Family-based mitochondrial association study of traits related to type 2 diabetes and the metabolic syndrome in adolescents

Diabetologia

Volumn 52, Issue 11, 2009, Pages 2359-2368

  Byrne, E M ^a,b   McRae, A F ^a   Duffy, D L ^a   Zhao, Z Z ^a   Martin, N G ^a   Whitfield, J B ^a   Visscher, P M ^a   Montgomery, G W ^a  

^a QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Australian; Diabetes; Mitochondria; Twins

Indexed keywords

ALANINE AMINOTRANSFERASE; FERRITIN; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL; URIC ACID;

ADOLESCENT; AGE DISTRIBUTION; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ARTICLE; AUSTRALIA; BODY HEIGHT; BODY MASS; CHILD; CHOLESTEROL BLOOD LEVEL; DIZYGOTIC TWINS; EXTRACHROMOSOMAL INHERITANCE; FAMILY; FEMALE; FERRITIN BLOOD LEVEL; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MITOCHONDRION; MONOZYGOTIC TWINS; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT; SCHOOL CHILD; SIBLING; SINGLE NUCLEOTIDE POLYMORPHISM; TRIACYLGLYCEROL BLOOD LEVEL; URIC ACID BLOOD LEVEL;

ADOLESCENT; BLOOD GLUCOSE; CHILD; CONTINENTAL POPULATION GROUPS; DIABETES MELLITUS, TYPE 2; DNA, MITOCHONDRIAL; FAMILY; FEMALE; GEOGRAPHY; HUMANS; LIPIDS; MALE; METABOLIC SYNDROME X; SIBLINGS;

EID: 70349862091     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-009-1510-9     Document Type: Article

References (42)

1. KF Petersen D Befroy S Dufour, et al. 2003 Mitochondrial dysfunction in the elderly: possible role in insulin resistance Science 300 1140 1142 12750520 10.1126/science.1082889 1:CAS:528:DC%2BD3sXjslGqtrw%3D (Pubitemid 36583097)
2. KF Petersen S Dufour D Befroy R Garcia GI Schulman 2004 Impaired mitochondrial activity in the insulin-resistant offspring of patients with type 2 diabetes N Engl J Med 350 664 671 14960743 10.1056/NEJMoa031314 1:CAS:528:DC%2BD2cXhtFCrtrc%3D (Pubitemid 38364625)
3. VK Mootha CM Lindgren KF Eriksson, et al. 2003 PGC-1-α-responsive genes involved in oxidative phosphorylation are co-ordinately downregulated in human diabetes Nat Genet 34 267 273 12808457 10.1038/ng1180 1:CAS:528: DC%2BD3sXkvFSrs7o%3D (Pubitemid 36792858)
4. ME Patti AJ Butte S Crunkhorn, et al. 2003 Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: potential role of PGC1 and NRF1 Proc Natl Acad Sci U S A 100 8466 8471 12832613 10.1073/pnas.1032913100 1:CAS:528:DC%2BD3sXlsFGntbs%3D (Pubitemid 36842568)
5. P Maechler S Carobbio B Rubi 2006 In beta-cells, mitochondria integrate and generate metabolic signals controlling insulin secretion Int J Biochem Cell Biol 38 696 709 16443386 10.1016/j.biocel.2005.12.006 1:CAS:528: DC%2BD28Xit1Ohtbw%3D (Pubitemid 43372052)
6. VB Ritov EV Menshikova J He RE Ferrell BH Goodpaster DE Kelley 2005 Deficiency of subsarcolemnal mitochondria in obesity and type 2 diabetes Diabetes 54 8 14 15616005 10.2337/diabetes.54.1.8 1:CAS:528:DC%2BD2MXhtVWjur4%3D (Pubitemid 40105089)
7. JC Alcolado K Laji R Gill-Randall 2002 Maternal transmission of diabetes Diabet Med 19 89 98 11874423 10.1046/j.1464-5491.2002.00675.x 1:STN:280:DC%2BD387jvVGksw%3D%3D (Pubitemid 34225221)
8. TG Barrett 2001 Mitochondrial diabetes, DIDMOAD and other inherited diabetes syndromes Best Pract Res Clin Endocrinol Metab 15 325 343 11554774 10.1053/beem.2001.0149 1:CAS:528:DC%2BD38Xhs1Omtg%3D%3D (Pubitemid 32916265)
9. JM van den Ouweland HH Lemkes W Ruitenbeek, et al. 1992 Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type 2 diabetes mellitus and deafness Nat Genet 1 368 371 1284550 10.1038/ng0892-368
10. DC Wallace 2007 Why do we still have a maternally inherited mitochondrial DNA? Insights from evolutionary medicine Annu Rev Biochem 76 781 821 17506638 10.1146/annurev.biochem.76.081205.150955 1:CAS:528:DC%2BD2sXhtVehtb3M
11. M Pravenec M Hyakukoku J Houstek, et al. 2007 Direct linkage of mitochondrial genome variation to risk factors for type 2 diabetes in conplastic strains Genome Res 17 1319 1326 17693571 10.1101/gr.6548207 1:CAS:528:DC%2BD2sXhtValu7nK (Pubitemid 47360906)
12. P Maechler CB Wollheim 2001 Mitochondrial function in normal and diabetic beta-cells Nature 414 807 812 11742413 10.1038/414807a 1:CAS:528: DC%2BD38XhtlylsA%3D%3D (Pubitemid 34000784)
13. J Poulton J Luan V Macaulay S Hennings J Mitchell NJ Wareham 2002 Type 2 diabetes is associated with a common mitochondrial variant: evidence from a population-based case-control study Hum Mol Genet 11 1581 1583 12045211 10.1093/hmg/11.13.1581 1:CAS:528:DC%2BD38XltVyrsLg%3D
14. JH Kim KS Park YM Cho, et al. 2002 The prevalence of mitochondrial DNA 16189 variant in non-diabetic Korean adults and its association with higher fasting glucose and body mass index Diabet Med 19 681 684 12147150 10.1046/j.1464-5491.2002.00747.x 1:STN:280:DC%2BD38zpvVeisg%3D%3D (Pubitemid 34985170)
15. SW Weng CW Liou TK Lin, et al. 2005 Association of mitochondrial DNA 16189 variant with metabolic syndrome in Chinese adults J Clin Endocrinol Metab 90 5037 5040 15972579 10.1210/jc.2005-0227 1:CAS:528:DC%2BD2MXhtVWkur7K (Pubitemid 41262251)
16. PF Chinnery HR Elliott S Patel, et al. 2005 Role of the mitochondrial DNA 16184-16193 poly-C tract in type 2 diabetes Lancet 366 1650 1651 16271646 10.1016/S0140-6736(05)67492-2 1:CAS:528:DC%2BD2MXhtFOhu7%2FM (Pubitemid 41552420)
17. KL Mohlke Au Jackson LJ Scott, et al. 2005 Mitochondrial polymorphisms and susceptibility to type 2 diabetes-related traits in Finns Hum Genet 118 245 254 16142453 10.1007/s00439-005-0046-4 1:CAS:528:DC%2BD2MXht1aitLzJ (Pubitemid 41672086)
18. N Raule F Sevini A Santoro S Altilia A Altilia C Franceschi 2007 Association studies on human mitochondrial DNA: methodological aspects and results in the most common age-related diseases Mitochondrion 7 29 38 17306632 10.1016/j.mito.2006.11.013 1:CAS:528:DC%2BD2sXisl2rsb4%3D (Pubitemid 46351973)
19. D Crispim LH Canani JL Gross B Tschiedel KEP Souto I Roisenberg 2006 The European-specific mitochondrial cluster J/T could confer an increased risk of insulin-resistance and type 2 diabetes: an analysis of the m.4216T>C and m.4917A>G variants Ann Hum Genet 70 488 495 16759180 10.1111/j.1469-1809. 2005.00249.x 1:CAS:528:DC%2BD28XmsFyqu7o%3D (Pubitemid 43797355)
20. N Fuku KS Park Y Yamada, et al. 2007 Mitochondrial haplogroup N9a confers resistance against Type 2 diabetes in Asians Am J Hum Genet 80 407 415 17273962 10.1086/512202 1:CAS:528:DC%2BD2sXit1Wlu7s%3D (Pubitemid 46310973)
21. R Saxena PI de Bakker K Singer, et al. 2006 Comprehensive association testing of common mitochondrial DNA variation in metabolic disease Am J Hum Genet 79 54 61 16773565 10.1086/504926 1:CAS:528:DC%2BD28Xmt1ent74%3D (Pubitemid 43927376)
22. WB Kannel 2000 The Framingham Study: its 50-year legacy and future promise J Atheroscler Thromb 6 60 66 10872616 1:STN:280:DC%2BD3cvptl2lsw%3D%3D
23. M Beekman BT Heijmans NG Martin, et al. 2002 Heritabilities of apolipoprotein and lipid levels in three countries Twin Res 5 87 97 11931686 10.1375/1369052022956 (Pubitemid 34407936)
24. AD Liese HW Hense H Lowel A Doring M Tietze U Keil 1999 Association of serum uric acid with all-cause and cardiovascular disease mortality and incident myocardial infarction in the MONICA Augsburg cohort. World Health Organization Monitoring Trends and Determinants in Cardiovascular Diseases Epidemiology 10 391 397 10401873 10.1097/00001648-199907000-00009 1:STN:280:DyaK1MzivVejsg%3D%3D
25. RPS Middelberg SE Medland NG Martin JB Whitfield 2007 A longitudinal genetic study of uric acid and liver enzymes in adolescent twins Twin Res Hum Gen 10 757 764 10.1375/twin.10.5.757 (Pubitemid 47608010)
26. A Pompella M Emdin C Passino A Paolicchi 2004 The significance of serum gamma-glutamyltransferase in cardiovascular diseases Clin Chem Lab Med 42 1085 1091 15552264 10.1515/CCLM.2004.224 1:CAS:528:DC%2BD2cXpslOht7Y%3D (Pubitemid 39481146)
27. M Nannipieri C Gonzales S Baldi, et al. 2005 Liver enzymes, the metabolic syndrome, and incident diabetes: The Mexico City diabetes study Diabetes Care 28 1757 1762 15983331 10.2337/diacare.28.7.1757 1:CAS:528:DC%2BD2MXms12nurw%3D (Pubitemid 40923089)
28. DH Lee DR Jacob M Gross, et al. 2003 Gamma-glutamyltransferase is a predictor of incident diabetes and hypertension: the Coronary Artery Risk Development in Young Adults (CARDIA) Study Clin Chem 49 1358 1366 12881453 10.1373/49.8.1358 1:CAS:528:DC%2BD3sXlvF2ntrY%3D (Pubitemid 36900623)
29. MJ Wright NG Martin 2004 Brisbane Adolescent Twin Study: outline of study methods and research projects Aust J Psychol 56 65 78 10.1080/ 00049530410001734865 (Pubitemid 39216642)
30. G Zhu DL Duffy A Eldridge, et al. 1999 A major quantitative-trait locus for mole density is linked to the familial melanoma gene CDKN2A: a maximum-likelihood combined linkage and association analysis in twins and their sibs Am J Hum Genet 65 483 492 10417291 10.1086/302494 1:CAS:528: DyaK1MXlsFSgsrc%3D (Pubitemid 30463006)
31. G Zhu GW Montgomery MR James, et al. 2007 A genome-wide scan for naevus count: linkage to CDKN2A and to other chromosome regions Eur J Hum Genet 15 94 102 17063143 10.1038/sj.ejhg.5201729 1:CAS:528:DC%2BD28XhtlSqtbfJ (Pubitemid 44921672)
32. DL Duffy GW Montgomery W Chen, et al. 2007 A three-single-nucleotide polymorphism haplotype in intron 1 of OCA2 explains most human eye-color variation Am J Hum Genet 80 241 252 17236130 10.1086/510885 1:CAS:528: DC%2BD2sXhtlOju74%3D (Pubitemid 46175673)
33. AF McRae EM Byrne ZZ Zhao, et al. 2008 Power and SNP tagging in whole mitochondrial genome association studies Genome Res 18 911 917 18356315 10.1101/gr.074872.107 1:CAS:528:DC%2BD1cXnsVygsbw%3D (Pubitemid 351793063)
34. EM Byrne AF McRae ZZ Zhao, et al. 2008 The use of common mitochondrial variants to detect and characterise population structure in the Australian population: implications for genome-wide association studies Eur J Hum Genet 16 1396 1403 18612324 10.1038/ejhg.2008.117 1:CAS:528:DC%2BD1cXht1OntL%2FL
35. RPS Middelberg NG Martin JB Whitfield 2007 A longitudinal genetic study of plasma lipids in adolescent twins Twin Res Hum Genet 10 127 135 17539372 10.1375/twin.10.1.127 (Pubitemid 46423383)
36. DR Nyholt 2004 A simple correction for multiple testing for SNPs in linkage disequilibrium with each other Am J Hum Genet 74 765 769 14997420 10.1086/383251 1:CAS:528:DC%2BD2cXivFCntL0%3D (Pubitemid 38420107)
37. J Li L Ji 2005 Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix Heredity 95 221 227 16077740 10.1038/sj.hdy.6800717 1:CAS:528:DC%2BD2MXovVOns7w%3D (Pubitemid 43093236)
38. JM Cheverud 2001 A simple correction for multiple comparisons in interval mapping genome scans Heredity 87 52 58 11678987 10.1046/j.1365-2540.2001.00901. x 1:CAS:528:DC%2BD3MXotVWns7w%3D (Pubitemid 32974332)
39. BK Cornes G Zhu NG Martin 2007 Sex differences in genetic variation in weight: a longitudinal study of body mass index in adolescent twins Behav Genet 37 648 660 17896175 10.1007/s10519-007-9165-0 (Pubitemid 47536218)
40. EE Jazin L Cavelier I Eriksson L Oreland U Gyllensten 1996 Human brain contains high levels of heteroplasmy in the noncoding regions of mitochondrial DNA Proc Natl Acad Sci U S A 93 12382 12387 8901590 10.1073/pnas.93.22.12382 1:CAS:528:DyaK28Xms1Gjur0%3D (Pubitemid 26367152)
41. AK Detjen S Tinschert D Kaufmann, et al. 2007 Analysis of mitochondrial DNA in discordant monozygotic twins with neurofibromatosis type 1 Twin Res Hum Genet 10 486 495 17564507 10.1375/twin.10.3.486 (Pubitemid 46984006)
42. PF Chinnery C Mowbray SK Patel, et al. 2007 Mitochondrial DNA haplogroups and type 2 diabetes: a study of 897 cases and 1010 controls J Med Genet 44 e80 17551080 10.1136/jmg.2007.048876 1:STN:280:DC%2BD2szjvVKgsQ%3D%3D