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A Cu-catalyzed procedure for homocoupling of aryl zinc halides by using N-methyl-N'-(3,4dinitrobenzoyl)piperazine has been successfully used to perform a few intramolecular heterocoupling reactions:
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A Cu-catalyzed procedure for homocoupling of aryl zinc halides by using N-methyl-N'-(3,4dinitrobenzoyl)piperazine has been successfully used to perform a few intramolecular heterocoupling reactions:
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70349912793
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Oxygen has also been employed as oxidant for metal-free homocoupling of Grignard reagents with 2,2,6,6tetramethylpiperidine-N-oxyl radical (TEMPO) as catalyst:
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Oxygen has also been employed as oxidant for metal-free homocoupling of Grignard reagents with 2,2,6,6tetramethylpiperidine-N-oxyl radical (TEMPO) as catalyst:
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45
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In the case of an ortho-substituted aryl group, the detrimental effect of steric hindrance on the formation of biaryl by crosscoupling reaction is well established. For reviews, see: a J. Hassan, M. Sevignon, C. Gozzi, E. Schulz, M. Lemaire, Chem. Rev. 2002, 102, 1359;
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In the case of an ortho-substituted aryl group, the detrimental effect of steric hindrance on the formation of biaryl by crosscoupling reaction is well established. For reviews, see: a) J. Hassan, M. Sevignon, C. Gozzi, E. Schulz, M. Lemaire, Chem. Rev. 2002, 102, 1359;
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37049111384
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For the influence of the π-electronic density of the aryl group on the reductive elimination rate, see: a
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2 commences
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2 commences
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70349896305
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See Supporting Information Figure Sl
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See Supporting Information (Figure Sl).
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