, Hill DJ. Ontogeny of regeneration of beta-cells in the neonatal rat after treatment with streptozotocin. Endocrinology 2006, 147:2346-2356.
32. Fernandes A, King LC, Guz Y, Stein R, Wright CV, Teitelman G. Differentiation of new insulin-producing cells is induced by injury in adult pancreatic islets. Endocrinology 1997, 138:1750-1762.
33. Kim BM, Han YM, Shin YJ, Min BH, Park IS. Clusterin expression during regeneration of pancreatic islet cells in streptozotocin-induced diabetic rats. Diabetologia 2001, 44:2192-2202.
34. Aughsteen AA. Immunofluorescence and electron-microscopic observations of intermediate cells in the pancreas of mice, rats and humans. Cells Tissues Organs 2002, 170:21-28.
35. De Haro-Hernandez R, Cabrera-Munoz L, Mendez JD. Regeneration of beta-cells and neogenesis from small ducts or acinar cells promote recovery of endocrine pancreatic function in alloxan-treated rats. Arch Med Res 2004, 35:114-120.
36. Holland AM, Hale MA, Kagami H, Hammer RE, MacDonald RJ. Experimental control of pancreatic development and maintenance. Proc Natl Acad Sci USA 2002, 99:12236-12241.
37. Holland AM, Gonez LJ, Naselli G, Macdonald RJ, Harrison LC. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes 2005, 54:2586-2595.
38. Okamoto H. The Reg gene family and Reg proteins: with special attention to the regeneration of pancreatic beta-cells. J Hepatobiliary Pancreat Surg 1999, 6:254-262.
39. Miki T, Tashiro F, Iwanaga T. Abnormalities of pancreatic islets by targeted expression of a dominant-negative KATP channel. Proc Natl Acad Sci USA 1997, 94:11969-11973.
40. Oyama K, Minami K, Ishizaki K, Fuse M, Miki T, Seino S. Spontaneous recovery from hyperglycemia by regeneration of pancreatic beta-cells in Kir6.2G132S transgenic mice. Diabetes 2006, 55:1930-1938.
41. Bartel DP. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116:281-297.
42. Poy MN, Hausser J, Trajkovski M. miR-375 maintains normal pancreatic {alpha}- and {beta}-cell mass. Proc Natl Acad Sci USA 2009, doi/10.1073/pnas. 0810550106
43. Saito M, Iwawaki T, Taya C. Diphtheria toxin receptor-mediated conditional and targeted cell ablation in transgenic mice. Nat Biotechnol 2001, 19:746-750.
44. Breitman ML, Clapoff S, Rossant J. Genetic ablation: targeted expression of a toxin gene causes microphthalmia in transgenic mice. Science (New York, NY) 1987, 238:1563-1565.
45. Breitman ML, Bryce DM, Giddens E. Analysis of lens cell fate and eye morphogenesis in transgenic mice ablated for cells of the lens lineage. Development 1989, 106:457-463.
46. Evans GA. Dissecting mouse development with toxigenics. Genes Dev 1989, 3:259-263.
47. Herrera PL, Huarte J, Zufferey R. Ablation of islet endocrine cells by targeted expression of hormone-promoter-driven toxigenes. Proc Natl Acad Sci USA 1994, 91:12999-13003.
48. Herrera PL, Nepote V, Delacour A. Pancreatic cell lineage analyses in mice. Endocrine 2002, 19:267-278.
49. Behringer RR, Mathews LS, Palmiter RD, Brinster RL. Dwarf mice produced by genetic ablation of growth hormone-expressing cells. Genes Dev 1988, 2:453-461.
50. Lem J, Applebury ML, Falk JD, Flannery JG, Simon MI. Tissue-specific and developmental regulation of rod opsin chimeric genes in transgenic mice. Neuron 1991, 6:201-210.
51. Lowell BB, S-Susulic V, Hamann A. Development of obesity in transgenic mice after genetic ablation of brown adipose tissue. Nature 1993, 366:740-742.
52. Palmiter RD, Behringer RR, Quaife CJ, Maxwell F, Maxwell IH, Brinster RL. Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene. Cell 1987, 50:435-443.
53. Ross SR, Graves RA, Spiegelman BM. Targeted expression of a toxin gene to adipose tissue: transgenic mice resistant to obesity. Genes Dev 1993, 7:1318-1324.
54. Naglich JG, Metherall JE, Russell DW, Eidels L. Expression cloning of a diphtheria toxin receptor: identity with a heparin-binding EGF-like growth factor precursor. Cell 1992, 69:1051-1061.
55. Naglich JG, Rolf JM, Eidels L. Expression of functional diphtheria toxin receptors on highly toxin-sensitive mouse cells that specifically bind radioiodinated toxin. Proc Natl Acad Sci USA 1992, 89:2170-2174.
56. Pappenheimer AM, Harper AA, Moynihan M, Brockes JP. Diphtheria toxin and related proteins: effect of route of injection on toxicity and the determination of cytotoxicity for various cultured cells. J Infect Dis 1982, 145:94-102. Jr.,
57. Nir T, Melton DA, Dor Y. Recovery from diabetes in mice by beta cell regeneration. J Clin Invest 2007, 117:2553-2561.
58. Cano DA, Rulifson IC, Heiser PW. Regulated beta-cell regeneration in the adult mouse pancreas. Diabetes 2008, 57:958-966.
59. Pelengaris S, Khan M, Evan GI. Suppression of Myc-induced apoptosis in beta cells exposes multiple oncogenic properties of Myc and triggers carcinogenic progression. Cell 2002, 109:321-334.
60. Wang ZV, Mu J, Schraw TD. PANIC-ATTAC: a mouse model for inducible and reversible beta-cell ablation. Diabetes 2008, 57:2137-2148.