A 140-kilodalton extracellular protein is essential for the accumulation of Staphylococcus epidermidis strains on surfaces

Infection and Immunity

Volumn 65, Issue 2, 1997, Pages 519-524

  Hussain, Muzaffar ^a   Herrmann, Mathias ^a   Von Eiff, Christof ^a   Perdreau Remington, Françoise ^b   Peters, Georg ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

^b UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; BACTERIUM ANTIBODY; FREUND ADJUVANT; GLASS; MITOMYCIN; POLYCLONAL ANTIBODY; POLYMER; POLYSTYRENE;

ANIMAL EXPERIMENT; ARTICLE; BACTERIAL GROWTH; BACTERIUM ADHERENCE; BACTERIUM ISOLATION; BACTERIUM MUTANT; BIOFILM; CONTROLLED STUDY; DIALYSIS MEMBRANE; FOREIGN BODY REACTION; IMMUNOGENICITY; IMMUNOTHERAPY; NONHUMAN; PRIORITY JOURNAL; RABBIT; STAPHYLOCOCCUS EPIDERMIDIS; SUBCUTANEOUS DRUG ADMINISTRATION;

EID: 0031017470     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.65.2.519-524.1997     Document Type: Article

References (56)

1. Ames, B. 1966. Assay of inorganic phosphorus, total phosphorus and phosphates. Methods Enzymol. 8:115-118.
2. Arvanati, A., N. K. Karamanos, G. Dimitracopoulos, and E. D. Anastassiou. 1994. Isolation and characterization of a novel 20 kDa sulfated polysaccharide from the extracellular slime layer of Staphylococcus epidermidis. Arch. Biochem. Biophys. 308:432-438.
3. Baldassari, L., G. Donelli, A. Gelosia, M. C. Voglino, A. W. Simpson, and G. D. Christensen. 1996. Purification and characterization of the staphylococcal slime-associated antigen and its occurrence among Staphylococcus epidermidis clinical isolates. Infect. Immun. 64:3410-3415.
4. Christensen, G. D., L. Baldassari, and W. A. Simpson. 1994. Colonization of medical devices by coagulase-negative staphylococci, p. 45-78. In A. L. Bisno and F. A. Waldvogel (ed.), Infections associated with indwelling medical devices. American Society for Microbiology, Washington, D.C.
5. Christensen, G. D., L. P. Barker, T. P. Mawhinney, L. M. Baddour, and W. A. Simpson. 1990. Identification of an antigenic marker of slime production for Staphylococcus epidermidis. Infect. Immun. 58:2906-2911.
6. Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1982. Adherence of slime-producing strains of Staphylococcus epidermidis to smooth surfaces. Infect. Immun. 37:318-326.
7. Christensen, G. D., W. A. Simpson, A. L. Bisno, and E. H. Beachey. 1983. Experimental foreign-body infections in mice challenged with slime-producing Staphylococcus epidermidis. Infect. Immun. 40:407-410.
8. Christensen, G. D., W. A. Simpson, J. J. Younger, L. M. Baddour, F. F. Barrett, D. M. Melton, and E. H. Beachey. 1985. Adherence of coagulase-negative staphylococci to plastic tissue culture plates: a quantitative model for the adherence of staphylococci to medical devices. J. Clin. Microbiol. 22:996-1006.
9. Costerton, J. W., K.-J. Cheng, G. G. Geesey, T. I. Ladd, J. C. Nickel, M. Dasgupta, and T. J. Marrie. 1987. Bacterial biofilms in nature and disease. Annu. Rev. Microbiol. 41:435-164.
10. Davenport, D. S., R. M. Masanari, M. A. Pfaller, M. J. Bale, S. A. Streed, and W. J. Hierholzer, Jr. 1986. Usefulness of a test for slime production as a marker for clinically significant infections with coagulase-negative staphylococci. J. Infect. Dis. 153:332-339.
11. Deighton, M. A., and B. Balkau. 1990. Adherence measured by microtiter assay as a virulence marker for Staphylococcus epidermidis infections. J. Clin. Microbiol. 28:2442-2447.
12. Diaz-Mitoma, F., G. K. M. Harding, D. J. Hoban, R. S. Roberts, and D. E. Low. 1987. Clinical significance for slime production in ventriculoperitoneal shunt infections caused by coagulase-negalive staphylococci. J. Infect. Dis. 156:555-560.
13. Drewry, D. T., L. Galbraith, B. J. Wilkinson, and S. G. Wilkinson. 1990. Staphylococcal slime: a cautionary tale. J. Clin. Microbiol. 28:1292-1296.
14. Dubois, M., K. A. Gilles, J. K. Hamilton, P. A. Rabers, and F. Smith. 1956. Colorimetric method for determination of sugars and related substances. Anal. Chcm. 28:350-356.
15. Evans, R. C., and C. J. Holmes. 1987. Effect of vancomycin hydrochloride on Staphylococcus epidermidis biofilm associated with silicone elastomer. Antimicrob. Agents Chemother. 31:889-894.
16. Farber, B. F., M. H. Kaplan, and A. G. Clogston. 1990. Staphylococcus epidermidis extracted slime inhibits the antimicrobial action of glycopeptide antibiotics. J. Infect. Dis. 161:37-40.
17. Gray, E. D., G. Peters, M. Verstegen, and W. E. Regelmann. 1984. Effect of extracellular slime substance from Staphylococcus epidermidis on the human cellular immune response. Lancet i:365-367.
18. Harlow, E., and D. Lane. 1988. Antibodies. A laboratory manual, p. 53-138. Cold Spring Harbor Laboratory. Cold Spring Harbor, N.Y.
19. Heilmann, C., C. Gerke, F. Perdreau-Remington, and F. Götz. 1996. Characterization of Tn917 insertion mutants of Staphylococcus epidermidis affected in biofilm formation. Infect. Immun. 64:277-282.
20. Heilmann, C., O. Schweitzer, C. Gerke, N. Vanittanakom, D. Mack, and F. Götz. 1996. Molecular basis of intercellular adhesion in the biofilm-forming Staphylococcus epidermidis. Mol. Microbiol. 20:1083-1091.
21. Hussain, M., C. Collins, J. G. M. Hastings, and P. J. White. 1992. Radiochemical assay to measure the biofilm produced by coagulase-negative staphylococci on solid surfaces and its use to quantitate the effects of various antibacterial compounds on the formation of the biofilm. J. Med. Microbiol. 37:62-69.
22. Hussain, M., J. G. Hastings, and J. G. White. 1992. Comparison of cell-wall teichoic acid with high-molecular-weight extracellular slime material from Staphylococcus epidermidis. J. Med. Microbiol. 37:368-375.
23. Hussain, M., J. G. M. Hastings, and P. J. White. 1991. Isolation and composition of the extracellular slime made by coagulase-negative staphylococci in a chemically defined medium. J. Infect. Dis. 163:534-541.
24. Hussain, M., J. G. M. Hastings, and P. J. White. 1991. A chemically defined medium for slime production by coagulase-negative staphylococci. J. Med. Microbiol. 34:143-147.
25. Hussain, M., M. H. Wilcox, and P. J. White. 1993. The slime of coagulase-negative staphylococci: biochemistry and relation to adherence. FEMS Microbiol. Rev. 104:191-208.
26. Ishak, M. A., D. G. M. Gröschel, G. L. Mandell, and R. P. Wenzel. 1985. Association of slime with pathogenicity of coagulase-negative staphylococci causing nosocomial septicemia. J. Clin. Microbiol. 22:1025-1029.
27. Johnson, G. M., P. E. Lee, W. E. Regelmann, E. D. Gray, G. Peters, and P. G. Quie. 1986. Interference with granulocyte function by Staphylococcus epidermidis slime. Infect. Immun. 54:13-20.
28. Kloos, W. E., and T. E. Bannerman. 1994. Update on clinical significance of coagulase-negative staphylococci. Clin. Microbiol. Rev. 7:117-140.
29. Kojima, Y., M. Tojo, D. A. Goldmann, T. D. Tosteson, and G. B. Pier. 1990. Antibody to the capsular polysaccharide/adhesin protects rabbits against catheter-related bacteremia due to coagulase-negative staphylococci. J. Infect. Dis. 162:435-441.
30. Kotilainen, P., J. Maki, P. Oksman, M. K. Viljanen, J. Nikoskelainen, and P. Houvinen. 1990. Immunochemical analysis of the extracellular slime of Staphylococcus epidermidis. Eur. J. Clin. Microbiol. Infect. Dis. 9:262-270.
31. Kristinsson, K. G., J. G. Hastings, and R. C. Spencer. 1988. The role of extracellular slime in opsonophagocytosis of Staphylococcus epidermidis. J. Med. Microbiol. 27:207-213.
32. Levvy, G. A., and A. McAllan. 1959. The N-acctylation and estimation of hexosamines. Biochem. J. 73:127-132.
33. Ludwicka, A., G. Ulenbruck, G. Peters, P. N. Seng, E. D. Gray, J. Jeljaszewicz, and G. Pulverer. 1984. Investigation on extracellular slime substance produced by Staphylococcus epidermidis. Zentralbl. Bakteriol. Hyg. 1 Abt. Orig. A 258:256-267.
34. Mack, D. 1995. Personal communication.
35. Mack, D., W. Fischer, A. Krokotsch, K. Leopold, R. Hartmann, H. Egge, and R. Laufs. 1996. The intercellular adhesin involved in biofilm accumulation of Staphylococcus epidermidis is a linear β-1,6-linked glucosaminoglycan: purification and structural analysis. J. Bacteriol. 178:175-183.
36. Mack, D., M. Nedelmann, A. Krokotsch, A. Schwarzkopf, J. Heesemann, and R. Lauts. 1994. Characterization of transposon mutants of biofilm-producing Staphylococcus epidermidis impaired in the accumulative phase of biofilm production: genetic identification of a hexosamine-containing polysaccharide intercellular adhesin. Infect. Immun. 62:3244-3253.
37. Mack, D., N. Siemssen, and R. Laufs. 1992. Parallel induction by glucose of adherence and a polysaccharide antigen specific for plastic-adherent Staphylococcus epidermidis. Infect. Immun. 60:2048-2057.
38. Marrie, T. J., and J. W. Costerton. 1984. Scanning and transmission electron microscopy of in situ bacterial colonization of intravenous and intraarterial catheters. J. Clin. Microbiol. 19:687-693.
39. McDonald, H. C., and W. W. Karakawa. 1970. Immunochemical analysis of uronic acid polymer of Staphylococcus epidermidis strain 53. J. Immunol. 105:389-395.
40. Muller, E., J. Hübner, N. Gutierrez, S. Takeda, D. A. Goldmann, and G. B. Pier. 1993. Isolation and characterization of transposon mutants of Staphylococcus epidermidis deficient in capsular polysaccharide/adhesin and slime. Infect. Immun. 61:551-558.
41. Muller, E., S. Takeda, H. Shiro, D. Goldmann, and G. D. Pier. 1993. Occurrence of capsular polysaccharide/adhesin among clinical isolates of coagulase-negative staphylococci. J. Infect. Dis. 168:1211-1218.
42. Patti, J. M., and M. Höök. 1994. Microbial adhesins recognizing extracellular matrix macromolecules. Curr. Opin. Cell Biol. 6:752-758.
43. Peters, G., R. Locci, and G. Pulverer. 1981. Microbial colonization of prosthetic devices. II. Scanning electron microscopy of naturally infected intravenous catheters. Zentralbl. Bakltriol. Hyg. 1 Abt. Orig. B 173:293-299.
44. Peters, G., R. Locci, and G. Pulverer. 1982. Adherence and growth of coagulase-negative staphylococci on surfaces of intravenous catheters. J. Infect Dis. 146:479-482.
45. Peters, G., F. Schumacher-Perdreau, B. Jansen, M. Bey, and G. Pulverer. 1987. Biology of Staphylococcus epidermidis extracellular slime, p. 15-32. In G. Pulverer, P. G. Quie, and G. Peters (ed.). Pathogenicity and clinical significance of coagulase-negative staphylococci. Gustav Fischer Verlag, Stuttgart, Germany.
46. Schumacher-Perdreau, F., C. Heilmann, G. Peters, F. Götz, and G. Pulverer. 1994. Comparative analysis of a biofilm forming Staphylococcus epidermidis strain and its adhesion-positive, accumulation-negative isogenic mutant. FEMS Microbiol. Lett. 117:71-78.
47. Sheth, N. K., T. R. Franson, and P. G. Sohnle. 1985. Influence of bacterial adherence to intravascular catheters on in vitro antibiotic susceptibility. Lancet ii: 1266-1268.
48. Shiro, H., E. Muller, N. Gutierrez, S. Boisot, M. Grout, T. D. Tosteson, D. Goldmann, and G. B. Pier. 1994. Transposon mutants of Staphylococcus epidermidis deficient in elaboration of capsular polysaccharide/adhesin and slime are avirulent in a rabbit model of endocarditis. J. Infect. Dis. 169:1042-1049.
49. 2 and interleukin 1 production and modulates tumor necrosis factor alpha and nitric oxide production. Infect. Immun. 62:4160-4166.
50. Takeda, J., G. B. Pier, Y. Kojima, M. Tojo, E. Muller, T. D. Tosteson, and D. A. Goldman. 1991. Protection against endocarditis due to Staphylococcus epidermidis by immunization with capsular polysaccharide/adhesin. Circulation 84:2539-2546.
51. Timmermann, C. P., J. M. Besnier, L. de Graaf, R. Torensma, A. J. Verkley, A. Fleer, and J. Verhoef. 1991. Characterisation and functional aspects of monoclonal antibodies specific for surface proteins of coagulase-negative staphlococci. J. Med. Microbiol. 35:65-71.
52. Timmermann, C. P., A. Fleer, J. M. Besnier, L. de Graaf, F. Cremers, and J. Verhoef. 1991. Characterization of a proteinaceous adhesion of Staphylococcus epidermidis which mediates attachment to polystyrene. Infect. Immun. 59:4187-4192.
53. Tojo, M., D. A. Yamashita, D. A. Goldman, and G. D. Pier. 1988. Isolation and characterization of a capsular polysaccharide adhesin from Staphylococcus epidermidis. J. Infect. Dis. 157:713-722.
54. Van der Rijn, I., and R. E. Kessler. 1985. Growth characteristics of group A streptococci in a new chemically defined medium. Infect. Immun. 27:444-448.
55. Veenstra, G. J. C., F. F. M. Cremers, H. Van Dijk, and A. Fleer. 1996. Ultrastructural organization and regulation of a biomaterial adhesin of Staphylococcus epidermidis. J. Bacteriol. 178:537-541.
56. Younger, J. J., G. D. Christensen, D. L. Bartley, J. C. H. Simmons, and F. F. Barrett. 1987. Coagulase-negative staphylococci isolated from cerebrospinal fluid shunts: importance of slime production, species identification, and shunt removal to clinical outcome. J. Infect. Dis. 156:548-554.