Mechanism of action of novel naphthofuranquinones on rat liver microsomal peroxidation

Chemico-Biological Interactions

Volumn 182, Issue 2-3, 2009, Pages 213-219

  Elingold, Igal ^a   Taboas, Melisa I ^a   Casanova, Marta B ^a   Galleano, Mónica ^b   Silva, Raphael S F ^c   Menna Barreto, Rubem F S ^d   Ventura Pinto, Antonio ^c   de Castro, Solange L ^d   Costa, Lidia E ^b,e   Dubin, Marta ^a  

^a Centre de Estudios Farmacologicos y Botanicos   (Argentina)

^b University of Buenos Aires   (Argentina)

^c FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^d INSTITUTO OSWALDO CRUZ   (Brazil)

^e ININCA   (Argentina)

Author keywords

Chagas disease; Lipid peroxidation; Naphthofuranquinones; Naphthoquinones; Oxidative stress

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 2 IODOMETHYL 2,3 DIHYDRO NAPHTO[1,2 B]FURAN 4,9 DIONE; 2 IODOMETHYL 2,3 DIHYDRO NAPHTOL[2,3 B]FURAN 4,9 DIONE; 2 METHYL 2,3 DIHYDRO NAPHTOL[1,2 B]FURAN 4,9 DIONE; ASCORBIC ACID; IRON; LIPID; NPPN 3222; NPPN 3223; NPPN 3226; OXYGEN; PEROXY RADICAL; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE FERRIHEMOPROTEIN REDUCTASE; SUPEROXIDE; TERT BUTYL HYDROPEROXIDE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; CHAGAS DISEASE; CONTROLLED STUDY; DRUG MECHANISM; DRUG SYNTHESIS; ELECTRON; ELECTRON SPIN RESONANCE; INHIBITION KINETICS; LIPID PEROXIDATION; LIVER MICROSOME METABOLISM; MALE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; OXYGEN CONSUMPTION; RAT;

ANIMALS; ASCORBIC ACID; BENZOQUINONES; FURANS; LIPID PEROXIDATION; MALE; MICROSOMES, LIVER; NADPH OXIDASE; NAPHTHOQUINONES; OXIDATION-REDUCTION; OXIDATIVE STRESS; OXYGEN; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SUPEROXIDES; TERT-BUTYLHYDROPEROXIDE;

MAMMALIA; RATTUS;

EID: 70350135235     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2009.09.002     Document Type: Article

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