Staphylococcus epidermidis isolated from newborn infants express pilus-like structures and are inhibited by the cathelicidin-derived antimicrobial peptide LL37

Pediatric Research

Volumn 66, Issue 2, 2009, Pages 174-178

  Annika, Nelson ^a   Kjell, Hultenby ^a   Eva, Hell ^a   Riedel, Hilde M ^a   Hjalmar, Brismar ^b   Flock, Jan Ingmar ^a   Joachim, Lundahl ^a   Giske, Christian G ^a   Giovanna, Marchini ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; ANTIINFECTIVE AGENT; ANTIMICROBIAL CATIONIC PEPTIDE; BACTERIAL PROTEIN; CATHELICIDIN ANTIMICROBIAL PEPTIDE;

AAP GENE; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM ISOLATE; BACTERIUM PILUS; BIOFILM; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; GENE; GRAM POSITIVE BACTERIUM; HUMAN; IMMUNE STATUS; IMMUNOFLUORESCENCE; IMMUNOGOLD ELECTRON MICROSCOPY; INFANT; MALE; NEWBORN; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SKIN FLORA; STAINING; STAPHYLOCOCCUS EPIDERMIDIS; TRANSMISSION ELECTRON MICROSCOPY; CYTOLOGY; FIMBRIA; GENETICS; IMMUNOHISTOCHEMISTRY; METABOLISM; MICROBIOLOGICAL EXAMINATION; MICROBIOLOGY; PATHOGENICITY; PREGNANCY; SKIN; STAPHYLOCOCCAL SKIN INFECTION; ULTRASTRUCTURE;

ANTI-BACTERIAL AGENTS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIAL PROTEINS; BIOFILMS; FEMALE; FIMBRIAE, BACTERIAL; HUMANS; IMMUNOHISTOCHEMISTRY; INFANT, NEWBORN; MALE; MICROBIAL SENSITIVITY TESTS; PREGNANCY; SKIN; STAPHYLOCOCCAL SKIN INFECTIONS; STAPHYLOCOCCUS EPIDERMIDIS;

EID: 70349918266     PISSN: 00313998     EISSN: 15300447     Source Type: Journal    
DOI: 10.1203/PDR.0b013e3181a9d80c     Document Type: Article

References (30)

1. Roth RR, James WD 1988 Microbial ecology of the skin. Annu Rev Microbiol 42:441-464
2. Keyworth N, Millar MR, Holland KT 1992 Development of cutaneous microflora in premature neonates. Arch Dis Child 67:797-801
3. Marchini G, Nelson A, Edner J, Lonne-Rahm S, Stavreus-Evers A, Hultenby K 2005 Erythema toxicum neonatorum is an innate immune response to commensal microbes penetrated into the skin of the newborn infant. Pediatr Res 58:613-616 (Pubitemid 41254533)
4. Bearman GM, Wenzel RP 2005 Bacteremias: a leading cause of death. Arch. Med Res 36:646-659
5. Strunk T, Richmond P, Simmer K, Currie A, Levy O, Burgner D 2007 Neonatal immune responses to coagulase-negative staphylococci. Curr Opin Infect Dis 20:370-375 (Pubitemid 47026233)
6. Marchini G, Lindow S, Brismar H, Stabi B, Berggren V, Ulfgren AK, Lonne-Rahm S, Agerberth B, Gudmundsson GH 2002 The newborn infant is protected by an innate antimicrobial barrier: peptide antibiotics are present in the skin, and vemix caseosa. Br J Dermatol 147:1127-1134 (Pubitemid 36963018)
7. Putsep K, Calisson G, Boman HG, Andersson. M 2002 Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study. Lancet 360:1144-1149 (Pubitemid 35246490)
8. Radek K, Gallo R. 2007 Antimicrobial peptides: natural effectors of the innate immune system. Semin Immunopathol 29:27-43 (Pubitemid 47596388)
9. Banner MA, Cunniff'e JG, Macintosh RL, Foster TJ, Rohde H, Mack D, Hoyes E, Derrick J, Upton M, Handley PS 2007 Localized tufts of fibrils on Staphylococcus epidermidis NCTC 11047 are comprised of the accumulation- associated protein. J Bacteriol 189:2793-2804
10. Burriel AR 1998 In vivo presence of capsular polysaccharide in coagulase-negative staphylococci of ovine origin. New Microbiol 21:49-54
11. Timmerman CP, Fleer A, Besnier JM, De Graaf L, Cremers F, Verhoef J 1991 Characterization of a proteinaceous adhesin of Staphylococcus epidermidis which mediates attachment to polystyrene. Infect Immun 59:4187-4192
12. Veenstra GJ, Cremers FF, van Dijk H, Fleer A 1996 Ultrastructural organization and regulation of a biomaterial adhesin of Staphylococcus epidermidis. J Bacteriol 178:537-541
13. Scott JR, Zahner D 2006 Pili with strong attachments: Gram-positive bacteria do it differently. Mol Microbiol 62:320-330 (Pubitemid 44477224)
14. Telford JL, Barocchi MA, Margarit I, Rappuoli R, Grandi G 2006 Pili in grampositive pathogens. Nat Rev Microbiol 4:509-519
15. Otto M 2004 Virulence factors of the coagulase-negative staphylococci. Front Biosci 9:841-863
16. Vuong C, Otto M 2002 Staphylococcus epidermidis infections. Microbes Infect 4:481-489
17. Hartford.O, O'Brien L, Schofield K, Weils J, Foster TJ 2001 The Fbe (SdrG) protein of Staphylococcus epidermidis HB promotes bacterial adherence to fibrinogen. Microbiology 147:2545-2552
18. Nilsson M, Frykberg L, Flock JI, Pei L, Lindberg M, Guss B 1998 A fibrinogen-binding protein of Staphylococcus epidermidis. Infect Immun 66:2666-2673
19. Pei L, Flock JI 2001 Lack of fbe, the gene for a fibrinogen-binding protein from Staphylococcus epidermidis, reduces its adherence to fibrinogen coated surfaces. Microb Pathog 31:185-193
20. Hussain M, Herrmann M, von Eiff C, Pcrdreau-Remington F, Peters G 1997 A 140-kilodalton extracellular protein is essential for the accumulation of Staphylococcus epidermidis strains on surfaces. Infect Immun 65:519-524
21. The Clinical and Laboratory Standards Institute (CLSI) 2008 Performance Standards for Antimicrobial Susceptibility Testing; 18th Informational Supplement. Clinical and Laboratory Standards Institute, Wayne, PA
22. Dudal S Turriere C, Bessoles S, Fontes P, Sanchez F, Liautard J, Liautard JP, Lafont V 2006 Release of LL-37 by activated human Vgamma9Vdelta2 T cells: a micro-bicidal weapon against Brucella suis. J Immunol 177:5533-5539 (Pubitemid 44527627)
23. Turner J, Cho Y, Dinh NN, Waring AJ, Lehrer RI 1998 Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother 42:2206-2214 (Pubitemid 28420351)
24. Niyonsaba F, Ogawa H 2005 Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme. J Dermatol Sci 40:157-168 (Pubitemid 41728963)
25. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY 2002 Endogenous antimicrobial, peptides and skin infections in atopic dermatitis. N Engl J Med 347:1151-1160
26. Yamasaki K, Di Nardo A, Bardan A, Murakami M, Ohtake T, Coda A, Dorschner RA, Bonnart C, Descargues P, Hovnanian A, Morhenn VB, Gallo RL 2007 Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea. Nat Med 13:975-980 (Pubitemid 47222043)
27. Rescigno M, Urbano M, Valzasina B, Francolini M, Rotta G, Bonasio R, Granucci F, Kraehenbuhl JP, Ricciardi-Castagnoli P 2001 Dendritic cells express tight junction proteins and penetrate gut epithelial, monolayers to sample bacteria. Nat Immunol 2:361-367 (Pubitemid 33706348)
28. Marchini G, Ulfgren AK, Lore K, Stabi B, Berggren V, Lonne-Rahm S 2001 Erythema toxicum neonatorum: an immunohistochemical analysis. Pediatr Dermatol 18:177-187 (Pubitemid 32567868)
29. Bradford R, Abdul Manan R, Daley AJ, Fearce C, Ramalingam A, D'Mello D, Mueller Y, Uahwatanasakul W, Qu Y, Grando D, Garland S, Deighton M 2006 Coagulase-negative staphylococci in very-low-birth-weight infants: inability of genetic markers to distinguish invasive strains from blood culture contaminants. Eur J Clin Microbiol Infect Dis 25:283-290
30. Rohde H, Kalitzky M, Kroger N, Scherpe S, Horstkotte MA, Knobloch JK, Zander AR, Mack D 2004 Detection of virulence-associated genes not useful, for discriminating between invasive and commensal Staphylococcus epidermidis strains from a bone marrow transplant unit. J Clin Microbiol 42:5614-5619