Development of iron/ethylcellulose (core/shell) nanoparticles loaded with diclofenac sodium for arthritis treatment

International Journal of Pharmaceutics

Volumn 382, Issue 1-2, 2009, Pages 270-276

  Arias, José L ^a   López Viota, Margarita ^a   López Viota, Julián ^b   Delgado, Ángel V ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF JAÉN   (Spain)

Author keywords

Controlled drug delivery; Diclofenac sodium; Ethylcellulose; Iron; Magnetic colloids; Stimuli sensitive drug carriers

Indexed keywords

DICLOFENAC; ETHYL CELLULOSE; IRON; NANOPARTICLE;

ADSORPTION; ARTHRITIS; ARTICLE; CONTROLLED STUDY; ELECTROPHORETIC MOBILITY; ENCAPSULATION; INFLAMMATION; MAGNETIC FIELD; NANOPHARMACEUTICS; PARTICLE SIZE; PRIORITY JOURNAL; SLOW DRUG RELEASE;

ABSORPTION; ADSORPTION; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ARTHRITIS; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DELAYED-ACTION PREPARATIONS; DICLOFENAC; DRUG CARRIERS; DRUG COMPOUNDING; EMULSIONS; IRON; KINETICS; MAGNETICS; METAL NANOPARTICLES; PARTICLE SIZE; SOLUBILITY; SOLVENTS; SURFACE PROPERTIES; SURFACE-ACTIVE AGENTS; TECHNOLOGY, PHARMACEUTICAL;

EID: 70350208800     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2009.08.019     Document Type: Article

References (34)

1. Arias J.L. Novel strategies to improve the anticancer action of 5-fluorouracil by using drug delivery systems. Molecules 13 (2008) 2340-2369
2. Arias J.L., Gallardo V., Linares-Molinero F., and Delgado A.V. Preparation and characterization of carbonyl iron/poly(butylcyanoacrylate) core/shell nanoparticles. J. Colloid Interface Sci. 299 (2006) 599-607
3. Arias J.L., López-Viota M., Ruiz M.A., López-Viota J., and Delgado A.V. Development of carbonyl iron/ethylcellulose core/shell nanoparticles for biomedical applications. Int. J. Pharm. 339 (2007) 237-245
4. Arias J.L., Ruiz M.A., López-Viota M., and Delgado A.V. Poly(alkylcyanoacrylate) colloidal particles as vehicles for antitumour drug delivery: A comparative study. Colloids Surf. B: Biointerfaces 62 (2008) 64-70
5. Bawa P., Pillay V., Choonara Y.E., and Toit L.C. Stimuli-responsive polymers and their applications in drug delivery. Biomed. Mater. 4 (2009) 022001
6. Brasseur N., Brault D., and Couvreur P. Adsorption of hematoporphyrin onto polyalkylcyanoacrylate nanoparticles: carrier capacity and drug release. Int. J. Pharm. 70 (1991) 126-135
7. ® nanospheres-encapsulated doxorubicin in an orthotopic murine brain tumor model. J. Control. Release 100 (2004) 29-40
8. Carson J., Notis W.M., and Orris E.S. Colonic ulceration and bleeding during diclofenac therapy. N. Engl. J. Med. 323 (1989) 135-137
9. Chua-anusorn W., Macey D.J., Webb J., de la Motte Hall P., and St Pierre T.G. Effects of prolonged iron loading in the rat using both parenteral and dietary routes. Biometals 12 (1999) 103-113
10. Couvreur P., and Vauthier C. Nanotechnology: Intelligent design to treat complex disease. Pharm. Res. 23 (2006) 1417-1450
11. Davies N.M. Sustained release and enteric coated NSAIDs: are they really GI safe?. J. Pharm. Pharm. Sci. 2 (1999) 5-14
12. DeMerlis C.C., Schoneker D.R., and Borzelleca J.F. A subchronic toxicity study in rats and genotoxicity tests with an aqueous ethylcellulose dispersion. Food Chem. Toxicol. 43 (2005) 1355-1364
13. Dubernet C., Rouland J.C., and Benoit J.P. Comparative study of two ethylcellulose forms (raw material and microspheres) carried out through thermal analysis. Int. J. Pharm. 64 (1990) 99-107
14. Farokhzad O.C., and Langer R. Impact of nanotechnology on drug delivery. ACS Nano 3 (2009) 16-20
15. Grattard N., Pernin M., Marty B., Roudaut G., Champion D., and LeMeste M. Study of release kinetics of small and high molecular weight substances dispersed into spray-dried ethylcellulose microspheres. J. Control. Release 84 (2002) 125-135
16. Hood E., Gonzalez M., Plaas A., Strom J., and VanAuker M. Immuno-targeting of nonionic surfactant vesicles to inflammation. Int. J. Pharm. 339 (2007) 222-230
17. nd Ed. (2001), Clarendon Press, Oxford
18. Ibrahim A., Couvreur P., Roland M., and Speiser P. New magnetic drug carrier. J. Pharm. Pharmacol. 35 (1983) 59-61
19. Kato T., Sato K., Sasaki R., Kakinuma H., and Moriyama M. Targeted cancer chemotherapy with arterial microcapsule chemoembolization: review of 1013 patients. Cancer Chemother. Pharmacol. 37 (1996) 289-296
20. Llovet M.I., Egea M.A., Valero J., Alsina M.A., García M.L., and Chauvet A. Methotrexate-loaded nanoparticles: analysis of drug content and study of the matrix structure. Drug Dev. Ind. Pharm. 21 (1995) 1761-1771
21. Lübbe A.S., Bergemann C., Riess H., Schriever F., Reichardt P., Possinger K., Matthias M., Doerken B., Herrmann F., Guertler R., Hohenberger P., Haas N., Sohr R., Sander B., Lemke A.J., Ohlendorf D., Huhnt W., and Huhn D. Clinical experiences with magnetic drug targeting: a phase I study with 4'-epidoxorubicin in 14 patients with advanced solid tumors. Cancer Res. 56 (1996) 4686-4693
22. Lübbe A.S., Bergemann C., Huhnt W., Fricke T., Riess H., Brock J.W., and Huhn D. Preclinical experiences with magnetic drug targeting: tolerance and efficacy. Cancer Res. 56 (1996) 4694-4701
23. McCarron P.A., Woolfson A.D., and Keating S.M. Sustained release of 5-fluorouracil from polymeric nanoparticles. J. Pharm. Pharmacol. 52 (2000) 1451-1459
24. Maitani Y., Nakagaki M., and Nagai T. Determination of the acid dissociation constants in ethanol-water mixtures and partition coefficients for diclofenac. Int. J. Pharm. 74 (1991) 105-116
25. Neuberger T., Schöpf B., Hofmann H., Hofmann M., and Rechenberg B. Superparamagnetic nanoparticles for biomedical applications: Possibilities and limitations of a new drug delivery system. J. Magn. Magn. Mater. 293 (2005) 483-496
26. Okon E., Pouliquen D., Okon P., Kovaleva Z.V., Stepanova T.P., Lavit S.G., Kudryavtsev B.N., and Jallet P. Biodegradation of magnetite dextran nanoparticles in the rat. A histologic and biophysical study. Lab. Invest. 71 (1994) 895-903
27. Palomo M.E., Ballesteros M.P., and Frutos P. Analysis of diclofenac sodium and derivatives. J. Pharm. Biomed. Anal. 21 (1999) 83-94
28. Reddy L.H. Drug delivery to tumors: recent strategies. J. Pharm. Pharmacol. 57 (2005) 1231-1242
29. Saravanan M., Bhaskar K., Maharajan G., and Pillai K.S. Ultrasonically controlled release and targeted delivery of diclofenac sodium via gelatin magnetic microspheres. Int. J. Pharm. 283 (2004) 71-82
30. Soppimath K.S., Aminabhavi T.M., Kulkarni A.R., and Rudzinski W.E. Biodegradable polymeric nanoparticles as drug delivery devices. J. Control. Release 70 (2001) 1-20
31. Stolnik S., Illum L., and Davis S.S. Long circulating microparticulate drug carriers. Adv. Drug Deliv. Rev. 16 (1995) 195-214
32. Wei H., Zhang X.Z., Cheng H., Chen W.Q., Cheng S.X., and Zhuo R.X. Self-assembled thermo- and pH-responsive micelles of poly(10-undecenoic acid-b-N-isopropylacrylamide) for drug delivery. J. Control. Release 116 (2006) 266-274
33. Whittaker P., Ali S.F., Imam S.F., and Dunkel V.C. Acute toxicity of carbonyl iron and sodium iron EDTA compared with ferrous sulfate in young rats. Regul. Toxicol. Pharmacol. 36 (2002) 280-286
34. Zinutti C., Kedzierewicz F., Hoffamn M., Benoit J.P., and Maincent P. Influence of the casting solvent on the physico-chemical properties of 5-fluorouracil loaded microspheres. Int. J. Pharm. 133 (1996) 97-105