The soluble transferrin receptor (TfR)-F-Index is not applicable as a test for iron status in patients with chronic lymphocytic leukemia

Clinical Chemistry and Laboratory Medicine

Volumn 47, Issue 10, 2009, Pages 1291-1295

  Metzgeroth, Georgia ^a   Kripp, Melanie ^a   Müller, Nadine ^a   Schultheis, Beate ^a   Bonatz, Karin ^a   Walz, Christoph ^a   Dorn Beineke, Alexandra ^a   Hastka, Jan ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Chronic lymphocytic leukemia; Soluble transferrin receptor; STfR log ferritin ratio index

Indexed keywords

C REACTIVE PROTEIN; FERRITIN; FLUDARABINE; IRON; TRANSFERRIN RECEPTOR;

ADULT; AGED; ANEMIA; ARTICLE; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST; DIAGNOSTIC VALUE; DISEASE CLASSIFICATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE CYCLE TREATMENT; NEPHELOMETRY; PRIORITY JOURNAL; SCREENING TEST; TREATMENT DURATION; TREATMENT OUTCOME; TUMOR LOCALIZATION; TUMOR REGRESSION; TUMOR VOLUME;

ADULT; AGED; AGED, 80 AND OVER; C-REACTIVE PROTEIN; FEMALE; FERRITINS; HUMANS; IRON; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; MALE; MIDDLE AGED; RECEPTORS, TRANSFERRIN; SOLUBILITY; TUMOR BURDEN;

EID: 70349798891     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2009.273     Document Type: Article

References (16)

1. Birgegard G, Aapro MS, Bokemeyer C, Dicato M, Drings P, Hornedo J, et al. Cancer-related anemia: pathogenesis, prevalence and treatment. Oncology 2005;68:3-11.
2. Cook JD, Skikne BS, Baynes RD. Serum transferrin receptor. Annu Rev Med 1993;44:63-74.
3. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor and its ratio to serum ferritin in the diagnosis of iron deficiency. Blood 1997;89:1052-1057
4. Thomas C, Thomas L. Biochemical markers and hematologic indices in the diagnosis of functional iron deficiency. Clin Chem 2002;48:1066-1076
5. Hastka J, Lasserre JJ, Schwarzbeck A, Hehlmann R. Central role of zinc protoporphyrin in staging iron deficiency. Clin Chem 1994;40:768-773
6. Cook JD. Iron-deficiency anaemia. Baillieres Clin Haematol 1994;7:787-804.
7. Punnonen K, Irjala K, Rajamaki A. Iron-deficiency anemia is associated with high concentrations of transferrin receptor in serum. Clin Chem 1994;40:774-776
8. Beguin Y. Soluble transferrin receptor for the evaluation of erythropoiesis and iron status. Clin Chim Acta 2003; 329:9-22.
9. Metzgeroth G, Schultheis B, Kuhn C, Dorn-Beineke A, LaRosee P, Hehlmann R, et al. The soluble transferrin receptor reflects tumor load in chronic lymphocytic leukemia. Clin Chem Lab Med 2007;45:1313-1318
10. Lee EJ, Oh EJ, Park YJ, Lee KH, Kim BK. Soluble transferrin receptor (sTfR), ferritin, and sTfR/log ferritin index in anemic patients with non-hematologic malignancy and chronic inflammation. Clin Chem 2002;48:1118-1121
11. Punnonen K, Irjala K, Rajamaki A. Serum transferrin receptor, ferritin and TfR-F index in identification of latent iron deficiency. Eur J Haematol 1998;60:135-137
12. Suominen P, Punnonen K, Rajamaki A, Irjala K. Serum transferrin receptor and transferrin receptor-ferritin index identify healthy subjects with subclinical iron deficits. Blood 1998;92:2934-2939
13. Suominen P, Mottonen T, Rajamaki A, Irjala K. Single values of serum transferrin receptor and transferrin receptor ferritin index can be used to detect true and functional iron deficiency in rheumatoid arthritis patients with anemia. Arthritis Rheum 2000;43:1016-1020
14. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brien S, et al. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996;87:4990-4997
15. Binet JL, Lepoprier M, Dighiero G, Charron D, d'Athis P, Vaugier G, et al. A clinical staging system for chronic lymphocytic leukemia: prognostic significance. Cancer 1977;40:855-864
16. Metzgeroth G, Adelberger V, Dorn-Beineke A, Kuhn C, Schatz M, Maywald O, et al. Soluble transferrin receptor and zinc protoporphyrin - competitors or efficient partners? Eur J Haematol 2005;75:309-317