Nerve fibers that were not stained with the non-specific acetylcholinesterase (NsAchE) method, and TRPV1- and IB4-positive nerve fibers in the rat cornea

Journal of Medical Investigation

Volumn 56, Issue 3-4, 2009, Pages 157-165

  Nakagawa, Hiroshi ^a,b   Hiura, Akio ^b   Mitome, Masato ^b   Ishimura, Kazunori ^b  

^a TOKUSHIMA UNIVERSITY HOSPITAL   (Japan)

^b UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Capsaicin; Cornea; IB4; Nociceptive sensory nerve fibers; TRPV1

Indexed keywords

ACETYLCHOLINESTERASE; CAPSAICIN; ISOLECTIN B4; VANILLOID RECEPTOR 1;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CORNEA; CORNEA STROMA; IMMUNOREACTIVITY; NERVE FIBER; NOCICEPTION; NONHUMAN; RAT; SENSORY NERVE CONDUCTION; STAINING;

RATTUS;

EID: 70350028188     PISSN: 13431420     EISSN: None     Source Type: Journal    
DOI: 10.2152/jmi.56.157     Document Type: Article

References (40)

1. Zander E, Weddell G: Observations on the innervation of the cornea. J Anat 85: 68-93, 1951
2. Rozsa AJ, Beuerman RW: Density and organization of free nerve endings in the corneal epithelium of the rabbit. Pain 14: 105-120, 1982
3. Robertson DM, Winkelmann RK: A wholemount cholinesterase technique for demonstrating corneal nerves: observations in the albino rabbit. Invest Ophthal 9: 710-715, 1970
4. Tervo T: Histochemical demonstration of cholinesterase activity in the cornea of the rat and the effect of various denervations on the corneal nerves. Histochemistry 47: 133-143, 1976
5. Tervo T, Palkama A: Innervation of the rabbit cornea. A histochemical and electron-microscopic study. Acta Anat 102: 164-175, 1978
6. Ishida N, Cerro MD, Rao GN, Mathe M: Corneal stromal innervation. A quantitative analysis of distribution. Ophtalmic Res 16: 139-144, 1984
7. Silverberg KR, Ogilvy CS, Borges LF: A modified gold chloride technique for optimal impregnation of nerves within corneal whole mounts and dura of the albino rat. J Histochem Cytochem 37: 269-271, 1989
8. Jacot JL, Glover JP, Robinson WG Jr: Improved gold chloride procedure for nerve staining in whole mounts of rat corneas. Biotech Histochem 70: 277-284, 1995
9. Jacot JL, Glover JP, Robinson WG Jr: Computer analysis of corneal innervation density using a novel double stain in rat corneal whole mounts. J Anat 191: 191-199, 1997
10. Miller A, Costa M, Furness JB, Chubb IW: Substance P immunoreactive sensory nerves supply the rat iris and cornea. Neurosci Lett 29: 243-249, 1981
11. Shimizu Y: Localization of neuropeptides in the cornea and uvea of the rat: an immunohistochemical study. Cell Mol Biol 28: 103-110, 1982
12. Tervo K, Tervo L, Eranko L, Eranko O: Substance P immunoreactive nerves in the rodent cornea. Neurosci Lett 25: 95-97, 1981
13. Marfurt CF, Kingsley RE, Echtenkamp SE: Sensory and sympathetic innervation of the mammalian cornea. Invest Ophthalmol Vis Sci 30: 461-472, 1989
14. Jones MA, Marfurt CF: Calcitonin gene-related peptide and corneal innervation: a developmental study in the rat. J Comp Neurol 313: 132-150, 1991
15. Colin S, Kruger L: Peptidergic nociceptive axon visualization in whole-mount preparations of cornea and tympanic membrane in rat. Brain Res 398: 199-203, 1986
16. Silverman JD, Kruger L: Lectin and neuropeptide labeling of separate populations of dorsal root ganglion neurons and associated "nocieptor" thin axons in rat testis and cornea wholemount preparations. Somatosens Res 5: 259-267, 1988
17. Stone RA, Kuwayama Y, Terenghi G, Polak JM: Calcitonin gene-related peptide: occurrence in corneal sensory nerves. Exp Eye Res 43: 279-283, 1986
18. Stindl G, Skofitsh G: Immunohistochemical localization of calcitonin gene-related peptide in the rat eye. Response to capsaicin pretreatment. Ann NY Acad Sci 657: 464-465, 1992
19. Hiura A, Nakagawa H: Capsaicin-resistant, nonspecific acetylcholinesterase (NsAchE) reactive nerve fibers in the rat cornea: A quantitative and developmental study. Okajimas Folia Anat Jpn 81: 75-84, 2004
20. Nakamura A, Hayakawa T, Kuwahara S, Maeda S, Tanaka K, Seki M, Mimura O: Morphological and immunohistochemical characterization of the trigeminal ganglion neurons innervating the cornea and upper eyelid of the rat. J Chem Neuroanat 34: 95-101, 2007
21. Zhang F, Yang H, Wang Z, Mergler S, Liu H, Kawakita T, Tachado SD, Pan Z, Capo-Aponte JE, Pleyer U, Koziel H, Kao WWY, Reinach PS: Transient receptor potential vanilloid 1 activation induces inflammatory cytokine release in corneal epithelium through MAPK signaling. J Cell Physiol 213: 730-739, 2007
22. Venkatachalam K, Montell C: TRP channels. Annu Rev Biochem 76: 387-417, 2007
23. Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D: The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21: 531-543, 1998
24. Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D: A capsaicin receptor homologue with a high threshold for noxious heat. Nature 398: 436-441, 1999
25. Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin J-P, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB: TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418: 186-190, 2002
26. Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A: A TRP channel that senses cold stimuli and menthol. Cell 108: 705-715, 2002
27. Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegra T, Bevan S, Patapoutian A: ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperature. Cell 112: 819-829, 2003
28. Madrid R, Rodriguez TD, Meseguer V, Acosta MC, Belmonte C, Viana F: Contribution of TRPM8 channels to cold transduction in primary sensory neurons and peripheral nerve terminals. J Neurosci 26: 12512-12525, 2006
29. Belmonte C, Giraldez F: Responses of cat corneal sensory receptors to mechanical and thermal stimulation. J Physiol 321: 355-368, 1981
30. Giraldez F, Grijo E, Belmonte C: Response characteristics of corneal sensory fibers to mechanical and thermal stimulation. Brain Res 177: 571-576, 1979
31. Acosta MC, Tan ME, Belmonte C, Gallar J: Sensations evoked by selective mechanical, chemical, and thermal stimulation of the conjunctiva and cornea. IOVS 42: 2063-2067, 2001
32. Beuerman RW, Tanelian DL: Corneal pain evoked by thermal stimulation. Pain 7: 1-14, 1979
33. Kenshalo DR: Comparison of thermal sensitivity of the forehead, lip, conjunctiva and cornea. J Appl Physiol 15: 987-991, 1960
34. Murata Y, Masuko S: Peripheral and central distribution of TRPV1, substance P and CGRP of rat corneal neurons. Brain Res 1085: 87-94, 2006
35. Zimmermann M: Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16: 109-110, 1983
36. Hiura A, Nakagawa H: Induction of corneal lesion and nerve fiber sprouting by neonatal capsaicin application depends on the dose of the drug and survival time after treatment. Okajimas Folia Anat Jpn 82: 57-66, 2005
37. Streit EJ, Schulte BA, Balentine JD, Spicer SS: Histochemical localization of galactose-containing glycoconjugates in sensory neurons and their processes in the central and peripheral nervous system of the rat. J Histochem Cytochem 33: 1042-1052, 1985
38. Guo A, Vulchanova L, Wang J, Li X, Elde R: Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11: 946-958, 1999
39. Liu M, Willmott NJ, Michael GJ, Priestrey JV: Differential pH and capsaicin responses of Griffonia simplicifolia IB4 (IB4)-positive and IB4-negative small sensory neurons. Neuroscience 127: 659-672, 2004
40. Hiura A, Ishizuka H: Quantitative electron-microscopic analyses of pulpal nerve fibres in the mouse lower incisor after neonatal capsaicin treatment. Arch Oral Biol 57: 1085-1090, 1992