Simvastatin attenuates intestinal ischaemia//reperfusion-induced injury in rat

Folia Morphologica

Volumn 68, Issue 3, 2009, Pages 156-162

  Hajipour, B ^a   Somi, M H ^b   Saberifar, F ^a   Hemmati, M R ^a   Asl, N A ^b   Moein, A ^a   Vatankhah, A M ^c   Nourazar, A R ^a   Nasirizade, M R ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Injury; Ischaemia reperfusion; Simvastatin intestine

Indexed keywords

GLUTATHIONE PEROXIDASE; MALONALDEHYDE; SIMVASTATIN; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY CLAMP; ARTERY LIGATION; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; INTESTINE INJURY; INTESTINE ISCHEMIA; MALE; NONHUMAN; RAT; REPERFUSION INJURY; SUPERIOR MESENTERIC ARTERY;

ANIMALS; ANTIOXIDANTS; DISEASE MODELS, ANIMAL; DOWN-REGULATION; FREE RADICAL SCAVENGERS; GLUTATHIONE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INTESTINAL DISEASES; ISCHEMIA; MALE; MALONDIALDEHYDE; OXIDATIVE STRESS; RATS; RATS, WISTAR; REGIONAL BLOOD FLOW; REPERFUSION INJURY; SIMVASTATIN; SUPEROXIDE DISMUTASE; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS; RATTUS NORVEGICUS;

EID: 70350043303     PISSN: 00155659     EISSN: 16443284     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Aldemir M, Gürel A, Büyükbayram H, Taçyildiz I (2003) The effects of glucose-insulin-potassium solution and BN 52021 in intestinal ischaemia-reperfusion injury. Vasc Endovascular Surg, 37: 345-351. (Pubitemid 37163410)
2. Ballabeni V, Barocelli E, Bertoni S, Impicciatore M (2002) Alterations of intestinal motor responsiveness in a model of mild mesenteric ischaemia/reperfusion in rats. Life Sci, 71: 2025-2035. (Pubitemid 34908007)
3. Balogh N, Krausz F, Lévai P, Ribiczeyné PS, Vajdovich P, Gaál T (2002) Effect of deferoxamine and L-arginine treatment on lipid peroxidation in an intestinal ischaemia-reperfusion model in rats. Acta Vet Hung, 50: 343-356. (Pubitemid 34983807)
4. Camara CR, Guzman FJ, Barrera EA, Cabello AJ, Garcia A, Fernandez NE, Caballero E, Ancer J (2008) Ketamine anesthesia reduces intestinal ischaemia/reperfusion injury in rats. World J Gastroenterol, 14: 5192-5196.
5. Carden DL, Granger DN (2000) Pathophysiology of ischaemia-reperfusion injury. J Pathol, 190: 255-266.
6. Carneado J, Alvarez de Sotomayor M, Perez-Guerrero C, Jimenez L, Herrera MD, Pamies E, Martin-Sanz MD, Stiefel P, Miranda M, Bravo L, Marhuenda E (2002) Simvastatin improves endothelial function in spontaneously hypertensive rats through a superoxide dismutase mediated antioxidant effect. J Hypertens, 20: 429-437. (Pubitemid 34913742)
7. Cerqueira NF, Hussni CA, Yoshida WB (2005) Pathophysiology of mesenteric ischemia/reperfusion. Acta Cir Bras, 20: 336-343.
8. Chang JX, Chen S, Ma LP, Jiang LY, Chen JW, Chang RM, Wen LQ, Wu W, Jiang ZP, Huang ZT (2005) Functional and morphological changes of the gut barrier during the restitution process after hemorrhagic shock. World J Gastroenterol, 11: 5485-5491. (Pubitemid 41684706)
9. Chang RW, Chang JB, Longo WE (2006) Update in management of mesenteric ischemia. World J Gastroenterol, 12: 3243-3247.
10. Chen Y, Lui VC, Rooijen NV, Tam PK (2004) Depletion of intestinal resident macrophages prevents ischaemia/ reperfusion injury in gut. Gut, 53: 1772-1780.
11. Collard CD, Gelman S (2001) Pathophysiology, clinical manifestations, and prevention of ischemia-reperfusion injury. Anesthesiology, 94: 1133-1138. (Pubitemid 32506143)
12. Dibazar F, Hajipour B, Hosseinian MM, Hemmati MR, Ghandiha A (2008) Simvastatin decreases hepatic ischaemia/reperfusion-induced liver and lung injury in rats. Folia Morphol, 67: 231-235.
13. Dinarello CA (1991) Interleukin-1 and interleukin-1 antagonism. Blood, 77: 1627-1652.
14. Emre A, Bayram O, Salman B, Ercan S, Anadol Z, Akin O (2008) Sodium nitroprusside as a nitric oxide donor in a rat intestinal ischemia-reperfusion model. Clinics, 63: 91-96.
15. Grewal HP, Mohey el Din A, Gaber L, Kotb M, Gaber AO (1994) Amelioration of the physiologic and biochemical changes of acute pancreatitis using an anti-TNF- alpha polyclonal antibody. Am J Surg, 167: 214-218.
16. Guven A, Tunc T, Topal T, Kul M, Korkmaz A, Gundogdu G, Onguru O, Ozturk H (2008) Alpha-lipoic acid and ebselen prevent ischemia/reperfusion injury in the rat intestine. Surg Today, 38: 1029-1035.
17. Hassoun HT, Kozar RA, Kone BC, Safi HJ, Moore FA (2002) Intraischemic hypothermia differentially modulates oxidative stress proteins during mesenteric ischemia/reperfusion. Surgery, 132: 369-376.
18. Hassoun HT, Weisbrodt NW, Mercer DW, Kozar RA, Moody FG, Moore FA (2001) Inducible nitric oxide synthase mediates gut ischemia/reperfusion-induced ileus only after severe insults. J Surg Res, 97: 150-154.
19. Higa OH, Parra ER, Ab'Saber AM, Farhat C, Higa R, Capelozzi VL (2007) Protective effects of ascorbic acid pretreatment in a rat model of intestinal ischemia-reperfusion injury: a histomorphometric study. Clinics, 62: 315-320.
20. Higuchi S, Wu R, Zhou M, Marini CP, Ravikumar TS, Wang P (2008) Gut hyperpermiability after ischemia and reperfusion: attenuation with adrenomedullin and its binding protein treatment. Int J Clin Exp Pathol, 1: 409-418.
21. Kagami S, Kanari H, Suto A, Fujiwara M, Ikeda K, Hirose K, Watanabe N, Iwamoto I, Nakajima H (2008) HMG-CoA reductase inhibitor simvastatin inhibits proinflammatory cytokine production from murine mast cells. Int Arch Allergy Immunol, 1461: 61-66.
22. Kalia N, Brown NJ, Hopkinson K, Stephenson TJ, Wood RF, Pockley AG (2002) FK409 inhibits both local and remote organ damage after intestinal ischaemia. J Pathol, 197: 595-602. (Pubitemid 34906556)
23. Kaya H, Sezik M, Ozkaya O, Dittrich R, Siebzehnrubl E, Wildt L (2004) Lipid peroxidation at various estradiol concentrations in human circulation during ovarian stimulation with exogenous gonadotropins. Horm Metab Res, 36: 693-695. (Pubitemid 39486969)
24. Khanna A, Rossman JE, Fung HL, Caty MG (2000) Attenuated nitric oxide synthase activity and protein expression accompany intestinal ischemia/reperfusion injury in rats. Biochem Biophys Res Commun, 269: 160-164. (Pubitemid 30440271)
25. Ladipo JK, Seidel SA, Bradshaw LA, Halter S, Wikswo JP Jr, Richards WO (2003) Histopathologic changes during mesenteric ischaemia and reperfusion. West Afr J Med, 22: 59-62. (Pubitemid 37266072)
26. Liaw WJ, Chen TH, Lai ZZ, Chen SJ, Chen A, Tzao C, Wu JY, Wu CC (2005) Effects of a membrane-permeable radical scavenger, Tempol, on intraperitoneal sepsis-induced organ injury in rats. Shock, 23: 88-96. (Pubitemid 40083033)
27. Liu KX, Rinne T, He W, Wang F, Xia Z (2007) Propofol attenuates intestinal mucosa injury induced by intestinal ischemia-reperfusion in the rat. Can J Anaesth, 54: 366-374. (Pubitemid 46902016)
28. Lodato RF, Khan AR, Zembowicz MJ, Weisbrodt NW, Pressley TA, Li YF, Lodato JA, Zembowicz A, Moody FG (1999) Roles of IL-1 and TNF in the decreased ileal muscle contractility induced by lipopolysaccharide. Am J Physiol, 276: 1356-1362.
29. Mallick IH, Yang W, Winslet MC, Seifalian AM (2004) Ischemia-reperfusion injury of the intestine and protective strategies against injury. Dig Dis Sci, 49: 1359-1377. (Pubitemid 39273608)
30. Mojís J, Hvisèová K, Germanová D, Bukovièová D, Mirossay L (2001) Protective effect of quercetin on ischemia/ reperfusion-induced gastric mucosal injury in rats. Physiol Res, 50: 501-506. (Pubitemid 33044222)
31. Moore-Olufemi SD, Kozar RA, Moore FA, Sato N, Hassoun HT, Cox CS Jr, Kone BC (2005) Ischemic preconditioning protects against gut dysfunction and mucosal injury after ischemia/reperfusion injury. Shock, 23: 258-263. (Pubitemid 40293827)
32. Nagira M, Tomita M, Mizuno S, Kumata M, Ayabe T, Hayashi M (2006) Ischemia/reperfusion injury in the monolayers of human intestinal epithelial cell line caco-2 and its recovery by antioxidants. Drug Metab Pharmacokinet, 21: 230-237.
33. Nakao M, Hirata Y, Taguchi T, Yamada T, Rahman MS, Suita S (1996) Energy metabolism and xanthine oxidase enzyme system during ischemia reperfusion in rat small intestine. Transplant Proc, 28: 2614. (Pubitemid 26339418)
34. Nalini S, Mathan MM, Balasubramanian KA (1993) Oxygen free radical induced damage during intestinal ischemia/reperfusion in normal and xanthine oxidase deficient rats. Mol Cell Biochem, 124: 59-66. (Pubitemid 23235811)
35. Noda T, Iwakiri R, Fujimoto K, Matsuo S, Aw TY (1998) Programmed cell death induced by ischaemia-reperfusion in rat intestinal mucosa. Am J Physiol, 274: 270-276. (Pubitemid 128731737)
36. Ozacmak VH, Sayan H, Igdem AA, Cetin A, Ozacmak ID (2007) Attenuation of contractile dysfunction by atorvastatin after intestinal ischemia reperfusion injury in rats. Eur J Pharmacol, 562: 138-147. (Pubitemid 46466760)
37. Paglia DE, Valentine WN (1967) Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med, 70: 158-169.
38. Park SY, Lee JS, Ko YJ, Kim AR, Choi MK, Kwak MK, Choi HG, Yong CS, Kim JA (2008) Inhibitory effect of simvastatin on the TNF-alpha- and angiotensin II-induced monocyte adhesion to endothelial cells is mediated through the suppression of geranylgeranyl isoprenoid-dependent ROS generation. Arch Pharm Res, 31: 195-204.
39. Pawlik WW, Thor P, Sendur R, Biernat J, Koziol R, Wasowicz P (1998) Myoelectric bowel activity in ischemia/reperfusion damage. Role sensory neurons. J Physiol Pharmacol, 49: 543-551. (Pubitemid 29024372)
40. Pedersen TR, Wilhelmsen L, Faergeman O, Strandberg TE, Thorgeirsson G, Troedsson L, Kristianson J, Berg K, Cook TJ, Haghfelt T, Kjekshus J, Miettinen T, Olsson AG, Pyörälä K, Wedel H (2000) Follow-up study of patients randomized in the Scandinavian simvastatin survival study (4S) of cholesterol lowering. Am J Cardiol, 86: 257-262. (Pubitemid 30462217)
41. Poussios D, Andreadou I, Papalois A, Rekka E, Gavalakis N, Aroni K, Kourounakis PN, Fotiadis C, Sechas MN (2003) Protective effect of a novel antioxidant non-steroidal anti-inflammatory agent (compound IA) on intestinal viability after acute mesenteric ischemia and reperfusion. Eur J Pharmacol, 465: 275-280.
42. Riaz AA, Wan MX, Schäfer T, Dawson P, Menger MD, Jeppsson B, Thorlacius H (2002) Allopurinol and superoxide dismutase protect against leucocyte-endothelium interactions in a novel model of colonic ischaemia- reperfusion. Br J Surg, 89: 1572-1580. (Pubitemid 35404328)
43. Rossoni G, Manfredi B, Civelli M, Berti F, Razzetti R (2008) Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats. Eur J Pharmacol, 587: 224-230.
44. Sakrak O, Kerem M, Bedirli A, Pasaoglu H, Akyurek N, Ofluoglu E, Gültekin FA (2008) Ergothioneine modulates proinflammatory cytokines and heat shock protein 70 in mesenteric ischemia and reperfusion injury. J Surg Res, 144: 36-42. (Pubitemid 350234966)
45. Sample AK, Czuprynski CJ (1991) Priming and stimulation of bovine neutrophils by recombinant human interleukin-1 alpha and tumor necrosis factor alpha. J Leukoc Biol, 49: 107-115.
46. Saugstad OD (1988) Hypoxanthine as an indicator of hypoxia: Its role in health and disease through free radical production. Pediatr Res, 23: 143.
47. Souza DG, Soares AC, Pinho V, Torloni H, Reis LF, Teixeira MM, Dias AA (2002) Increased mortality and inflammation in tumor necrosis factor-stimulated gene- 14 transgenic mice after ischemia and reperfusion injury. Am J Pathol, 160: 1755-1765. (Pubitemid 34525655)
48. Souza DG, Vieira AT, Pinho V, Sousa LP, Andrade AA, Bonjardim CA, McMillan M, Kahn M, Teixeira MM (2005) NF-kappaB plays a major role during the systemic and local acute inflammatory response following intestinal reperfusion injury. Br J Pharmacol, 145: 246.
49. Souza Neto JL, Araujo Filho I, Rego AC, Dominici VA, Azevedo IM, Egito ES, Brandão-Neto J, Medeiros AC (2006) Effects of simvastatin in abdominal sepsis in rats. Acta Cir Bras, 21: 8-12. (Pubitemid 46239451)
50. Sun Y, Oberley LW, Li Y (1988) A simple method for clinical assay of superoxide dismutase. Clin Chem, 34: 497-500. (Pubitemid 18102175)
51. Teke Z, Kabay B, Ozden A, Yenisey C, Bir F, Demirkan NC, Bicakci T, Erdem E (2008) Effects of tempol, a membrane-permeable radical scavenger, on local and remote organ injuries caused by intestinal ischemia/re perfusion in rats. J Surg Res, 149: 259-271.
52. Todorovic Z, Nesic Z, Stojanović R, Basta-Jovanović G, Radojevic-Skodrić S, Velicković R, Chatterjee PK, Thiemermann C, Prostran M (2008) Acute protective effects of simvastatin in the rat model of renal ischemia- reperfusion injury: it is never too late for the pretreatment. J Pharmacol Sci, 107: 465-470.
53. Tracey KJ, Fong Y, Hesse DG, Manogue KR, Lee AT, Kuo GC, Lowry SF, Cerami A (1987) Anti-cachectin/TNF monoclonal antibodies prevent septic shock during lethal bacteraemia, Nature, 330: 662-664. (Pubitemid 18005583)
54. Ungureanu D, Filip C, Artenie A, Artenie R (2003) Evaluation of simvastatin antioxidant effects. Rev Med Chir Soc Med Nat Iasi, 107: 66-71.
55. Wasowicz W, Neve J, Peretz A (1993) Optimized steps in fluorometric determination of thiobarbituric acid- reactive substances in serum: importance of extraction pH and influence of sample preservation and storage. Clin Chem, 39: 2522-2526. (Pubitemid 24008241)
56. Yamamoto S, Tanabe M, Wakabayashi G, Shimazu M, Matsumoto K, Kitajima M (2001) The role of tumor necrosis factor-alpha and interleukin-1beta in ischaemia-reperfusion injury of the rat small intestine. J Surg Res, 99: 134-141. (Pubitemid 32613970)
57. Zhang H, Slutsky AS, Vincent JL (2000) Oxygen free radicals in ARDS, septic shock, and organ dysfunction. Intensive Care Med, 26: 474-476. (Pubitemid 30301532)