Chronic progressive nephropathy (CPN) in the rat: Review of pathology and relationship to renal tumorigenesis

Journal of Toxicologic Pathology

Volumn 21, Issue 4, 2008, Pages 199-205

  Seely, John Curtis ^a   Hard, Gordon C ^b  

^a EXPERIMENTAL PATHOLOGY LABORATORIES INC   (United States)

^b NONE

Author keywords

Chronic progressive nephropathy; Kidney; Pathology; Rat; Risk assessment; Tumorigenesis

Indexed keywords

CHEMICAL AGENT; CYCLINE; DNA;

ATROPHY; CANCER RISK; CARCINOGENESIS; CELL PROLIFERATION; CHRONIC KIDNEY DISEASE; CHRONIC PROGRESSIVE NEPHROPATHY; DISEASE ASSOCIATION; DISEASE EXACERBATION; DISEASE SEVERITY; DNA REPLICATION; HISTOPATHOLOGY; HUMAN; HYPERPLASIA; KIDNEY ADENOMA; KIDNEY FAILURE; KIDNEY TUBULE DISORDER; KIDNEY TUMOR; NONHUMAN; RAT; RAT STRAIN; REVIEW;

EID: 70349805655     PISSN: 09149198     EISSN: None     Source Type: Journal    
DOI: 10.1293/tox.21.199     Document Type: Review

References (45)

1. Gray JE. Chronic progressive nephrosis in the albino rat. CRC Crit Rev Toxicol. 5: 115-144. 1977.
2. Barthold SW. Chronic progressive nephropathy. Rat In: Urinary System, 2nd ed. TC Jones, GC Hard and U Mohr (eds). Springer-Verlag, Berlin. 228-233. 1989.
3. Hard GC and Khan KN. A contemporary overview of chronic progressive nephropathy in the laboratory rat, and its significance for human risk assessment. Toxicol Pathol. 32: 171-180. 2004.
4. Goldstein RS, Tarloff JB and Hook JB. Age-related nephropathy in laboratory rats. FASEB. J2: 2241-2251. 1988.
5. Baylis C. Age-dependent glomerular changes in the rat. Dissociation between glomerular injury and both glomerular hypertension and hypertrophy. Male gender as a primary risk factor. J Clin Invest. 94: 1823-1829. 1994.
6. Gray JE, Van Zwieten MJ and Hollander CF. Early light microscopic changes in chronic progressive nephrosis in several strains of aging laboratory rats. J Gerontol. 27: 142-150. 1982.
7. Peter CP, Burek JD and van Zwieten MJ. Spontaneous nephropathies in rats. Toxicol Pathol. 14: 91-100. 1986.
8. Solleveld HA and Boorman GA. Spontaneous renal lesions in five rat strains. Toxicol Pathol. 14: 168-174. 1986.
9. Percy DH and Barthold SW. Pathology of Laboratory Rodents and Rabbits. Iowa State University Press, Ames. 149-151. 2001.
10. Palm M. The incidence of chronic progressive nephrosis in young Sprague-Dawley rats from two different breeders. Lab Anim. 32: 477-482. 1998.
11. Owen RA and Haywood R. Age-related variations in renal structure and function in Sprague-Dawley rats. Toxicol Pathol. 14: 158-167. 1986.
12. Abrass CK. The nature of chronic progressive nephropathy in aging rats. Adv Renal Replacement Therapy. 7: 4-10. 2000.
13. Rao GN. Diet and kidney diseases in rats. Toxicol Pathol. 30: 651-656. 2002.
14. Rao GN, Morris RW and Seely JC. Beneficial effects of NTP-2000 diet on growth, survival and kidney and heart diseases of Fischer 344 rats in chronic studies. Toxicol Sci. 63: 245-255. 2001.
15. Everitt AV, Porter BD and Barnard DJ. Effects of caloric intake and dietary composition on the development of proteinuria, age-associated renal disease and longevity in the male rat. Gerontology. 28: 168-175. 1982.
16. Masoro EJ, Iwasaki K, Gleiser CA, McMahan CA, Seo EJ, and Yu BP. Dietary modulation of the progression of nephropathy in aging rats: an evaluation of the importance of protein. Am J Clin Nutr. 49: 1217-1227. 1989.
17. Short BG and Goldstein RS. Nonneoplastic lesions in the kidney. In: Pathology of the Aging Rat. U Mohr, DL Dungworth, CC Capen (eds). ILSI Press, Washington, DC. 211-219. 1992.
18. Keenan KP, Coleman JB, McCoy CL, Hoe C-M, Soper KA and Laroque P. Chronic nephropathy in ad libitum overfed Sprague-Dawley rats and its early attenuation by increasing degrees of dietary (caloric) restriction to control growth. Toxicol Pathol. 28: 788-798. 2000.
19. Sworn MJ and Fox M. Renal age changes in the rat compared with human renal senescence. An autoradiographic study. Invest Urol. 12: 140-145. 1974.
20. Konishi N and Ward JM. Increased levels of DNA synthesis in hyperplastic renal tubules of aging nephropathy in female F344/NCA rats. Vet Pathol. 26: 6-10. 1989.
21. Short BG, Burnett VL and Swenberg JA. Elevated proliferation of proximal tubule cells and localization of accumulated alpha 2-microglobulin in F344 rats during chronic exposure to unleaded gasoline or 2,2,4-trimethylpentane. Toxicol Appl Pharmacol. 101: 414-431. 1989.
22. Hard GC and Seely JC. Recommendations for the interpretation of renal tubule proliferative lesions occurring in rat kidneys with advanced chronic progressive nephropathy (CPN). Toxicol Pathol. 33: 641-649. 2005.
23. Hard GC, Whysner J, English JC, Zang E and Williams GM. Relationship of hydroquinone-associated rat renal tumors with spontaneous chronic progressive nephropathy. Toxicol Pathol. 25: 132-143. 1997.
24. Hard GC. Significance of the renal effects of ethyl benzene in rodents for assessing human carcinogenic risk. Toxicol Sci. 69: 30-41. 2002.
25. Hard GC, Seely JC, Betz LJ and Hayashi S. Re-evaluation of the kidney tumors and renal histopathology occurring in a 2-year carcinogenicity bioassay of quercetin. Food Chem Toxicol. 45: 600-608. 2007.
26. Montgomery CA and Seely JC. Kidney. In: Pathology of the Fischer Rat. Reference and Atlas. GA Boorman, SL Eustis, MR Elwell, CA Montgomery and WF Mackenzie (eds). Academic Press, San Diego. 127-153. 1990.
27. Greaves P. Urinary tract. In: Histopathology of Preclinical Toxicity Studies. (3rd ed). Elsevier, Amsterdam. 581-584. 2007.
28. Thudium D, Adams D, Sellers T, Rehm S, Ennulat D and Schwartz L. Urinary albumin as a sensitive marker for nephropathy in aged male rats. Vet Pathol. 38: 571. 2001.
29. Gray JE, Weaver RM and Purmalis A. Ultrastructural observations of chronic progressive nephrosis in the Sprague-Dawley rat. Vet Pathol. 11: 153-164. 1974.
30. Nakatsuji S, Yamate J and Sakuma S. Relationship between vimentin expressing renal tubules and interstitial fibrosis in chronic progressive nephropathy in aged rats. Virchows Arch. 433: 359-367. 1998.
31. Nakatsuji S, Yamate J and Sakuma S. Macrophages, myofibroblasts, and extracellular matrix accumulation in interstitial fibrosis of chronic progressive nephropathy in aged rats. Vet Pathol. 35: 352-360. 1998.
32. Ward JM and Reznik-Schuller H. Morphological and histochemical characteristics of pigments in aging F344 rats. Vet Pathol. 17: 678-685. 1980.
33. Hard GC, Alden CL, Stula EF and Trump BF. Proliferative lesions of the kidney in rats. In: Guides for Toxicologic Pathology. STP/ARP/AFIP, Washington, DC. 1995.
34. Hardisty JF. Personal communication. 2007.
35. Hard, GC. Mechanisms of chemically induced renal carcinogenesis in the laboratory rodent. Toxicol Pathol. 26: 104-112. 1998.
36. Hard GC and Seely JC. Histological investigation of diagnostically challenging tubule profiles in advanced chronic progressive nephropathy (CPN) in the Fischer 344 rat. Toxicol Pathol. 34: 941-948. 2006.
37. Lipsky MM and Trump BF. Chemically induced renal epithelial neoplasia in experimental animals. Int Rev Exp Pathol. 30: 357-383. 1988.
38. Dietrich DR and Swenberg JA. Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents: predictive nature and comparison of lesions induced by genotoxic carcinogens. Mutation Res. 248: 239-260. 1991.
39. Anver MR, Cohen BJ, Lattuada CSP and Foster SJ. Age-associated lesions in barrier-reared male Sprague-Dawley rats: A comparison between Hap: (SD) and Cal:COBS® SD stocks. Exp Aging Res. 8: 3-24. 1982.
40. Seely JC, Haseman JK, Nyska A, Wolf DC, Everitt JI and Hailey JR. The effect of chronic progressive nephropathy on the incidence of renal tubule cell neoplasms in control male F344 rats. Toxicol Pathol. 30: 681-686. 2002.
41. Khan KNM and Alden CL. Kidney. In: Handbook of Toxicologic Pathology, 2nd ed. WM Hascheck, CG Rousseaux and MA Walling (eds). Academic Press, San Diego, 255-335. 2002.
42. Tomatis L. Cell proliferation and carcinogenesis. A brief history and current view based on IARC Workshop report. Environ Healh Perspect. 100 (Suppl.5): 149-152. 1993.
43. Cohen SM. Role of cell proliferation in regenerative and neoplastic disease. Toxicol Letter. 82/83: 15-21. 1995.
44. Ward JM. The two-year rodent carcinogenesis bioassay- will it survive. J Toxicol Pathol. 20: 13-19. 2007.
45. Meek ME, Bucher JR, Cohen SM, Dellarco V, Hill RN, Lehman-Mckeeman LD, Longfellow DG, Pastoor T, Seed J and Patton DE. A framework for human relevance analysis of information on carcinogenic modes of action. Crit Rev Toxicol. 33: 591-653. 2003.