NC2213: A novel methionine aminopeptidase 2 inhibitor in human colon cancer HT29 cells

Molecular Cancer

Volumn 8, Issue , 2009, Pages 65-

  Selvakumar, Ponniah ^a,b   Lakshmikuttyamma, Ashakumary ^a,b   Das, Umashankar ^c   Pati, Hari N ^c   Dimmock, Jonathan R ^c   Sharma, Rajendra K ^a,b  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b SASKATCHEWAN CANCER AGENCY   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

METHIONYL AMINOPEPTIDASE 2; NC 2213; PIPERIDONE DERIVATIVE; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL PROLIFERATION; CELL STRAIN HT29; COLON CANCER; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; ENZYME INHIBITION; GROWTH INHIBITION; HUMAN; HUMAN CELL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

AMINOPEPTIDASES; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE; CELL DIVISION; CELL PROLIFERATION; COLONIC NEOPLASMS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; G2 PHASE; GLYCOPROTEINS; HT29 CELLS; HUMANS; MOLECULAR STRUCTURE; PHOSPHORYLATION; PIPERIDONES; PROTO-ONCOGENE PROTEINS PP60(C-SRC); SULFONIC ACIDS;

EID: 70350099250     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-8-65     Document Type: Article

References (37)

1. Jackson R, Hunter T. Role of methionine in the initiation of haemoglobin synthesis. Nature 1970, 227:672-676. 10.1038/227672a0, 5432061.
2. Solbiati J, Chapman-Smith A, Miller JL, Miller CG, Cronan JE. Processing of the N termini of nascent polypeptide chains requires deformylation prior to methionine removal. J Mol Biol 1999, 290:607-614. 10.1006/jmbi.1999.2913, 10395817.
3. Selvakumar P, Lakshmikuttyamma A, Dimmock JR, Sharma RK. Methionine aminopeptidase 2 and cancer. Biochim Biophys Acta 2006, 1765:148-154.
4. Selvakumar P, Lakshmikuttyamma A, Shrivastav A, Das SB, Dimmock JR, Sharma RK. Potential role of N-myristoyltransferase in cancer. Prog Lipid Res 2007, 46:1-36. 10.1016/j.plipres.2006.05.002, 16846646.
5. Datta R, Choudhury P, Ghosh A, Datta B. A glycosylation site, 60SGTS63, of p67 is required for its ability to regulate the phosphorylation and activity of eukaryotic initiation factor 2 alpha. Biochemistry 2003, 42:5453-5460. 10.1021/bi020699g, 12731887.
6. Datta B, Datta R. Induction of apoptosis due to lowering the level of eukaryotic initiation factor 2-associated protein, p67, from mammalian cells by antisense approach. Exp Cell Res 1999, 246:376-383. 10.1006/excr.1998.4313, 9925753.
7. Sheen IS, Jeng KS, Jeng WJ, Jeng CJ, Wang YC, Gu SL, Tseng SY, Chu CM, Lin CH, Chang KM. Fumagillin treatment of hepatocellular carcinoma in rats: an in vivo study of antiangiogenesis. World J Gastroenterol 2005, 11:771-777.
8. Catalano A, Romano M, Robuffo I, Strizzi L, Procopio A. Methionine aminopeptidase-2 regulates human mesothelioma cell survival: role of Bcl-2 expression and telomerase activity. Am J Pathol 2001, 159:721-731. 1850571, 11485930.
9. Kanno T, Endo H, Takeuchi K, Morishita Y, Fukayama M, Mori S. High expression of methionine aminopeptidase type 2 in germinal center B cells and their neoplastic counterparts. Lab Invest 2002, 82:893-901.
10. Bo H, Ghazizadeh M, Shimizu H, Kurihara Y, Egawa S, Moriyama Y, Tajiri T, Kawanami O. Effect of ionizing irradiation on human esophageal cancer cell lines by cDNA microarray gene expression analysis. J Nippon Med Sch 2004, 71:172-180. 10.1272/jnms.71.172, 15226608.
11. Morowitz MJ, Barr R, Wang Q, King R, Rhodin N, Pawel B, Zhao H, Erickson SA, Sheppard GS, Wang J, Maris JM, Shusterman S. Methionine aminopeptidase 2 inhibition is an effective treatment strategy for neuroblastoma in preclinical models. Clin Cancer Res 2005, 11:2680-2685. 10.1158/1078-0432.CCR-04-1917, 15814649.
12. Selvakumar P, Lakshmikuttyamma A, Kanthan R, Kanthan SC, Dimmock JR, Sharma RK. High expression of methionine aminopeptidase 2 in human colorectal adenocarcinomas. Clin Cancer Res 2004, 10:2771-2775. 10.1158/1078-0432.CCR-03-0218, 15102683.
13. Pati HN, Das U, Quail JW, Kawase M, Sakagami H, Dimmock JR. Cytotoxic 3,5-bis(benzylidene)piperidin-4-ones and N-acyl analogs displaying selective toxicity for malignant cells. Eur J Med Chem 2008, 43:1-7. 10.1016/j.ejmech.2007.03.010, 17499885.
14. Tucker LA, Zhang Q, Sheppard GS, Lou P, Jiang F, McKeegan E, Lesniewski R, Davidsen SK, Bell RL, Wang J. Ectopic expression of methionine aminopeptidase-2 causes cell transformation and stimulates proliferation. Oncogene 2008, 27:3967-3976. 10.1038/onc.2008.14, 18264137.
15. Abe J, Zhou W, Takuwa N, Taguchi J, Kurokawa K, Kumada M, Takuwa Y. A fumagillin derivative angiogenesis inhibitor, AGM-inhibits activation of cyclin-dependent kinases and phosphorylation of retinoblastoma gene product but not protein tyrosyl phosphorylation or protooncogene expression in vascular endothelial cells. Cancer Res 1470, 54:3407-3412.
16. Adams BK, Ferstl EM, Davis MC, Herold M, Kurtkaya S, Camalier RF, Hollingshead MG, Kaur G, Sausville EA, Rickles FR, Snyder JP, Liotta DC, Shoji M. Synthesis and biological evaluation of novel curcumin analogs as anti-cancer and anti-angiogenesis agents. Bioorg Med Chem 2004, 12:3871-3883. 10.1016/j.bmc.2004.05.006, 15210154.
17. Hu X, Dang Y, Tenney K, Crews P, Tsai CW, Sixt KM, Cole PA, Liu JO. Regulation of c-Src nonreceptor tyrosine kinase activity by bengamide A through inhibition of methionine aminopeptidases. Chem Biol 2007, 14:764-774. 10.1016/j.chembiol.2007.05.010, 17656313.
18. Dezube BJ, Von Roenn JH, Holden-Wiltse J, Cheung TW, Remick SC, Cooley TP, Moore J, Sommadossi JP, Shriver SL, Suckow CW, Gill PS. Fumagillin analog in the treatment of Kaposi's sarcoma: a phase I AIDS Clinical Trial Group study. J Clin Oncol 1998, 16:1444-1449.
19. Kruger EA, Figg WD. TNP-470: an angiogenesis inhibitor in clinical development for cancer. Expert Opin Investig Drugs 2000, 9:1383-1396. 10.1517/13543784.9.6.1383, 11060750.
20. Kudelka AP, Levy T, Verschraegen CF, Edwards CL, Piamsomboon S, Termrungruanglert W, Freedman RS, Kaplan AL, Kieback DG, Meyers CA, Jaeckle KA, Loyer E, Steger M, Mante R, Mavligit G, Killian A, Tang RA, Gutterman JU, Kavanagh JJ. A phase I study of TNP-470 administered to patients with advanced squamous cell cancer of the cervix. Clin Cancer Res 1997, 3:1501-1505.
21. Griffith EC, Su Z, Niwayama S, Ramsay CA, Chang YH, Liu JO. Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. Proc Natl Acad Sci USA 1998, 95:15183-15188. 10.1073/pnas.95.26.15183, 28017, 9860943.
22. Antoine N, Greimers R, De Roanne C, Kusaka M, Heinen E, Simar LJ, Castronovo V. AGM a potent angiogenesis inhibitor, prevents the entry of normal but not transformed endothelial cells into the G1 phase of the cell cycle. Cancer Res 1470, 54:2073-2076.
23. Kusaka M, Sudo K, Matsutani E, Kozai Y, Marui S, Fujita T, Ingber D, Folkman J. Cytostatic inhibition of endothelial cell growth by the angiogenesis inhibitor TNP-470 [AGM-1470]. Br J Cancer 1994, 69:212-216.
24. Wang J, Lou P, Henkin J. Selective inhibition of endothelial cell proliferation by fumagillin is not due to differential expression of methionine aminopeptidases. J Cell Biochem 2000, 77:465-473. 10.1002/(SICI)1097-4644(20000601)77:3<465::AID-JCB11>3.0.CO;2-M, 10760954.
25. Yeh JR, Mohan R, Crews CM. The antiangiogenic agent TNP-470 requires p53 and p21CIP/WAF for endothelial cell growth arrest. Proc Natl Acad Sci USA 2000, 97:12782-12787. 10.1073/pnas.97.23.12782, 18841, 11070090.
26. Zhang Y, Griffith EC, Sage J, Jacks T, Liu JO. Cell cycle inhibition by the anti-angiogenic agent TNP-470 is mediated by p53 and p21WAF1/CIP1. Proc Natl Acad Sci USA 2000, 97:6427-6432. 10.1073/pnas.97.12.6427, 18619, 10841547.
27. Selvakumar P, Lakshmikuttyamma A, Lawman Z, Bonham K, Dimmock JR, Sharma RK. Expression of methionine aminopeptidase 2, N-myristoyltransferase, and N-myristoyltransferase inhibitor protein 71 in HT29. Biochem Biophys Res Commun 2004, 322:1012-1017. 10.1016/j.bbrc.2004.08.021, 15336565.
28. Rajala RV, Radhi JM, Kakkar R, Datla RS, Sharma RK. Increased expression of N-myristoyltransferase in gallbladder carcinomas. Cancer 2000, 88:1992-1999. 10.1002/(SICI)1097-0142(20000501)88:9<1992::AID-CNCR3>3.0.CO;2-G, 10813869.
29. Yu HG, Yu LL, Yang Y, Luo HS, Yu JP, Meier JJ, Schrader H, Bastian A, Schmidt WE, Schmitz F. Increased expression of RelA/nuclear factor-kappa B protein correlates with colorectal tumorigenesis. Oncology 2003, 65:37-45. 10.1159/000071203, 12837981.
30. Valassiadou KE, Stefanaki K, Tzardi M, Datseris G, Georgoulias V, Melissas J, Tsiftsis DD, Delides G, Kanavaros P. Immunohistochemical expression of p53, bcl-2, mdm2 and waf1/p21 proteins in colorectal adenocarcinomas. Anticancer Res 1997, 17:2571-2576.
31. Reinacher-Schick A, Schoeneck A, Graeven U, Schwarte-Waldhoff I, Schmiegel W. Mesalazine causes a mitotic arrest and induces caspase-dependent apoptosis in colon carcinoma cells. Carcinogenesis 2003, 24:443-451. 10.1093/carcin/24.3.443, 12663503.
32. Chen T, Yang I, Irby R, Shain KH, Wang HG, Quackenbush J, Coppola D, Cheng JQ, Yeatman TJ. Regulation of caspase expression and apoptosis by adenomatous polyposis coli. Cancer Res 2003, 63:4368-4374.
33. Carmichael J, DeGraff WG, Gazdar AF, Minna JD, Mitchell JB. Evaluation of a tetrazolium-based semiautomated colorimetric assay: assessment of chemosensitivity testing. Cancer Res 1987, 47:936-942.
34. Lakshmikuttyamma A, Pastural E, Takahashi N, Sawada K, Sheridan DP, DeCoteau JF, Geyer CR. Bcr-Abl induces autocrine IGF-1 signaling. Oncogene 2008, 27:3831-3844. 10.1038/onc.2008.8, 18246120.
35. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685. 10.1038/227680a0, 5432063.
36. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979, 76:4350-4354. 10.1073/pnas.76.9.4350, 411572, 388439.
37. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976, 72:248-254. 10.1016/0003-2697(76)90527-3, 942051.