FK09 inhibits both local and remote organ damage after intestinal ischaemia

Journal of Pathology

Volumn 197, Issue 5, 2002, Pages 595-602

  Kalia, Neena ^a,b   Brown, Nicola J ^a   Hopkinson, Kay ^a   Stephenson, Tim J ^b   Wood, Richard F M ^a   Pockley, A Graham ^a  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ROYAL HALLAMSHIRE HOSPITAL   (United Kingdom)

Author keywords

Ischaemia reperfusion; Lung; Microcirculation; Neutrophil; Nitric oxide; Small intestine; Villus

Indexed keywords

4 ETHYL 2 HYDROXYIMINO 5 NITRO 3 HEXENAMIDE; NITRIC OXIDE DONOR; NITRO DERIVATIVE; VASODILATOR AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DENSITY; CONTROLLED STUDY; DRUG INHIBITION; FLUORESCENCE MICROSCOPY; HISTOPATHOLOGY; ILEUM; IN VIVO STUDY; INCISION; INTESTINE ISCHEMIA; INTESTINE MUCOSA; INTESTINE TRANSPLANTATION; INTESTINE VILLUS; LEUKOCYTE ADHERENCE; LEUKOCYTE DIFFERENTIAL COUNT; LUNG ALVEOLUS; LUNG COLLAPSE; LUNG INFILTRATE; LUNG INJURY; LUNG INTERSTITIUM; LUNG PARENCHYMA; MALE; MICROCIRCULATION; MORTALITY; NEUTROPHIL; NONHUMAN; PERIPHERAL CIRCULATION; PRIORITY JOURNAL; RAT; REPERFUSION INJURY; SURVIVAL; TISSUE INJURY; TREATMENT OUTCOME; ANIMAL; BLOOD PRESSURE; CELL ADHESION; DRUG EFFECT; HEART RATE; ISCHEMIA; LEUKOCYTE; LEUKOCYTE COUNT; LUNG; PATHOLOGY; PHYSIOLOGY; RAT STRAIN; SMALL INTESTINE; VASCULARIZATION;

ANIMALS; BLOOD PRESSURE; CELL ADHESION; HEART RATE; INTESTINE, SMALL; ISCHEMIA; LEUKOCYTE COUNT; LEUKOCYTES; LUNG; MALE; NITRIC OXIDE DONORS; NITRO COMPOUNDS; RATS; RATS, INBRED STRAINS; REPERFUSION INJURY; SURVIVAL ANALYSIS; VASODILATOR AGENTS;

EID: 0035984338     PISSN: 00223417     EISSN: None     Source Type: Journal    
DOI: 10.1002/path.1136     Document Type: Article

References (35)

1. Pathology of human intestinal transplantation
2. Intestinal transplantation in 31 adults
3. Isolated and combined liver-small bowel transplantation in Paris: 1987-1995
4. The impact of ischaemia-reperfusion injury on specific and non-specific early and late chronic events after organ transplantation
5. Intestinal ischaemia and reperfusion impairs vasomotor functions of pulmonary vascular bed
6. The relationship between visceral ischaemia, proinflammatory cytokines, and organ injury in patients undergoing thoracoabdominal aortic aneurysm repair
7. Neutrophil leukotriene generation and pulmonary dysfunction after abdominal aortic aneurysm repair
8. The horror autotoxicus and multiple-organ failure
9. Gut phospholipase A2 mediates neutrophil priming and lung injury after mesenteric ischaemia-reperfusion
10. Protection against gastric ischaemia-reperfusion injury by NO generators
11. The role of NO and NO-donor agents in myocardial protection from surgical ischaemic-reperfusion injury
12. Nitric oxide in the gut
13. A new nitric oxide (NO) releaser - Spontaneous NO release from FK409
14. Beneficial effects of FK409, a novel nitric oxide donor, on reperfusion injury of rat liver
15. Effect of FK409, a novel nitric oxide donor, on acute experimental myocardial ischaemia
16. Beneficial effects of novel nitric oxide donor FK409 on pulmonary ischaemia-reperfusion injury in rats
17. Protective effects of FK409, a spontaneous nitric oxide releaser, on ischaemic acute renal failure in rats
18. Effects of FK409 on intestinal ischaemia-reperfusion injury and ischaemia-induced changes in the rat mucosal villus microcirculation
19. Ischaemia-reperfusion injury to the intestine
20. Bowel ischaemia and organ impairment in elective abdominal aortic aneurysm repair
21. Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair
22. Acute mesenteric ischaemia after cardiopulmonary bypass
23. Ischaemia-reperfusion injury - A review
24. Ischaemia-reperfusion-induced mucosal dysfunction: Role of neutrophils
25. The role of the neutrophil in ischaemia-reperfusion injury: Potential therapeutic interventions
26. Role of nitric oxide in intestinal ischaemia-reperfusion injury studied using electron paramagnetic resonance
27. Attenuated nitric oxide synthase activity and protein expression accompany intestinal ischaemia/reperfusion injury in rats
28. Endothelial function - General considerations - Review
29. Nitric oxide: An endogenous modulator of leukocyte adhesion
30. Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species
31. Nitric oxide-releasing compounds inhibit neutrophil adhesion to endothelial cells
32. Modulation of basal and post-ischaemic leukocyte-endothelial adherence by nitric oxide
33. Endotoxin related early neutrophil activation is associated with outcome after thoracoabdominal aortic aneurysm repair
34. Effect of ischaemia on intestinal permeability of lipopolysaccharide
35. Bacterial translocation in trauma patients