Chemopreventive effect of Panax ginseng

Phytotherapy Research

Volumn 23, Issue 10, 2009, Pages 1399-1403

  Varjas, T ^a   Nowrasteh, G ^a   Budan F ^a   Nadasi, E ^b   Horvath G ^a   Makai, S ^d   Gracza, T ^a   Cseh, J ^c   Ember, Istvan ^a  

^a UNIVERSITY OF PÉCS   (Hungary)

^b IQVIA   (United States)

^c Szent Gyorgy Hospital   (Hungary)

^d NONE

Author keywords

Apoptosis; Chemoprevention; Gene expression; Panax ginseng

Indexed keywords

CYCLIN D1; DIMETHYLBENZ[A]ANTHRACENE; GINSENG EXTRACT; GINSENOSIDE; MESSENGER RNA; PROTEIN BCL 2; PROTEIN BCL X; SAPONIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER PREVENTION; CELL CYCLE ARREST; CELL DIFFERENTIATION; CHEMICAL CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; METASTASIS; MOUSE; NONHUMAN; PLANT ROOT;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-X PROTEIN; CARCINOGENS; CYCLIN D1; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION; MICE; MICE, INBRED AKR; NEOPLASMS; PANAX; PHYTOTHERAPY; PLANT PREPARATIONS; PLANT ROOTS; POWDERS; PROTO-ONCOGENE PROTEINS C-BCL-2;

ANIMALIA; PANAX GINSENG;

EID: 70349899274     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.2786     Document Type: Article

References (29)

1. Adams LS, Seeram NP, Hardy ML, Carpenter C, Heber D. 2006. Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines. Evid Based Complement Altern Med 3: 117-124. (Pubitemid 43999659)
2. Aggarwal BB, Shishodia S. 2006. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421.
3. Block KI, Mead MN. 2003. Immune system effects of Echinacea, Ginseng, and Astragalus: A review. Integr Cancer Ther 2: 247-267.
4. Chen XC, Chen Y, Zhu YG, Fang F, Chen LM. 2002. Protective effect of ginsenoside Rg1 against MPTP-induced apoptosis in mouse substantia nigra neurons. Acta Pharmacol Sin 23: 829-834. (Pubitemid 35012987)
5. Cheng CC, Yang SM, Huang CY, Chen JC, Chang WM, Hsu SL. 2005. Molecular mechanisms of ginsenoside Rh2-mediated G1 growth arrest and apoptosis in human lung adenocarcinoma A549 cells. Cancer Chemother Pharmacol 55: 531-540.
6. Ember I, Kiss I, Pusztai Z. 1998. Effect of 7,12-dimethylbenz(a) anthracene on onco/suppressor gene action in vivo: a short-term experiment. Anticancer Res 18: 445-447. (Pubitemid 28174746)
7. Fukushima S, Wanibuchi H, Li W. 2001. Inhibition by ginseng of colon carcinogenesis in rats. J Korean Med Sci 16(Suppl): S75-S80.
8. Gyöngyi Z, Somlyai G. 2000. Deuterium depletion can decrease the expression of C-myc Ha-ras and p53 gene in carcinogen-treated mice. In Vivo 3: 437-439. (Pubitemid 30433371)
9. Helms S. 2004. Cancer prevention and therapeutics: Panax ginseng. Altern Med Rev 9: 259-274. (Pubitemid 39299200)
10. Kiefer D, Pantuso T. 2003. Panax ginseng. Am Fam Physician 68: 1539-1542.
11. Kim YS, Jin SH, Lee YH, Kim SI, Park JD. 1999. Ginsenoside Rh2 induces apoptosis independently of Bcl-2, Bcl-xL, or Bax in C6Bu-1 cells. Arch Pharm Res 22: 448-453.
12. Kim EH, Jang MH, Shin MC, Shin MS, Kim CJ. 2003. Protective effect of aqueous extract of Ginseng radix against 1-methyl-4-phenylpyridinium-induced apoptosis in PC12 cells. Biol Pharm Bull 26: 1668-1673.
13. Kim HS, Lee EH, Ko SR, Choi KJ, Park JH, Im DS. 2004. Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch Pharm Res 27: 429-435.
14. Kundu JK, Surh Y-J. 2005. Breaking the relay in deregulated cellular signal transduction as a rationale for chemoprevention with anti-inflammatory phytochemicals. Mutat Res 591: 123-146.
15. Liu K, Xu SX, Che CT. 2000. Anti-proliferative effect of ginseng saponins on human prostate cancer cell line. Life Sci 67: 1297-1306. (Pubitemid 30640817)
16. Mahady GB, Gyllenhall C, Fong HHS, Farnsworth NR. 2000. Ginsengs: a review of safety and efficacy. Nutr Clin Care 3: 90-101.
17. Meijerman I, Beijnen JH, Schellens JHM. 2006. Herb-drug interactions in oncology: focus on mechanisms of induction. Oncologist 11: 742-752. (Pubitemid 44157562)
18. Nakata H, Kikuchi Y, Tode T et al. 1989. Inhibitory effects of ginsenoside Rh2 on tumor growth in nude mice bearing human ovarian cancer cells. Jpn J Cancer Res 89: 733-740.
19. Oh M, Choi YH, Choi S et al. 1999. Anti-proliferating effects of ginsenoside Rh2 on MCF-7 human breast cancer cells. Int J Oncol 14: 869-875.
20. Oh S-H, Lee B-H. 2004. A ginseng saponin metabolite-induced apoptosis in HepG2 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and Bid cleavage. Toxicol Appl Pharmacol 194: 221-229.
21. Panwar M, Samarth R, Kumar M, Yoon WJ, Kumar A. 2005. Inhibition of benzo(a)pyrene induced lung adenoma by Panax ginseng extract, EFLA400, in Swiss albino mice. Biol Pharm Bull 28: 2063-2067. (Pubitemid 41634253)
22. Popovich DG, Kitts DD. 2004. Ginsenosides 20(S)-protopanaxadiol and Rh2 reduce cell proliferation and increase sub-G1 cells in two cultured intestinal cell lines, Int-407 and Caco-2. Can J Physiol Pharmacol 82: 183-190.
23. Radad K, Gille G, Liu L, Rausch WD. 2006. Use of Ginseng in medicine with emphasis on neurodegenerative disorders. J Pharmacol Sci 100: 175-186.
24. Sato K, Mochizuki M, Saiki I, Yoo JC, Samukawa K, Azuma I. 1994. Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull 17: 635-639. (Pubitemid 24186106)
25. Tackikawa E, Kudo K, Harada K et al. 1999. Effects of ginseng saponins on responses induced by various receptor stimuli. Eur J Pharmacol 369: 23-32. (Pubitemid 29129536)
26. Xu TY, Xin Y, Cui MH, Jiang X, Gu LP. 2007. Inhibitory effect of ginsenoside Rg3 combined with cyclophosphamide on growth and angiogenesis of ovarian cancer. Chin Med J 120: 584-588. (Pubitemid 46629914)
27. Yue PY, Mak NK, Cheng YK et al. 2007. Pharmacogenomics and the Yin/Yang actions of ginseng: anti-tumor, angiomodulating and steroid-like activities of ginsenosides. Chin Med 2: 6.
28. Yun TK, Choi SY. 1990. A case-control study of ginseng intake and cancer. Int J Epidemiol 19: 871-876.
29. Yun TK, Choi SY. 1995. Preventive effect of ginseng intake against various human cancers: a case-control study on 1987 pairs. Cancer Epidemiol Biomarkers Prev 4: 401-408.