Guided bone regeneration using rhGDF-5- and rhBMP-2-coated natural bone mineral in rat calvarial defects

Clinical Oral Implants Research

Volumn 20, Issue 11, 2009, Pages 1219-1230

  Schwarz, Frank ^a   Ferrari, Daniel ^a   Sager, Martin ^a   Herten, Monika ^a   Hartig, Brigitte ^a   Becker, Jürgen ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

Animal study; Guided bone regeneration; Immunohistochemistry; RhBMP 2; RhGDF 5

Indexed keywords

BIOMATERIAL; BONE MORPHOGENETIC PROTEIN 2; GROWTH DIFFERENTIATION FACTOR 5; RECOMBINANT PROTEIN;

ANIMAL; ARTICLE; ARTIFICIAL MEMBRANE; BONE DEVELOPMENT; BONE MATRIX; BONE REGENERATION; BONE TRANSPLANTATION; DRUG EFFECT; FOLLOW UP; HISTOLOGY; HUMAN; MALE; METHODOLOGY; NONPARAMETRIC TEST; OSTEOTOMY; PHYSIOLOGY; RANDOMIZATION; RAT; SKULL; TISSUE REGENERATION; TRANSPLANTATION; WISTAR RAT; WOUND HEALING;

ANIMALS; BONE MATRIX; BONE MORPHOGENETIC PROTEIN 2; BONE REGENERATION; BONE TRANSPLANTATION; COATED MATERIALS, BIOCOMPATIBLE; FOLLOW-UP STUDIES; GROWTH DIFFERENTIATION FACTOR 5; GUIDED TISSUE REGENERATION; HUMANS; MALE; MEMBRANES, ARTIFICIAL; OSTEOGENESIS; OSTEOTOMY; RANDOM ALLOCATION; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SKULL; STATISTICS, NONPARAMETRIC; WOUND HEALING;

EID: 70350105168     PISSN: 09057161     EISSN: 16000501     Source Type: Journal    
DOI: 10.1111/j.1600-0501.2009.01796.x     Document Type: Article

References (51)

1. Alberius, P. Johnell, O. (1990) Immunohistochemical assessment of cranial suture development in rats. Journal of Anatomy 173: 61 68.
2. Archer, C.W., Dowthwaite, G.P. Francis-West, P. (2003) Development of synovial joints. Birth Defects Research. Part C, Embryo Today 69: 144 155.
3. Boivin, G., Morel, G., Lian, J.B., Anthoine-Terrier, C., Dubois, P.M. Meunier, P.J. (1990) Localization of endogenous osteocalcin in neonatal rat bone and its absence in articular cartilage: effect of warfarin treatment. Virchows Archiv. A, Pathological Anatomy and Histopathology 417: 505 512.
4. Boyne, P.J., Marx, R.E., Nevins, M., Triplett, G., Lazaro, E., Lilly, L.C., Alder, M. Nummikoski, P. (1997) A feasibility study evaluating rhBMP-2/absorbable collagen sponge for maxillary sinus floor augmentation. International Journal of Periodontics and Restorative Dentistry 17: 11 25. (Pubitemid 127499619)
5. Buemi, M., Galeano, M., Sturiale, A., Ientile, R., Crisafulli, C., Parisi, A., Catania, M., Calapai, G., Impala, P., Aloisi, C., Squadrito, F., Altavilla, D., Bitto, A., Tuccari, G. Frisina, N. (2004) Recombinant human erythropoietin stimulates angiogenesis and healing of ischemic skin wounds. Shock 22: 169 173. (Pubitemid 40228196)
6. Buxton, P., Edwards, C., Archer, C.W. Francis-West, P. (2001) Growth/differentiation factor-5 (GDF-5) and skeletal development. Journal of Bone and Joint Surgery. American Volume 83-A (Suppl. 1): S23 S30.
7. Chang, S.C., Hoang, B., Thomas, J.T., Vukicevic, S., Luyten, F.P., Ryba, N.J., Kozak, C.A., Reddi, A.H. Moos Jr., M. (1994) Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development. Journal of Biological Chemistry 269: 28227 28234.
8. Cochran, D.L., Schenk, R., Buser, D., Wozney, J.M. Jones, A.A. (1999) Recombinant human bone morphogenetic protein-2 stimulation of bone formation around endosseous dental implants. Journal of Periodontology 70: 139 150.
9. Donath, K. (1985) The diagnostic value of the new method for the study of undecalcified bones and teeth with attached soft tissue (Säge-Schliff (sawing and grinding) technique). Pathology Research and Practice 179: 631 633.
10. Eyre-Brook, A.L. (1984) The periosteum: its function reassessed. Clinical Orthopaedics and Related Research 189: 300 307.
11. Gallop, P.M., Lian, J.B. Hauschka, P.V. (1980) Carboxylated calcium-binding proteins and vitamin K. New England Journal of Medicine 302: 1460 1466.
12. Gruber, R.M., Ludwig, A., Merten, H.A., Achilles, M., Poehling, S. Schliephake, H. (2008) Sinus floor augmentation with recombinant human growth and differentiation factor-5 (rhGDF-5): a histological and histomorphometric study in the Goettingen miniature pig. Clinical Oral Implants Research 19: 522 529.
13. Haroon, Z.A., Hettasch, J.M., Lai, T.S., Dewhirst, M.W. Greenberg, C.S. (1999) Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. Faseb Journal 13: 1787 1795.
14. Hauschka, P.V., Lian, J.B., Cole, D.E. Gundberg, C.M. (1989) Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiological Reviews 69: 990 1047.
15. Hockers, T., Abensur, D., Valentini, P., Legrand, R. Hämmerle, C.H. (1999) The combined use of bioresorbable membranes and xenografts or autografts in the treatment of bone defects around implants. A study in beagle dogs. Clinical Oral Implants Research 10: 487 498.
16. Howell, T.H., Fiorellini, J., Jones, A., Alder, M., Nummikoski, P., Lazaro, M., Lilly, L. Cochran, D. (1997) A feasibility study evaluating rhBMP-2/absorbable collagen sponge device for local alveolar ridge preservation or augmentation. International Journal of Periodontics and Restorative Dentistry 17: 124 139.
17. Hughes, F.J., Turner, W., Belibasakis, G. Martuscelli, G. (2006) Effects of growth factors and cytokines on osteoblast differentiation. Periodontology 2000 41: 48 72.
18. Hyun, S.J., Han, D.K., Choi, S.H., Chai, J.K., Cho, K.S., Kim, C.K. Kim, C.S. (2005) Effect of recombinant human bone morphogenetic protein-2, -4, and -7 on bone formation in rat calvarial defects. Journal of Periodontology 76: 1667 1674.
19. Inoda, H., Yamamoto, G. Hattori, T. (2004) Histological investigation of osteoinductive properties of rh-BMP2 in a rat calvarial bone defect model. Journal of Craniomaxillofacial Surgery 32: 365 369.
20. Jensen, S.S., Yeo, A., Dard, M., Hunziker, E., Schenk, R. Buser, D. (2007) Evaluation of a novel biphasic calcium phosphate in standardized bone defects: a histologic and histomorphometric study in the mandibles of minipigs. Clinical Oral Implants Research 18: 752 760.
21. Jovanovic, S.A., Hunt, D.R., Bernard, G.W., Spiekermann, H., Wozney, J.M. Wikesjö, U.M. (2007) Bone reconstruction following implantation of rhBMP-2 and guided bone regeneration in canine alveolar ridge defects. Clinical Oral Implants Research 18: 224 230.
22. Jung, R.E., Glauser, R., Scharer, P., Hämmerle, C.H., Sailer, H.F. Weber, F.E. (2003) Effect of rhBMP-2 on guided bone regeneration in humans. Clinical Oral Implants Research 14: 556 568.
23. Jung, R.E., Thoma, D.S. Hämmerle, C.H. (2008) Assessment of the potential of growth factors for localized alveolar ridge augmentation: a systematic review. Journal of Clinical Periodontology 35 (Suppl.): 255 281.
24. Kuniyasu, H., Hirose, Y., Ochi, M., Yajima, A., Sakaguchi, K., Murata, M. Pohl, J. (2003) Bone augmentation using rhGDF-5-collagen composite. Clinical Oral Implants Research 14: 490 499.
25. Lee, Y.M., Nam, S.H., Seol, Y.J., Kim, T.I., Lee, S.J., Ku, Y., Rhyu, I.C., Chung, C.P., Han, S.B. Choi, S.M. (2003) Enhanced bone augmentation by controlled release of recombinant human bone morphogenetic protein-2 from bioabsorbable membranes. Journal of Periodontology 74: 865 872.
26. Long, M.W., Robinson, J.A., Ashcraft, E.A. Mann, K.G. (1995) Regulation of human bone marrow-derived osteoprogenitor cells by osteogenic growth factors. Journal of Clinical Investigation 95: 881 887.
27. Nishitoh, H., Ichijo, H., Kimura, M., Matsumoto, T., Makishima, F., Yamaguchi, A., Yamashita, H., Enomoto, S. Miyazono, K. (1996) Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5. Journal of Biological Chemistry 271: 21345 21352. (Pubitemid 26292996)
28. Poehling, S., Pippig, S.D., Hellerbrand, K., Siedler, M., Schutz, A. Dony, C. (2006) Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model. Journal of Periodontology 77: 1582 1590.
29. Raida, M., Clement, J.H., Leek, R.D., Ameri, K., Bicknell, R., Niederwieser, D. Harris, A.L. (2005) Bone morphogenetic protein 2 (BMP-2) and induction of tumor angiogenesis. Journal of Cancer Research and Clinical Oncology 131: 741 750.
30. Reddi, A.H. (1998) Role of morphogenetic proteins in skeletal tissue engineering and regeneration. Nature Biotechnology 16: 247 252.
31. Rickard, D.J., Kassem, M., Hefferan, T.E., Sarkar, G., Spelsberg, T.C. Riggs, B.L. (1996) Isolation and characterization of osteoblast precursor cells from human bone marrow. Journal of Bone and Mineral Research 11: 312 324.
32. Sandhu, H.S., Kanim, L.E., Kabo, J.M., Toth, J.M., Zeegen, E.N., Liu, D., Delamarter, R.B. Dawson, E.G. (1996) Effective doses of recombinant human bone morphogenetic protein-2 in experimental spinal fusion. Spine 21: 2115 2122.
33. Schenk, R.K., Olah, A.J. Herrmann, W. (1984) Preparation of calcified tissues for light microscopy. In: Dickson, G.R., ed. Methods of Calcified Tissue Preparation, 1 56. Amsterdam: Elsevier.
34. Schlegel, K.A., Lang, F.J., Donath, K., Kulow, J.T. Wiltfang, J. (2006) The monocortical critical size bone defect as an alternative experimental model in testing bone substitute materials. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology 102: 7 13.
35. Schwarz, F., Sager, M., Ferrari, D., Herten, M., Wieland, M. Becker, J. (2008a) Bone regeneration in dehiscence-type defects at non-submerged and submerged chemically modified (SLActive) and conventional SLA titanium implants: an immunohistochemical study in dogs. Journal of Clinical Periodontology 35: 64 75.
36. Schwarz, F., Rothamel, D., Herten, M., Wustefeld, M., Sager, M., Ferrari, D. Becker, J. (2008b) Immunohistochemical characterization of guided bone regeneration at a dehiscence-type defect using different barrier membranes: an experimental study in dogs. Clinical Oral Implants Research 19: 402 415.
37. Schwarz, F., Rothamel, D., Herten, M., Ferrari, D., Sager, M. Becker, J. (2008c) Lateral ridge augmentation using particulated or block bone substitutes biocoated with rhGDF-5 and rhBMP-2: an immunohistochemical study in dogs. Clinical Oral Implants Research 19: 642 652.
38. Sena, K., Morotome, Y., Baba, O., Terashima, T., Takano, Y. Ishikawa, I. (2003) Gene expression of growth differentiation factors in the developing periodontium of rat molars. Journal of Dental Research 82: 166 171.
39. Settle Jr., S.H., Rountree, R.B., Sinha, A., Thacker, A., Higgins, K. Kingsley, D.M. (2003) Multiple joint and skeletal patterning defects caused by single and double mutations in the mouse Gdf6 and Gdf5 genes. Development Biology 254: 116 130.
40. Sigurdsson, T.J., Fu, E., Tatakis, D.N., Rohrer, M.D. Wikesjö, U.M. (1997) Bone morphogenetic protein-2 for peri-implant bone regeneration and osseointegration. Clinical Oral Implants Research 8: 367 374.
41. Skawina, A. Gorczyca, W. (1984) The role of nutrient and periosteal blood vessels in the vascularization of the cortex of shafts of the long bones in human fetuses. Folia Morphologica (Warsaw) 43: 159 164.
42. Tatakis, D.N., Koh, A., Jin, L., Wozney, J.M., Rohrer, M.D. Wikesjö, U.M. (2002) Peri-implant bone regeneration using recombinant human bone morphogenetic protein-2 in a canine model: a dose-response study. Journal of Periodontal Research 37: 93 100.
43. Urist, M.R. (1965) Bone: formation by autoinduction. Science 150: 893 899.
44. Verna, C., Bosch, C., Dalstra, M., Wikesjö, U.M. Trombelli, L. (2002) Healing pattern in calvarial bone defects following guided bone regeneration in rats. Journal of Clinical Periodontology 29: 865 870.
45. von Arx, T., Cochran, D.L., Hermann, J.S., Schenk, R.K. Buser, D. (2001) Lateral ridge augmentation using different bone fillers and barrier membrane application. A histologic and histomorphometric pilot study in the canine mandible. Clinical Oral Implants Research 12: 260 269.
46. Wang, E.A., Rosen, V., D'Alessandro, J.S., Bauduy, M., Cordes, P., Harada, T., Israel, D.I., Hewick, R.M., Kerns, K.M., LaPan, P., Luxenberg, D.P., McQuaid, D., Moutsatsos, I.K., Nove, J. Wozney, J.M. (1990) Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences of the United States of America 87: 2220 2224.
47. Wikesjö, U.M., Guglielmoni, P., Promsudthi, A., Cho, K.S., Trombelli, L., Selvig, K.A., Jin, L. Wozney, J.M. (1999) Periodontal repair in dogs: effect of rhBMP-2 concentration on regeneration of alveolar bone and periodontal attachment. Journal of Clinical Periodontology 26: 392 400.
48. Wozney, J.M., Rosen, V., Celeste, A.J., Mitsock, L.M., Whitters, M.J., Kriz, R.W., Hewick, R.M. Wang, E.A. (1988) Novel regulators of bone formation: molecular clones and activities. Science 242: 1528 1534.
49. Yoshimoto, T., Yamamoto, M., Kadomatsu, H., Sakoda, K., Yonamine, Y. Izumi, Y. (2006) Recombinant human growth/differentiation factor-5 (rhGDF-5) induced bone formation in murine calvariae. Journal of Periodontal Research 41: 140 147.
50. Zeng, Q., Li, X., Beck, G., Balian, G. Shen, F.H. (2007) Growth and differentiation factor-5 (GDF-5) stimulates osteogenic differentiation and increases vascular endothelial growth factor (VEGF) levels in fat-derived stromal cells in vitro. Bone 40: 374 378.
51. Zitzmann, N.U., Naef, R. Scharer, P. (1997) Resorbable versus nonresorbable membranes in combination with Bio-Oss for guided bone regeneration. International Journal of Oral and Maxillofacial Implants 12: 844 852.