Evolution of putrescine N-methyltransferase from spermidine synthase demanded alterations in substrate binding

FEBS Letters

Volumn 583, Issue 20, 2009, Pages 3367-3374

  Biastoff, Stefan ^a   Reinhardt, Nicole ^a   Reva, Veaceslav ^b   Brandt, Wolfgang ^c   Dräger, Birgit ^a  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b MOLDOVA STATE UNIVERSITY   (Moldova)

^c LEIBNIZ INSTITUTE OF PLANT BIOCHEMISTRY   (Germany)

Author keywords

Alkaloid biosynthesis; Protein evolution; Putrescine N methyltransferase; S Adenosylmethionine; Spermidine synthase

Indexed keywords

METHYLTRANSFERASE; PUTRESCINE METHYLTRANSFERASE; SPERMIDINE SYNTHASE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING SITE; BIOSYNTHESIS; CATALYSIS; CONTROLLED STUDY; DATURA STRAMONIUM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; MOLECULAR DOCKING; MOLECULAR EVOLUTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN STRUCTURE; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; CATALYTIC DOMAIN; DATURA STRAMONIUM; EVOLUTION, MOLECULAR; HUMANS; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; PHYLOGENY; PROTEIN STRUCTURE, TERTIARY; PUTRESCINE; S-ADENOSYLMETHIONINE; SEQUENCE ALIGNMENT; SPERMIDINE SYNTHASE;

DATURA STRAMONIUM;

EID: 70349883921     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2009.09.043     Document Type: Article

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