Involvement of constitutive nitric oxide synthase in ghrelin-induced cytosolic phospholipase A2 activation in gastric mucosal cell protection against ethanol cytotoxicity

Inflammopharmacology

Volumn 17, Issue 5, 2009, Pages 245-253

  Slomiany, B L ^a   Slomiany, A ^a  

^a RUTGERS SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

CNOS; CPLA2 activation; Ethanol cytotoxicity; Gastric mucosa; Ghrelin; PGE2; S nitrosylation

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ALCOHOL; ARACHIDONIC ACID; CYTOSOLIC PHOSPHOLIPASE A2; GHRELIN; INDOMETACIN; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N [3 (AMINOMETHYL)BENZYL]ACETAMIDINE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PROSTAGLANDIN E2; PROSTAGLANDIN SYNTHASE;

ANIMAL CELL; ARTICLE; CELL PROTECTION; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; NITROSYLATION; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN PHOSPHORYLATION; RAT; STOMACH MUCOSA; UPREGULATION;

ANIMALS; ARACHIDONIC ACID; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DINOPROSTONE; ETHANOL; GASTRIC MUCOSA; GHRELIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PHOSPHOLIPASES A2, CYTOSOLIC; PHOSPHORYLATION; RATS; RECEPTORS, GHRELIN; UP-REGULATION;

EID: 70350140549     PISSN: 09254692     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10787-009-0013-0     Document Type: Article

References (37)

1. T Brzozowski PC Konturek SJ Konturek, et al. 2004 Exogenous and endogenous ghrelin in gastroprotection against stress-induced gastric damage Regul Pept 120 39 51 10.1016/j.regpep.2004.02.010 15177919 1:CAS:528: DC%2BD2cXks1Wktb0%3D (Pubitemid 38726190)
2. T Brzozowski PC Konturek Z Sliwowski, et al. 2006 Prostaglandin/ cyclooxygenase pathway in ghrelin-induced gastroprotection against ischemia-reperfusion injury J Pharmacol Exp Ther 319 477 487 10.1124/jpet.106.105932 16868036 1:CAS:528:DC%2BD28XhtVCksLjP (Pubitemid 44455155)
3. P Ceranowicz Z Warzecha A Dembinski, et al. 2009 Treatment with ghrelin accelerates the healing of acetic acid-induced gastric and duodenal ulcers in rats J Physiol Pharmacol 60 87 98 19439811 1:CAS:528:DC%2BD1MXltVWksbs%3D
4. R Clancy B Varenika W Huang, et al. 2000 Nitric oxide synthase/COX cross-talk: nitric oxide activates COX-1 but inhibits COX-2 derived prostaglandin production J Immunol 165 1582 1587 10903767 1:STN:280: DC%2BD3cvgsFegtQ%3D%3D
5. M Colasanti H Suzuki 2000 The dual personality of NO Trends Pharmacol Sci 21 249 252 10.1016/S0165-6147(00)01499-1 10979862 1:CAS:528: DC%2BD3cXkvVyrt7s%3D (Pubitemid 30445251)
6. S Cuzzocrea D Salvemini 2007 Molecular mechanisms involved in the reciprocal regulation of cyclooxygenase and nitric oxide synthase enzymes Kidney Int 71 290 297 10.1038/sj.ki.5002058 17200681 1:CAS:528:DC%2BD2sXhsVersLY%3D (Pubitemid 46227087)
7. MT Forrester MW Forrester JS Stamler 2007 Assessment and application of the biotin switch technique for examining protein S-nitrosylation under conditions of pharmacologically induced oxidative stress J Biol Chem 282 13977 13983 10.1074/jbc.M609684200 17376775 1:CAS:528:DC%2BD2sXkvVygu74%3D (Pubitemid 47100466)
8. M Guslandi 1987 Effects of ethanol on the gastric mucosa Dig Dis Sci 5 21 32 10.1159/000171159 1:STN:280:DyaL2s3ksFSnsg%3D%3D
9. 2 Biochim Biophys Acta 1488 124 138 11080682 1:CAS:528:DC%2BD3cXotlGitro%3D
10. SR Jaffrey H Erdjument-Bromage D Ferris, et al. 2001 Protein S-nitrosylation: a physiological signal for neuronal nitric acid Nat Cell Biol 3 193 197 10.1038/35055104 11175752 1:CAS:528:DC%2BD3MXht1Kmsb4%3D (Pubitemid 32118373)
11. SF Kim DA Huri SH Snyder 2005 Inducible nitric oxide synthase binds, S-nitrosylates, and activates cyclooxygenase-2 Science 310 1966 1970 10.1126/science.1119407 16373578 1:CAS:528:DC%2BD2MXhtlagurvK (Pubitemid 43005992)
12. M Kojima H Hosoda Y Date, et al. 1999 Ghrelin is a growth-hormone- releasing acylated peptide from stomach Nature 402 656 660 10.1038/45230 10604470 1:CAS:528:DC%2BD3cXjs1Ki
13. Konturek SJ, Brzozowski T, Konturek W et al (1993) Growth factors in gastric mucosal integrity, protection and healing of acute and chronic ulcerations. In: Domschke W, Konturek SJ et al (eds) The stomach. Springer-Verlag, Berlin, pp 159-176
14. PC Konturek T Brzozowski R Pajdo, et al. 2004 Ghrelin-a new gastroprotective factor in gastric mucosa J Physiol Pharmacol 55 325 336 15213356 1:CAS:528:DC%2BD2cXmt1Cmu70%3D
15. PC Konturek T Brzozowski B Walter, et al. 2006 Ghrelin-induced gastroprotection against ischemia-reperfusion injury involves an activation of sensory afferent nerves and hyperemia mediated by nitric oxide Eur J Pharmacol 536 171 181 10.1016/j.ejphar.2006.02.032 16581065 1:CAS:528:DC%2BD28Xjs1ajs7o%3D
16. JB Mannick YQ Miao JS Stamler 1997 Nitric oxide inhibits Fas-induced apoptosis J Biol Chem 272 24125 24128 10.1074/jbc.272.39.24125 9305857 1:CAS:528:DyaK2sXmsFanurw%3D (Pubitemid 27418605)
17. LJ Marnett TL Wright BC Crews, et al. 2000 Regulation of prostaglandin biosynthesis by nitric oxide is revealed by target deletion of inducible nitric-oxide synthase J Biol Chem 275 13427 13430 10.1074/jbc.275.18.13427 10788454 1:CAS:528:DC%2BD3cXjtFyktrs%3D (Pubitemid 30257405)
18. E Masuda S Kawano K Nagano 1995 Endogenous nitric oxide modulates ethanol-induced gastric mucosal injury in rats Gastroenterology 108 58 64 10.1016/0016-5085(95)90008-X 7806064 1:CAS:528:DyaK2MXjs12ltbs%3D
19. V Mollace C Muscoli E Masini, et al. 2005 Modulation of prostaglandin biosynthesis by nitric oxide and nitric oxide donors Pharmacol Rev 57 217 252 10.1124/pr.57.2.1 15914468 1:CAS:528:DC%2BD2MXlsFejtLs%3D (Pubitemid 41043885)
20. 2 synthase that acts in concert with cyclooxygenase-2 J Biol Chem 275 32783 32792 10.1074/jbc.M003505200 10869354 1:CAS:528:DC%2BD3cXnslOiuro%3D
21. BM Peskar 2001 Role of cyclooxygenase isoforms in gastric mucosal defense J Physiol Paris 95 3 9 10.1016/S0928-4257(01)00003-1 11595412 1:CAS:528:DC%2BD3MXot1Shurg%3D (Pubitemid 33020212)
22. K Price P Hanson 1998 Constitutive nitric oxide synthase in rat gastric mucosa: subcellular distribution, relative activity and different carboxyl-terminal antigenicity of the neuronal form compared with cerebellum Digestion 59 308 313 10.1159/000007507 9693200 1:CAS:528:DyaK1cXltlKitbw%3D (Pubitemid 28360684)
23. 2 as defined by gene knockout Biochim Biophys Acta 1488 139 148 11080683 1:CAS:528:DC%2BD3cXotlGitrs%3D
24. A Schmassmann G Zoidl BM Peskar, et al. 2006 Role of the different isoforms of cyclooxygenase and nitric oxide synthase during ulcer healing in cyclooxygenase-1 and -2 knockout mice Am J Physiol Gastrointest Liver Physiol 290 G747 G756 10.1152/ajpgi.00416.2005 16373427 1:CAS:528:DC%2BD28Xks1Slt7g%3D
25. 1 macrophages using GFP/REP constructs Biochim Biophys Acta 1735 119 129 15967714 1:CAS:528:DC%2BD2MXmtFGhtb0%3D
26. V Sibilia G Rindi F Pagani, et al. 2003 Ghrelin protects against ethanol-induced gastric ulcers in rats: studies on the mechanism of action Endocrinology 144 353 359 10.1210/en.2002-220756 12488364 1:CAS:528: DC%2BD3sXhtFSksg%3D%3D (Pubitemid 36076125)
27. V Sibilia F Pagani G Rindi 2008 Central ghrelin gastroprotection involves nitric oxide/prostaglandin cross-talk Br J Pharmacol 154 688 697 10.1038/bjp.2008.120 18414388 1:CAS:528:DC%2BD1cXmt1KqtLc%3D (Pubitemid 351744947)
28. 2 activation in gastric mucosal cells J Physiol Pharmacol 58 117 130 17440231 1:CAS:528:DC%2BD2sXks1GntrY%3D
29. BL Slomiany A Slomiany 2008 Src kinase-mediated parallel activation of prostaglandin and constitutive nitric oxide synthase pathways in leptin protection of gastric mucosa against ethanol cytotoxicity J Physiol Pharmacol 59 301 314 18622047 1:CAS:528:DC%2BD1cXptlegtbw%3D
30. 2 activation in gastric mucosal protection against ethanol cytotoxicity involves epidermal growth factor receptor transactivation Inflammopharmacology 17 6 14 10.1007/s10787-008-8037-4 19127349 1:CAS:528:DC%2BD1MXhtFelu7g%3D
31. A Slomiany M Morita S Sano, et al. 1997 Effect of ethanol on mucus glycoprotein synthesis, translocation, transport, glycosylation and secretion Alcohol Clin Exp Res 21 417 423 9161600 1:CAS:528:DyaK2sXktVersbY%3D
32. G Sowa J Liu A Papapetropoulos, et al. 1999 Trafficking of endothelial nitric-oxide synthase in living cells J Biol Chem 274 22524 22531 10.1074/jbc.274.32.22524 10428829 1:CAS:528:DyaK1MXlt1CnsLs%3D (Pubitemid 29379294)
33. 15N]nitrate in biological fluids J Anal Biochem 126 131 138 10.1016/0003-2697(82)90105-1
34. JL Wallace PR Devchand 2005 Emerging roles for cyclooxygenase-2 in gastrointestinal mucosal defense Br J Pharmacol 145 275 282 10.1038/sj.bjp. 0706201 15778736 1:CAS:528:DC%2BD2MXks1Gnurs%3D (Pubitemid 40896072)
35. BJ Whittle J Lopez-Belmonte S Moncada 1990 Regulation of gastric mucosal integrity by endogenous nitric oxide: interactions with prostanoids and sensory neuropeptides in the rat Br J Pharmacol 99 607 611 2110019 1:CAS:528: DyaK3cXhslKitr4%3D
36. 2α through nitric oxide-induced S-nitrosylation. Involvement of inducible nitric-oxide synthase and cyclooxygenase-2 J Biol Chem 283 3077 3087 10.1074/jbc.M705709200 18029351 1:CAS:528:DC%2BD1cXhtlyjsLs%3D
37. M Yamada M Watanabe S Mue, et al. 1996 Platelet-activating factor production in stimulated macrophages is down-regulated by concurrently produced prostaglandin E2 J Pharmacol Exp Ther 277 1607 1614 8667229 1:CAS:528: DyaK28XjslGlurg%3D