Combined simvastatin-manidipine protect against ischemia-reperfusion injury in isolated hearts from normocholesterolemic rats

European Journal of Pharmacology

Volumn 587, Issue 1-3, 2008, Pages 224-230

  Rossoni, Giuseppe ^a   Manfredi, Barbara ^a   Civelli, Maurizio ^b   Berti, Ferruccio ^a   Razzetti, Roberta ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b CHIESI FARMACEUTICI S P A   (Italy)

Author keywords

Myocardial ischemia reperfusion; Normocholesterolemic rat; Perfused heart; Simvastatin manidipine combination

Indexed keywords

6 OXOPROSTAGLANDIN F1 ALPHA; CREATINE KINASE; LACTATE DEHYDROGENASE; MANIDIPINE; NITRATE; NITRITE; SIMVASTATIN; THROMBOXANE B2; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE MEASUREMENT; CHEMICAL ANALYSIS; CONTROLLED STUDY; CREATINE KINASE BLOOD LEVEL; HEART LEFT VENTRICLE ENDDIASTOLIC PRESSURE; HEART LEFT VENTRICLE FUNCTION; HEART PERFUSION; HEART RATE; ISCHEMIC HEART DISEASE; ISOLATED HEART; LACTATE DEHYDROGENASE BLOOD LEVEL; MALE; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SYMPATHETIC REFLEX; SYSTOLIC BLOOD PRESSURE; UREA CYCLE;

ANIMALS; BLOOD GLUCOSE; BLOOD PRESSURE; CALCIUM CHANNEL BLOCKERS; CHOLESTEROL; CREATINE KINASE; DIHYDROPYRIDINES; EPOPROSTENOL; HEART RATE; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; L-LACTATE DEHYDROGENASE; LIPIDS; MALE; RATS; REPERFUSION INJURY; SIMVASTATIN; THROMBOXANE B2; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 44249090617     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.03.026     Document Type: Article

References (43)

1. Bergmeyer H.U., Rich W., Butter H., Schmidt E., Hillmann G., Kreuz F.H., Stamm D., Lang H., Szasz D., and Laue D. Standardization of methods for estimation of enzyme activity in biological fluids. Z. Klin. Chem. Klin. Biochem. 8 (1970) 658-660
2. Berti F., Rossoni G., Omini C., Daffonchio L., Tondo C., and Cali G. Defibrotide, an antithrombotic substance which prevents myocardial contracture in ischemic rabbit heart. Eur. J. Phamacol. 135 (1987) 375-382
3. Birnbaum Y., Ye Y., Rosanio S., Tavackoli S., Hu Z., and Schwarz E.R. Prostaglandins mediate the cardioprotective effects of atorvastatin against ischemia-reperfusion injury. Cardiovasc. Res. 65 (2005) 345-355
4. Borgers M., Thone F.J., Van Reempts J., and Verheyen F. The role of calcium in cellular dysfunction. Am. J. Emerg. Med. 1 (1983) 154-161
5. Calabrò P., and Yeh E.T. The pleiotropic effects of statins. Curr. Opin. Cardiol. 20 (2005) 541-546
6. de Sotomayor M.A., Perez-Guerrero C., Herrera M.D., Jimenez L., Marin R., Marhuenda E., and Andriantsitohaina R. Improvement of age-related endothelial dysfunction by simvastatin: effect on NO and COX pathways. Br. J. Pharmacol. 146 (2005) 1130-1138
7. Di Napoli P., Antonio Taccardi A., Grilli A., Spina R., Felaco M., Barsotti A., and De Caterina R. Simvastatin reduces reperfusion injury by modulating nitric oxide synthase expression: an ex vivo study in isolated working rat hearts. Cardiovasc. Res. 51 (2001) 283-293
8. Ferdinandy P., and Schulz R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischaemia-reperfusion injury and preconditioning. Br. J. Pharmacol. 138 (2003) 532-543
9. Ferdinandy P., Schulz R., and Baxter G.F. Interaction of cardiovascular risk factors with myocardial ischemia/reperfusion injury, preconditioning, and postconditioning. Pharmacol. Rev. 59 (2007) 418-458
10. Gergely J. Excitation-contraction coupling-cardiac muscle events in the myofilaments. Fed. Proc. 35 (1976) 1283-1287
11. Gurevitch J., Frolkis I., Yuhas Y., Paz Y., Matsa M., Mohr R., and Yakirevich V. Tumor necrosis factor-alpha is released from the isolated heart undergoing ischemia and reperfusion. J. Am. Coll. Cardiol. 28 (1996) 247-252
12. Gurevitch J., Frolkis I., Yuhas Y., Lifschitz-Mercer B., Berger E., Paz Y., Matsa M., Kramer A., and Mohr R. Anti-tumor necrosis factor-alpha improves myocardial recovery after ischemia and reperfusion. J. Am. Coll. Cardiol. 30 (1997) 1554-1561
13. Henry P.D., Schuchleib R., Davis J., Weiss E.S., and Sobel B.E. Myocardial contracture and accumulation of mitochondrial calcium in ischemic rabbit heart. Am. J. Physiol. 233 (1977) H677-H684
14. Hernandez-Perera O., Perez-Sala D., Navarro-Antolin J., Sanchez-Pascula R., Hernandez G., Diaz C., and Lamas S. Effects of 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors, atorvastatin and simvastatin, on the expression of endothelin-1 and endothelial nitric oxide synthase in vascular endothelial cells. J. Clin. Invest. 101 (1998) 2711-2719
15. Hohorst H.J. L-(+)-lactate. In: Bergmeyer H.U. (Ed). Methods of Enzymatic Analysis (1963), Academic Press Inc., New York 215-219
16. Lefer A.M., Campbell B., Shin Y.K., Scalia R., Hayward R., and Lefer D.J. Simvastatin preserves the ischemic-reperfused myocardium in normocholesterolemic rat hearts. Circulation 100 (1999) 178-184
17. Laufs U., and Liao J.K. Post-trascriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J. Biol. Chem. 273 (1998) 24266-24271
18. Liao J.K., and Laufs U. Pleiotropic effects of statins. Annu. Rev. Pharmacol. Toxicol. 45 (2005) 89-118
19. McKeage K., and Scott L.J. Manidipine: a review of its use in the management of hypertension. Drugs 64 (2004) 1923-1940
20. Mital S., Magneson A., Loke K.E., Liao J., Forfia P.R., and Hintze T.H. Simvastatin acts synergistically with ACE inhibitors or amlodipine to decrease oxygen consumption in rat hearts. J. Cardiovasc. Pharmacol. 36 (2000) 248-254
21. Mital S., and Liao J.K. Statins and the myocardium. Semin. Vasc. Med. 4 (2004) 377-384
22. Ogletree M.L., Lefer A.M., Smith J.B., and Nicolau K.C. Studies on the protective effect of prostacyclin in acute myocardial ischemia. Eur. J. Pharmacol. 56 (1979) 95-103
23. Pedersen T.R., Kjekshus J., Pyorala K., Olsson A.G., Cook T.J., Musliner T.A., Tobert J.A., and Haghfelt T. Effect of simvastatin on ischemic signs and symptoms in the Scandinavian simvastatin survival study (4S). Am. J. Cardiol. 81 (1998) 333-335
24. Porstmann T., and Kiessing S.T. Enzyme immunoassay techniques. An overview. J. Immunol. Methods 150 (1992) 5-21
25. Pradelles P., Grassi J., and Maclouf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal. Chem. 57 (1985) 1170-1173
26. Purves R. Optimum numerical integration methods for estimation of area-under-the-curve (AUC) and area-under-the-moment-curve (AUMC). J. Pharmacokinet. Biopharm. 20 (1992) 211-226
27. Roca-Cusachs A., and Triposkiadis F. Antihypertensive effect of manidipine. Drugs 65 (2005) 11-19
28. Rossoni G., Radice S., Bernareggi M., Polvani G.L., Oriani G., Chiesara E., and Berti F. Influence of acetylcysteine on aggravation of ischemic damage in ex vivo hearts of rats exposed to hyperbaric oxygen. Arzneim.-Forsch. 47 (1997) 710-715
29. Rossoni G., De Gennaro Colonna V., Bernareggi M., Polvani G.L., Muller E.E., and Berti F. Protectant activity of hexarelin or growth hormone against postischemic ventricular dysfunction in hearts from aged rats. J. Cardiovasc. Pharmacol. 32 (1998) 260-265
30. Rossoni G., Manfredi B., De Gennaro Colonna V., Brini A.T., Polvani G.L., Clement M.G., and Berti F. Nitric oxide and prostacyclin pathways: an integrated mechanism that limits myocardial infarction progression in anaesthetized rats. Pharmacol. Res. 53 (2006) 359-366
31. Sakaguchi M., Shibata T., Hattori K., Hirai H., Hosono M., Aoyama T., Ikuta T., Bito Y., and Suehiro S. Orally administered benidipine and manidipine prevent ischemia-reperfusion injury in the rat heart. Circ. J. 68 (2004) 241-246
32. Squadrito F., Altavilla D., Zingarelli B., Ioculano M., Calapai G., Campo G.M., Miceli A., and Caputi A.P. Tumor necrosis factor involvement in myocardial ischaemia-reperfusion injury. Eur. J. Pharmacol. 237 (1993) 223-230
33. Tikhonoff V., Mazza A., Casiglia E., and Pessina A.C. Role of manidipine in the management of patients with hypertension. Expert Rev. Cardiovasc. Ther. 2 (2004) 815-827
34. G-nitro-l-arginine methyl ester-induced hypertensive rat aorta: vasoprotective effects beyond the blood pressure-lowering effects of amlodipine and manidipine. Hypertens. Res. 28 (2005) 689-700
35. Tracey K.J., Vlasara H., and Cerami A. Cachectin/tumor necrosis factor. Lancet 20 (1989) 1122-1226
36. Trochu J.N., Mital S., Zhang X., Xu X., Ochoa M., Liao J.K., Recchia F.A., and Hintze T.H. Preservation of NO production by statins in the treatment of heart failure. Cardiovasc. Res. 60 (2003) 250-258
37. Weintraub W.S., Hattori S., Agarwal J.B., Bodenheimer M.M., Banka V.S., and Helfant R.H. The effects of nifedipine on myocardial blood flow and contraction during ischemia in the dog. Circulation 65 (1982) 49-53
38. Wildenthal K., Decker R.S., Poole A.R., Griffin E.E., and Dingle J.T. Sequential lysosomal alterations during cardiac ischemia. I. Biochemical and immunohistochemical changes. Lab. Investig. 38 (1978) 656-661
39. Wolfrum S., Dendorfer A., Schutt M., Weidtmann B., Heep A., Tempel K., Klein H.H., Dominiak P., and Richardt G. Simvastatin acutely reduces myocardial reperfusion injury in vivo by activating the phosphatidylinositide 3-kinase/Akt pathway. J. Cardiovasc. Pharmacol. 44 (2004) 348-355
40. Wright D.G., and Lefer D.J. Statin-mediated protection of the ischemic myocardium. Vascul. Pharmacol. 42 (2005) 265-270
41. Yamamoto F., Manning A.S., Braimbridge M.V., and Hearse D.J. Calcium antagonists and myocardial protection: diltiazem during cardioplegic arrest. Thorac. Cardiovasc. Surg. 31 (1983) 369-373
42. Yeh K.C., and Kwan K.C. A comparison of numerical integrating algorithms by trapezoidal, Lagrange, and spline approximation. J. Pharmacokinet. Biopharm. 6 (1978) 79-98
43. Yoshiyama M., Takeuchi K., Kim S., Hanatani A., Omura T., Toda I., Akioka K., Teragaki M., Ywao H., and Yoshikawa J. Effect of manidipine hydrochloride, a calcium antagonist, on isoproterenol-induced left ventricular hypertrophy. Jpn. Circ. J. 62 (1998) 47-52