Evaluation of consumer risk resulting from exposure against diphenylmethane-4,4'-diisocyanate (MDI) from polyurethane foam

EXCLI Journal

Volumn 8, Issue , 2009, Pages 58-65

  Hoffmann, Hans Dieter ^a   Schupp, Thomas ^b  

^a BASF SE   (Germany)

^b Elastogran GmbH   (Germany)

Author keywords

Consumer risk; Diphenylmethane diisocyanate; Emission; Migration; Polyurethane

Indexed keywords

EID: 70349905312     PISSN: None     EISSN: 16112156     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Cole KC, Gheluwe P. Flexible Polyurethane Foam. I. FTIR Analysis of residual Isocyanate. J Appl Polym Sc 1987;34:395-407.
2. Conte A, Cossi G. Gas chromatographic determination of free toluene diisocyanate in flexible urethane foam. J of Chromatogr 1981;213:162-5.
3. Deutsche Forschungsgemeinschaft, Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Occupational toxicants, critical data evaluation for MAK-values and classification of carcinogens. (4,4'-Methylene diphe-nyl isocyanate (MDI) and "polymeric MDI" (PMDI)). Weinheim: VCH Verlagsgesellschaft, 1992.
4. Deutsche Forschungsgemeinschaft, Commission for the Investigation of Health Jaz-ards of Chemical Compounds in the Work Area. Occupational toxicants, critical data evaluation for MAK-values and classification of carcinogens. (Diphenylamethan-4,4'-diisocyanat (MDI) und "polymers MDI" (pMDI)). Nachtrag 2008. Weinheim: VCH Verlagsgesellschaft, 2008a.
5. Deutsche Forschungsgemeinschaft. MAK-und BAT-Werte-Liste 2008. Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area. Weinheim: Wiley-VCH, 2008b.
6. Dick C, Dominguez-Rosado E, Eling B, Liggat JJ, Lindsay CI, Martin SC, Moham-med MH, Seeley G, Snape CE. The flammability of urethane-modified polyiso-cyanurates and its relationship to thermal degradation chemistry. Polymer 2001;42: 913-23.
7. 13C CP/MAS NMR. Macromolecules 1991;24:387-97.
8. European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterisation of dose [concentration]-response for human health. Appendix R.8-11, May 2008a.
9. European Chemicals Agency. Guidance on information requirements and chemical safety assessment. Chapter R.8: Characterisation of dose [concentration]-response for human health. Chapter R.8.4.3.1, May 2008b.
10. European Communities. European Union Risk Assessment Report methylene di-phenyl diisocyanate (MDI), CAS No: 26447-40-5, EINECS No: 247-714-0. Lux-embourg: Office for the Official Publications of the European Communities, 2005.
11. European Communities, COMMISSION DIRECTIVE 2008/58/EC of 21 August 2008. Index No. 615-005-00-9.
12. Feron VJ, Kittel B, Kuper CF, Ernst H, Rit-tinghausen S, Muhle H, Koch W, Gamer A, Mallet AK, Hoffmann HD. Chronic pulmonary effects of respirable methylene di-phenyl diisocyanate (MDI) aerosol in rats: combination of findings from two bioassays. Arch Toxicol 2001;75:159-75.
13. Hugo JM, Spence MW, Lickly, TD. The determination of the ability of polyurethane foam to release toluene diisocyanate into air. Appl Occup Environ Hyg 2000;15:512-9.
14. Jedrzejczak K, Gaind VS. Determination of free toluene diisocyanates in flexible poly-urethane foams using negative chemical-ionization mass spectrometry. Analyst 1993;118:149-52.
15. Mormann W, Lucas-Vaquero R, Seel K. Interaction of aromatic isocyanates with N-Acetyl cysteine under physiological condi-tions. Formation of conjugates, ureas and amines. EXCLI J 2006;5:191-208.
16. Pauluhn J. Acute inhalation toxicity of polymeric diphenylmethane-4,4'-diisocya-nate (MDI) in rats: Time course of changes in broncho-alveolar lavage. Arch Toxicol 2000;74:257-69.
17. Pauluhn J. Short-term inhalation toxicity of polyisocyanate aerosols in rats: comparative assessment of irritant threshold concentra-tions by bronchoalveolar lavage. Inhal Tox 2002;14:287-301.
18. Pauluhn J. Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate. Inhal Tox 2005;17:729-39.
19. Pauluhn J. Brown Norway rat asthma model of diphenylmethane-4,4'-diisocyanate (MDI): analysis of the elicitation dose-response relationship. Toxicol Sci 2008; 104:320-31.
20. Safford RJ. The dermal sensitization threshold - a TTC approach for allergic contact dermatitis. Regul Toxicol Pharmacol 2008;51:195-200.
21. th print. New York: Interscience Publ., Wiley & Sons, 1967.
22. Selgrade MK, Boykin EH, Haykal-Coates N, Woolhiser MR, Wiecinski C, Andrews DL, Farraj AK, Doerfler DL, Gavett SH. Inconsistencies between cytokine profiiles, antibody responses, and respiratory hyper-responsiveness following dermal exposure to isocyanates. Toxicol Sci 2006;94:108-17.
23. United States Environmental Protection Agency. Integrated Risk Information System. Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (CASRN 101-68-8 and 9016-87-9). 1998. http://www.epa.gov/iris/subst/0529.htm
24. United States Occupational Safety and Health Administration. Methylene Biphenyl Isocyanate (MDI), method no. 47; July 1984, revised march 1989. http://www.osha.gov/dts/sltc/methods/organic/org047/org047.html
25. Yakabe Y, Henderson KM, Thompson WC, Pemberton D, Tury B, Bailey RE. Fate of methylenediphenyl diisocyanate and toluene diisocyanate in the aquatic environment. Environ Sci Technol 1999;33:2579-83.