HIV-1 mRNA 3′ End Processing Is Distinctively Regulated by eIF3f, CDK11, and Splice Factor 9G8

Molecular Cell

Volumn 36, Issue 2, 2009, Pages 279-289

  Valente, Susana T ^a   Gilmartin, Greg M ^b   Venkatarama, Krishnan ^b   Arriagada, Gloria ^a   Goff, Stephen P ^a  

^a Columbia University ^*  (United States)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

HUMDISEASE; PROTEINS; RNA

Indexed keywords

CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 11; INITIATION FACTOR 3; MESSENGER RNA; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; EUKARYOTE; GENE EXPRESSION; GENE OVEREXPRESSION; GENETIC SCREENING; HUMAN IMMUNODEFICIENCY VIRUS 1; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; VIRUS EXPRESSION; VIRUS REPLICATION;

BASE SEQUENCE; BINDING SITES; CELL EXTRACTS; CELL NUCLEUS; CYCLIN-DEPENDENT KINASES; EUKARYOTIC INITIATION FACTOR-3; HELA CELLS; HIV LONG TERMINAL REPEAT; HIV-1; HUMANS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; NUCLEOCYTOPLASMIC TRANSPORT PROTEINS; POLY A; PROTEIN BINDING; RNA 3' END PROCESSING; RNA, MESSENGER; RNA, VIRAL; RNA-BINDING PROTEINS; VIRUS REPLICATION;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 70350004235     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molcel.2009.10.004     Document Type: Article

References (49)

1. Asamitsu K., Morishima T., Tsuchie H., Kurimura T., and Okamoto T. Conservation of the central proline-rich (PxxP) motifs of human immunodeficiency virus type 1 Nef protein during the disease progression in two hemophiliac patients. FEBS Lett. 459 (1999) 399-404
2. Awasthi S., and Alwine J.C. Association of polyadenylation cleavage factor I with U1 snRNP. RNA 9 (2003) 1400-1409
3. Berkhout B., Klaver B., and Das A.T. A conserved hairpin structure predicted for the poly(A) signal of human and simian immunodeficiency viruses. Virology 207 (1995) 276-281
4. Brackenridge S., and Proudfoot N.J. Recruitment of a basal polyadenylation factor by the upstream sequence element of the human lamin B2 polyadenylation signal. Mol. Cell. Biol. 20 (2000) 2660-2669
5. Brown K.M., and Gilmartin G.M. A mechanism for the regulation of pre-mRNA 3′ processing by human cleavage factor Im. Mol. Cell 12 (2003) 1467-1476
6. Cavaloc Y., Bourgeois C.F., Kister L., and Stevenin J. The splicing factors 9G8 and SRp20 transactivate splicing through different and specific enhancers. RNA 5 (1999) 468-483
7. Colgan D.F., and Manley J.L. Mechanism and regulation of mRNA polyadenylation. Genes Dev. 11 (1997) 2755-2766
8. Cramer P., Srebrow A., Kadener S., Werbajh S., de la Mata M., Melen G., Nogues G., and Kornblihtt A.R. Coordination between transcription and pre-mRNA processing. FEBS Lett. 498 (2001) 179-182
9. Danckwardt S., Gehring N.H., Neu-Yilik G., Hundsdoerfer P., Pforsich M., Frede U., Hentze M.W., and Kulozik A.E. The prothrombin 3′end formation signal reveals a unique architecture that is sensitive to thrombophilic gain-of-function mutations. Blood 104 (2004) 428-435
10. Danckwardt S., Kaufmann I., Gentzel M., Foerstner K.U., Gantzert A.S., Gehring N.H., Neu-Yilik G., Bork P., Keller W., Wilm M., et al. Splicing factors stimulate polyadenylation via USEs at non-canonical 3′ end formation signals. EMBO J. 26 (2007) 2658-2669
11. Dettwiler S., Aringhieri C., Cardinale S., Keller W., and Barabino S.M. Distinct sequence motifs within the 68-kDa subunit of cleavage factor Im mediate RNA binding, protein-protein interactions, and subcellular localization. J. Biol. Chem. 279 (2004) 35788-35797
12. Gao G., Guo X., and Goff S.P. Inhibition of retroviral RNA production by ZAP, a CCCH-type zinc finger protein. Science 297 (2002) 1703-1706
13. Geyer M., and Peterlin B.M. Domain assembly, surface accessibility and sequence conservation in full length HIV-1 Nef. FEBS Lett. 496 (2001) 91-95
14. Gilmartin G.M. In vitro analysis of mammalian cell mRNA 3′ processing. In: Richter J.D. (Ed). mRNA Formation and Function (1997), Academic Press, New York 79-98
15. Gilmartin G.M., Fleming E.S., Oetjen J., and Graveley B.R. CPSF recognition of an HIV-1 mRNA 3′-processing enhancer: multiple sequence contacts involved in poly(A) site definition. Genes Dev. 9 (1995) 72-83
16. Graveley B.R. Sorting out the complexity of SR protein functions. RNA 6 (2000) 1197-1211
17. Gunderson S.I., Beyer K., Martin G., Keller W., Boelens W.C., and Mattaj L.W. The human U1A snRNP protein regulates polyadenylation via a direct interaction with poly(A) polymerase. Cell 76 (1994) 531-541
18. Hall-Pogar T., Zhang H., Tian B., and Lutz C.S. Alternative polyadenylation of cyclooxygenase-2. Nucleic Acids Res. 33 (2005) 2565-2579
19. Hinnebusch A.G. eIF3: a versatile scaffold for translation initiation complexes. Trends Biochem. Sci. 31 (2006) 553-562
20. Hu D., Mayeda A., Trembley J.H., Lahti J.M., and Kidd V.J. CDK11 complexes promote pre-mRNA splicing. J. Biol. Chem. 278 (2003) 8623-8629
21. Huang Y., and Steitz J.A. Splicing factors SRp20 and 9G8 promote the nucleocytoplasmic export of mRNA. Mol. Cell 7 (2001) 899-905
22. Jacquenet S., Decimo D., Muriaux D., and Darlix J.L. Dual effect of the SR proteins ASF/SF2, SC35 and 9G8 on HIV-1 RNA splicing and virion production. Retrovirology 2 (2005) 33
23. Kyburz A., Friedlein A., Langen H., and Keller W. Direct interactions between subunits of CPSF and the U2 snRNP contribute to the coupling of pre-mRNA 3′ end processing and splicing. Mol. Cell 23 (2006) 195-205
24. Loyer P., Trembley J.H., Grenet J.A., Busson A., Corlu A., Zhao W., Kocak M., Kidd V.J., and Lahti J.M. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J. Biol. Chem. 283 (2008) 7721-7732
25. Maciolek N.L., and McNally M.T. Serine/arginine-rich proteins contribute to negative regulator of splicing element-stimulated polyadenylation in rous sarcoma virus. J. Virol. 81 (2007) 11208-11217
26. Maniatis T., and Reed R. An extensive network of coupling among gene expression machines. Nature 416 (2002) 499-506
27. Millevoi S., Loulergue C., Dettwiler S., Karaa S.Z., Keller W., Antoniou M., and Vagner S. An interaction between U2AF 65 and CF I(m) links the splicing and 3′ end processing machineries. EMBO J. 25 (2006) 4854-4864
28. Misteli T., Caceres J.F., Clement J.Q., Krainer A.R., Wilkinson M.F., and Spector D.L. Serine phosphorylation of SR proteins is required for their recruitment to sites of transcription in vivo. J. Cell Biol. 143 (1998) 297-307
29. Moreira A., Takagaki Y., Brackenridge S., Wollerton M., Manley J.L., and Proudfoot N.J. The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms. Genes Dev. 12 (1998) 2522-2534
30. Rappsilber J., Ryder U., Lamond A.I., and Mann M. Large-scale proteomic analysis of the human spliceosome. Genome Res. 12 (2002) 1231-1245
31. Ruegsegger U., Beyer K., and Keller W. Purification and characterization of human cleavage factor Im involved in the 3′ end processing of messenger RNA precursors. J. Biol. Chem. 271 (1996) 6107-6113
32. Schaal T.D., and Maniatis T. Selection and characterization of pre-mRNA splicing enhancers: identification of novel SR protein-specific enhancer sequences. Mol. Cell. Biol. 19 (1999) 1705-1719
33. Scott J.M., and Imperiale M.J. Reciprocal effects of splicing and polyadenylation on human immunodeficiency virus type 1 pre-mRNA processing. Virology 224 (1996) 498-509
34. Sherr C.J., and Roberts J.M. Living with or without cyclins and cyclin-dependent kinases. Genes Dev. 18 (2004) 2699-2711
35. Shi L., Nishioka W.K., Th'ng J., Bradbury E.M., Litchfield D.W., and Greenberg A.H. Premature p34cdc2 activation required for apoptosis. Science 263 (1994) 1143-1145
36. Shi J., Feng Y., Goulet A.C., Vaillancourt R.R., Sachs N.A., Hershey J.W., and Nelson M.A. The p34cdc2-related cyclin-dependent kinase 11 interacts with the p47 subunit of eukaryotic initiation factor 3 during apoptosis. J. Biol. Chem. 278 (2003) 5062-5071
37. Shi J., Kahle A., Hershey J.W., Honchak B.M., Warneke J.A., Leong S.P., and Nelson M.A. Decreased expression of eukaryotic initiation factor 3f deregulates translation and apoptosis in tumor cells. Oncogene 25 (2006) 4923-4936
38. Shi Y., Di Giammartino D.C., Taylor D., Sarkeshik A., Rice W.J., Yates III J.R., Frank J., and Manley J.L. Molecular architecture of the human pre-mRNA 3′ processing complex. Mol. Cell 33 (2009) 365-376
39. Shin C., and Manley J.L. Cell signalling and the control of pre-mRNA splicing. Nat. Rev. Mol. Cell Biol. 5 (2004) 727-738
40. Smith C.W., and Valcarcel J. Alternative pre-mRNA splicing: the logic of combinatorial control. Trends Biochem. Sci. 25 (2000) 381-388
41. Swartz J.E., Bor Y.C., Misawa Y., Rekosh D., and Hammarskjold M.L. The shuttling SR protein 9G8 plays a role in translation of unspliced mRNA containing a constitutive transport element. J. Biol. Chem. 282 (2007) 19844-19853
42. Valente S., and Goff S.P. Inhibition of HIV-1 gene expression by a fragment of hnRNP U. Mol. Cell 23 (2006) 597-605
43. Valente S.T., Gilmartin G.M., Mott C., Falkard B., and Goff S.P. Inhibition of HIV-1 replication by eIF3f. Proc. Natl. Acad. Sci. USA 106 (2009) 4071-4078
44. Venkataraman K., Brown K.M., and Gilmartin G.M. Analysis of a noncanonical poly(A) site reveals a tripartite mechanism for vertebrate poly(A) site recognition. Genes Dev. 19 (2005) 1315-1327
45. Wahle E., and Ruegsegger U. 3′-end processing of pre-mRNA in eukaryotes. FEMS Microbiol. Rev. 23 (1999) 277-295
46. Wassarman K.M., and Steitz J.A. Association with terminal exons in pre-mRNAs: a new role for the U1 snRNP?. Genes Dev. 7 (1993) 647-659
47. Xiao S.H., and Manley J.L. Phosphorylation of the ASF/SF2 RS domain affects both protein-protein and protein-RNA interactions and is necessary for splicing. Genes Dev. 11 (1997) 334-344
48. Yang L., Li N., Wang C., Yu Y., Yuan L., Zhang M., and Cao X. Cyclin L2, a novel RNA polymerase II-associated cyclin, is involved in pre-mRNA splicing and induces apoptosis of human hepatocellular carcinoma cells. J. Biol. Chem. 279 (2004) 11639-11648
49. Zhou Z., Sim J., Griffith J., and Reed R. Purification and electron microscopic visualization of functional human spliceosomes. Proc. Natl. Acad. Sci. USA 99 (2002) 12203-12207