Cobalt-catalyzed cross-coupling reaction between functionalized primary and secondary alkyl halides and aliphatic Grignard reagents

Advanced Synthesis and Catalysis

Volumn 350, Issue 10, 2008, Pages 1484-1488

  Cahiez, Gérard ^a   Chaboche, Christophe ^a   Duplais, Christophe ^a   Giulliani, Arianna ^a   Moyeux, Alban ^a  

^a Allée du Réseau Jean Marie Buckmaster   (France)

Author keywords

Aliphatic Grignard reagents; Alkyl alkyl; Cobalt catalyzed reaction; Cross coupling; Secondary alkyl bromides

Indexed keywords

EID: 53849091310     PISSN: 16154150     EISSN: 15213897     Source Type: Journal    
DOI: 10.1002/adsc.200800166     Document Type: Article

References (74)

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70. 2-Xantphos (1:2) in diethyl ether at room temperature. Yields are moderate (46-64%), in addition, the use of cyclic secondary alkyl bromides resulted in poor yields (8-43%) and no example of an acyclic secondary alkyl bromide was described.
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73. [4d,e]
74. 2·2 LiI, 4TMEDA) with 2-bromooctane (ratio LiI/s-OctBr = 1:1), only 4% of 2-iodobutane were detected after 16 h at room temperature.